The network for 'aldosterone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

aldosterone secretion

The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.

NameDescriptionProbabilityFunc Analog Organism
C1QBcomplement component 1, q subcomponent, B chain1.000
MYO6myosin VI0.527
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.411
VSIG4V-set and immunoglobulin domain containing 40.099
SMURF2SMAD specific E3 ubiquitin protein ligase 20.075
FN1fibronectin 10.074
CSF1Rcolony stimulating factor 1 receptor0.072
LRP6low density lipoprotein receptor-related protein 60.058
SLCO2B1solute carrier organic anion transporter family, member 2B10.047
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.044
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.043
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.028
MARCOmacrophage receptor with collagenous structure0.028
ADAP2ArfGAP with dual PH domains 20.026
SLC15A3solute carrier family 15, member 30.022
SLC25A47solute carrier family 25, member 470.021
DVL3dishevelled, dsh homolog 3 (Drosophila)0.021
TGFB1transforming growth factor, beta 10.019
AVPR2arginine vasopressin receptor 20.018
FBLN1fibulin 10.018
TGFB3transforming growth factor, beta 30.017
C1Scomplement component 1, s subcomponent0.017
CMKLR1chemokine-like receptor 10.015
CTSZcathepsin Z0.015
SOX18SRY (sex determining region Y)-box 180.014
PDLIM5PDZ and LIM domain 50.014
FCHO2FCH domain only 20.013
APOC1apolipoprotein C-I0.012
THRSPthyroid hormone responsive0.011
ZFYVE9zinc finger, FYVE domain containing 90.011
TGFBR1transforming growth factor, beta receptor 10.011
HSPG2heparan sulfate proteoglycan 20.011
RPS23ribosomal protein S230.011
RPL9ribosomal protein L90.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.050
Fn1fibronectin 10.036
Col1a1collagen, type I, alpha 10.031
Tgfbr2transforming growth factor, beta receptor II0.022
Lhcgrluteinizing hormone/choriogonadotropin receptor0.020
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.016
Bmp6bone morphogenetic protein 60.013
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.012
Madcam1mucosal vascular addressin cell adhesion molecule 10.011
Col5a2collagen, type V, alpha 20.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism