The network for 'regulation of dna dependent dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of dna dependent dna replication

Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

NameDescriptionProbabilityFunc Analog Organism
CDK2cyclin-dependent kinase 20.744
RAD21RAD21 homolog (S. pombe)0.602
E2F7E2F transcription factor 70.438
SMC1Astructural maintenance of chromosomes 1A0.423
NBNnibrin0.405
STAG2stromal antigen 20.330
MCM7minichromosome maintenance complex component 70.287
PDS5BPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.217
E2F8E2F transcription factor 80.203
YY1YY1 transcription factor0.195
RPA1replication protein A1, 70kDa0.169
BMPR1Abone morphogenetic protein receptor, type IA0.142
BLMBloom syndrome, RecQ helicase-like0.136
TOPBP1topoisomerase (DNA) II binding protein 10.135
WAPALwings apart-like homolog (Drosophila)0.129
SMC3structural maintenance of chromosomes 30.107
FANCD2Fanconi anemia, complementation group D20.098
RAD50RAD50 homolog (S. cerevisiae)0.097
CPNE6copine VI (neuronal)0.073
CCNE1cyclin E10.072
STAG1stromal antigen 10.070
ORC1origin recognition complex, subunit 10.065
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.062
ANAPC7anaphase promoting complex subunit 70.060
MRFAP1Morf4 family associated protein 10.060
RBBP4retinoblastoma binding protein 40.053
ARRB1arrestin, beta 10.046
PDS5APDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)0.042
BMPR1Bbone morphogenetic protein receptor, type IB0.041
ACTL6Aactin-like 6A0.038
CHEK1CHK1 checkpoint homolog (S. pombe)0.033
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.032
BRCA2breast cancer 2, early onset0.031
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.030
MDC1mediator of DNA-damage checkpoint 10.028
JUNjun proto-oncogene0.027
HDAC1histone deacetylase 10.027
H2AFXH2A histone family, member X0.026
CDC6cell division cycle 6 homolog (S. cerevisiae)0.026
SSU72SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)0.026
CNOT1CCR4-NOT transcription complex, subunit 10.026
SKP2S-phase kinase-associated protein 2 (p45)0.024
UHRF2ubiquitin-like with PHD and ring finger domains 20.024
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.024
ATMataxia telangiectasia mutated0.023
NOGnoggin0.022
ATF2activating transcription factor 20.022
E2F1E2F transcription factor 10.022
MCM6minichromosome maintenance complex component 60.020
RBBP7retinoblastoma binding protein 70.020
CNOT2CCR4-NOT transcription complex, subunit 20.020
KRTAP4-12keratin associated protein 4-120.019
RBL1retinoblastoma-like 1 (p107)0.017
MORF4L1mortality factor 4 like 10.017
MCM2minichromosome maintenance complex component 20.016
CDR2cerebellar degeneration-related protein 2, 62kDa0.016
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.016
CDCA5cell division cycle associated 50.016
RB1retinoblastoma 10.016
LARP7La ribonucleoprotein domain family, member 70.015
ACTR5ARP5 actin-related protein 5 homolog (yeast)0.015
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.015
HEXIM1hexamethylene bis-acetamide inducible 10.015
CCNT1cyclin T10.015
CCDC6coiled-coil domain containing 60.014
FSTL1follistatin-like 10.014
POLR2Epolymerase (RNA) II (DNA directed) polypeptide E, 25kDa0.013
MCMBPminichromosome maintenance complex binding protein0.013
NR2E3nuclear receptor subfamily 2, group E, member 30.013
ANAPC4anaphase promoting complex subunit 40.013
MIER3mesoderm induction early response 1, family member 30.013
GTF2Igeneral transcription factor IIi0.013
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.013
PRMT1protein arginine methyltransferase 10.012
EZH2enhancer of zeste homolog 2 (Drosophila)0.012
BCLAF1BCL2-associated transcription factor 10.012
CDC45cell division cycle 45 homolog (S. cerevisiae)0.012
TOP1topoisomerase (DNA) I0.012
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.012
SOCS3suppressor of cytokine signaling 30.012
FANCAFanconi anemia, complementation group A0.011
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.011
SHPRHSNF2 histone linker PHD RING helicase0.011
RUVBL1RuvB-like 1 (E. coli)0.011
LBRlamin B receptor0.011
CKS1BCDC28 protein kinase regulatory subunit 1B0.011
WDR76WD repeat domain 760.011
PSIP1PC4 and SFRS1 interacting protein 10.010
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.010
CUL7cullin 70.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
zyg-9Protein ZYG-90.012
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG10267CG10267 gene product from transcript CG10267-RB0.054
Mcm3Minichromosome maintenance 30.028
tldtolloid0.020
Mcm2Minichromosome maintenance 20.017
dlpdally-like0.016
pimpimples0.016
Rab23CG2108 gene product from transcript CG2108-RA0.014
mus101mutagen-sensitive 1010.014
lunaCG33473 gene product from transcript CG33473-RB0.013
SlbpStem-loop binding protein0.013
mei-9meiotic 90.013
CDC45LCG3658 gene product from transcript CG3658-RA0.012
piwiCG6122 gene product from transcript CG6122-RA0.011
Slip1CG1783 gene product from transcript CG1783-RA0.011
l(2)dtllethal-(2)-denticleless0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mapk14mitogen-activated protein kinase 140.950
Mecp2methyl CpG binding protein 20.735
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.725
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.528
Atf2activating transcription factor 20.486
Ccna2cyclin A20.459
Atmataxia telangiectasia mutated homolog (human)0.377
Foxc1forkhead box C10.339
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.309
Prc1protein regulator of cytokinesis 10.262
Brca1breast cancer 10.241
Kif11kinesin family member 110.205
Zic3zinc finger protein of the cerebellum 30.174
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.169
Stag2stromal antigen 20.167
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.158
Cdk4cyclin-dependent kinase 40.154
Ncaphnon-SMC condensin I complex, subunit H0.143
Mapkapk2MAP kinase-activated protein kinase 20.137
Pola1polymerase (DNA directed), alpha 10.107
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.103
Mki67antigen identified by monoclonal antibody Ki 670.100
Cdt1chromatin licensing and DNA replication factor 10.099
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.097
Tcf19transcription factor 190.095
Ccnb1cyclin B10.094
Rad51ap1RAD51 associated protein 10.092
Mapk11mitogen-activated protein kinase 110.088
Ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.086
Cdk1cyclin-dependent kinase 10.079
Cdca7lcell division cycle associated 7 like0.067
Cdca5cell division cycle associated 50.065
Cdca8cell division cycle associated 80.063
Rock2Rho-associated coiled-coil containing protein kinase 20.061
Bmp7bone morphogenetic protein 70.060
CtcfCCCTC-binding factor0.060
Rnf220ring finger protein 2200.058
Aurkbaurora kinase B0.053
Kdm5blysine (K)-specific demethylase 5B0.053
Mdm2transformed mouse 3T3 cell double minute 20.051
Ccnb2cyclin B20.050
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.049
Ccne1cyclin E10.048
Hellshelicase, lymphoid specific0.045
Dtldenticleless homolog (Drosophila)0.043
Kif2akinesin family member 2A0.043
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.039
Dna2DNA replication helicase 2 homolog (yeast)0.039
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.037
Timelesstimeless homolog (Drosophila)0.037
Orc1origin recognition complex, subunit 10.035
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.035
Rad50RAD50 homolog (S. cerevisiae)0.034
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.033
Mapk8mitogen-activated protein kinase 80.032
Rrm2ribonucleotide reductase M20.032
Mapk1mitogen-activated protein kinase 10.031
Hdac1histone deacetylase 10.031
Rad51RAD51 homolog (S. cerevisiae)0.031
Pou5f1POU domain, class 5, transcription factor 10.030
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.030
Cdca7cell division cycle associated 70.030
Smc2structural maintenance of chromosomes 20.029
Otx2orthodenticle homolog 2 (Drosophila)0.029
E2f8E2F transcription factor 80.028
Atp11cATPase, class VI, type 11C0.028
Kif22kinesin family member 220.028
Plk4polo-like kinase 4 (Drosophila)0.025
Brca2breast cancer 20.024
Msh2mutS homolog 2 (E. coli)0.024
Plk1polo-like kinase 1 (Drosophila)0.024
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.023
Ccnfcyclin F0.023
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.023
Rad21RAD21 homolog (S. pombe)0.023
Trp53transformation related protein 530.022
Lig1ligase I, DNA, ATP-dependent0.022
TtkTtk protein kinase0.022
H2afxH2A histone family, member X0.022
Mis18bp1MIS18 binding protein 10.021
Smc4structural maintenance of chromosomes 40.020
Dyrk1adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a0.020
Chek1checkpoint kinase 1 homolog (S. pombe)0.020
Kif2ckinesin family member 2C0.019
Fmr1fragile X mental retardation syndrome 1 homolog0.019
Tk1thymidine kinase 10.019
Rbl1retinoblastoma-like 1 (p107)0.018
Pds5aPDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)0.018
Trip13thyroid hormone receptor interactor 130.018
Prkceprotein kinase C, epsilon0.018
Lmnb1lamin B10.017
Zfp644zinc finger protein 6440.017
Otud4OTU domain containing 40.017
Kif23kinesin family member 230.017
Mdm4transformed mouse 3T3 cell double minute 40.016
Smc1astructural maintenance of chromosomes 1A0.016
Sass6spindle assembly 6 homolog (C. elegans)0.016
Kif4kinesin family member 40.015
Top2atopoisomerase (DNA) II alpha0.015
Nbnnibrin0.015
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RAD53Rad53p0.238
MDN1Mdn1p0.220
DIA2Dia2p0.192
HST1Hst1p0.172
ORC3Orc3p0.131
PDS5Pds5p0.130
YLR455Whypothetical protein0.116
RAD59Rad59p0.115
HSL1Hsl1p0.113
AKL1Akl1p0.110
CDC14Cdc14p0.110
RLF2Rlf2p0.108
SNT1Snt1p0.106
PDS1Pds1p0.096
PTK2Ptk2p0.096
SET2Set2p0.095
HDA2Hda2p0.094
RSC8Rsc8p0.085
SDS3Sds3p0.085
MRC1Mrc1p0.083
SIN3Sin3p0.080
CTF18Ctf18p0.080
MCM3Mcm3p0.078
YLR257Whypothetical protein0.076
SPT21Spt21p0.075
CLB5Clb5p0.073
CHD1Chd1p0.072
HRK1Hrk1p0.072
MCM2Mcm2p0.069
CAK1Cak1p0.069
CYC8Cyc8p0.069
MCM10Mcm10p0.068
RAD17Rad17p0.067
CKA1Cka1p0.065
UME6Ume6p0.065
TOP1Top1p0.065
DBF4Dbf4p0.062
CDC7Cdc7p0.061
SUM1Sum1p0.060
MCM4Mcm4p0.057
ORC2Orc2p0.054
RAD50Rad50p0.053
MCM7Mcm7p0.053
SLD3Sld3p0.053
MDS3Mds3p0.052
PHO23Pho23p0.052
HAL5Hal5p0.051
RSC58Rsc58p0.051
TOF1Tof1p0.051
UME1Ume1p0.050
TAX4Tax4p0.050
RSC9Rsc9p0.049
UTR1Utr1p0.048
TCO89Tco89p0.048
MSI1Msi1p0.047
DOC1Doc1p0.047
RGC1Rgc1p0.047
RFC1Rfc1p0.046
ROD1Rod1p0.046
BUB1Bub1p0.045
RIF1Rif1p0.045
ARP4Arp4p0.045
YLR177Whypothetical protein0.044
UBP10Ubp10p0.043
CDH1Cdh1p0.042
STH1Sth1p0.042
CLB6Clb6p0.042
PRI1Pri1p0.041
CTI6Cti6p0.041
FPK1Fpk1p0.040
SWI6Swi6p0.040
RSC4Rsc4p0.040
SIR3Sir3p0.040
RRP14Rrp14p0.039
CIK1Cik1p0.039
DUN1Dun1p0.038
CMK2Cmk2p0.038
IMG1Img1p0.038
SPT16Spt16p0.037
YPL260Whypothetical protein0.037
RSA4Rsa4p0.037
RAD5Rad5p0.036
HOP1Hop1p0.036
HOT1Hot1p0.036
KIN82Kin82p0.035
SGV1Sgv1p0.035
BIT61Bit61p0.035
IES3Ies3p0.034
RSC2Rsc2p0.034
SAE2Sae2p0.034
MMS1Mms1p0.034
SIP1Sip1p0.034
MKS1Mks1p0.033
DNA2Dna2p0.033
CDC6Cdc6p0.033
ACC1Acc1p0.032
MSH6Msh6p0.031
NRD1Nrd1p0.031
AIM21Aim21p0.031
EST2Est2p0.030