The network for 'vasodilation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure.

NameDescriptionProbabilityFunc Analog Organism
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.960
NAMPTnicotinamide phosphoribosyltransferase0.892
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.874
NOSTRINnitric oxide synthase trafficker0.854
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.847
DRD2dopamine receptor D20.839
NR4A1nuclear receptor subfamily 4, group A, member 10.718
BBS10Bardet-Biedl syndrome 100.669
VAC14Vac14 homolog (S. cerevisiae)0.598
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.560
PDZK1PDZ domain containing 10.523
RLN3relaxin 30.420
TGFB1I1transforming growth factor beta 1 induced transcript 10.366
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.320
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.299
BCAR1breast cancer anti-estrogen resistance 10.286
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.263
TIMP3TIMP metallopeptidase inhibitor 30.259
TECPR1tectonin beta-propeller repeat containing 10.243
ADORA2Aadenosine A2a receptor0.206
APOC1apolipoprotein C-I0.182
PTPN1protein tyrosine phosphatase, non-receptor type 10.178
WDFY3WD repeat and FYVE domain containing 30.177
PTPN23protein tyrosine phosphatase, non-receptor type 230.176
HDAC6histone deacetylase 60.147
ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae)0.132
NFIL3nuclear factor, interleukin 3 regulated0.124
TBC1D10ATBC1 domain family, member 10A0.114
MAP3K7mitogen-activated protein kinase kinase kinase 70.113
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.113
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.113
ADORA1adenosine A1 receptor0.110
CTSBcathepsin B0.108
HSPB1heat shock 27kDa protein 10.105
PRKG1protein kinase, cGMP-dependent, type I0.103
FRZBfrizzled-related protein0.102
BCRbreakpoint cluster region0.098
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.095
DNM1dynamin 10.093
PTENphosphatase and tensin homolog0.090
NECAB2N-terminal EF-hand calcium binding protein 20.087
ZNF331zinc finger protein 3310.082
KRT5keratin 50.080
C7orf36chromosome 7 open reading frame 360.075
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.073
EHMT2euchromatic histone-lysine N-methyltransferase 20.072
RIPK2receptor-interacting serine-threonine kinase 20.072
PTPRAprotein tyrosine phosphatase, receptor type, A0.071
CHMP4Bchromatin modifying protein 4B0.070
TNK2tyrosine kinase, non-receptor, 20.067
RIN3Ras and Rab interactor 30.066
ARRDC3arrestin domain containing 30.065
SDCBPsyndecan binding protein (syntenin)0.064
CHAC1ChaC, cation transport regulator homolog 1 (E. coli)0.063
PITX1paired-like homeodomain 10.062
SAT1spermidine/spermine N1-acetyltransferase 10.060
MRVI1murine retrovirus integration site 1 homolog0.060
BDKRB2bradykinin receptor B20.060
LOXL4lysyl oxidase-like 40.058
PTPN12protein tyrosine phosphatase, non-receptor type 120.057
MAPK6mitogen-activated protein kinase 60.057
ADRB2adrenergic, beta-2-, receptor, surface0.055
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.053
PTPN2protein tyrosine phosphatase, non-receptor type 20.051
IL8interleukin 80.050
CSNK1Ecasein kinase 1, epsilon0.047
PTK2PTK2 protein tyrosine kinase 20.046
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.046
FTLferritin, light polypeptide0.046
PLTPphospholipid transfer protein0.045
IFNGR1interferon gamma receptor 10.045
RBM11RNA binding motif protein 110.044
NEU4sialidase 40.043
RADILRas association and DIL domains0.043
ND1NADH dehydrogenase, subunit 1 (complex I)0.042
CALCRLcalcitonin receptor-like0.042
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.042
GLT25D1glycosyltransferase 25 domain containing 10.041
SPRR2Asmall proline-rich protein 2A0.041
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.041
GCH1GTP cyclohydrolase 10.039
RARRES2retinoic acid receptor responder (tazarotene induced) 20.039
CYB5R4cytochrome b5 reductase 40.039
UTP6UTP6, small subunit (SSU) processome component, homolog (yeast)0.038
MBOAT7membrane bound O-acyltransferase domain containing 70.038
PGDphosphogluconate dehydrogenase0.038
ARRB1arrestin, beta 10.038
ADAM15ADAM metallopeptidase domain 150.037
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.037
MMEmembrane metallo-endopeptidase0.037
MTNR1Amelatonin receptor 1A0.037
ZBTB32zinc finger and BTB domain containing 320.036
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.036
ABCC9ATP-binding cassette, sub-family C (CFTR/MRP), member 90.035
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.035
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nos3nitric oxide synthase 3, endothelial cell0.999
Ren1renin 1 structural0.996
Klk1b5kallikrein 1-related peptidase b50.952
Bbs4Bardet-Biedl syndrome 4 (human)0.892
Klk1b21kallikrein 1-related peptidase b210.887
Klk1b11kallikrein 1-related peptidase b110.882
Leprleptin receptor0.867
Pnpla2patatin-like phospholipase domain containing 20.758
Klk1b1kallikrein 1-related peptidase b10.739
Gucy1b3guanylate cyclase 1, soluble, beta 30.719
Klk1kallikrein 10.678
Klk1b16kallikrein 1-related peptidase b160.677
Drd2dopamine receptor D20.631
Scn5asodium channel, voltage-gated, type V, alpha0.594
Vegfavascular endothelial growth factor A0.556
ND6NADH dehydrogenase subunit 60.517
Ptprbprotein tyrosine phosphatase, receptor type, B0.483
Pcdh12protocadherin 120.439
Ppargperoxisome proliferator activated receptor gamma0.429
Crhr1corticotropin releasing hormone receptor 10.429
Trpv1transient receptor potential cation channel, subfamily V, member 10.394
Sox7SRY-box containing gene 70.325
Klk1b4kallikrein 1-related pepidase b40.305
Kitkit oncogene0.301
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.293
Klk1b27kallikrein 1-related peptidase b270.278
Ngfnerve growth factor0.269
Klk1b9kallikrein 1-related peptidase b90.266
Sstr3somatostatin receptor 30.261
Pdgfbplatelet derived growth factor, B polypeptide0.251
Agtr1aangiotensin II receptor, type 1a0.250
Klk1b26kallikrein 1-related petidase b260.249
Klk1b24kallikrein 1-related peptidase b240.238
Cckbrcholecystokinin B receptor0.235
Col4a3collagen, type IV, alpha 30.230
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.229
Gjb6gap junction protein, beta 60.221
Ptpn11protein tyrosine phosphatase, non-receptor type 110.218
5430421N21RikRIKEN cDNA 5430421N21 gene0.208
Gucy1a3guanylate cyclase 1, soluble, alpha 30.198
Ctrb1chymotrypsinogen B10.194
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.193
Flt1FMS-like tyrosine kinase 10.169
Nos1nitric oxide synthase 1, neuronal0.168
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.166
Npy2rneuropeptide Y receptor Y20.166
Cnr1cannabinoid receptor 1 (brain)0.166
Wnt7awingless-related MMTV integration site 7A0.159
Fbn1fibrillin 10.154
Vdrvitamin D receptor0.153
Fgf23fibroblast growth factor 230.152
Adra2cadrenergic receptor, alpha 2c0.151
Cela2achymotrypsin-like elastase family, member 2A0.143
Klk1b8kallikrein 1-related peptidase b80.143
Nrp1neuropilin 10.142
Klk1b3kallikrein 1-related peptidase b30.142
Kitlkit ligand0.134
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.133
Ldlrlow density lipoprotein receptor0.128
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.128
Adrb1adrenergic receptor, beta 10.125
Cav1caveolin 1, caveolae protein0.123
Gjb5gap junction protein, beta 50.109
Dmddystrophin, muscular dystrophy0.109
Krt17keratin 170.106
Npy1rneuropeptide Y receptor Y10.106
Epas1endothelial PAS domain protein 10.105
Foxd2forkhead box D20.101
Lhx6LIM homeobox protein 60.101
Mogmyelin oligodendrocyte glycoprotein0.100
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.099
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.097
Sprr1bsmall proline-rich protein 1B0.095
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.093
Edn1endothelin 10.092
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.090
Nos2nitric oxide synthase 2, inducible0.089
Bdkrb1bradykinin receptor, beta 10.085
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.085
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.084
Zfpm2zinc finger protein, multitype 20.084
Sox10SRY-box containing gene 100.084
Adrb3adrenergic receptor, beta 30.084
Ldb2LIM domain binding 20.083
Rem1rad and gem related GTP binding protein 10.082
Gcgrglucagon receptor0.080
Itgb2lintegrin beta 2-like0.080
Ddah1dimethylarginine dimethylaminohydrolase 10.079
Tekendothelial-specific receptor tyrosine kinase0.076
Adrb2adrenergic receptor, beta 20.075
Prkg1protein kinase, cGMP-dependent, type I0.075
Bbs1Bardet-Biedl syndrome 1 (human)0.074
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.133
Il1rninterleukin 1 receptor antagonist0.081
Aqp6aquaporin 6, kidney specific0.077
Fgf2fibroblast growth factor 20.076
Myo1amyosin IA0.075
Cdh17cadherin 170.072
Tff1trefoil factor 10.071
Mmp3matrix metallopeptidase 30.067
LOC299282Serine protease inhibitor0.061
Mchr1melanin-concentrating hormone receptor 10.061
Prl6a1prolactin family 6, subfamily a, member 10.059
Prg2proteoglycan 2, bone marrow0.055
Mmp10matrix metallopeptidase 100.054
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.054
Dmrta1DMRT-like family A10.053
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.049
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.048
Flt1FMS-related tyrosine kinase 10.048
Ednraendothelin receptor type A0.048
Oaz3ornithine decarboxylase antizyme 30.046
Esr1estrogen receptor 10.045
GperG protein-coupled estrogen receptor 10.043
Ccr5chemokine (C-C motif) receptor 50.043
Selpselectin P0.042
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.042
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.042
Gucy1b3guanylate cyclase 1, soluble, beta 30.042
Vom2r27vomeronasal 2 receptor, 270.040
Vom1r97vomeronasal 1 receptor 970.040
C5ar1complement component 5a receptor 10.038
Tbxa2rthromboxane A2 receptor0.038
Scube1signal peptide, CUB domain, EGF-like 10.038
Arandrogen receptor0.037
Mbl1mannose-binding lectin (protein A) 10.037
Tbxas1thromboxane A synthase 1, platelet0.036
Lifleukemia inhibitory factor0.036
Nmuneuromedin U0.035
Mmp7matrix metallopeptidase 70.035
Cps1carbamoyl-phosphate synthetase 10.035
Ptafrplatelet-activating factor receptor0.035
Ngfnerve growth factor (beta polypeptide)0.034
KitlgKIT ligand0.034
RorbRAR-related orphan receptor B0.034
Lypd3Ly6/Plaur domain containing 30.034
Apoa5apolipoprotein A-V0.034
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.033
F2rl1coagulation factor II (thrombin) receptor-like 10.033
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.033
Clec11aC-type lectin domain family 11, member a0.033
Tpbpatrophoblast specific protein alpha0.033
Nrg1neuregulin 10.032
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.032
Ccr3chemokine (C-C motif) receptor 30.032
Magmyelin-associated glycoprotein0.031
Casq2calsequestrin 2 (cardiac muscle)0.031
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.031
Csf3colony stimulating factor 3 (granulocyte)0.031
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.031
Cmklr1chemokine-like receptor 10.031
Acox3acyl-Coenzyme A oxidase 3, pristanoyl0.030
Foxi2forkhead box I20.030
Bdkrb2bradykinin receptor B20.030
Leprleptin receptor0.030
Syt8synaptotagmin VIII0.030
Calcacalcitonin-related polypeptide alpha0.030
F13a1coagulation factor XIII, A1 polypeptide0.029
Galgalanin prepropeptide0.029
Slco2a1solute carrier organic anion transporter family, member 2a10.029
LOC360479similar to hypothetical protein0.029
Sox17SRY (sex determining region Y)-box 170.029
Itgamintegrin, alpha M0.029
Adora3adenosine A3 receptor0.029
Sval1seminal vesicle antigen-like 10.029
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.028
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.028
Rhbdl1rhomboid, veinlet-like 1 (Drosophila)0.028
Gabra6gamma-aminobutyric acid (GABA) A receptor, alpha 60.028
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.028
Ptprhprotein tyrosine phosphatase, receptor type, H0.028
Tff3trefoil factor 3, intestinal0.028
Svs1seminal vesicle secretory protein 10.028
Fgf14fibroblast growth factor 140.028
Trim29tripartite motif-containing 290.028
Kcnj15potassium inwardly-rectifying channel, subfamily J, member 150.027
Strnstriatin, calmodulin binding protein0.027
Cd52CD52 antigen0.027
Olr416olfactory receptor 4160.027
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.026
Cryba4crystallin, beta A40.026
Nos3nitric oxide synthase 3, endothelial cell0.026
Cdx1caudal type homeo box 10.026
Gipgastric inhibitory polypeptide0.026
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.026
Dhrs9dehydrogenase/reductase (SDR family) member 90.026
Zp2zona pellucida glycoprotein 2 (sperm receptor)0.026
Acox2acyl-Coenzyme A oxidase 2, branched chain0.026
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.025
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism