The network for 'vasculature development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.

NameDescriptionProbabilityFunc Analog Organism
CREBBPCREB binding protein1.000
EGFRepidermal growth factor receptor1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
SMAD2SMAD family member 20.999
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.997
VEGFAvascular endothelial growth factor A0.997
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.996
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.995
YAP1Yes-associated protein 10.994
THBS1thrombospondin 10.992
EP300E1A binding protein p3000.992
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.990
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.983
JAG1jagged 10.980
NOTCH1notch 10.977
NRP1neuropilin 10.977
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.976
ARandrogen receptor0.976
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.976
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.974
NR4A1nuclear receptor subfamily 4, group A, member 10.971
FN1fibronectin 10.971
FGFR2fibroblast growth factor receptor 20.965
CTGFconnective tissue growth factor0.965
NOTCH3notch 30.962
FGFR1fibroblast growth factor receptor 10.959
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.955
FASFas (TNF receptor superfamily, member 6)0.952
EGR1early growth response 10.945
CDH5cadherin 5, type 2 (vascular endothelium)0.943
ACTBactin, beta0.940
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.938
CAV1caveolin 1, caveolae protein, 22kDa0.934
SMAD1SMAD family member 10.927
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.926
SMAD3SMAD family member 30.923
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.920
PMLpromyelocytic leukemia0.917
FOSFBJ murine osteosarcoma viral oncogene homolog0.916
PAX3paired box 30.913
COL4A1collagen, type IV, alpha 10.907
SIRT1sirtuin 10.907
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.906
TEKTEK tyrosine kinase, endothelial0.905
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.901
FHL2four and a half LIM domains 20.895
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.890
COL4A2collagen, type IV, alpha 20.887
COL1A2collagen, type I, alpha 20.872
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.872
HOXB5homeobox B50.854
COL1A1collagen, type I, alpha 10.853
CALD1caldesmon 10.853
TIMP2TIMP metallopeptidase inhibitor 20.848
IL8interleukin 80.843
MEF2Cmyocyte enhancer factor 2C0.836
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.826
CTNND1catenin (cadherin-associated protein), delta 10.825
TIMP3TIMP metallopeptidase inhibitor 30.815
PDX1pancreatic and duodenal homeobox 10.813
PLAURplasminogen activator, urokinase receptor0.804
COL2A1collagen, type II, alpha 10.801
CAV2caveolin 20.799
DUSP1dual specificity phosphatase 10.799
JUNjun proto-oncogene0.797
RAMP2receptor (G protein-coupled) activity modifying protein 20.774
SMAD7SMAD family member 70.769
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.763
SKILSKI-like oncogene0.756
RUNX1runt-related transcription factor 10.756
RASSF5Ras association (RalGDS/AF-6) domain family member 50.743
CD34CD34 molecule0.733
RGS2regulator of G-protein signaling 2, 24kDa0.733
TGFBItransforming growth factor, beta-induced, 68kDa0.733
FOXF1forkhead box F10.727
COL5A1collagen, type V, alpha 10.727
CASP8caspase 8, apoptosis-related cysteine peptidase0.726
IL2RBinterleukin 2 receptor, beta0.722
TJP1tight junction protein 1 (zona occludens 1)0.720
TCF4transcription factor 40.717
MYOD1myogenic differentiation 10.709
HOXA10homeobox A100.709
IER3immediate early response 30.707
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.705
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.701
CXCL2chemokine (C-X-C motif) ligand 20.698
GJA1gap junction protein, alpha 1, 43kDa0.696
TBX2T-box 20.694
EPAS1endothelial PAS domain protein 10.694
SMAD6SMAD family member 60.694
PHLDA1pleckstrin homology-like domain, family A, member 10.690
TAL1T-cell acute lymphocytic leukemia 10.683
PLAUplasminogen activator, urokinase0.676
KLF4Kruppel-like factor 4 (gut)0.675
MDM2Mdm2 p53 binding protein homolog (mouse)0.673
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.668
COL3A1collagen, type III, alpha 10.654
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.999
gata2aGATA-binding protein 2a0.997
notch3notch homolog 30.995
dll4delta-like 4 (Drosophila)0.994
tal1T-cell acute lymphocytic leukemia 10.993
efnb2aephrin B2a0.993
ccm2cerebral cavernous malformation 20.990
nrp1aneuropilin 1a0.988
cdh5cadherin 50.986
edn1endothelin 10.985
fli1afriend leukemia integration 1a0.985
tbx1T-box 10.984
mibmind bomb0.984
alcamaactivated leukocyte cell adhesion molecule a0.971
traf4atnf receptor-associated factor 4a0.960
flt4fms-related tyrosine kinase 40.955
aldh1a2aldehyde dehydrogenase 1 family, member A20.949
foxc1aforkhead box C1a0.946
fn1fibronectin 10.946
cxcr4achemokine (C-X-C motif) receptor 4a0.940
vegfcvascular endothelial growth factor c0.940
etv2ets variant gene 20.939
runx1runt-related transcription factor 10.935
plcg1phospholipase C, gamma 10.932
tie2endothelium-specific receptor tyrosine kinase 20.923
cdx4caudal type homeo box transcription factor 40.921
rargbretinoic acid receptor, gamma b0.917
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.916
mpxmyeloid-specific peroxidase0.914
nrp2bneuropilin 2b0.896
dag1dystroglycan 10.894
tp53tumor protein p530.892
nrarpanotch-regulated ankyrin repeat protein a0.891
krit1KRIT1, ankyrin repeat containing0.891
tbx20T-box 200.888
sox7SRY-box containing gene 70.882
mtpmicrosomal triglyceride transfer protein0.872
her9hairy-related 90.860
meis1myeloid ecotropic viral integration 10.858
jag2jagged 20.857
arnt2aryl hydrocarbon receptor nuclear translocator 20.852
sox9bSRY-box containing gene 9b0.845
fabp11afatty acid binding protein 11a0.844
robo4roundabout homolog 40.842
sox2SRY-box containing gene 20.836
fbn2bfibrillin 2b0.827
plxnd1plexin D10.824
igf1insulin-like growth factor 10.813
gli2aGLI-Kruppel family member GLI2a0.808
myf5myogenic factor 50.805
fgfr4fibroblast growth factor receptor 40.800
ptgs1prostaglandin-endoperoxide synthase 10.797
alcambactivated leukocyte cell adhesion molecule b0.794
vegfaavascular endothelial growth factor Aa0.792
col1a2collagen, type I, alpha 20.787
aplnraapelin receptor a0.786
sarsseryl-tRNA synthetase0.784
cyp1acytochrome P450, family 1, subfamily A0.784
bmp2bbone morphogenetic protein 2b0.783
gata1aGATA binding protein 1a0.779
shhasonic hedgehog a0.777
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.774
col12a1collagen, type XII, alpha 10.771
fgfrl1afibroblast growth factor receptor-like 1a0.763
birc2baculoviral IAP repeat-containing 20.762
notch1bnotch homolog 1b0.761
gng2guanine nucleotide binding protein (G protein), gamma 20.760
pak2ap21 (CDKN1A)-activated kinase 2a0.752
nr2f2nuclear receptor subfamily 2, group F, member 20.749
mmp2matrix metalloproteinase 20.744
s1pr2sphingosine-1-phosphate receptor 20.744
rargaretinoic acid receptor gamma a0.738
lamb1alaminin, beta 1a0.738
hspg2heparan sulfate proteoglycan 20.732
fgfrl1bfibroblast growth factor receptor-like 1b0.724
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.722
hey1hairy/enhancer-of-split related with YRPW motif 10.714
vaspvasodilator-stimulated phosphoprotein0.712
dab2disabled homolog 2 (Drosophila)0.707
sema3fasemaphorin 3fa0.699
sox32SRY-box containing gene 320.694
her7hairy and enhancer of split related-70.693
tbx2aT-box gene 2a0.691
unc5bunc-5 homolog B (C. elegans)0.688
ahr2aryl hydrocarbon receptor 20.678
fgfr2fibroblast growth factor receptor 20.675
evx1even-skipped homeobox 10.662
pea3ETS-domain transcription factor pea30.660
fli1bfriend leukemia integration 1b0.660
rxrabretinoid x receptor, alpha b0.659
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl2chemokine (C-C motif) ligand 20.824
FosFBJ osteosarcoma oncogene0.440
Rhojras homolog gene family, member J0.418
Igfbp5insulin-like growth factor binding protein 50.383
Col1a2collagen, type I, alpha 20.376
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.333
Ccl4chemokine (C-C motif) ligand 40.326
Fgfr2fibroblast growth factor receptor 20.302
Il1binterleukin 1 beta0.292
Edn1endothelin 10.290
Trim47tripartite motif-containing 470.270
Nfibnuclear factor I/B0.267
Zfp36l1zinc finger protein 36, C3H type-like 10.246
Dusp1dual specificity phosphatase 10.234
Col1a1collagen, type I, alpha 10.230
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.225
Nr4a3nuclear receptor subfamily 4, group A, member 30.210
Cpxm2carboxypeptidase X (M14 family), member 20.204
Sellselectin L0.202
Fgfr1Fibroblast growth factor receptor 10.200
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.186
Col5a3collagen, type V, alpha 30.186
Fstl1follistatin-like 10.185
Ednrbendothelin receptor type B0.185
Col5a1collagen, type V, alpha 10.183
MdficMyoD family inhibitor domain containing0.183
Calcrlcalcitonin receptor-like0.182
Id3inhibitor of DNA binding 30.181
Acvrl1activin A receptor type II-like 10.180
Mbl1mannose-binding lectin (protein A) 10.168
Trib1tribbles homolog 1 (Drosophila)0.160
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.159
Prok2prokineticin 20.153
Mmp10matrix metallopeptidase 100.151
RGD1564327similar to integrin alpha 80.151
Ccr5chemokine (C-C motif) receptor 50.148
Gulogulonolactone (L-) oxidase0.146
Egfl7EGF-like-domain, multiple 70.143
Egr2early growth response 20.142
Il1r1interleukin 1 receptor, type I0.142
Mmp9matrix metallopeptidase 90.138
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.138
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.136
Col12a1collagen, type XII, alpha 10.134
Jak1Janus kinase 10.131
Col4a1collagen, type IV, alpha 10.131
Il8rbinterleukin 8 receptor, beta0.131
Csf1colony stimulating factor 1 (macrophage)0.130
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.128
Col5a2collagen, type V, alpha 20.127
Fkbp1aFK506 binding protein 1a0.125
Cmklr1chemokine-like receptor 10.125
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.125
Arhgef15Rho guanine nucleotide exchange factor (GEF) 150.125
Has2hyaluronan synthase 20.123
Wisp1WNT1 inducible signaling pathway protein 10.121
Adam7ADAM metallopeptidase domain 70.119
Elk3ELK3, ETS-domain protein0.118
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.117
Cd200r1CD200 receptor 10.115
Htr65-hydroxytryptamine (serotonin) receptor 60.114
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.113
Anxa4annexin A40.113
Ncr1natural cytotoxicity triggering receptor 10.107
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.106
Apohapolipoprotein H (beta-2-glycoprotein I)0.105
Hspa1aheat shock 70kD protein 1A0.105
Mmp3matrix metallopeptidase 30.104
Flt1FMS-related tyrosine kinase 10.104
Crisp1cysteine-rich secretory protein 10.097
Pld2phospholipase D20.095
S100a8S100 calcium binding protein A80.095
Wwtr1WW domain containing transcription regulator 10.095
Bglapbone gamma-carboxyglutamate (gla) protein0.093
Neurl3neuralized homolog 3 (Drosophila)0.092
Aebp1AE binding protein 10.092
F13a1coagulation factor XIII, A1 polypeptide0.092
Stip1stress-induced phosphoprotein 10.092
Elf1E74-like factor 10.091
Mmp2matrix metallopeptidase 20.091
Plauplasminogen activator, urokinase0.091
Lamc1laminin, gamma 10.091
Galgalanin prepropeptide0.090
Twist2twist homolog 2 (Drosophila)0.089
Sgk1serum/glucocorticoid regulated kinase 10.088
Spata19spermatogenesis associated 190.088
Tgfb3transforming growth factor, beta 30.087
Ccl3chemokine (C-C motif) ligand 30.087
P2ry12purinergic receptor P2Y, G-protein coupled, 120.087
Sox17SRY (sex determining region Y)-box 170.086
Dab2disabled homolog 2 (Drosophila)0.084
Bcl2B-cell CLL/lymphoma 20.083
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism