The network for 'regulation of mast cell degranulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of mast cell degranulation

Any process that modulates the frequency, rate, or extent of mast cell degranulation.

NameDescriptionProbabilityFunc Analog Organism
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.779
TFF1trefoil factor 10.750
IL4Rinterleukin 4 receptor0.680
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.648
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.608
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.547
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.512
HCKhemopoietic cell kinase0.506
SYKspleen tyrosine kinase0.503
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.464
PTPN6protein tyrosine phosphatase, non-receptor type 60.400
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.381
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.352
VAV1vav 1 guanine nucleotide exchange factor0.338
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.303
SHC1SHC (Src homology 2 domain containing) transforming protein 10.303
ZNF746zinc finger protein 7460.283
IL4interleukin 40.277
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.230
IL2RGinterleukin 2 receptor, gamma0.225
BTKBruton agammaglobulinemia tyrosine kinase0.193
PLCG1phospholipase C, gamma 10.152
CRHcorticotropin releasing hormone0.149
LCKlymphocyte-specific protein tyrosine kinase0.140
BLNKB-cell linker0.111
BAI1brain-specific angiogenesis inhibitor 10.111
GRB2growth factor receptor-bound protein 20.092
ZNF775zinc finger protein 7750.072
UBASH3Bubiquitin associated and SH3 domain containing B0.069
LATlinker for activation of T cells0.069
CARD11caspase recruitment domain family, member 110.064
IRS1insulin receptor substrate 10.057
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.055
SH3BP2SH3-domain binding protein 20.053
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.050
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.045
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.045
CPA3carboxypeptidase A3 (mast cell)0.041
FASLGFas ligand (TNF superfamily, member 6)0.041
GAB1GRB2-associated binding protein 10.040
GRAP2GRB2-related adaptor protein 20.039
HK3hexokinase 3 (white cell)0.039
C1orf93chromosome 1 open reading frame 930.039
AIF1allograft inflammatory factor 10.037
SIRPB1signal-regulatory protein beta 10.037
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 10.033
CD300CCD300c molecule0.031
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.030
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.030
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.028
C15orf29chromosome 15 open reading frame 290.027
BCL10B-cell CLL/lymphoma 100.027
DLG4discs, large homolog 4 (Drosophila)0.025
PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.023
CMIPc-Maf-inducing protein0.023
SLAMF1signaling lymphocytic activation molecule family member 10.022
HCLS1hematopoietic cell-specific Lyn substrate 10.022
VAV2vav 2 guanine nucleotide exchange factor0.020
ZC3HC1zinc finger, C3HC-type containing 10.020
LAIR1leukocyte-associated immunoglobulin-like receptor 10.019
FYBFYN binding protein0.018
NSFN-ethylmaleimide-sensitive factor0.018
DUSP23dual specificity phosphatase 230.018
C5AR1complement component 5a receptor 10.017
SIGLEC9sialic acid binding Ig-like lectin 90.017
SHC2SHC (Src homology 2 domain containing) transforming protein 20.017
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.017
EPHA8EPH receptor A80.017
PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)0.016
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.016
CSF3Rcolony stimulating factor 3 receptor (granulocyte)0.016
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.016
FOXF2forkhead box F20.016
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.016
MTORmechanistic target of rapamycin (serine/threonine kinase)0.015
CR1complement component (3b/4b) receptor 1 (Knops blood group)0.015
DOK4docking protein 40.015
DOK1docking protein 1, 62kDa (downstream of tyrosine kinase 1)0.015
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.015
CYTH4cytohesin 40.015
FCN1ficolin (collagen/fibrinogen domain containing) 10.015
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.015
DOK3docking protein 30.015
SRGAP2SLIT-ROBO Rho GTPase activating protein 20.015
HDChistidine decarboxylase0.015
CD33CD33 molecule0.014
PIM1pim-1 oncogene0.014
TYROBPTYRO protein tyrosine kinase binding protein0.014
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.014
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.014
DENND1CDENN/MADD domain containing 1C0.014
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.013
MYO1Fmyosin IF0.013
CEACAM3carcinoembryonic antigen-related cell adhesion molecule 30.013
ABI3ABI family, member 30.013
PDE4DIPphosphodiesterase 4D interacting protein0.013
FGFR1fibroblast growth factor receptor 10.013
NFAM1NFAT activating protein with ITAM motif 10.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Inpp5dinositol polyphosphate-5-phosphatase D0.992
Grb2growth factor receptor bound protein 20.979
Il4interleukin 40.974
Cd247CD247 antigen0.965
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.951
MefvMediterranean fever0.910
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.857
Ptprcprotein tyrosine phosphatase, receptor type, C0.856
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.761
Ikzf1IKAROS family zinc finger 10.735
Latlinker for activation of T cells0.721
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.620
Cd19CD19 antigen0.591
Ifnginterferon gamma0.495
Dok1docking protein 10.488
CblCasitas B-lineage lymphoma0.485
Dok3docking protein 30.426
Ptk2PTK2 protein tyrosine kinase 20.402
Cd40CD40 antigen0.352
Ighimmunoglobulin heavy chain complex0.323
Nfam1Nfat activating molecule with ITAM motif 10.314
C5ar1complement component 5a receptor 10.276
Cd22CD22 antigen0.274
Trpv1transient receptor potential cation channel, subfamily V, member 10.239
Clec4nC-type lectin domain family 4, member n0.221
Msr1macrophage scavenger receptor 10.217
Metmet proto-oncogene0.188
BtkBruton agammaglobulinemia tyrosine kinase0.175
Il2rbinterleukin 2 receptor, beta chain0.165
Il2interleukin 20.161
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.157
Shc1src homology 2 domain-containing transforming protein C10.148
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.139
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.130
Hcsthematopoietic cell signal transducer0.130
Lcklymphocyte protein tyrosine kinase0.130
TcraT-cell receptor alpha chain0.126
WasWiskott-Aldrich syndrome homolog (human)0.121
S1pr4sphingosine-1-phosphate receptor 40.116
TyrobpTYRO protein tyrosine kinase binding protein0.113
Snai1snail homolog 1 (Drosophila)0.110
Clec4dC-type lectin domain family 4, member d0.107
Lyl1lymphoblastomic leukemia 10.106
Sykbspleen tyrosine kinase0.103
Rag1recombination activating gene 10.100
Foxn1forkhead box N10.100
Fcgr2bFc receptor, IgG, low affinity IIb0.091
Plcg2phospholipase C, gamma 20.088
Cd4CD4 antigen0.087
Stat6signal transducer and activator of transcription 60.085
Il2rginterleukin 2 receptor, gamma chain0.082
Dok2docking protein 20.082
Lair1leukocyte-associated Ig-like receptor 10.082
Trem3triggering receptor expressed on myeloid cells 30.077
Fesfeline sarcoma oncogene0.076
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.076
Galnt6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 60.074
Tbxas1thromboxane A synthase 1, platelet0.071
Itgb3integrin beta 30.069
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.066
FasFas (TNF receptor superfamily member 6)0.066
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.066
Kitkit oncogene0.065
Ccr1chemokine (C-C motif) receptor 10.064
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.063
Ccr6chemokine (C-C motif) receptor 60.062
Il10rainterleukin 10 receptor, alpha0.062
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.057
Pilrapaired immunoglobin-like type 2 receptor alpha0.057
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.055
Ptenphosphatase and tensin homolog0.055
Il13interleukin 130.052
Il4rainterleukin 4 receptor, alpha0.050
Mmp8matrix metallopeptidase 80.050
Hmox1heme oxygenase (decycling) 10.048
Slpisecretory leukocyte peptidase inhibitor0.048
Siglecesialic acid binding Ig-like lectin E0.045
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.044
Nos2nitric oxide synthase 2, inducible0.043
Csf1rcolony stimulating factor 1 receptor0.043
Plcg1phospholipase C, gamma 10.041
Ptgs2prostaglandin-endoperoxide synthase 20.041
Mvpmajor vault protein0.041
Cmklr1chemokine-like receptor 10.041
Irg1immunoresponsive gene 10.041
Zap70zeta-chain (TCR) associated protein kinase0.039
Cxcr2chemokine (C-X-C motif) receptor 20.038
Il1rninterleukin 1 receptor antagonist0.038
Cd28CD28 antigen0.037
Relreticuloendotheliosis oncogene0.037
Gpr132G protein-coupled receptor 1320.037
AF251705cDNA sequence AF2517050.036
Gpr35G protein-coupled receptor 350.035
Marcomacrophage receptor with collagenous structure0.035
Fcgr4Fc receptor, IgG, low affinity IV0.034
Pou2f2POU domain, class 2, transcription factor 20.034
Hcls1hematopoietic cell specific Lyn substrate 10.034
Ptpreprotein tyrosine phosphatase, receptor type, E0.033
Ptpraprotein tyrosine phosphatase, receptor type, A0.033
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd38CD38 molecule0.015
Tgfbr2transforming growth factor, beta receptor II0.011
Folr2folate receptor 2 (fetal)0.011
Cybbcytochrome b-245, beta polypeptide0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism