The network for 'negative regulation of blood vessel morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of blood vessel morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis.

NameDescriptionProbabilityFunc Analog Organism
TEKTEK tyrosine kinase, endothelial0.984
YAP1Yes-associated protein 10.847
FGAfibrinogen alpha chain0.703
IL2RBinterleukin 2 receptor, beta0.647
FASFas (TNF receptor superfamily, member 6)0.581
NOTCH1notch 10.511
PTPN1protein tyrosine phosphatase, non-receptor type 10.485
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.481
CCR5chemokine (C-C motif) receptor 50.477
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.476
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.475
IL8interleukin 80.464
IL4Rinterleukin 4 receptor0.428
COL3A1collagen, type III, alpha 10.415
ARandrogen receptor0.400
NOTCH3notch 30.363
CXCL2chemokine (C-X-C motif) ligand 20.344
AMOTL1angiomotin like 10.342
CCR2chemokine (C-C motif) receptor 20.335
ANGPT2angiopoietin 20.319
COL1A1collagen, type I, alpha 10.316
HOXA5homeobox A50.296
MAP3K5mitogen-activated protein kinase kinase kinase 50.284
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.267
HOXB5homeobox B50.262
IFNGinterferon, gamma0.261
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.252
PLAUplasminogen activator, urokinase0.218
COL1A2collagen, type I, alpha 20.215
COL5A1collagen, type V, alpha 10.202
ESR1estrogen receptor 10.193
CXCL11chemokine (C-X-C motif) ligand 110.183
CXCL10chemokine (C-X-C motif) ligand 100.180
JAG1jagged 10.178
FHL2four and a half LIM domains 20.176
AMOTangiomotin0.172
HOXA10homeobox A100.171
HOXA7homeobox A70.170
PLATplasminogen activator, tissue0.152
MEF2Cmyocyte enhancer factor 2C0.146
COL4A1collagen, type IV, alpha 10.139
CXCL3chemokine (C-X-C motif) ligand 30.134
RUNX1runt-related transcription factor 10.131
MDM2Mdm2 p53 binding protein homolog (mouse)0.129
MAP3K3mitogen-activated protein kinase kinase kinase 30.125
PF4platelet factor 40.123
KLF4Kruppel-like factor 4 (gut)0.122
HOXB7homeobox B70.118
MAPK7mitogen-activated protein kinase 70.117
CXCL9chemokine (C-X-C motif) ligand 90.116
EP300E1A binding protein p3000.114
CCL5chemokine (C-C motif) ligand 50.112
IFNAR2interferon (alpha, beta and omega) receptor 20.110
LAMC1laminin, gamma 1 (formerly LAMB2)0.107
GFI1Bgrowth factor independent 1B transcription repressor0.106
CAV1caveolin 1, caveolae protein, 22kDa0.106
KLF6Kruppel-like factor 60.105
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.104
IFNAR1interferon (alpha, beta and omega) receptor 10.103
NCOR1nuclear receptor corepressor 10.098
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.096
CXCR3chemokine (C-X-C motif) receptor 30.095
LOXlysyl oxidase0.095
HOXA4homeobox A40.094
HOXA11homeobox A110.093
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.092
MAP3K2mitogen-activated protein kinase kinase kinase 20.089
FBN1fibrillin 10.088
COL5A2collagen, type V, alpha 20.084
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.083
HOXC6homeobox C60.083
CTGFconnective tissue growth factor0.081
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.079
HOXB3homeobox B30.077
EFNA1ephrin-A10.075
CXCR6chemokine (C-X-C motif) receptor 60.074
ANGPT1angiopoietin 10.073
JAK2Janus kinase 20.072
CCL2chemokine (C-C motif) ligand 20.072
CXCL5chemokine (C-X-C motif) ligand 50.072
CYR61cysteine-rich, angiogenic inducer, 610.071
HOXB9homeobox B90.070
HOXB6homeobox B60.069
CCL20chemokine (C-C motif) ligand 200.069
SKILSKI-like oncogene0.069
TIMP3TIMP metallopeptidase inhibitor 30.067
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.067
HOXA6homeobox A60.067
CD163CD163 molecule0.067
SFRP4secreted frizzled-related protein 40.066
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.065
IRF9interferon regulatory factor 90.065
SMURF1SMAD specific E3 ubiquitin protein ligase 10.064
HOXC10homeobox C100.062
DLL1delta-like 1 (Drosophila)0.061
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.059
MEF2Amyocyte enhancer factor 2A0.058
NID1nidogen 10.058
COL4A2collagen, type IV, alpha 20.058
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.058
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.107
etv2ets variant gene 20.033
dll4delta-like 4 (Drosophila)0.019
vegfcvascular endothelial growth factor c0.019
ccm2cerebral cavernous malformation 20.018
plcg1phospholipase C, gamma 10.018
flt4fms-related tyrosine kinase 40.017
nrp1aneuropilin 1a0.015
notch3notch homolog 30.015
emilin1aelastin microfibril interfacer 1a0.013
plxnd1plexin D10.013
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.012
col9a3collagen, type IX, alpha 30.012
tie2endothelium-specific receptor tyrosine kinase 20.012
col12a1collagen, type XII, alpha 10.011
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.011
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ccr2chemokine (C-C motif) receptor 20.665
Smad3MAD homolog 3 (Drosophila)0.652
Trp53transformation related protein 530.482
Col3a1collagen, type III, alpha 10.435
Leprleptin receptor0.417
Cd44CD44 antigen0.413
Col5a2collagen, type V, alpha 20.376
Col4a5collagen, type IV, alpha 50.331
Col1a1collagen, type I, alpha 10.330
Fstl1follistatin-like 10.269
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.269
Postnperiostin, osteoblast specific factor0.266
Fzd1frizzled homolog 1 (Drosophila)0.241
Meox2mesenchyme homeobox 20.236
Emcnendomucin0.222
Pcdh12protocadherin 120.217
Il1r1interleukin 1 receptor, type I0.215
Prl8a2prolactin family 8, subfamily a, member 20.201
Cdh5cadherin 50.198
SkilSKI-like0.195
Bmp5bone morphogenetic protein 50.194
Egfrepidermal growth factor receptor0.194
Ccr5chemokine (C-C motif) receptor 50.179
Itgb1integrin beta 1 (fibronectin receptor beta)0.176
Cxcl12chemokine (C-X-C motif) ligand 120.157
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.154
Vhlvon Hippel-Lindau tumor suppressor0.154
Ctnnb1catenin (cadherin associated protein), beta 10.149
Angpt1angiopoietin 10.149
Col6a1collagen, type VI, alpha 10.147
Notch2Notch gene homolog 2 (Drosophila)0.146
Apoeapolipoprotein E0.146
Cfhcomplement component factor h0.138
Per1period homolog 1 (Drosophila)0.135
Cry2cryptochrome 2 (photolyase-like)0.129
Sdprserum deprivation response0.128
Grb10growth factor receptor bound protein 100.128
Ifnginterferon gamma0.125
Nr3c1nuclear receptor subfamily 3, group C, member 10.122
Trp63transformation related protein 630.119
Myod1myogenic differentiation 10.113
Igfbp7insulin-like growth factor binding protein 70.110
Clockcircadian locomotor output cycles kaput0.109
Lumlumican0.109
Runx1runt related transcription factor 10.108
Ikzf1IKAROS family zinc finger 10.106
Mid2midline 20.100
Tlr2toll-like receptor 20.098
Fbln2fibulin 20.098
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.096
Twist2twist homolog 2 (Drosophila)0.096
Fgf7fibroblast growth factor 70.093
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.092
Cyr61cysteine rich protein 610.090
Prdm1PR domain containing 1, with ZNF domain0.087
Apcadenomatosis polyposis coli0.086
Prl7d1prolactin family 7, subfamily d, member 10.085
Ccl3chemokine (C-C motif) ligand 30.085
Vegfavascular endothelial growth factor A0.085
H2-Obhistocompatibility 2, O region beta locus0.083
Col1a2collagen, type I, alpha 20.082
C1qtnf1C1q and tumor necrosis factor related protein 10.082
Islrimmunoglobulin superfamily containing leucine-rich repeat0.081
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.078
Loxlysyl oxidase0.077
Tgfbr3transforming growth factor, beta receptor III0.077
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.076
Ccr1chemokine (C-C motif) receptor 10.076
Dll4delta-like 4 (Drosophila)0.075
Thbs2thrombospondin 20.070
Nognoggin0.070
Ccdc80coiled-coil domain containing 800.070
Pdgfbplatelet derived growth factor, B polypeptide0.068
Ptgs2prostaglandin-endoperoxide synthase 20.067
Klklotho0.067
Cd19CD19 antigen0.067
Kdrkinase insert domain protein receptor0.067
Hgfhepatocyte growth factor0.066
Tekendothelial-specific receptor tyrosine kinase0.065
Map3k14mitogen-activated protein kinase kinase kinase 140.064
Ppargperoxisome proliferator activated receptor gamma0.064
Mfap2microfibrillar-associated protein 20.064
Ptgfrprostaglandin F receptor0.063
Sema3csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C0.063
Adrb3adrenergic receptor, beta 30.063
Stab2stabilin 20.062
Klrk1killer cell lectin-like receptor subfamily K, member 10.061
Sox17SRY-box containing gene 170.061
Gprc6aG protein-coupled receptor, family C, group 6, member A0.061
Sfrp4secreted frizzled-related protein 40.061
Col18a1collagen, type XVIII, alpha 10.059
Elnelastin0.059
Ctsrcathepsin R0.059
Csnk1ecasein kinase 1, epsilon0.058
Fgfr4fibroblast growth factor receptor 40.058
Nos2nitric oxide synthase 2, inducible0.057
Dock1dedicator of cytokinesis 10.057
Dlg4discs, large homolog 4 (Drosophila)0.057
Snai1snail homolog 1 (Drosophila)0.056
Col6a3collagen, type VI, alpha 30.056
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl2chemokine (C-C motif) ligand 20.433
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.282
Ccl4chemokine (C-C motif) ligand 40.273
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.164
Ahsgalpha-2-HS-glycoprotein0.154
Albalbumin0.149
Il6interleukin 60.118
Fgf2fibroblast growth factor 20.108
Cxcl10chemokine (C-X-C motif) ligand 100.102
Rup2urinary protein 20.087
Gcgroup specific component0.079
Fosl1fos-like antigen 10.078
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.069
Ambpalpha-1-microglobulin/bikunin precursor0.060
LOC299282Serine protease inhibitor0.057
Mmp3matrix metallopeptidase 30.057
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.054
Csf1colony stimulating factor 1 (macrophage)0.046
Adam7ADAM metallopeptidase domain 70.046
Gfapglial fibrillary acidic protein0.042
Map3k8mitogen-activated protein kinase kinase kinase 80.041
Edn1endothelin 10.040
Ngfnerve growth factor (beta polypeptide)0.039
Prdm2PR domain containing 2, with ZNF domain0.038
Nos3nitric oxide synthase 3, endothelial cell0.035
Asgr2asialoglycoprotein receptor 20.034
Pemtphosphatidylethanolamine N-methyltransferase0.033
Socs3suppressor of cytokine signaling 30.032
Oprk1opioid receptor, kappa 10.031
Plaurplasminogen activator, urokinase receptor0.030
Olr416olfactory receptor 4160.029
Ccr2chemokine (C-C motif) receptor 20.028
Il1rninterleukin 1 receptor antagonist0.026
Mbl1mannose-binding lectin (protein A) 10.026
Ccl20chemokine (C-C motif) ligand 200.025
Apohapolipoprotein H (beta-2-glycoprotein I)0.025
Cd4Cd4 molecule0.025
Dio2deiodinase, iodothyronine, type II0.024
Testintestin gene0.023
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.023
Crhbpcorticotropin releasing hormone binding protein0.022
Cxcl2chemokine (C-X-C motif) ligand 20.022
Cd200r1CD200 receptor 10.022
Cd14CD14 molecule0.022
RGD1565859RGD15658590.022
Apcsamyloid P component, serum0.021
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.021
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.020
Ifit3interferon-induced protein with tetratricopeptide repeats 30.020
Iappislet amyloid polypeptide0.020
Cysscystatin S0.019
Syt8synaptotagmin VIII0.019
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.018
Cfdcomplement factor D (adipsin)0.018
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.018
Fgfr2fibroblast growth factor receptor 20.018
Mmp12matrix metallopeptidase 120.018
Cxcr5chemokine (C-X-C motif) receptor 50.018
Gucy1a2guanylate cyclase 1, soluble, alpha 20.017
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.017
Col10a1collagen, type X, alpha 10.017
Trhthyrotropin releasing hormone0.016
Pla1aphospholipase A1 member A0.016
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.016
Spp2secreted phosphoprotein 20.016
Ccl11chemokine (C-C motif) ligand 110.016
Olr1082olfactory receptor 10820.016
Arl11ADP-ribosylation factor-like 110.015
Lpllipoprotein lipase0.015
Trpm1transient receptor potential cation channel, subfamily M, member 10.015
Cgaglycoprotein hormones, alpha polypeptide0.015
LOC690358similar to PR domain containing 110.015
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.015
Rgs1regulator of G-protein signaling 10.015
Cxcl9chemokine (C-X-C motif) ligand 90.015
Ptgs2prostaglandin-endoperoxide synthase 20.015
Pzppregnancy-zone protein0.015
Arl5cADP-ribosylation factor-like 5C0.015
Atf3activating transcription factor 30.014
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.014
Foxd3forkhead box D30.014
Cpb1carboxypeptidase B1 (tissue)0.014
Col8a1collagen, type VIII, alpha 10.014
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.014
Twist2twist homolog 2 (Drosophila)0.014
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.014
Procprotein C0.014
Egr2early growth response 20.014
Dnase1l3deoxyribonuclease 1-like 30.014
Chrna6cholinergic receptor, nicotinic, alpha 60.013
Ghrgrowth hormone receptor0.013
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.013
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.013
Cyyr1cysteine/tyrosine-rich 10.013
Tlr4toll-like receptor 40.013
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.013
Lsm6LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.012
Smgbneonatal submandibular gland protein B0.012
Hpxhemopexin0.012
Gucy1b2guanylate cyclase 1, soluble, beta 20.012
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism