The network for 'erythrocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

erythrocyte differentiation

The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.

NameDescriptionProbabilityFunc Analog Organism
JUNjun proto-oncogene1.000
SP1Sp1 transcription factor0.973
CASP3caspase 3, apoptosis-related cysteine peptidase0.970
EP300E1A binding protein p3000.970
SMAD2SMAD family member 20.954
TAL1T-cell acute lymphocytic leukemia 10.947
CREBBPCREB binding protein0.899
MDM2Mdm2 p53 binding protein homolog (mouse)0.896
TP53tumor protein p530.890
ATF3activating transcription factor 30.876
DDIT3DNA-damage-inducible transcript 30.871
HSPA1Bheat shock 70kDa protein 1B0.839
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.746
RUNX1runt-related transcription factor 10.732
FOSFBJ murine osteosarcoma viral oncogene homolog0.724
XIAPX-linked inhibitor of apoptosis0.723
DUSP1dual specificity phosphatase 10.617
INSRinsulin receptor0.603
TCF12transcription factor 120.601
GATA1GATA binding protein 1 (globin transcription factor 1)0.517
SMAD3SMAD family member 30.505
CDK2cyclin-dependent kinase 20.480
NCOR2nuclear receptor corepressor 20.402
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.393
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.385
KLF4Kruppel-like factor 4 (gut)0.378
GATA2GATA binding protein 20.368
KLF6Kruppel-like factor 60.331
HBBhemoglobin, beta0.330
SMAD1SMAD family member 10.326
HSPA1Aheat shock 70kDa protein 1A0.322
PTPN1protein tyrosine phosphatase, non-receptor type 10.321
SIN3ASIN3 homolog A, transcription regulator (yeast)0.319
HBG2hemoglobin, gamma G0.317
RPS11ribosomal protein S110.312
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.311
HOXA5homeobox A50.310
NFE2L2nuclear factor (erythroid-derived 2)-like 20.309
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.304
ARandrogen receptor0.302
RPS15ribosomal protein S150.301
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.295
RPS10ribosomal protein S100.295
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.290
NCOA6nuclear receptor coactivator 60.286
STAT1signal transducer and activator of transcription 1, 91kDa0.281
DAXXdeath-domain associated protein0.271
APAF1apoptotic peptidase activating factor 10.268
CCND1cyclin D10.262
HOXB5homeobox B50.260
HOXA10homeobox A100.259
RPS5ribosomal protein S50.234
KAT2BK(lysine) acetyltransferase 2B0.228
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.227
NRP1neuropilin 10.223
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.218
NCOA1nuclear receptor coactivator 10.214
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.194
JUNBjun B proto-oncogene0.191
FOXO1forkhead box O10.177
BMP2bone morphogenetic protein 20.175
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.171
CFLARCASP8 and FADD-like apoptosis regulator0.166
SPTBspectrin, beta, erythrocytic0.162
RHAGRh-associated glycoprotein0.160
PBX1pre-B-cell leukemia homeobox 10.156
RPS27ribosomal protein S270.154
GHRgrowth hormone receptor0.154
FASFas (TNF receptor superfamily, member 6)0.142
RBBP4retinoblastoma binding protein 40.139
HIPK2homeodomain interacting protein kinase 20.134
ANK1ankyrin 1, erythrocytic0.134
BAG3BCL2-associated athanogene 30.132
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.132
SKIv-ski sarcoma viral oncogene homolog (avian)0.129
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.129
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.126
RPS16ribosomal protein S160.123
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.118
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.109
NCOA2nuclear receptor coactivator 20.107
SQSTM1sequestosome 10.106
CASP9caspase 9, apoptosis-related cysteine peptidase0.104
BMPR1Abone morphogenetic protein receptor, type IA0.102
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.099
RPS19ribosomal protein S190.098
HOXB6homeobox B60.092
RPS4Xribosomal protein S4, X-linked0.091
RPS3Aribosomal protein S3A0.089
SMAD4SMAD family member 40.087
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.087
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.084
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.083
MYOD1myogenic differentiation 10.080
GAS7growth arrest-specific 70.078
HOXA7homeobox A70.077
E2F1E2F transcription factor 10.072
RPS2ribosomal protein S20.072
KITLGKIT ligand0.071
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.071
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
alas2aminolevulinate, delta-, synthetase 20.997
gata1aGATA binding protein 1a0.993
tfr1atransferrin receptor 1a0.992
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.986
pitx2paired-like homeodomain transcription factor 20.984
slc4a1asolute carrier family 4, anion exchanger, member 1a0.984
hbbe1.1hemoglobin beta embryonic-1.10.983
LOC566708FL cytokine receptor-like0.976
pax2apaired box gene 2a0.948
klf4Kruppel-like factor 40.937
hbae3hemoglobin alpha embryonic-30.880
gata6GATA-binding protein 60.877
cmybtranscription factor cmyb0.850
hbae1hemoglobin alpha embryonic-10.781
hbbe3hemoglobin beta embryonic-30.761
tbx5aT-box 5a0.743
trim33tripartite motif-containing 330.737
plcg1phospholipase C, gamma 10.727
bmp2bbone morphogenetic protein 2b0.713
znfl2azinc finger-like gene 2a0.711
cahzcarbonic anhydrase0.644
rpl11ribosomal protein L110.634
gfi1.1growth factor independent 1.10.621
hand2heart and neural crest derivatives expressed transcript 20.608
ikzf1IKAROS family zinc finger 1 (Ikaros)0.600
lmo2LIM domain only 2 (rhombotin-like 1)0.596
LOC100151531zinc finger protein Gfi-1b-like0.553
eporerythropoietin receptor0.553
hoxd4ahomeo box D4a0.551
pdcd2programmed cell death 20.545
fgf24fibroblast growth factor 240.532
hbbe2hemoglobin beta embryonic-20.497
hnf1baHNF1 homeobox Ba0.496
hhexhematopoietically expressed homeobox0.494
hdrhematopoietic death receptor0.478
mycamyelocytomatosis oncogene a0.447
rhagRhesus blood group-associated glycoprotein0.442
slc25a37solute carrier family 25, member 370.438
tbx1T-box 10.426
myl7myosin, light polypeptide 7, regulatory0.419
ppoxprotoporphyrinogen oxidase0.418
tbx16T-box gene 160.394
sox7SRY-box containing gene 70.389
trpv6transient receptor potential cation channel, subfamily V, member 60.376
rpl23aribosomal protein L23a0.366
tbx6T-box gene 60.366
tal1T-cell acute lymphocytic leukemia 10.365
runx1runt-related transcription factor 10.356
urosuroporphyrinogen III synthase0.350
cfl2lcofilin 2, like0.345
rpl36aribosomal protein L36A0.338
smchd1structural maintenance of chromosomes flexible hinge domain containing 10.311
spns2spinster homolog 2 (Drosophila)0.305
mpxmyeloid-specific peroxidase0.302
hmbsbhydroxymethylbilane synthase, b0.292
sptbspectrin, beta, erythrocytic0.285
atoh1aatonal homolog 1a0.281
aplnrbapelin receptor b0.274
cx30.3connexin 30.30.265
cpoxcoproporphyrinogen oxidase0.260
f2rcoagulation factor II (thrombin) receptor0.257
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.254
rpl14ribosomal protein L140.251
atoh1batonal homolog 1b0.238
fgf10afibroblast growth factor 10a0.237
nkx2.5NK2 transcription factor related 50.232
hoxc6ahomeo box C6a0.217
eomesaeomesodermin homolog a0.210
wnt2bbwingless-type MMTV integration site family, member 2Bb0.208
glcci1glucocorticoid induced transcript 10.202
olig4oligodendrocyte transcription factor 40.195
vegfcvascular endothelial growth factor c0.189
kitakit receptor a0.185
lcp1lymphocyte cytosolic plastin 10.184
msxcmuscle segment homeobox C0.181
gon4lgon-4-like (C.elegans)0.173
cdx4caudal type homeo box transcription factor 40.163
rpl12ribosomal protein L120.159
mll4bmyeloid/lymphoid or mixed-lineage leukemia 4b0.158
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.154
eef1b2eukaryotic translation elongation factor 1 beta 20.148
vldlrvery low density lipoprotein receptor0.146
acvr2bactivin receptor IIb0.145
uroduroporphyrinogen decarboxylase0.143
hoxb4ahomeo box B4a0.139
rpl9ribosomal protein L90.139
ass1argininosuccinate synthetase 10.138
tbx2bT-box 2b0.134
tbx24T-box 240.131
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.129
rxrbaretinoid x receptor, beta a0.129
nfe2nuclear factor, erythroid-derived 20.129
adora2aaadenosine A2a receptor a0.125
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Spna1spectrin alpha 11.000
Eporerythropoietin receptor1.000
Slc4a1solute carrier family 4 (anion exchanger), member 11.000
Hbb-b1hemoglobin, beta adult major chain1.000
Ank1ankyrin 1, erythroid1.000
Ptenphosphatase and tensin homolog1.000
Gata4GATA binding protein 40.999
Shhsonic hedgehog0.999
Gata1GATA binding protein 10.998
Ikzf1IKAROS family zinc finger 10.996
Spnb1spectrin beta 10.996
Klf1Kruppel-like factor 1 (erythroid)0.995
Nos3nitric oxide synthase 3, endothelial cell0.993
Smad4MAD homolog 4 (Drosophila)0.991
Hbb-b2hemoglobin, beta adult minor chain0.990
Tal1T-cell acute lymphocytic leukemia 10.989
Kitkit oncogene0.987
Pbx1pre B-cell leukemia transcription factor 10.981
Trp53transformation related protein 530.976
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.973
Neurod1neurogenic differentiation 10.968
Apcadenomatosis polyposis coli0.968
Add2adducin 2 (beta)0.968
Ctnnb1catenin (cadherin associated protein), beta 10.967
Tgfbr2transforming growth factor, beta receptor II0.966
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.965
Fgfr1fibroblast growth factor receptor 10.965
Hand2heart and neural crest derivatives expressed transcript 20.963
Exoc6exocyst complex component 60.961
Bmp4bone morphogenetic protein 40.958
Isl1ISL1 transcription factor, LIM/homeodomain0.957
Smad1MAD homolog 1 (Drosophila)0.956
Jak2Janus kinase 20.954
Gypaglycophorin A0.944
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.944
Stat5bsignal transducer and activator of transcription 5B0.937
Cdkn1bcyclin-dependent kinase inhibitor 1B0.933
Gfi1bgrowth factor independent 1B0.931
Ascl1achaete-scute complex homolog 1 (Drosophila)0.925
Gata6GATA binding protein 60.924
Gli3GLI-Kruppel family member GLI30.921
Kdrkinase insert domain protein receptor0.917
Vegfavascular endothelial growth factor A0.911
Kiss1KiSS-1 metastasis-suppressor0.908
Stat3signal transducer and activator of transcription 30.905
Zic3zinc finger protein of the cerebellum 30.900
Pax6paired box gene 60.889
Otx2orthodenticle homolog 2 (Drosophila)0.882
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.879
Hes1hairy and enhancer of split 1 (Drosophila)0.874
Tgfb1transforming growth factor, beta 10.868
Ptf1apancreas specific transcription factor, 1a0.867
Vhlvon Hippel-Lindau tumor suppressor0.866
Meox2mesenchyme homeobox 20.854
Sox4SRY-box containing gene 40.847
Irf9interferon regulatory factor 90.840
Pitx2paired-like homeodomain transcription factor 20.839
Lhx3LIM homeobox protein 30.837
Fgfr2fibroblast growth factor receptor 20.832
Hif1ahypoxia inducible factor 1, alpha subunit0.832
Rargretinoic acid receptor, gamma0.827
Jag1jagged 10.809
Smad3MAD homolog 3 (Drosophila)0.801
Tcfap2atranscription factor AP-2, alpha0.796
Smad2MAD homolog 2 (Drosophila)0.786
Rspo2R-spondin 2 homolog (Xenopus laevis)0.781
Id1inhibitor of DNA binding 10.779
Notch2Notch gene homolog 2 (Drosophila)0.776
Acvr1activin A receptor, type 10.776
Stat1signal transducer and activator of transcription 10.775
Sox2SRY-box containing gene 20.767
Hoxa13homeobox A130.760
Neurog2neurogenin 20.759
Nr5a1nuclear receptor subfamily 5, group A, member 10.756
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.755
Pax8paired box gene 80.748
Arid4aAT rich interactive domain 4A (RBP1-like)0.739
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.738
Foxp3forkhead box P30.737
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.734
Notch1Notch gene homolog 1 (Drosophila)0.734
Csf1colony stimulating factor 1 (macrophage)0.733
Trim10tripartite motif-containing 100.729
Stat5asignal transducer and activator of transcription 5A0.725
Arandrogen receptor0.721
Ptpn11protein tyrosine phosphatase, non-receptor type 110.720
Fgf8fibroblast growth factor 80.720
Rararetinoic acid receptor, alpha0.718
Thrathyroid hormone receptor alpha0.713
Id3inhibitor of DNA binding 30.711
Esr1estrogen receptor 1 (alpha)0.711
Smad6MAD homolog 6 (Drosophila)0.695
Hba-a2hemoglobin alpha, adult chain 20.691
Mapk8mitogen-activated protein kinase 80.683
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.673
Tgfb2transforming growth factor, beta 20.672
Epas1endothelial PAS domain protein 10.666
Tcf21transcription factor 210.662
Rxraretinoid X receptor alpha0.662
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hbb-b1hemoglobin, beta adult major chain0.568
Alas2aminolevulinate, delta-, synthase 20.481
Jak1Janus kinase 10.214
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.153
LOC100134871beta globin minor gene0.123
Casp3caspase 30.076
Cfpcomplement factor properdin0.073
Gja5gap junction protein, alpha 50.065
Ckmcreatine kinase, muscle0.061
Sp1Sp1 transcription factor0.060
Jak2Janus kinase 20.056
Slco2b1solute carrier organic anion transporter family, member 2b10.051
Smad1SMAD family member 10.051
Rpl34ribosomal protein L340.050
Ptprcprotein tyrosine phosphatase, receptor type, C0.048
N4bp2l2NEDD4 binding protein 2-like 20.048
Hif1ahypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.046
Sirpasignal-regulatory protein alpha0.046
Actc1actin, alpha, cardiac muscle 10.045
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.044
Dok1docking protein 10.044
Marcksmyristoylated alanine rich protein kinase C substrate0.043
H3f3bH3 histone, family 3B0.043
Baz1abromodomain adjacent to zinc finger domain, 1A0.041
Smc4structural maintenance of chromosomes 40.040
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.040
Prdm2PR domain containing 2, with ZNF domain0.037
Pecam1platelet/endothelial cell adhesion molecule 10.036
Pcdhga11protocadherin gamma subfamily A, 110.036
Stk3serine/threonine kinase 3 (STE20 homolog, yeast)0.036
Vegfavascular endothelial growth factor A0.036
Rpl36aribosomal protein L36a0.036
Hpcal1hippocalcin-like 10.035
Rassf5Ras association (RalGDS/AF-6) domain family member 50.035
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.034
Adam17ADAM metallopeptidase domain 170.034
LOC499782similar to 60S ribosomal protein L120.034
Sox17SRY (sex determining region Y)-box 170.033
Nrd1nardilysin 10.033
Gpr116G protein-coupled receptor 1160.033
Myo1bmyosin Ib0.032
Il1r1interleukin 1 receptor, type I0.031
Hnrpmheterogeneous nuclear ribonucleoprotein M0.031
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.031
Trim28tripartite motif-containing 280.031
Mcm6minichromosome maintenance complex component 60.030
Hbbhemoglobin, beta0.030
Ptpn12protein tyrosine phosphatase, non-receptor type 120.030
Map3k1mitogen activated protein kinase kinase kinase 10.030
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.030
Bcl2B-cell CLL/lymphoma 20.030
Pls3plastin 3 (T-isoform)0.030
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.029
Asipagouti signaling protein0.029
Cox8bcytochrome c oxidase, subunit VIIIb0.028
UgdhUDP-glucose dehydrogenase0.028
Usf2upstream transcription factor 2, c-fos interacting0.028
Rpl3lribosomal protein L3-like0.027
Rararetinoic acid receptor, alpha0.027
Flt1FMS-related tyrosine kinase 10.027
Esamendothelial cell adhesion molecule0.027
Mmp3matrix metallopeptidase 30.027
Map3k7ip1mitogen-activated protein kinase kinase kinase 7 interacting protein 10.027
Chd4chromodomain helicase DNA binding protein 40.027
Casp2caspase 20.027
HrasHarvey rat sarcoma virus oncogene0.026
Cishcytokine inducible SH2-containing protein0.026
Cpdcarboxypeptidase D0.026
Tgfbr2transforming growth factor, beta receptor II0.026
Laptm5lysosomal protein transmembrane 50.026
Acvr1activin A receptor, type I0.026
Bmp7bone morphogenetic protein 70.026
Elk4ELK4, ETS-domain protein (SRF accessory protein 1)0.025
Bmp6bone morphogenetic protein 60.025
Cskc-src tyrosine kinase0.025
Tnni2troponin I type 2 (skeletal, fast)0.025
Rap1bRAP1B, member of RAS oncogene family0.025
Iqgap1IQ motif containing GTPase activating protein 10.025
Acsl5acyl-CoA synthetase long-chain family member 50.025
Ckmt2creatine kinase, mitochondrial 2, sarcomeric0.024
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.024
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.024
Gja3gap junction protein, alpha 30.024
Myoz2myozenin 20.024
Foxc2forkhead box C20.024
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.024
Myom1myomesin 10.023
Cacng1calcium channel, voltage-dependent, gamma subunit 10.023
LOC287167globin, alpha0.023
Ptgesprostaglandin E synthase0.023
Pde4bphosphodiesterase 4B, cAMP specific0.023
Birc2baculoviral IAP repeat-containing 20.023
Bat3HLA-B-associated transcript 30.023
Gdf10growth differentiation factor 100.023
Arntaryl hydrocarbon receptor nuclear translocator0.023
Leprleptin receptor0.023
Zfp36zinc finger protein 360.023
Rab3il1RAB3A interacting protein (rabin3)-like 10.022
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism