The network for 'regulation of heart morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of heart morphogenesis

Any process that modulates the frequency, rate or extent of heart morphogenesis.

NameDescriptionProbabilityFunc Analog Organism
DVL1dishevelled, dsh homolog 1 (Drosophila)0.928
LRP6low density lipoprotein receptor-related protein 60.910
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.906
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.904
CSNK1Ecasein kinase 1, epsilon0.899
BMPR1Abone morphogenetic protein receptor, type IA0.812
NOTCH1notch 10.799
LRRK2leucine-rich repeat kinase 20.760
SP1Sp1 transcription factor0.727
FOXD3forkhead box D30.726
JAG1jagged 10.714
PAX3paired box 30.662
SETD8SET domain containing (lysine methyltransferase) 80.634
SOX10SRY (sex determining region Y)-box 100.622
SPENspen homolog, transcriptional regulator (Drosophila)0.612
DVL3dishevelled, dsh homolog 3 (Drosophila)0.596
AXIN1axin 10.545
SOX2SRY (sex determining region Y)-box 20.507
SMAD3SMAD family member 30.491
CTNNBIP1catenin, beta interacting protein 10.450
WWP2WW domain containing E3 ubiquitin protein ligase 20.416
FZD1frizzled homolog 1 (Drosophila)0.377
MAML1mastermind-like 1 (Drosophila)0.278
NOTCH3notch 30.275
SNIP1Smad nuclear interacting protein 10.240
FSTL1follistatin-like 10.199
ATXN1Lataxin 1-like0.197
BTRCbeta-transducin repeat containing0.182
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.178
SMAD1SMAD family member 10.166
GSK3Bglycogen synthase kinase 3 beta0.165
GATA4GATA binding protein 40.161
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.160
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.146
TCF4transcription factor 40.135
NR4A1nuclear receptor subfamily 4, group A, member 10.133
ZFYVE9zinc finger, FYVE domain containing 90.124
ZNF512Bzinc finger protein 512B0.123
CEP164centrosomal protein 164kDa0.122
SMAD7SMAD family member 70.107
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.106
CTNND1catenin (cadherin-associated protein), delta 10.103
MDFIMyoD family inhibitor0.102
HMGA1high mobility group AT-hook 10.101
SMAD2SMAD family member 20.094
DKK1dickkopf homolog 1 (Xenopus laevis)0.086
WT1Wilms tumor 10.082
CSNK1Dcasein kinase 1, delta0.072
SNW1SNW domain containing 10.069
EP300E1A binding protein p3000.069
SOX11SRY (sex determining region Y)-box 110.063
BTF3basic transcription factor 30.061
DVL2dishevelled, dsh homolog 2 (Drosophila)0.060
TAOK1TAO kinase 10.058
FZD8frizzled homolog 8 (Drosophila)0.053
XIAPX-linked inhibitor of apoptosis0.048
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.048
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.046
SMURF1SMAD specific E3 ubiquitin protein ligase 10.044
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.044
ATF7IPactivating transcription factor 7 interacting protein0.043
BBS10Bardet-Biedl syndrome 100.042
CXXC5CXXC finger protein 50.040
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.039
SKIv-ski sarcoma viral oncogene homolog (avian)0.037
JAG2jagged 20.037
ATN1atrophin 10.037
PITX1paired-like homeodomain 10.036
NR5A1nuclear receptor subfamily 5, group A, member 10.034
MEOX2mesenchyme homeobox 20.034
KLF5Kruppel-like factor 5 (intestinal)0.034
TSC22D1TSC22 domain family, member 10.034
PTPRFprotein tyrosine phosphatase, receptor type, F0.034
EYA2eyes absent homolog 2 (Drosophila)0.034
MCCmutated in colorectal cancers0.033
HOXC8homeobox C80.032
BAHD1bromo adjacent homology domain containing 10.032
SOX1SRY (sex determining region Y)-box 10.032
NOTCH2notch 20.031
PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.030
PITX2paired-like homeodomain 20.030
FUNDC2FUN14 domain containing 20.030
MYST2MYST histone acetyltransferase 20.029
APCadenomatous polyposis coli0.029
EYA1eyes absent homolog 1 (Drosophila)0.029
PDX1pancreatic and duodenal homeobox 10.029
DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae)0.029
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.028
RAC3ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)0.028
FOXE1forkhead box E1 (thyroid transcription factor 2)0.028
HCFC1host cell factor C1 (VP16-accessory protein)0.028
RPL41ribosomal protein L410.028
FOXO3forkhead box O30.028
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.028
CIR1corepressor interacting with RBPJ, 10.027
BMP4bone morphogenetic protein 40.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.998
bmp2bbone morphogenetic protein 2b0.956
ndr2nodal-related 20.952
ntlano tail a0.930
nkx2.5NK2 transcription factor related 50.924
bmp4bone morphogenetic protein 40.899
tbx16T-box gene 160.886
shhasonic hedgehog a0.868
tbx5aT-box 5a0.818
flhfloating head0.783
fn1fibronectin 10.775
myf5myogenic factor 50.774
wnt5bwingless-type MMTV integration site family, member 5b0.753
tbx20T-box 200.749
sox32SRY-box containing gene 320.646
foxi1forkhead box I10.580
smosmoothened homolog (Drosophila)0.557
gata4GATA-binding protein 40.557
dkk1bdickkopf 1b0.500
oepone-eyed pinhead0.494
six4bsine oculis homeobox homolog 4b0.475
ndr1nodal-related 10.457
myl7myosin, light polypeptide 7, regulatory0.440
hand2heart and neural crest derivatives expressed transcript 20.433
cdh2cadherin 2, neuronal0.430
mibmind bomb0.428
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.400
nkx3.2NK3 homeobox 20.394
fgf10afibroblast growth factor 10a0.384
hhexhematopoietically expressed homeobox0.345
pcdh8protocadherin 80.292
myod1myogenic differentiation 10.255
foxd5forkhead box D50.250
wnt11wingless-type MMTV integration site family, member 110.242
fgf8afibroblast growth factor 8 a0.234
axin1axin 10.226
nkx2.2bNK2 transcription factor related 2b0.221
pitx2paired-like homeodomain transcription factor 20.221
ptch2patched 20.216
mespamesoderm posterior a0.206
bmp7abone morphogenetic protein 7a0.198
pkd2polycystic kidney disease 20.187
has2hyaluronan synthase 20.170
foxa1forkhead box A10.156
bonbonnie and clyde0.153
foxa2forkhead box A20.149
igf1rbinsulin-like growth factor 1b receptor0.149
nog1noggin 10.148
six4asine oculis homeobox homolog 4a0.148
tnnt2atroponin T2a, cardiac0.147
plcg1phospholipase C, gamma 10.139
tnnc1atroponin C type 1a (slow)0.134
her7hairy and enhancer of split related-70.118
gata5GATA-binding protein 50.115
admpanti-dorsalizing morphogenic protein0.115
her1hairy-related 10.114
runx2brunt-related transcription factor 2b0.112
nppanatriuretic peptide precursor A0.111
wif1wnt inhibitory factor 10.107
pomcaproopiomelanocortin a0.106
ptch1patched 10.105
fgf3fibroblast growth factor 30.099
sox17SRY-box containing gene 170.098
vasavasa homolog0.096
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.095
cmlc1cardiac myosin light chain-10.094
gro2groucho 20.091
hnf1baHNF1 homeobox Ba0.088
vmhclventricular myosin heavy chain-like0.086
klf4Kruppel-like factor 40.085
snai1asnail homolog 1a (Drosophila)0.084
eya1eyes absent homolog 10.082
msgn1mesogenin 10.080
lhx1aLIM homeobox 1a0.077
gli1GLI-Kruppel family member 10.076
cdh1cadherin 1, epithelial0.076
tbx5bT-box 5b0.074
fzd10frizzled homolog 100.071
shhbsonic hedgehog b0.068
foxh1forkhead box H10.067
wacaWW domain containing adaptor with coiled-coil a0.067
rx3retinal homeobox gene 30.067
elk4ELK4, ETS-domain protein0.065
acvr1bactivin A receptor, type IB0.064
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.063
nkx2.1aNK2 homeobox 1a0.062
lhx5LIM homeobox 50.060
tcf21transcription factor 210.057
aplnrbapelin receptor b0.057
hoxd11ahomeo box D11a0.056
her5hairy-related 50.055
pax2apaired box gene 2a0.055
tbx2aT-box gene 2a0.055
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.940
cicubitus interruptus0.869
eyaeyes absent0.640
Rac1CG2248 gene product from transcript CG2248-RA0.607
sosine oculis0.601
Mef2Myocyte enhancer factor 20.282
gbbglass bottom boat0.275
fasfaint sausage0.218
Su(H)Suppressor of Hairless0.198
hydhyperplastic discs0.145
slp1sloppy paired 10.119
Lim1CG11354 gene product from transcript CG11354-RA0.115
opaodd paired0.107
dallydivision abnormally delayed0.104
slp2sloppy paired 20.103
Wnt4Wnt oncogene analog 40.096
sogshort gastrulation0.088
fkhfork head0.085
argosCG4531 gene product from transcript CG4531-RA0.084
DadDaughters against dpp0.080
HLH54FCG5005 gene product from transcript CG5005-RA0.080
l(2)gllethal (2) giant larvae0.068
nkdnaked cuticle0.062
stmAstambha A0.057
AdamCG12131 gene product from transcript CG12131-RA0.044
bab2CG9102 gene product from transcript CG9102-RA0.044
vavCG7893 gene product from transcript CG7893-RB0.039
pashapartner of drosha0.038
gcmglial cells missing0.038
eveeven skipped0.038
nulloCG14426 gene product from transcript CG14426-RB0.037
stumpsCG31317 gene product from transcript CG31317-RC0.035
NotumCG13076 gene product from transcript CG13076-RB0.034
aopanterior open0.032
kirrekin of irre0.031
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Gli3GLI-Kruppel family member GLI31.000
Bmp4bone morphogenetic protein 41.000
Pitx2paired-like homeodomain transcription factor 21.000
Eya1eyes absent 1 homolog (Drosophila)1.000
Foxc2forkhead box C21.000
Pax3paired box gene 31.000
Fgfr2fibroblast growth factor receptor 21.000
Foxc1forkhead box C11.000
Pax2paired box gene 21.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Pax6paired box gene 60.999
Foxg1forkhead box G10.998
Bmp7bone morphogenetic protein 70.997
Fgf8fibroblast growth factor 80.996
Sox2SRY-box containing gene 20.996
Tbx1T-box 10.994
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.994
Rargretinoic acid receptor, gamma0.993
Tcfap2atranscription factor AP-2, alpha0.993
Msx1homeobox, msh-like 10.993
Ctnnb1catenin (cadherin associated protein), beta 10.991
Tbx3T-box 30.987
Fgfr1fibroblast growth factor receptor 10.987
Vangl2vang-like 2 (van gogh, Drosophila)0.985
Hand1heart and neural crest derivatives expressed transcript 10.985
Sox9SRY-box containing gene 90.971
Tgfb2transforming growth factor, beta 20.970
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.967
Gata4GATA binding protein 40.967
Prrx1paired related homeobox 10.945
Lmx1aLIM homeobox transcription factor 1 alpha0.932
Hoxa1homeobox A10.931
Dlx5distal-less homeobox 50.913
Jag1jagged 10.893
Isl1ISL1 transcription factor, LIM/homeodomain0.887
Gscgoosecoid homeobox0.887
Emx2empty spiracles homolog 2 (Drosophila)0.886
Pitx1paired-like homeodomain transcription factor 10.882
Gbx2gastrulation brain homeobox 20.875
Emx1empty spiracles homolog 1 (Drosophila)0.870
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.866
Hes1hairy and enhancer of split 1 (Drosophila)0.856
Hoxd13homeobox D130.825
Msx2homeobox, msh-like 20.804
Hoxa13homeobox A130.796
Meox2mesenchyme homeobox 20.784
Ascl1achaete-scute complex homolog 1 (Drosophila)0.781
Smosmoothened homolog (Drosophila)0.779
Zic3zinc finger protein of the cerebellum 30.772
Vegfavascular endothelial growth factor A0.766
Prrx2paired related homeobox 20.747
Lmx1bLIM homeobox transcription factor 1 beta0.746
Zeb1zinc finger E-box binding homeobox 10.745
Smad6MAD homolog 6 (Drosophila)0.741
Pbx1pre B-cell leukemia transcription factor 10.717
Gli2GLI-Kruppel family member GLI20.704
Ror2receptor tyrosine kinase-like orphan receptor 20.677
Runx2runt related transcription factor 20.656
Alx4aristaless-like homeobox 40.655
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.647
Fgf10fibroblast growth factor 100.631
Chd7chromodomain helicase DNA binding protein 70.623
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.619
Hmx1H6 homeobox 10.580
En1engrailed 10.571
Pax8paired box gene 80.554
Wnt3awingless-related MMTV integration site 3A0.534
Otx1orthodenticle homolog 1 (Drosophila)0.523
Hoxd11homeobox D110.512
Rarbretinoic acid receptor, beta0.502
Sox11SRY-box containing gene 110.493
Lrp6low density lipoprotein receptor-related protein 60.487
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.484
Neurog2neurogenin 20.471
Neurod1neurogenic differentiation 10.457
Hoxa2homeobox A20.453
Dvl2dishevelled 2, dsh homolog (Drosophila)0.452
Snai1snail homolog 1 (Drosophila)0.448
Hoxa10homeobox A100.448
Foxa2forkhead box A20.446
Ptpn11protein tyrosine phosphatase, non-receptor type 110.393
Fgfr3fibroblast growth factor receptor 30.375
Smad4MAD homolog 4 (Drosophila)0.373
Tbx15T-box 150.360
Sox3SRY-box containing gene 30.350
Nr5a1nuclear receptor subfamily 5, group A, member 10.338
Gata6GATA binding protein 60.320
Tlx3T-cell leukemia, homeobox 30.319
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.314
Gdf5growth differentiation factor 50.303
Notch2Notch gene homolog 2 (Drosophila)0.302
Dlx6distal-less homeobox 60.301
Axin1axin 10.293
Smad1MAD homolog 1 (Drosophila)0.290
Ednraendothelin receptor type A0.290
Notch1Notch gene homolog 1 (Drosophila)0.290
Alx3aristaless-like homeobox 30.286
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Laptm5lysosomal protein transmembrane 50.027
Arpc1bactin related protein 2/3 complex, subunit 1B0.022
Fcer1gFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.021
C1scomplement component 1, s subcomponent0.017
RT1-DaRT1 class II, locus Da0.017
Ctsscathepsin S0.014
Ifitm3interferon induced transmembrane protein 30.014
Cd53Cd53 molecule0.014
C1qacomplement component 1, q subcomponent, A chain0.014
Rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.013
TyrobpTyro protein tyrosine kinase binding protein0.013
C1qbcomplement component 1, q subcomponent, B chain0.013
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.013
Mgpmatrix Gla protein0.012
Lyz2lysozyme 20.012
Ear11eosinophil-associated, ribonuclease A family, member 110.012
Lgals3lectin, galactoside-binding, soluble, 30.012
Rpl11ribosomal protein L110.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism