The network for 'negative regulation of cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell fate commitment

Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

NameDescriptionProbabilityFunc Analog Organism
ARandrogen receptor0.997
CSNK1Ecasein kinase 1, epsilon0.993
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.990
DVL1dishevelled, dsh homolog 1 (Drosophila)0.987
LRP6low density lipoprotein receptor-related protein 60.981
DVL3dishevelled, dsh homolog 3 (Drosophila)0.979
BMPR1Abone morphogenetic protein receptor, type IA0.971
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.926
AXIN1axin 10.901
DAXXdeath-domain associated protein0.885
FZD1frizzled homolog 1 (Drosophila)0.856
CDK11Bcyclin-dependent kinase 11B0.856
SMAD1SMAD family member 10.778
CREBBPCREB binding protein0.715
BMP2bone morphogenetic protein 20.677
NCOA2nuclear receptor coactivator 20.602
ZNF512Bzinc finger protein 512B0.579
APCadenomatous polyposis coli0.552
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.540
MYST2MYST histone acetyltransferase 20.510
CTNNBIP1catenin, beta interacting protein 10.488
RFWD2ring finger and WD repeat domain 20.487
LRRK2leucine-rich repeat kinase 20.459
NEDD4neural precursor cell expressed, developmentally down-regulated 40.448
FGF1fibroblast growth factor 1 (acidic)0.425
TCF4transcription factor 40.408
CEP164centrosomal protein 164kDa0.404
BBS10Bardet-Biedl syndrome 100.373
ZFYVE9zinc finger, FYVE domain containing 90.356
TWIST2twist homolog 2 (Drosophila)0.353
JUNjun proto-oncogene0.348
FGF2fibroblast growth factor 2 (basic)0.303
WT1Wilms tumor 10.285
FSTL1follistatin-like 10.283
WNT5Awingless-type MMTV integration site family, member 5A0.270
FOXO1forkhead box O10.259
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.244
FOXD3forkhead box D30.223
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.222
CTNND1catenin (cadherin-associated protein), delta 10.219
NKX3-1NK3 homeobox 10.205
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.155
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.151
NCOA1nuclear receptor coactivator 10.148
WNT3Awingless-type MMTV integration site family, member 3A0.123
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.121
NDPNorrie disease (pseudoglioma)0.115
ZBTB8Azinc finger and BTB domain containing 8A0.111
REPS2RALBP1 associated Eps domain containing 20.109
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.109
ARHGEF1Rho guanine nucleotide exchange factor (GEF) 10.109
SFRP1secreted frizzled-related protein 10.106
GSK3Bglycogen synthase kinase 3 beta0.105
GLIS2GLIS family zinc finger 20.103
PITX1paired-like homeodomain 10.100
MCCmutated in colorectal cancers0.097
DVL2dishevelled, dsh homolog 2 (Drosophila)0.090
EMDemerin0.090
PLCG1phospholipase C, gamma 10.087
FOXA1forkhead box A10.084
DUSP1dual specificity phosphatase 10.078
BMP4bone morphogenetic protein 40.077
FBXW11F-box and WD repeat domain containing 110.076
U2AF2U2 small nuclear RNA auxiliary factor 20.075
DSPdesmoplakin0.073
TAOK1TAO kinase 10.072
CSNK1Dcasein kinase 1, delta0.071
NOGnoggin0.070
LATlinker for activation of T cells0.069
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.069
RASSF1Ras association (RalGDS/AF-6) domain family member 10.068
CRMP1collapsin response mediator protein 10.067
BAHD1bromo adjacent homology domain containing 10.067
RBPMSRNA binding protein with multiple splicing0.063
FAM110Afamily with sequence similarity 110, member A0.059
RGS2regulator of G-protein signaling 2, 24kDa0.058
SCAF1SR-related CTD-associated factor 10.056
JUNDjun D proto-oncogene0.055
ZMYND8zinc finger, MYND-type containing 80.055
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.053
FAM110Cfamily with sequence similarity 110, member C0.051
PMLpromyelocytic leukemia0.049
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.049
USP5ubiquitin specific peptidase 5 (isopeptidase T)0.048
FHL2four and a half LIM domains 20.048
MXRA5matrix-remodelling associated 50.047
FGFR1fibroblast growth factor receptor 10.047
C9orf100chromosome 9 open reading frame 1000.047
FBLN1fibulin 10.046
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.044
FZD2frizzled homolog 2 (Drosophila)0.043
NCOA6nuclear receptor coactivator 60.042
NR4A1nuclear receptor subfamily 4, group A, member 10.042
FOXO3forkhead box O30.041
DSG2desmoglein 20.041
FOXF2forkhead box F20.040
FOSFBJ murine osteosarcoma viral oncogene homolog0.039
HOXC8homeobox C80.039
KAT5K(lysine) acetyltransferase 50.039
CDH3cadherin 3, type 1, P-cadherin (placental)0.038
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gli1GLI-Kruppel family member 10.683
fgf17fibroblast growth factor 170.582
hmx4H6 family homeobox 40.546
wnt5bwingless-type MMTV integration site family, member 5b0.522
bmp2bbone morphogenetic protein 2b0.522
sfrp1asecreted frizzled-related protein 1a0.499
wnt8bwingless-type MMTV integration site family, member 8b0.484
bmp4bone morphogenetic protein 40.435
wnt4awingless-type MMTV integration site family, member 4a0.359
wnt10awingless-type MMTV integration site family, member 10a0.357
dkk1bdickkopf 1b0.313
wnt11rwingless-type MMTV integration site family, member 11, related0.289
tbx1T-box 10.266
twist1btwist1b0.263
notch2notch homolog 20.261
wnt2bbwingless-type MMTV integration site family, member 2Bb0.236
wnt9awingless-type MMTV integration site family, member 9A0.224
bmp2abone morphogenetic protein 2a0.219
tbx20T-box 200.172
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.164
gata4GATA-binding protein 40.140
msxcmuscle segment homeobox C0.136
twist3twist30.135
oepone-eyed pinhead0.133
gbx2gastrulation brain homeo box 20.129
dharmadharma0.121
nkx6.1NK6 transcription factor related, locus 1 (Drosophila)0.120
tbx5aT-box 5a0.120
her5hairy-related 50.119
fgf10afibroblast growth factor 10a0.118
wnt11wingless-type MMTV integration site family, member 110.117
fzd7afrizzled homolog 7a0.108
notch3notch homolog 30.108
hoxd11ahomeo box D11a0.106
six4bsine oculis homeobox homolog 4b0.105
hnf1baHNF1 homeobox Ba0.104
pcdh8protocadherin 80.102
foxa3forkhead box A30.096
mespbmesoderm posterior b0.093
jag1bjagged 1b0.087
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.086
tagln2transgelin 20.084
pdlim7PDZ and LIM domain 70.074
flhfloating head0.072
wif1wnt inhibitory factor 10.066
wnt1wingless-type MMTV integration site family, member 10.065
fgf3fibroblast growth factor 30.061
ndr2nodal-related 20.061
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.058
dusp6dual specificity phosphatase 60.057
sox17SRY-box containing gene 170.056
hoxa11ahomeo box A11a0.055
spry4sprouty (Drosophila) homolog 40.054
tbx6T-box gene 60.053
foxd5forkhead box D50.052
wnt10bwingless-type MMTV integration site family, member 10b0.052
meis3myeloid ecotropic viral integration site 30.052
msxbmuscle segment homeobox B0.052
dmrta2doublesex and mab-3 related transcription factor like family A20.052
hapln3hyaluronan and proteoglycan link protein 30.050
wnt7bawingless-type MMTV integration site family, member 7Ba0.050
neo1neogenin 10.048
axin1axin 10.047
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.046
restRE1-silencing transcription factor0.045
lef1lymphocyte enhancer binding factor 10.044
chdchordin0.044
tbx18T-box 180.044
gdnfglial cell derived neurotrophic factor0.042
frem3Fras1 related extracellular matrix 30.042
col2a1acollagen type II, alpha-1a0.040
dhrs3adehydrogenase/reductase (SDR family) member 3a0.040
hoxb5ahomeo box B5a0.040
hoxd13ahomeo box D13a0.040
gata6GATA-binding protein 60.040
ef1ETS-related factor10.039
etv5bets variant 5b0.038
hhiphedgehog interacting protein0.038
lama5laminin, alpha 50.037
perpPERP, TP53 apoptosis effector0.036
cdh1cadherin 1, epithelial0.036
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.036
mapk6mitogen-activated protein kinase 60.035
bmpr1aabone morphogenetic protein receptor, type 1aa0.035
wnt3wingless-type MMTV integration site family, member 30.034
rx1retinal homeobox gene 10.034
wacaWW domain containing adaptor with coiled-coil a0.032
hoxd10ahomeo box D10a0.032
osr2odd-skipped related 2 (Drosophila)0.032
epha4beph receptor A4b0.031
sox11bSRY-box containing gene 11b0.031
hmx3homeo box (H6 family) 30.031
jag2jagged 20.030
gata2aGATA-binding protein 2a0.029
tnfsf10l3tumor necrosis factor (ligand) superfamily, member 10 like 30.029
wnt2wingless-type MMTV integration site family member 20.029
hoxa13bhomeo box A13b0.028
fli1afriend leukemia integration 1a0.028
mespamesoderm posterior a0.028
tgfb3transforming growth factor, beta 30.027
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
dppdecapentaplegic0.256
HHairless0.199
hhhedgehog0.199
wgwingless0.122
runrunt0.119
enengrailed0.113
UbxUltrabithorax0.081
hbshibris0.077
slp2sloppy paired 20.075
gtgiant0.075
EgfrEpidermal growth factor receptor0.074
slp1sloppy paired 10.072
argosCG4531 gene product from transcript CG4531-RA0.069
bnlbranchless0.064
slislit0.064
SerSerrate0.063
tldtolloid0.062
NNotch0.059
stysprouty0.059
kirrekin of irre0.058
rhorhomboid0.057
slouslouch0.039
spispitz0.038
wbwing blister0.036
RalaRas-related protein0.032
Vrp1Verprolin 10.030
dacdachshund0.029
tintinman0.029
tlltailless0.029
nkdnaked cuticle0.028
gsbgooseberry0.027
sogshort gastrulation0.027
pbproboscipedia0.026
eveeven skipped0.026
edlETS-domain lacking0.026
crbcrumbs0.025
zfh1Zn finger homeodomain 10.025
TolloCG6890 gene product from transcript CG6890-RA0.023
cicubitus interruptus0.022
foxoforkhead box, sub-group O0.022
twitwist0.022
araaraucan0.022
dosdaughter of sevenless0.021
btlbreathless0.021
invinvected0.021
Traf4TNF-receptor-associated factor 40.020
brkbrinker0.020
rstroughest0.019
pntpointed0.019
bab2CG9102 gene product from transcript CG9102-RA0.019
frcfringe connection0.018
Mkp3Mitogen-activated protein kinase phosphatase 30.018
rorough0.018
pdm2POU domain protein 20.018
vgvestigial0.018
neurneuralized0.018
lbeladybird early0.017
KrKruppel0.017
cnocanoe0.017
ftzfushi tarazu0.017
abd-Aabdominal A0.017
hthhomothorax0.017
bynbrachyenteron0.016
kniknirps0.016
zenzerknullt0.016
pzgputzig0.016
Wnt4Wnt oncogene analog 40.016
Pp2B-14DProtein phosphatase 2B at 14D0.015
Hr4CG16902 gene product from transcript CG16902-RC0.015
tsltorso-like0.015
Doc2Dorsocross20.015
nubnubbin0.014
Dsor1Downstream of raf10.014
ph-ppolyhomeotic proximal0.014
Su(var)3-7Suppressor of variegation 3-70.014
Su(dx)Suppressor of deltex0.014
MntCG13316 gene product from transcript CG13316-RD0.014
CG12496CG12496 gene product from transcript CG12496-RA0.014
htlheartless0.014
NotumCG13076 gene product from transcript CG13076-RB0.014
dgodiego0.014
tsgtwisted gastrulation0.013
trktrunk0.013
dibdisembodied0.013
aopanterior open0.013
acachaete0.013
rokRho-kinase0.013
stumpsCG31317 gene product from transcript CG31317-RC0.013
fzfrizzled0.013
B-H1BarH10.013
hkbhuckebein0.013
DadDaughters against dpp0.012
naunautilus0.012
CG14869CG14869 gene product from transcript CG14869-RB0.012
omeomega0.012
ribribbon0.012
InRInsulin-like receptor0.012
worworniu0.012
pnrpannier0.012
cgcombgap0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.840
Fgfr2fibroblast growth factor receptor 20.657
Foxc1forkhead box C10.593
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.536
Vangl2vang-like 2 (van gogh, Drosophila)0.411
Hand1heart and neural crest derivatives expressed transcript 10.409
Otx2orthodenticle homolog 2 (Drosophila)0.409
Dvl2dishevelled 2, dsh homolog (Drosophila)0.397
Pax3paired box gene 30.381
Fgf8fibroblast growth factor 80.348
Tcfap2atranscription factor AP-2, alpha0.284
Foxc2forkhead box C20.232
Bmp4bone morphogenetic protein 40.229
Gli3GLI-Kruppel family member GLI30.223
Rargretinoic acid receptor, gamma0.217
Sox9SRY-box containing gene 90.174
Isl1ISL1 transcription factor, LIM/homeodomain0.147
Hand2heart and neural crest derivatives expressed transcript 20.143
Pou5f1POU domain, class 5, transcription factor 10.124
Prrx1paired related homeobox 10.122
Meox2mesenchyme homeobox 20.113
Fgfr1fibroblast growth factor receptor 10.103
Vangl1vang-like 1 (van gogh, Drosophila)0.103
Smosmoothened homolog (Drosophila)0.098
Eya1eyes absent 1 homolog (Drosophila)0.094
Ednraendothelin receptor type A0.086
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.073
Rararetinoic acid receptor, alpha0.072
Msx1homeobox, msh-like 10.063
Dlx5distal-less homeobox 50.061
Foxg1forkhead box G10.061
Alx4aristaless-like homeobox 40.060
Dvl3dishevelled 3, dsh homolog (Drosophila)0.056
Sall4sal-like 4 (Drosophila)0.054
Bmp7bone morphogenetic protein 70.052
Sfrp2secreted frizzled-related protein 20.050
Tbx1T-box 10.047
Pax2paired box gene 20.047
Hes1hairy and enhancer of split 1 (Drosophila)0.045
Pax6paired box gene 60.044
Prrx2paired related homeobox 20.043
Gbx2gastrulation brain homeobox 20.043
Sall3sal-like 3 (Drosophila)0.042
Wnt3awingless-related MMTV integration site 3A0.040
Acvr1activin A receptor, type 10.040
Nkx2-1NK2 homeobox 10.040
Sox4SRY-box containing gene 40.037
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.036
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.033
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.028
Edaectodysplasin-A0.027
Emx1empty spiracles homolog 1 (Drosophila)0.026
Smad6MAD homolog 6 (Drosophila)0.026
Lrp6low density lipoprotein receptor-related protein 60.026
Dkk1dickkopf homolog 1 (Xenopus laevis)0.025
Fgfr3fibroblast growth factor receptor 30.025
Gata4GATA binding protein 40.025
Gscgoosecoid homeobox0.025
Sox2SRY-box containing gene 20.024
Gli2GLI-Kruppel family member GLI20.022
En1engrailed 10.022
Pitx1paired-like homeodomain transcription factor 10.021
Chrdchordin0.021
Chd7chromodomain helicase DNA binding protein 70.020
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.020
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.020
Pitx2paired-like homeodomain transcription factor 20.020
Retret proto-oncogene0.019
Sfrp1secreted frizzled-related protein 10.018
Dll1delta-like 1 (Drosophila)0.018
SharpinSHANK-associated RH domain interacting protein0.018
Efnb2ephrin B20.018
Nkx3-2NK3 homeobox 20.016
Whrnwhirlin0.016
Rxraretinoid X receptor alpha0.016
Smad3MAD homolog 3 (Drosophila)0.015
Foxf1aforkhead box F1a0.015
Ror2receptor tyrosine kinase-like orphan receptor 20.015
Pax8paired box gene 80.015
Sox3SRY-box containing gene 30.015
Smad7MAD homolog 7 (Drosophila)0.014
Alx3aristaless-like homeobox 30.013
Nodalnodal0.013
Hoxa5homeobox A50.013
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.013
Tcf15transcription factor 150.013
Smurf2SMAD specific E3 ubiquitin protein ligase 20.013
Tbrachyury0.012
Shesrc homology 2 domain-containing transforming protein E0.012
Lrp2low density lipoprotein receptor-related protein 20.012
Axin1axin 10.012
Nf1neurofibromatosis 10.012
Rspo2R-spondin 2 homolog (Xenopus laevis)0.012
Alx1ALX homeobox 10.012
Sox10SRY-box containing gene 100.011
Sox13SRY-box containing gene 130.011
Cldn7claudin 70.011
Hoxa3homeobox A30.011
Nognoggin0.011
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism