The network for 'negative regulation of blood pressure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of blood pressure

Any process in which the force of blood traveling through the circulatory system is decreased.

NameDescriptionProbabilityFunc Analog Organism
C1QAcomplement component 1, q subcomponent, A chain0.993
ADORA2Aadenosine A2a receptor0.923
HBBhemoglobin, beta0.907
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.850
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.749
ENGendoglin0.709
C1QCcomplement component 1, q subcomponent, C chain0.680
BMP2bone morphogenetic protein 20.604
HBG2hemoglobin, gamma G0.580
NCOR2nuclear receptor corepressor 20.563
TGFB3transforming growth factor, beta 30.537
PLCG1phospholipase C, gamma 10.512
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.467
C1QBcomplement component 1, q subcomponent, B chain0.395
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.331
GDF5growth differentiation factor 50.324
VAC14Vac14 homolog (S. cerevisiae)0.300
EXOC7exocyst complex component 70.241
PRKG1protein kinase, cGMP-dependent, type I0.236
BBS2Bardet-Biedl syndrome 20.229
CRHR1corticotropin releasing hormone receptor 10.203
TGFB1transforming growth factor, beta 10.191
SMAD7SMAD family member 70.172
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.158
FKBP1AFK506 binding protein 1A, 12kDa0.156
BMPR1Abone morphogenetic protein receptor, type IA0.153
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.146
ZMYND11zinc finger, MYND-type containing 110.143
ARRDC3arrestin domain containing 30.141
BBS1Bardet-Biedl syndrome 10.118
ACVR1activin A receptor, type I0.104
PRNPprion protein0.103
ARNTaryl hydrocarbon receptor nuclear translocator0.101
BBS9Bardet-Biedl syndrome 90.094
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.093
SMURF2SMAD specific E3 ubiquitin protein ligase 20.091
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.087
NRP1neuropilin 10.087
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.081
ACVR1Bactivin A receptor, type IB0.080
TIMP3TIMP metallopeptidase inhibitor 30.080
DUSP6dual specificity phosphatase 60.077
WNK1WNK lysine deficient protein kinase 10.077
TTC8tetratricopeptide repeat domain 80.065
RXRAretinoid X receptor, alpha0.062
FSTL1follistatin-like 10.062
BBS7Bardet-Biedl syndrome 70.058
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.052
HBA2hemoglobin, alpha 20.051
NCOA7nuclear receptor coactivator 70.051
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.049
AVPR2arginine vasopressin receptor 20.048
CUX1cut-like homeobox 10.048
HBE1hemoglobin, epsilon 10.047
NCOA6nuclear receptor coactivator 60.046
MAPK8mitogen-activated protein kinase 80.046
HBDhemoglobin, delta0.044
GAB2GRB2-associated binding protein 20.044
USP15ubiquitin specific peptidase 150.043
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.043
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.042
VEGFAvascular endothelial growth factor A0.042
RIPK2receptor-interacting serine-threonine kinase 20.040
CHD9chromodomain helicase DNA binding protein 90.039
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.038
RB1retinoblastoma 10.037
TKTtransketolase0.036
SLC2A4solute carrier family 2 (facilitated glucose transporter), member 40.036
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.036
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.034
MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)0.034
PTPN1protein tyrosine phosphatase, non-receptor type 10.034
SKILSKI-like oncogene0.033
PURApurine-rich element binding protein A0.032
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.032
DUSP5dual specificity phosphatase 50.032
BMP4bone morphogenetic protein 40.032
ARL6ADP-ribosylation factor-like 60.031
BHLHE23basic helix-loop-helix family, member e230.031
SLCO2B1solute carrier organic anion transporter family, member 2B10.031
NDFIP2Nedd4 family interacting protein 20.030
ALDOBaldolase B, fructose-bisphosphate0.030
CXCL3chemokine (C-X-C motif) ligand 30.029
HSCBHscB iron-sulfur cluster co-chaperone homolog (E. coli)0.028
CXCL2chemokine (C-X-C motif) ligand 20.027
RAMP2receptor (G protein-coupled) activity modifying protein 20.027
ANTXR2anthrax toxin receptor 20.027
GATAD2BGATA zinc finger domain containing 2B0.027
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.026
PAX7paired box 70.026
NCOR1nuclear receptor corepressor 10.026
GLB1galactosidase, beta 10.026
HIPK3homeodomain interacting protein kinase 30.026
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.025
PYYpeptide YY0.025
PGRprogesterone receptor0.025
CHRNA4cholinergic receptor, nicotinic, alpha 40.025
BMP8Abone morphogenetic protein 8a0.025
SMAD2SMAD family member 20.025
E2F2E2F transcription factor 20.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.948
Ren1renin 1 structural0.802
Ghrgrowth hormone receptor0.762
Drd2dopamine receptor D20.705
Klklotho0.560
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.541
Crhr1corticotropin releasing hormone receptor 10.499
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.480
Pnpla2patatin-like phospholipase domain containing 20.441
Cckbrcholecystokinin B receptor0.421
Slc12a1solute carrier family 12, member 10.397
Nos1nitric oxide synthase 1, neuronal0.356
Agtr1aangiotensin II receptor, type 1a0.347
Npy1rneuropeptide Y receptor Y10.257
Plauplasminogen activator, urokinase0.248
Nr3c1nuclear receptor subfamily 3, group C, member 10.242
Bbs2Bardet-Biedl syndrome 2 (human)0.241
Ppargperoxisome proliferator activated receptor gamma0.236
Arandrogen receptor0.228
Cav1caveolin 1, caveolae protein0.215
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.209
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.206
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.201
Insrinsulin receptor0.192
Npy2rneuropeptide Y receptor Y20.181
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.175
Mas1MAS1 oncogene0.172
Chrm1cholinergic receptor, muscarinic 1, CNS0.154
Hrh1histamine receptor H10.153
Esr1estrogen receptor 1 (alpha)0.141
Pgrprogesterone receptor0.141
Sstr4somatostatin receptor 40.139
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.135
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.135
Sstr3somatostatin receptor 30.131
Cnr1cannabinoid receptor 1 (brain)0.128
Nos2nitric oxide synthase 2, inducible0.128
Grid1glutamate receptor, ionotropic, delta 10.124
Lepleptin0.116
Sstr1somatostatin receptor 10.112
Mogmyelin oligodendrocyte glycoprotein0.108
Tcf7l2transcription factor 7-like 2, T-cell specific, HMG-box0.105
Adra2badrenergic receptor, alpha 2b0.100
Gpr27G protein-coupled receptor 270.098
Adrb1adrenergic receptor, beta 10.097
Cyldcylindromatosis (turban tumor syndrome)0.094
Rac1RAS-related C3 botulinum substrate 10.093
Ddah1dimethylarginine dimethylaminohydrolase 10.092
Aqp2aquaporin 20.090
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.088
ND6NADH dehydrogenase subunit 60.087
Ptgs2prostaglandin-endoperoxide synthase 20.086
Htr45 hydroxytryptamine (serotonin) receptor 40.085
Pomcpro-opiomelanocortin-alpha0.084
Bbs1Bardet-Biedl syndrome 1 (human)0.084
Tacr1tachykinin receptor 10.083
Oprm1opioid receptor, mu 10.080
Umoduromodulin0.079
Krt86keratin 860.079
Adora2aadenosine A2a receptor0.076
Ikzf4IKAROS family zinc finger 40.074
Neurod2neurogenic differentiation 20.073
Smad7MAD homolog 7 (Drosophila)0.071
Bhlhe40basic helix-loop-helix family, member e400.069
Adrb2adrenergic receptor, beta 20.069
Fzd4frizzled homolog 4 (Drosophila)0.069
Oprd1opioid receptor, delta 10.067
Cacna1ecalcium channel, voltage-dependent, R type, alpha 1E subunit0.066
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.066
Bglapbone gamma carboxyglutamate protein0.062
Lhx6LIM homeobox protein 60.061
Acracrosin prepropeptide0.061
Agtr2angiotensin II receptor, type 20.060
Kcns2K+ voltage-gated channel, subfamily S, 20.060
Tmem64transmembrane protein 640.060
Kcnk3potassium channel, subfamily K, member 30.059
Slc22a12solute carrier family 22 (organic anion/cation transporter), member 120.059
Htr75-hydroxytryptamine (serotonin) receptor 70.058
Adra2cadrenergic receptor, alpha 2c0.057
Adra1badrenergic receptor, alpha 1b0.057
Epha8Eph receptor A80.057
Tgfb1transforming growth factor, beta 10.057
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.055
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.055
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.054
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.052
Cdkn1bcyclin-dependent kinase inhibitor 1B0.052
Adipoqadiponectin, C1Q and collagen domain containing0.052
Ccl2chemokine (C-C motif) ligand 20.052
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.051
Wnt7awingless-related MMTV integration site 7A0.050
Alx3aristaless-like homeobox 30.050
Snta1syntrophin, acidic 10.050
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.049
Inhbcinhibin beta-C0.049
Mc5rmelanocortin 5 receptor0.049
Foxd2forkhead box D20.048
Col4a4collagen, type IV, alpha 40.047
Clcnkachloride channel Ka0.047
Olfr71olfactory receptor 710.047
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Alas2aminolevulinate, delta-, synthase 20.414
Hbbhemoglobin, beta0.210
LOC689064beta-globin0.072
LOC100134871beta globin minor gene0.066
Pipprolactin induced protein0.055
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.047
Rgs14regulator of G-protein signaling 140.047
Olr1500olfactory receptor 15000.042
Hbb-b1hemoglobin, beta adult major chain0.042
LOC60591calcium-activated potassium channel beta subunit0.042
Tpbpatrophoblast specific protein alpha0.037
Cmklr1chemokine-like receptor 10.036
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.036
Il1rninterleukin 1 receptor antagonist0.032
Mmp9matrix metallopeptidase 90.032
Foxi2forkhead box I20.032
Glp1rglucagon-like peptide 1 receptor0.029
Lifleukemia inhibitory factor0.029
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.028
Ednraendothelin receptor type A0.028
Galgalanin prepropeptide0.026
Ppypancreatic polypeptide0.026
Cxcr5chemokine (C-X-C motif) receptor 50.026
Dio3deiodinase, iodothyronine, type III0.025
Magmyelin-associated glycoprotein0.025
Tbx2T-box 20.025
Lim2lens intrinsic membrane protein 20.024
Ompolfactory marker protein0.023
Il13interleukin 130.023
Aqp2aquaporin 2 (collecting duct)0.022
Ptafrplatelet-activating factor receptor0.022
Padi1peptidyl arginine deiminase, type I0.021
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.021
Sgp158proline-rich glycoprotein (sgp158)0.020
Prlhprolactin releasing hormone0.019
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.019
Crybb1crystallin, beta B10.019
Fgf17fibroblast growth factor 170.019
Sisucrase-isomaltase (alpha-glucosidase)0.019
Tacr2tachykinin receptor 20.019
Prp15proline-rich protein 150.018
Ush1cUsher syndrome 1C homolog (human)0.018
Gastgastrin0.018
Itgamintegrin, alpha M0.018
Acot12acyl-CoA thioesterase 120.018
Cpb1carboxypeptidase B1 (tissue)0.018
Iappislet amyloid polypeptide0.018
Gfra1GDNF family receptor alpha 10.018
Rgs9regulator of G-protein signaling 90.018
Nlrp6NLR family, pyrin domain containing 60.017
Pdk4pyruvate dehydrogenase kinase, isozyme 40.017
Selpselectin P0.017
Avpr2arginine vasopressin receptor 20.017
Irf2interferon regulatory factor 20.017
Il1r1interleukin 1 receptor, type I0.017
Cgaglycoprotein hormones, alpha polypeptide0.017
RorbRAR-related orphan receptor B0.017
S1pr2sphingosine-1-phosphate receptor 20.017
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.016
Fam70bfamily with sequence similarity 70, member B0.016
Prg2proteoglycan 2, bone marrow0.016
Syt6synaptotagmin VI0.016
Grm6glutamate receptor, metabotropic 60.016
Vom2r53vomeronasal 2 receptor, 530.016
Ifna1interferon-alpha 10.016
Prss3protease, serine, 30.016
Flt1FMS-related tyrosine kinase 10.015
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.015
Tac2tachykinin 20.015
Il8rainterleukin 8 receptor, alpha0.015
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.015
Drd2dopamine receptor D20.015
Egfl7EGF-like-domain, multiple 70.015
Hoxa2homeo box A20.015
Tff1trefoil factor 10.014
Lpllipoprotein lipase0.014
GperG protein-coupled estrogen receptor 10.014
Olr1361olfactory receptor 13610.014
Cd52CD52 antigen0.014
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.014
Drd1adopamine receptor D1A0.014
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.014
Cryba4crystallin, beta A40.014
C1qtnf6C1q and tumor necrosis factor related protein 60.014
Ctrcchymotrypsin C (caldecrin)0.014
Pitx3paired-like homeodomain 30.014
Prl8a2prolactin family 8, subfamily a, member 20.014
Chrna6cholinergic receptor, nicotinic, alpha 60.014
Ube2d4ubiquitin-conjugating enzyme E2D 40.014
Hk2hexokinase 20.014
Nrg1neuregulin 10.013
Smad3SMAD family member 30.013
Pparaperoxisome proliferator activated receptor alpha0.013
Trhr2thyrotropin releasing hormone receptor 20.013
RhdRh blood group, D antigen0.013
Sox17SRY (sex determining region Y)-box 170.013
Aspgasparaginase homolog (S. cerevisiae)0.013
Ngfnerve growth factor (beta polypeptide)0.012
Gja4gap junction protein, alpha 40.012
Syt8synaptotagmin VIII0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism