The network for 'keratinocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

keratinocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.

NameDescriptionProbabilityFunc Analog Organism
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.999
KRT15keratin 150.996
STK3serine/threonine kinase 30.996
KRT6Bkeratin 6B0.995
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.991
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.991
NME2non-metastatic cells 2, protein (NM23B) expressed in0.982
IQGAP1IQ motif containing GTPase activating protein 10.971
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.962
KRT5keratin 50.953
CREBBPCREB binding protein0.946
KRT1keratin 10.932
NCOR2nuclear receptor corepressor 20.927
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.897
KRT6Akeratin 6A0.897
KRT8keratin 80.881
XIAPX-linked inhibitor of apoptosis0.870
SPRR1Asmall proline-rich protein 1A0.863
KRT17keratin 170.863
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.851
ANXA1annexin A10.842
PSEN1presenilin 10.804
EGFRepidermal growth factor receptor0.801
EP300E1A binding protein p3000.788
TJP1tight junction protein 1 (zona occludens 1)0.770
KRT14keratin 140.770
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.765
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.743
NCOA1nuclear receptor coactivator 10.738
TP63tumor protein p630.733
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.710
KRT34keratin 340.702
ARandrogen receptor0.680
TRIM29tripartite motif containing 290.678
NOTCH1notch 10.672
SFNstratifin0.664
KRT19keratin 190.662
IVLinvolucrin0.608
SORBS2sorbin and SH3 domain containing 20.514
KRT6Ckeratin 6C0.512
CDH3cadherin 3, type 1, P-cadherin (placental)0.500
RHOAras homolog gene family, member A0.491
ABI2abl-interactor 20.482
RARAretinoic acid receptor, alpha0.476
SPRR1Bsmall proline-rich protein 1B0.465
HOXB6homeobox B60.463
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.420
HOXB5homeobox B50.401
JAG1jagged 10.385
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.382
JUPjunction plakoglobin0.377
KRT4keratin 40.359
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.351
KLK10kallikrein-related peptidase 100.340
SPINT1serine peptidase inhibitor, Kunitz type 10.338
GJB3gap junction protein, beta 3, 31kDa0.337
KRT18keratin 180.334
CASP9caspase 9, apoptosis-related cysteine peptidase0.334
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.329
TMBIM6transmembrane BAX inhibitor motif containing 60.322
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.322
KRT75keratin 750.317
HRhairless homolog (mouse)0.312
PPP2R2Bprotein phosphatase 2, regulatory subunit B, beta0.312
PKP3plakophilin 30.289
CTSBcathepsin B0.278
HOXA10homeobox A100.275
KRT33Bkeratin 33B0.275
SRSF6serine/arginine-rich splicing factor 60.260
NCOA3nuclear receptor coactivator 30.259
KRT16keratin 160.232
ANXA2annexin A20.220
AMOTL1angiomotin like 10.218
SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 50.209
EFNA1ephrin-A10.208
GSK3Bglycogen synthase kinase 3 beta0.208
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.204
FHL1four and a half LIM domains 10.202
LY6Dlymphocyte antigen 6 complex, locus D0.196
KRT13keratin 130.193
KLK7kallikrein-related peptidase 70.176
FGFBP1fibroblast growth factor binding protein 10.172
KRT2keratin 20.171
ITGB4integrin, beta 40.158
SRSF4serine/arginine-rich splicing factor 40.156
DSG2desmoglein 20.154
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.139
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.138
S100A10S100 calcium binding protein A100.138
DSG3desmoglein 30.134
PKP4plakophilin 40.132
LYPD3LY6/PLAUR domain containing 30.131
SPRR3small proline-rich protein 30.130
SLURP1secreted LY6/PLAUR domain containing 10.129
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.128
EPPK1epiplakin 10.126
KLF5Kruppel-like factor 5 (intestinal)0.125
C1orf116chromosome 1 open reading frame 1160.122
HOXB3homeobox B30.121
DSG1desmoglein 10.119
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
krt4keratin 40.874
sdprbserum deprivation response b0.717
gata3GATA-binding protein 30.695
perpPERP, TP53 apoptosis effector0.683
wu:fb36d12wu:fb36d120.674
pitx3paired-like homeodomain transcription factor 30.579
anxa1aannexin A1a0.556
dsc2ldesmocollin 2 like0.553
cdh1cadherin 1, epithelial0.518
jupjunction plakoglobin0.503
tp63tumor protein p630.476
dlcdeltaC0.419
fgf8afibroblast growth factor 8 a0.414
pkp1plakophilin 10.408
zgc:152778zgc:1527780.384
krt5keratin 50.383
evplenvoplakin0.354
her6hairy-related 60.339
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.338
pkp3plakophilin 30.313
dlddeltaD0.310
foxn4forkhead box N40.295
notch1anotch homolog 1a0.267
zgc:55813zgc:558130.265
ascl1aachaete-scute complex-like 1a (Drosophila)0.262
klf2bKruppel-like factor 2b0.258
krt18keratin 180.255
anxa2aannexin A2a0.253
her9hairy-related 90.249
si:ch211-166a6.5si:ch211-166a6.50.211
nrarpanotch-regulated ankyrin repeat protein a0.188
foxi1forkhead box I10.172
lamc1laminin, gamma 10.171
capn9calpain 90.170
ascl1bachaete-scute complex-like 1b (Drosophila)0.168
cdh2cadherin 2, neuronal0.165
pplperiplakin0.159
fzd10frizzled homolog 100.158
slc38a3solute carrier family 38, member 30.143
hoxa3ahomeo box A3a0.140
sox2SRY-box containing gene 20.136
cldneclaudin e0.132
si:dkeyp-113d7.7si:dkeyp-113d7.70.130
dsg2desmoglein 20.128
irx3airoquois homeobox protein 3a0.127
alcambactivated leukocyte cell adhesion molecule b0.127
rasgef1baRasGEF domain family, member 1Ba0.126
rhoabras homolog gene family, member Ab0.125
pax2apaired box gene 2a0.120
anxa1bannexin A1b0.119
s100a10bS100 calcium binding protein A10b0.117
crabp2acellular retinoic acid binding protein 2, a0.116
wlswntless homolog (Drosophila)0.114
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.105
zgc:92061zgc:920610.102
dlx3bdistal-less homeobox gene 3b0.101
esrp1epithelial splicing regulatory protein 10.099
pld1aphospholipase D1a0.099
capns1bcalpain, small subunit 1 b0.096
tmem2transmembrane protein 20.096
bmp4bone morphogenetic protein 40.096
nkx2.2aNK2 transcription factor related 2a0.094
prdm1aPR domain containing 1a, with ZNF domain0.089
ptgs2aprostaglandin-endoperoxide synthase 2a0.087
frem3Fras1 related extracellular matrix 30.085
esrraestrogen-related receptor alpha0.085
cldnbclaudin b0.085
neurod4neurogenic differentiation 40.083
ctnnb1catenin (cadherin-associated protein), beta 10.080
zgc:92242zgc:922420.080
vsx2visual system homeobox 20.080
wnt11wingless-type MMTV integration site family, member 110.078
bactin2bactin20.074
krt8keratin 80.074
klf2aKruppel-like factor 2a0.069
bmp2bbone morphogenetic protein 2b0.067
six4bsine oculis homeobox homolog 4b0.067
cfl1cofilin 1 (non-muscle)0.067
hnf1baHNF1 homeobox Ba0.065
anxa1cannexin A1c0.065
thtyrosine hydroxylase0.062
cyt1type I cytokeratin, enveloping layer0.060
col14a1collagen, type XIV, alpha 10.059
crb2acrumbs homolog 2a0.057
notch1bnotch homolog 1b0.056
lfnglunatic fringe homolog0.056
foxb1.1forkhead box B1.10.056
epcamepithelial cell adhesion molecule0.055
fzd7afrizzled homolog 7a0.055
lhx5LIM homeobox 50.053
hoxd3ahomeo box D3a0.051
lims1LIM and senescent cell antigen-like domains 10.050
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.050
st8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.050
hoxa4ahomeo box A4a0.050
supt6hsuppressor of Ty 6 homolog0.050
net1neuroepithelial cell transforming gene 10.049
yap1Yes-associated protein 10.049
sox3SRY-box containing gene 30.049
sox11bSRY-box containing gene 11b0.048
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.999
Sfnstratifin0.997
Notch1Notch gene homolog 1 (Drosophila)0.995
Trp63transformation related protein 630.995
Foxn1forkhead box N10.993
Rpgrip1lRpgrip1-like0.993
Krt14keratin 140.987
Pkp1plakophilin 10.987
Ctnnb1catenin (cadherin associated protein), beta 10.975
Hrhairless0.964
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.961
Wwtr1WW domain containing transcription regulator 10.950
Tcfap2atranscription factor AP-2, alpha0.948
Sox2SRY-box containing gene 20.925
Krt8keratin 80.924
Krt33bkeratin 33B0.910
Fgfr2fibroblast growth factor receptor 20.901
Egfrepidermal growth factor receptor0.896
Otx2orthodenticle homolog 2 (Drosophila)0.890
Krt5keratin 50.887
Msx2homeobox, msh-like 20.884
Shhsonic hedgehog0.864
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.864
Dlx3distal-less homeobox 30.856
Casp4caspase 4, apoptosis-related cysteine peptidase0.834
Gata3GATA binding protein 30.828
Krt27keratin 270.827
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.818
Asprv1aspartic peptidase, retroviral-like 10.784
Sprr1asmall proline-rich protein 1A0.768
Atoh7atonal homolog 7 (Drosophila)0.760
Krt35keratin 350.722
Krt71keratin 710.717
Krt32keratin 320.716
Eya1eyes absent 1 homolog (Drosophila)0.715
Pax6paired box gene 60.701
Gli3GLI-Kruppel family member GLI30.699
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.666
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.651
Rb1retinoblastoma 10.632
Emx1empty spiracles homolog 1 (Drosophila)0.621
Wnt10awingless related MMTV integration site 10a0.612
Krt7keratin 70.595
Psapl1prosaposin-like 10.589
Yap1yes-associated protein 10.581
Wnt7bwingless-related MMTV integration site 7B0.579
Krt19keratin 190.579
Hif1ahypoxia inducible factor 1, alpha subunit0.576
Irf6interferon regulatory factor 60.567
Krt6akeratin 6A0.564
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.561
Tgm3transglutaminase 3, E polypeptide0.558
Krtap8-1keratin associated protein 8-10.540
Isl1ISL1 transcription factor, LIM/homeodomain0.528
Slurp1secreted Ly6/Plaur domain containing 10.518
Lgals7lectin, galactose binding, soluble 70.509
Pplperiplakin0.506
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.499
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.498
Tcfap2ctranscription factor AP-2, gamma0.492
Krt72-pskeratin 72, pseudogene0.488
Krtap3-1keratin associated protein 3-10.477
Klk7kallikrein related-peptidase 7 (chymotryptic, stratum corneum)0.474
Krt31keratin 310.466
Notch2Notch gene homolog 2 (Drosophila)0.460
Casp1caspase 10.458
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.453
Msnmoesin0.449
Padi3peptidyl arginine deiminase, type III0.448
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.442
Krt17keratin 170.440
Alox12earachidonate lipoxygenase, epidermal0.424
Pax3paired box gene 30.417
Cdcp1CUB domain containing protein 10.401
Vangl2vang-like 2 (van gogh, Drosophila)0.391
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.389
Foxc1forkhead box C10.388
Apaf1apoptotic peptidase activating factor 10.384
Klk6kallikrein related-peptidase 60.378
Syt8synaptotagmin VIII0.371
Sfpi1SFFV proviral integration 10.370
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.368
Dll1delta-like 1 (Drosophila)0.361
Krt18keratin 180.357
Pkp3plakophilin 30.355
Dsg4desmoglein 40.346
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.345
Chd7chromodomain helicase DNA binding protein 70.335
Nr3c1nuclear receptor subfamily 3, group C, member 10.329
Serpinb5serine (or cysteine) peptidase inhibitor, clade B, member 50.317
Wfdc2WAP four-disulfide core domain 20.309
Socs1suppressor of cytokine signaling 10.306
Tcfap2btranscription factor AP-2 beta0.305
Calm4calmodulin 40.296
Rac1RAS-related C3 botulinum substrate 10.291
S100a14S100 calcium binding protein A140.288
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.287
Lama5laminin, alpha 50.286
Trp53transformation related protein 530.284
Tgfatransforming growth factor alpha0.277
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Itga6integrin, alpha 60.018
LOC498222similar to specifically androgen-regulated protein0.017
Krt5keratin 50.016
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.016
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.015
Flt1FMS-related tyrosine kinase 10.015
Podxlpodocalyxin-like0.015
Socs3suppressor of cytokine signaling 30.015
LOC207127similar to preprotein translocase0.015
Muc1mucin 1, cell surface associated0.014
Lims1LIM and senescent cell antigen-like domains 10.014
Mcammelanoma cell adhesion molecule0.014
Gja5gap junction protein, alpha 50.014
Tmem79transmembrane protein 790.014
Sdcbp2syndecan binding protein (syntenin) 20.014
RGD1311493similar to CG13379-PA0.014
Mapk6mitogen-activated protein kinase 60.013
Fkbp1aFK506 binding protein 1a0.013
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.013
Nraddneurotrophin receptor associated death domain0.013
Elf3E74-like factor 30.013
Nckap1NCK-associated protein 10.013
Elf1E74-like factor 10.013
Scnn1asodium channel, nonvoltage-gated 1 alpha0.013
Chd4chromodomain helicase DNA binding protein 40.013
F2rl1coagulation factor II (thrombin) receptor-like 10.012
Rab10RAB10, member RAS oncogene family0.012
Tead3TEA domain family member 30.012
Edn1endothelin 10.012
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.012
Chrngcholinergic receptor, nicotinic, gamma0.012
Prp2proline rich protein 20.012
Cubncubilin (intrinsic factor-cobalamin receptor)0.012
Pthparathyroid hormone0.012
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.012
Fut1fucosyltransferase 10.012
Nrg1neuregulin 10.012
Reg3bregenerating islet-derived 3 beta0.012
Prdm2PR domain containing 2, with ZNF domain0.011
Gjb3gap junction protein, beta 30.011
Gzmbgranzyme B0.011
Rod1ROD1 regulator of differentiation 1 (S. pombe)0.011
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.011
Fosl1fos-like antigen 10.011
Taok1TAO kinase 10.011
Ccl28chemokine (C-C motif) ligand 280.011
Ms4a8amembrane-spanning 4-domains, subfamily A, member 8A0.011
Pdia6protein disulfide isomerase family A, member 60.011
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.011
Cbfbcore-binding factor, beta subunit0.011
Gpr116G protein-coupled receptor 1160.011
Duox2dual oxidase 20.011
Nptnneuroplastin0.011
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.011
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.011
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.011
Sfrs12splicing factor, arginine/serine-rich 120.011
Krt15keratin 150.011
Olr1530olfactory receptor 15300.011
RhdRh blood group, D antigen0.010
Itpr3inositol 1,4,5-triphosphate receptor, type 30.010
Adh6aalcohol dehydrogenase 6A (class V)0.010
Mmp3matrix metallopeptidase 30.010
Plauplasminogen activator, urokinase0.010
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.010
Gprc5aG protein-coupled receptor, family C, group 5, member A0.010
Sptbn1spectrin, beta, non-erythrocytic 10.010
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.010
LOC680711hypothetical protein LOC6807110.010
Sprr1alsmall proline-rich protein 1A-like0.010
Art2ADP-ribosyltransferase 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism