The network for 'response to glucocorticoid' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to glucocorticoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

NameDescriptionProbabilityFunc Analog Organism
IL8interleukin 80.759
ESR1estrogen receptor 10.533
JUNjun proto-oncogene0.511
RNF144Bring finger protein 144B0.439
IL1R1interleukin 1 receptor, type I0.376
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.363
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.355
SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 20.352
EGFRepidermal growth factor receptor0.297
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.295
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.278
FOSFBJ murine osteosarcoma viral oncogene homolog0.213
SULT1A4sulfotransferase family, cytosolic, 1A, phenol-preferring, member 40.176
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.175
BCL2L1BCL2-like 10.164
CASP9caspase 9, apoptosis-related cysteine peptidase0.160
APAF1apoptotic peptidase activating factor 10.150
ANXA1annexin A10.145
PLAUplasminogen activator, urokinase0.134
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.127
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.120
PLAURplasminogen activator, urokinase receptor0.114
CXCL2chemokine (C-X-C motif) ligand 20.097
JUNBjun B proto-oncogene0.086
NRP1neuropilin 10.086
RB1retinoblastoma 10.084
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.082
ATF3activating transcription factor 30.079
IL6interleukin 6 (interferon, beta 2)0.076
S100A10S100 calcium binding protein A100.076
MAPK8mitogen-activated protein kinase 80.074
NOSTRINnitric oxide synthase trafficker0.073
XIAPX-linked inhibitor of apoptosis0.073
CASP3caspase 3, apoptosis-related cysteine peptidase0.072
THBS1thrombospondin 10.069
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.068
NR4A2nuclear receptor subfamily 4, group A, member 20.062
IER3immediate early response 30.055
DUSP1dual specificity phosphatase 10.054
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.054
CDK2cyclin-dependent kinase 20.051
CRHR1corticotropin releasing hormone receptor 10.050
NRIP1nuclear receptor interacting protein 10.049
TNFAIP3tumor necrosis factor, alpha-induced protein 30.048
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.043
NCOA1nuclear receptor coactivator 10.041
ANXA5annexin A50.040
CRHcorticotropin releasing hormone0.039
RPL18Aribosomal protein L18a0.037
IQGAP1IQ motif containing GTPase activating protein 10.035
CCL20chemokine (C-C motif) ligand 200.034
JAK2Janus kinase 20.033
IL22RA2interleukin 22 receptor, alpha 20.031
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.031
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.029
RICTORRPTOR independent companion of MTOR, complex 20.028
CCR5chemokine (C-C motif) receptor 50.027
CXCL3chemokine (C-X-C motif) ligand 30.027
LATlinker for activation of T cells0.027
PTPRBprotein tyrosine phosphatase, receptor type, B0.027
EIF3Feukaryotic translation initiation factor 3, subunit F0.027
CREBBPCREB binding protein0.027
EMP1epithelial membrane protein 10.027
CCL2chemokine (C-C motif) ligand 20.026
PTPN1protein tyrosine phosphatase, non-receptor type 10.026
APOA1apolipoprotein A-I0.026
MDM2Mdm2 p53 binding protein homolog (mouse)0.025
SCP2sterol carrier protein 20.025
IGF1Rinsulin-like growth factor 1 receptor0.024
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.024
ARRDC3arrestin domain containing 30.024
UHRF2ubiquitin-like with PHD and ring finger domains 20.023
STAT5Asignal transducer and activator of transcription 5A0.023
MAPK3mitogen-activated protein kinase 30.022
RARAretinoic acid receptor, alpha0.022
BCL2B-cell CLL/lymphoma 20.022
PGFplacental growth factor0.021
BIDBH3 interacting domain death agonist0.021
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.021
FSTL1follistatin-like 10.021
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.021
FOSL1FOS-like antigen 10.020
C16orf53chromosome 16 open reading frame 530.020
MAPTmicrotubule-associated protein tau0.020
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.020
C1QAcomplement component 1, q subcomponent, A chain0.019
SMAD3SMAD family member 30.019
LY96lymphocyte antigen 960.019
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.019
KLF4Kruppel-like factor 4 (gut)0.018
PLATplasminogen activator, tissue0.018
PMLpromyelocytic leukemia0.018
IFNGR1interferon gamma receptor 10.018
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.018
CCND3cyclin D30.018
DUSP5dual specificity phosphatase 50.017
KLF6Kruppel-like factor 60.017
AHRaryl hydrocarbon receptor0.017
BCL2L11BCL2-like 11 (apoptosis facilitator)0.017
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
apoebapolipoprotein Eb0.899
sox9aSRY-box containing gene 9a0.527
il6stinterleukin 6 signal transducer0.417
ghrbgrowth hormone receptor b0.412
igf2binsulin-like growth factor 2b0.393
trpv6transient receptor potential cation channel, subfamily V, member 60.353
anxa1bannexin A1b0.347
ptgs2aprostaglandin-endoperoxide synthase 2a0.340
atf3activating transcription factor 30.338
ghragrowth hormone receptor a0.316
ctsl1acathepsin L, 1 a0.313
epas1bendothelial PAS domain protein 1b0.305
bcl2B-cell leukemia/lymphoma 20.304
ptger2aprostaglandin E receptor 2a (subtype EP2)0.300
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.277
bbc3BCL2 binding component 30.256
alcamaactivated leukocyte cell adhesion molecule a0.254
pdx1pancreatic and duodenal homeobox 10.253
sat1aspermidine/spermine N1-acetyltransferase 1a0.246
inhbaainhibin, beta Aa0.242
mmp9matrix metalloproteinase 90.237
shhasonic hedgehog a0.235
esr1estrogen receptor 10.226
mstnbmyostatin b0.222
th2tyrosine hydroxylase 20.213
inhainhibin, alpha0.210
igfbp1binsulin-like growth factor binding protein 1b0.209
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.196
igf2ainsulin-like growth factor 2a0.189
cyp1b1cytochrome P450, family 1, subfamily B, polypeptide 10.184
rag1recombination activating gene 10.182
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.181
slc8a1bsolute carrier family 8 (sodium/calcium exchanger), member 1b0.181
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.171
kal1aKallmann syndrome 1a sequence0.165
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.164
LOC100003330melanocortin-2 receptor accessory protein 2-like0.163
rspo1R-spondin homolog (Xenopus laevis)0.152
ptprfprotein tyrosine phosphatase, receptor type, F0.146
cx32.3connexin 32.30.144
bmp15bone morphogenetic protein 150.143
stc1lstanniocalcin 1, like0.141
mep1a.1meprin A, alpha.10.134
prmt1protein arginine methyltransferase 10.134
slc34a2asolute carrier family 34 (sodium phosphate), member 2a0.125
tlr21toll-like receptor 210.124
insrbinsulin receptor b0.123
slc13a1solute carrier family 13 (sodium/sulphate symporters), member 10.122
wnt11rwingless-type MMTV integration site family, member 11, related0.122
slc2a9l1solute carrier family 2 (facilitated glucose transporter), member 9-like 10.120
krt18keratin 180.118
thtyrosine hydroxylase0.117
gnav1guanine nucleotide binding protein (G protein) alpha v10.117
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.116
fosl2fos-like antigen 20.115
cd63Cd63 antigen0.113
dlx5adistal-less homeobox gene 5a0.111
ca2carbonic anhydrase II0.111
ptgs1prostaglandin-endoperoxide synthase 10.111
gstp1glutathione S-transferase pi0.111
tp63tumor protein p630.110
il1binterleukin 1, beta and interleukin 1, beta0.109
rhcgbRhesus blood group, C glycoprotein b0.109
ucp2uncoupling protein 20.108
tlr3toll-like receptor 30.108
mfn2mitofusin 20.108
bcl2l10BCL2-like 10 (apoptosis facilitator)0.107
ptgdsprostaglandin D2 synthase0.107
uts1urotensin 10.106
acadlacyl-Coenzyme A dehydrogenase, long chain0.104
mcl1bmyeloid cell leukemia sequence 1b0.103
icn2ictacalcin 20.102
mt2metallothionein 20.102
slit1aslit homolog 1a (Drosophila)0.100
tyrp1btyrosinase-related protein 1b0.097
tnfatumor necrosis factor a (TNF superfamily, member 2)0.097
vdravitamin D receptor a0.096
igf1insulin-like growth factor 10.094
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.092
angptl7angiopoietin-like 70.091
faslgFas ligand (TNF superfamily, member 6)0.091
rtn4rl1reticulon 4 receptor-like 10.090
il8interleukin 80.089
tp53bp2tumor protein p53 binding protein, 20.089
piwil1piwi-like 1 (Drosophila)0.089
mapk1mitogen-activated protein kinase 10.088
dmbx1bdiencephalon/mesencephalon homeobox 1b0.088
spns2spinster homolog 2 (Drosophila)0.087
agrpagouti related protein homolog0.087
slit1bslit homolog 1b (Drosophila)0.087
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptgs2prostaglandin-endoperoxide synthase 20.991
Leprleptin receptor0.926
Stat3signal transducer and activator of transcription 30.919
Trp53transformation related protein 530.786
Nos1nitric oxide synthase 1, neuronal0.749
Ptenphosphatase and tensin homolog0.711
Lyz2lysozyme 20.680
Robo1roundabout homolog 1 (Drosophila)0.654
Ptpn11protein tyrosine phosphatase, non-receptor type 110.587
Il1r1interleukin 1 receptor, type I0.558
Bglapbone gamma carboxyglutamate protein0.524
Tlr4toll-like receptor 40.482
Csf1colony stimulating factor 1 (macrophage)0.421
Drd2dopamine receptor D20.384
Il6interleukin 60.361
Tgfbr2transforming growth factor, beta receptor II0.331
Il6stinterleukin 6 signal transducer0.309
Ren1renin 1 structural0.294
Apcadenomatosis polyposis coli0.287
Esr1estrogen receptor 1 (alpha)0.284
Nos3nitric oxide synthase 3, endothelial cell0.230
Prlrprolactin receptor0.221
Cav1caveolin 1, caveolae protein0.220
Cdkn1bcyclin-dependent kinase inhibitor 1B0.206
Tgfb1transforming growth factor, beta 10.182
Nr3c1nuclear receptor subfamily 3, group C, member 10.172
Apoeapolipoprotein E0.171
Col1a1collagen, type I, alpha 10.162
Cd44CD44 antigen0.155
Cdk2cyclin-dependent kinase 20.130
Tnftumor necrosis factor0.129
Vhlvon Hippel-Lindau tumor suppressor0.123
Ahraryl-hydrocarbon receptor0.114
Cdk4cyclin-dependent kinase 40.113
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.113
Fbn1fibrillin 10.112
C1qacomplement component 1, q subcomponent, alpha polypeptide0.108
Ppargperoxisome proliferator activated receptor gamma0.101
Spp1secreted phosphoprotein 10.092
Egfrepidermal growth factor receptor0.091
C1qccomplement component 1, q subcomponent, C chain0.088
Vdrvitamin D receptor0.086
Ccl2chemokine (C-C motif) ligand 20.085
Oprm1opioid receptor, mu 10.082
Il10interleukin 100.077
Agtr2angiotensin II receptor, type 20.077
Tgfb2transforming growth factor, beta 20.070
FasFas (TNF receptor superfamily member 6)0.068
Agtr1aangiotensin II receptor, type 1a0.068
Arandrogen receptor0.067
Has1hyaluronan synthase10.067
Vegfavascular endothelial growth factor A0.062
Osmroncostatin M receptor0.062
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.062
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.060
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.060
Npy1rneuropeptide Y receptor Y10.057
Klf3Kruppel-like factor 3 (basic)0.057
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.055
Gsdma3gasdermin A30.054
Fshrfollicle stimulating hormone receptor0.053
Casp4caspase 4, apoptosis-related cysteine peptidase0.053
Jag1jagged 10.052
Tgfatransforming growth factor alpha0.050
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.049
Prf1perforin 1 (pore forming protein)0.048
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.047
Lbrlamin B receptor0.046
Il1binterleukin 1 beta0.046
Nf1neurofibromatosis 10.045
Tgfbr1transforming growth factor, beta receptor I0.044
Ptmaprothymosin alpha0.044
Crhcorticotropin releasing hormone0.044
Pnpla2patatin-like phospholipase domain containing 20.043
Smr3asubmaxillary gland androgen regulated protein 3A0.041
Ms4a6dmembrane-spanning 4-domains, subfamily A, member 6D0.041
Smad3MAD homolog 3 (Drosophila)0.040
Il18interleukin 180.040
Mybphmyosin binding protein H0.039
BaxBCL2-associated X protein0.039
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.039
Mmp9matrix metallopeptidase 90.039
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.038
Lgr5leucine rich repeat containing G protein coupled receptor 50.038
Ldlrlow density lipoprotein receptor0.037
Upp2uridine phosphorylase 20.037
Stat5bsignal transducer and activator of transcription 5B0.037
Tnni2troponin I, skeletal, fast 20.037
Slc10a6solute carrier family 10 (sodium/bile acid cotransporter family), member 60.036
Itgb1integrin beta 1 (fibronectin receptor beta)0.036
Ccr1chemokine (C-C motif) receptor 10.035
Sos1son of sevenless homolog 1 (Drosophila)0.035
Csf1rcolony stimulating factor 1 receptor0.035
Otcornithine transcarbamylase0.035
Ifna2interferon alpha 20.034
Hmgb1high mobility group box 10.034
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Insrrinsulin receptor-related receptor0.917
Ptgs2prostaglandin-endoperoxide synthase 20.854
S100a10S100 calcium binding protein A100.787
Testintestin gene0.781
Chrna7cholinergic receptor, nicotinic, alpha 70.776
Akr1c18aldo-keto reductase family 1, member C180.757
Agtr1aangiotensin II receptor, type 1a0.703
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.686
Bcl2B-cell CLL/lymphoma 20.679
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.646
Egfrepidermal growth factor receptor0.643
G6pcglucose-6-phosphatase, catalytic subunit0.642
Ephx1epoxide hydrolase 1, microsomal0.636
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.636
RT1-BaRT1 class II, locus Ba0.628
Cd14CD14 molecule0.627
Il1ainterleukin 1 alpha0.611
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.611
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.605
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.590
Egr1early growth response 10.589
Il1binterleukin 1 beta0.580
Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.549
Lgals3lectin, galactoside-binding, soluble, 30.540
Gfapglial fibrillary acidic protein0.531
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.527
Ccl2chemokine (C-C motif) ligand 20.518
Orm1orosomucoid 10.518
Spink1serine peptidase inhibitor, Kazal type 10.515
RT1-DaRT1 class II, locus Da0.514
Fn1fibronectin 10.509
Mgst2microsomal glutathione S-transferase 20.508
Rarres2retinoic acid receptor responder (tazarotene induced) 20.500
Slc27a2solute carrier family 27 (fatty acid transporter), member 20.485
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.484
Slco2a1solute carrier organic anion transporter family, member 2a10.475
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.471
Il1r2interleukin 1 receptor, type II0.467
Slc14a2solute carrier family 14 (urea transporter), member 20.465
Il1r1interleukin 1 receptor, type I0.459
Tshrthyroid stimulating hormone receptor0.457
Socs3suppressor of cytokine signaling 30.457
Il6interleukin 60.453
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.452
Atp7bATPase, Cu++ transporting, beta polypeptide0.450
Gstm2glutathione S-transferase mu 20.449
Pcdhb12protocadherin beta 120.447
Cishcytokine inducible SH2-containing protein0.444
Nr1h4nuclear receptor subfamily 1, group H, member 40.444
Ms4a8amembrane-spanning 4-domains, subfamily A, member 8A0.441
Csf1colony stimulating factor 1 (macrophage)0.440
Slc6a1solute carrier family 6 (neurotransmitter transporter, GABA), member 10.439
Cd9CD9 molecule0.439
Aspgasparaginase homolog (S. cerevisiae)0.432
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.428
Fosl1fos-like antigen 10.427
S100a6S100 calcium binding protein A60.426
C1qccomplement component 1, q subcomponent, C chain0.425
Chrm1cholinergic receptor, muscarinic 10.423
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.422
Col3a1collagen, type III, alpha 10.419
Tgfbr2transforming growth factor, beta receptor II0.418
Acacbacetyl-Coenzyme A carboxylase beta0.417
Smad7SMAD family member 70.413
VgfVGF nerve growth factor inducible0.410
Gpx3glutathione peroxidase 30.410
Sftpdsurfactant protein D0.403
Ptgfrprostaglandin F receptor0.403
Mgst1microsomal glutathione S-transferase 10.401
Apohapolipoprotein H (beta-2-glycoprotein I)0.399
Anxa1annexin A10.397
Marcksmyristoylated alanine rich protein kinase C substrate0.393
Mug1murinoglobulin 10.392
Avparginine vasopressin0.391
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.389
Hnf4ahepatocyte nuclear factor 4, alpha0.386
Sv2csynaptic vesicle glycoprotein 2c0.386
LOC494499LOC494499 protein0.383
CartptCART prepropeptide0.383
Hes3hairy and enhancer of split 3 (Drosophila)0.378
Prok2prokineticin 20.376
Irs1insulin receptor substrate 10.370
Gja5gap junction protein, alpha 50.367
Cd36CD36 molecule (thrombospondin receptor)0.365
Sisucrase-isomaltase (alpha-glucosidase)0.364
Galr2galanin receptor 20.363
Lbplipopolysaccharide binding protein0.360
Defb4defensin beta 40.359
Errfi1ERBB receptor feedback inhibitor 10.357
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.356
Gpr83G protein-coupled receptor 830.355
Cfpcomplement factor properdin0.352
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.351
Nr4a3nuclear receptor subfamily 4, group A, member 30.351
Anxa5annexin A50.347
Gsta3glutathione S-transferase A30.347
Cxcl10chemokine (C-X-C motif) ligand 100.346
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism