The network for 'neuroendocrine cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.

NameDescriptionProbabilityFunc Analog Organism
TAL1T-cell acute lymphocytic leukemia 11.000
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.995
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.995
BMPR1Abone morphogenetic protein receptor, type IA0.992
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.988
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.985
FGFR1fibroblast growth factor receptor 10.984
TRIM33tripartite motif containing 330.976
MYOD1myogenic differentiation 10.965
TCF12transcription factor 120.955
TCF4transcription factor 40.953
FERMT2fermitin family member 20.937
ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix protein0.935
ARandrogen receptor0.835
RUNX1runt-related transcription factor 10.820
ASCL1achaete-scute complex homolog 1 (Drosophila)0.617
FSTL1follistatin-like 10.508
FGF18fibroblast growth factor 180.412
FGF1fibroblast growth factor 1 (acidic)0.327
GATA2GATA binding protein 20.299
EP300E1A binding protein p3000.292
IHHIndian hedgehog0.180
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.174
FOXL1forkhead box L10.156
NPAS1neuronal PAS domain protein 10.153
HES2hairy and enhancer of split 2 (Drosophila)0.149
CREBBPCREB binding protein0.144
GSCgoosecoid homeobox0.141
LBX1ladybird homeobox 10.138
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 30.135
FGFR2fibroblast growth factor receptor 20.125
FGFBP1fibroblast growth factor binding protein 10.123
WNT1wingless-type MMTV integration site family, member 10.119
FGF8fibroblast growth factor 8 (androgen-induced)0.118
NOGnoggin0.112
RPL23ribosomal protein L230.110
BBS10Bardet-Biedl syndrome 100.103
FOXD3forkhead box D30.100
GATA1GATA binding protein 1 (globin transcription factor 1)0.099
BHLHE23basic helix-loop-helix family, member e230.098
BAZ1Bbromodomain adjacent to zinc finger domain, 1B0.097
SOX21SRY (sex determining region Y)-box 210.095
SMAD4SMAD family member 40.088
FGF3fibroblast growth factor 30.084
NEDD4neural precursor cell expressed, developmentally down-regulated 40.081
ONECUT1one cut homeobox 10.080
GLIS2GLIS family zinc finger 20.079
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.075
LMX1ALIM homeobox transcription factor 1, alpha0.073
MNX1motor neuron and pancreas homeobox 10.072
AQP5aquaporin 50.071
PDX1pancreatic and duodenal homeobox 10.071
PLCG1phospholipase C, gamma 10.067
RAXretina and anterior neural fold homeobox0.067
SFRP5secreted frizzled-related protein 50.066
POU4F3POU class 4 homeobox 30.064
CDX2caudal type homeobox 20.063
WIF1WNT inhibitory factor 10.063
PAX7paired box 70.060
LEF1lymphoid enhancer-binding factor 10.060
SOX1SRY (sex determining region Y)-box 10.059
FOXH1forkhead box H10.059
TAOK1TAO kinase 10.057
FZD8frizzled homolog 8 (Drosophila)0.057
SFRP1secreted frizzled-related protein 10.057
DLX4distal-less homeobox 40.055
KAT2BK(lysine) acetyltransferase 2B0.055
TLX3T-cell leukemia homeobox 30.054
TLX2T-cell leukemia homeobox 20.053
HOXB9homeobox B90.053
AXIN1axin 10.053
C1QL1complement component 1, q subcomponent-like 10.052
WNT10Awingless-type MMTV integration site family, member 10A0.052
FOXE1forkhead box E1 (thyroid transcription factor 2)0.052
PYYpeptide YY0.051
HOXD13homeobox D130.050
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.049
BMP4bone morphogenetic protein 40.049
OTPorthopedia homeobox0.048
DVL1dishevelled, dsh homolog 1 (Drosophila)0.047
WNT3wingless-type MMTV integration site family, member 30.047
GBX2gastrulation brain homeobox 20.047
BTRCbeta-transducin repeat containing0.046
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.045
FGF10fibroblast growth factor 100.044
HS3ST6heparan sulfate (glucosamine) 3-O-sulfotransferase 60.044
HOXB13homeobox B130.043
LYL1lymphoblastic leukemia derived sequence 10.043
NKX2-1NK2 homeobox 10.043
COL2A1collagen, type II, alpha 10.043
CSNK1Ecasein kinase 1, epsilon0.043
NEUROG3neurogenin 30.042
FRS2fibroblast growth factor receptor substrate 20.042
ENTPD2ectonucleoside triphosphate diphosphohydrolase 20.041
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.040
FOXN4forkhead box N40.039
TCF21transcription factor 210.039
HOXC8homeobox C80.039
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.038
NEUROG2neurogenin 20.038
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Otx2orthodenticle homolog 2 (Drosophila)0.996
Gli3GLI-Kruppel family member GLI30.995
Pax2paired box gene 20.995
Fgfr2fibroblast growth factor receptor 20.964
Nodalnodal0.955
Nognoggin0.954
Lhx1LIM homeobox protein 10.914
Hoxd11homeobox D110.834
Fgf8fibroblast growth factor 80.823
Alx4aristaless-like homeobox 40.722
Ror2receptor tyrosine kinase-like orphan receptor 20.708
Chrdchordin0.704
Gli2GLI-Kruppel family member GLI20.691
Wnt3awingless-related MMTV integration site 3A0.679
Foxa2forkhead box A20.661
Hand2heart and neural crest derivatives expressed transcript 20.616
Hoxa13homeobox A130.586
Nkx2-1NK2 homeobox 10.564
Hoxd13homeobox D130.528
En1engrailed 10.528
Fgf10fibroblast growth factor 100.483
Otx1orthodenticle homolog 1 (Drosophila)0.452
Emx2empty spiracles homolog 2 (Drosophila)0.431
Sox9SRY-box containing gene 90.426
Fgf3fibroblast growth factor 30.424
Gbx2gastrulation brain homeobox 20.392
Fgf15fibroblast growth factor 150.373
Dkk1dickkopf homolog 1 (Xenopus laevis)0.372
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.333
Foxc1forkhead box C10.323
Pax3paired box gene 30.322
Emx1empty spiracles homolog 1 (Drosophila)0.322
Lmx1aLIM homeobox transcription factor 1 alpha0.310
Twist2twist homolog 2 (Drosophila)0.271
Dlx5distal-less homeobox 50.266
Sox2SRY-box containing gene 20.266
Fgfr3fibroblast growth factor receptor 30.264
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.263
Pdx1pancreatic and duodenal homeobox 10.248
Hand1heart and neural crest derivatives expressed transcript 10.230
Tbrachyury0.223
Pou3f3POU domain, class 3, transcription factor 30.210
Onecut1one cut domain, family member 10.208
Ascl1achaete-scute complex homolog 1 (Drosophila)0.190
Wnt3wingless-related MMTV integration site 30.175
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.175
Nkx6-1NK6 homeobox 10.173
Pax6paired box gene 60.173
Lmx1bLIM homeobox transcription factor 1 beta0.160
Tcf21transcription factor 210.151
Hmx3H6 homeobox 30.148
Ctnnb1catenin (cadherin associated protein), beta 10.144
Acanaggrecan0.140
Lhx5LIM homeobox protein 50.134
Neurog3neurogenin 30.132
Prrx1paired related homeobox 10.128
Pax8paired box gene 80.126
Zic3zinc finger protein of the cerebellum 30.123
Hoxa2homeobox A20.113
Rargretinoic acid receptor, gamma0.110
Wnt2bwingless related MMTV integration site 2b0.108
Retret proto-oncogene0.103
Tbx3T-box 30.103
Tcf4transcription factor 40.102
Bmp7bone morphogenetic protein 70.097
Pthlhparathyroid hormone-like peptide0.095
Wnt4wingless-related MMTV integration site 40.094
Tcfap2atranscription factor AP-2, alpha0.093
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.088
Foxa1forkhead box A10.084
Gscgoosecoid homeobox0.083
Hoxa11homeobox A110.083
Fgf18fibroblast growth factor 180.080
Pitx2paired-like homeodomain transcription factor 20.078
Fgfr1fibroblast growth factor receptor 10.077
Vax1ventral anterior homeobox containing gene 10.077
Gdnfglial cell line derived neurotrophic factor0.075
Foxb1forkhead box B10.074
Fgf9fibroblast growth factor 90.074
Meox2mesenchyme homeobox 20.073
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.070
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.068
Gata6GATA binding protein 60.068
Sox3SRY-box containing gene 30.068
Fzd8frizzled homolog 8 (Drosophila)0.067
Gdf1growth differentiation factor 10.066
Lhx3LIM homeobox protein 30.065
Alx3aristaless-like homeobox 30.062
Pitx1paired-like homeodomain transcription factor 10.061
Prrx2paired related homeobox 20.061
Neurod1neurogenic differentiation 10.060
Cdx1caudal type homeobox 10.060
Foxd3forkhead box D30.059
Isl1ISL1 transcription factor, LIM/homeodomain0.056
Sox1SRY-box containing gene 10.055
Gli1GLI-Kruppel family member GLI10.055
Hes1hairy and enhancer of split 1 (Drosophila)0.055
Btbd17BTB (POZ) domain containing 170.055
Eya1eyes absent 1 homolog (Drosophila)0.054
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism