The network for 'angiogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

NameDescriptionProbabilityFunc Analog Organism
CREBBPCREB binding protein0.998
JAG1jagged 10.985
NOTCH1notch 10.984
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.982
FGFR2fibroblast growth factor receptor 20.980
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.975
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.974
EP300E1A binding protein p3000.973
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.971
FN1fibronectin 10.968
COL4A2collagen, type IV, alpha 20.968
PTPN1protein tyrosine phosphatase, non-receptor type 10.966
IQGAP1IQ motif containing GTPase activating protein 10.964
NR4A1nuclear receptor subfamily 4, group A, member 10.963
EGFRepidermal growth factor receptor0.957
THBS1thrombospondin 10.956
CDH5cadherin 5, type 2 (vascular endothelium)0.956
SMAD2SMAD family member 20.955
TEKTEK tyrosine kinase, endothelial0.955
VEGFAvascular endothelial growth factor A0.946
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.941
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.930
PAX3paired box 30.924
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.919
METmet proto-oncogene (hepatocyte growth factor receptor)0.914
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.901
ANXA1annexin A10.899
FGFR1fibroblast growth factor receptor 10.898
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.894
CALM1calmodulin 1 (phosphorylase kinase, delta)0.871
CD34CD34 molecule0.867
CAV2caveolin 20.861
NOTCH3notch 30.860
NRP1neuropilin 10.846
RAMP2receptor (G protein-coupled) activity modifying protein 20.829
FGF1fibroblast growth factor 1 (acidic)0.817
TIMP3TIMP metallopeptidase inhibitor 30.817
PRKCAprotein kinase C, alpha0.816
TGFB1transforming growth factor, beta 10.807
HOXB5homeobox B50.790
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.790
YAP1Yes-associated protein 10.789
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.776
COL4A1collagen, type IV, alpha 10.776
COL1A1collagen, type I, alpha 10.763
CAV1caveolin 1, caveolae protein, 22kDa0.762
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.762
TCF4transcription factor 40.756
CCR2chemokine (C-C motif) receptor 20.747
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.742
CYR61cysteine-rich, angiogenic inducer, 610.740
RAMP3receptor (G protein-coupled) activity modifying protein 30.735
SKILSKI-like oncogene0.730
COL6A2collagen, type VI, alpha 20.728
LTBP2latent transforming growth factor beta binding protein 20.722
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.716
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.711
CTGFconnective tissue growth factor0.693
BCAR1breast cancer anti-estrogen resistance 10.681
PLCG1phospholipase C, gamma 10.672
PMLpromyelocytic leukemia0.666
COL5A1collagen, type V, alpha 10.665
ANGPTL2angiopoietin-like 20.655
ARandrogen receptor0.648
COL1A2collagen, type I, alpha 20.639
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.635
E2F7E2F transcription factor 70.634
PECAM1platelet/endothelial cell adhesion molecule0.632
ITGB5integrin, beta 50.629
BMP2bone morphogenetic protein 20.617
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.604
COL6A1collagen, type VI, alpha 10.600
SMAD7SMAD family member 70.598
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.575
TJP1tight junction protein 1 (zona occludens 1)0.569
MDM2Mdm2 p53 binding protein homolog (mouse)0.564
CXCL2chemokine (C-X-C motif) ligand 20.560
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.545
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.534
ILKintegrin-linked kinase0.523
PTENphosphatase and tensin homolog0.520
RASSF5Ras association (RalGDS/AF-6) domain family member 50.516
CRYABcrystallin, alpha B0.500
HOXA10homeobox A100.486
ANXA5annexin A50.477
MEF2Cmyocyte enhancer factor 2C0.475
EPHA2EPH receptor A20.474
SMAD3SMAD family member 30.473
IL2RBinterleukin 2 receptor, beta0.470
CD44CD44 molecule (Indian blood group)0.470
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.470
POU5F1POU class 5 homeobox 10.468
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.461
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.453
FHL2four and a half LIM domains 20.450
EGR3early growth response 30.441
BCL6B-cell CLL/lymphoma 60.430
NR0B1nuclear receptor subfamily 0, group B, member 10.425
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.958
cxcr4achemokine (C-X-C motif) receptor 4a0.957
fgfrl1bfibroblast growth factor receptor-like 1b0.923
cdh5cadherin 50.921
notch3notch homolog 30.918
kdrlkinase insert domain receptor like0.909
pitx3paired-like homeodomain transcription factor 30.905
fli1afriend leukemia integration 1a0.903
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.900
cxcr4bchemokine (C-X-C motif), receptor 4b0.852
pea3ETS-domain transcription factor pea30.850
alcamaactivated leukocyte cell adhesion molecule a0.835
gata2aGATA-binding protein 2a0.826
runx1runt-related transcription factor 10.808
hapln3hyaluronan and proteoglycan link protein 30.803
edn1endothelin 10.802
fn1fibronectin 10.792
tp53tumor protein p530.786
jag2jagged 20.777
efnb2aephrin B2a0.767
sema3fasemaphorin 3fa0.762
dll4delta-like 4 (Drosophila)0.758
lef1lymphocyte enhancer binding factor 10.751
grnagranulin a0.746
eng2aengrailed 2a0.741
pcdh18bprotocadherin 18b0.740
wnt9bwingless-type MMTV integration site family, member 9B0.739
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.725
tie2endothelium-specific receptor tyrosine kinase 20.722
aldh1a2aldehyde dehydrogenase 1 family, member A20.717
gro2groucho 20.705
lmx1b.1LIM homeobox transcription factor 1, beta 10.693
tbx16T-box gene 160.661
wnt11rwingless-type MMTV integration site family, member 11, related0.656
gli2aGLI-Kruppel family member GLI2a0.655
wnt9awingless-type MMTV integration site family, member 9A0.638
col12a1collagen, type XII, alpha 10.638
her11hairy-related 110.634
mmp2matrix metalloproteinase 20.629
traf4atnf receptor-associated factor 4a0.627
myf5myogenic factor 50.604
osr2odd-skipped related 2 (Drosophila)0.598
fbn2bfibrillin 2b0.589
sema3aasemaphorin 3aa0.584
mpxmyeloid-specific peroxidase0.567
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.566
tbx2aT-box gene 2a0.560
nrarpanotch-regulated ankyrin repeat protein a0.560
ndr2nodal-related 20.560
nrp1aneuropilin 1a0.559
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.545
vegfcvascular endothelial growth factor c0.531
shhbsonic hedgehog b0.528
ephb4beph receptor B4b0.520
pax8paired box gene 80.511
sox2SRY-box containing gene 20.508
sox9aSRY-box containing gene 9a0.501
tgfb3transforming growth factor, beta 30.496
her9hairy-related 90.493
alcambactivated leukocyte cell adhesion molecule b0.480
zfyve26zinc finger, FYVE domain containing 260.479
notch1bnotch homolog 1b0.478
tp63tumor protein p630.478
hey1hairy/enhancer-of-split related with YRPW motif 10.477
birc2baculoviral IAP repeat-containing 20.474
ilkintegrin linked kinase0.469
sulf1sulfatase 10.465
ednraendothelin receptor type A0.459
itgb1bintegrin, beta 1b0.459
wnt5bwingless-type MMTV integration site family, member 5b0.458
sim1asingle-minded homolog 1a (Drosophila)0.454
grem2gremlin 2, cysteine knot superfamily0.454
wnt3wingless-type MMTV integration site family, member 30.439
runx2brunt-related transcription factor 2b0.433
lama5laminin, alpha 50.432
pcdh8protocadherin 80.412
tagln2transgelin 20.411
rargbretinoic acid receptor, gamma b0.409
tgfbitransforming growth factor, beta-induced0.406
coro1acoronin, actin binding protein, 1A0.401
sox7SRY-box containing gene 70.398
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.398
ttnatitin a0.397
tal1T-cell acute lymphocytic leukemia 10.394
unc5bunc-5 homolog B (C. elegans)0.392
hoxa9bhomeo box A9b0.392
rtn4breticulon 4b0.387
notch2notch homolog 20.386
flot1flotillin 10.385
gng2guanine nucleotide binding protein (G protein), gamma 20.380
plcg1phospholipase C, gamma 10.380
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.378
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 21.000
Pax2paired box gene 20.998
Gli3GLI-Kruppel family member GLI30.995
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.995
Efnb2ephrin B20.994
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.993
Ptenphosphatase and tensin homolog0.993
Nos3nitric oxide synthase 3, endothelial cell0.987
Otx2orthodenticle homolog 2 (Drosophila)0.985
Fgfr1fibroblast growth factor receptor 10.984
Vegfavascular endothelial growth factor A0.982
Ptgs2prostaglandin-endoperoxide synthase 20.981
Gdnfglial cell line derived neurotrophic factor0.978
Csf1colony stimulating factor 1 (macrophage)0.977
Fgf8fibroblast growth factor 80.974
Tgfbr2transforming growth factor, beta receptor II0.970
Foxc1forkhead box C10.968
Fgfr3fibroblast growth factor receptor 30.968
Epha4Eph receptor A40.966
Wt1Wilms tumor 1 homolog0.965
Shhsonic hedgehog0.954
Pax3paired box gene 30.951
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.951
Smad3MAD homolog 3 (Drosophila)0.950
Rargretinoic acid receptor, gamma0.950
Tcf21transcription factor 210.947
Bmp4bone morphogenetic protein 40.938
Sox7SRY-box containing gene 70.938
Apcadenomatosis polyposis coli0.937
Ascl1achaete-scute complex homolog 1 (Drosophila)0.936
Hoxa13homeobox A130.934
Gli2GLI-Kruppel family member GLI20.933
Pitx2paired-like homeodomain transcription factor 20.932
Tgfb2transforming growth factor, beta 20.927
Foxc2forkhead box C20.926
Cav1caveolin 1, caveolae protein0.923
Lef1lymphoid enhancer binding factor 10.923
Twist2twist homolog 2 (Drosophila)0.918
Eya1eyes absent 1 homolog (Drosophila)0.915
Ccl2chemokine (C-C motif) ligand 20.913
Sox9SRY-box containing gene 90.904
Ntf3neurotrophin 30.902
Arandrogen receptor0.901
Ptch1patched homolog 10.900
Epas1endothelial PAS domain protein 10.899
Acvrl1activin A receptor, type II-like 10.886
Dab1disabled homolog 1 (Drosophila)0.884
Pbx1pre B-cell leukemia transcription factor 10.882
Tbx3T-box 30.878
Mapk14mitogen-activated protein kinase 140.875
Sox3SRY-box containing gene 30.874
Leprleptin receptor0.872
Smad6MAD homolog 6 (Drosophila)0.869
Pgrprogesterone receptor0.861
Kdrkinase insert domain protein receptor0.861
Hand1heart and neural crest derivatives expressed transcript 10.858
Mgat3mannoside acetylglucosaminyltransferase 30.857
Hif1ahypoxia inducible factor 1, alpha subunit0.855
Dll4delta-like 4 (Drosophila)0.852
Nos2nitric oxide synthase 2, inducible0.850
Rb1retinoblastoma 10.849
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.846
Pax8paired box gene 80.843
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.840
Ror1receptor tyrosine kinase-like orphan receptor 10.834
Hoxd13homeobox D130.832
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.831
Gpc3glypican 30.831
Pax6paired box gene 60.830
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.823
Dll1delta-like 1 (Drosophila)0.822
Foxf1aforkhead box F1a0.815
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.815
Fgf10fibroblast growth factor 100.814
Ccr2chemokine (C-C motif) receptor 20.813
Ephb2Eph receptor B20.809
Cdh5cadherin 50.807
Timp3tissue inhibitor of metalloproteinase 30.806
Bmp5bone morphogenetic protein 50.805
Ror2receptor tyrosine kinase-like orphan receptor 20.804
Sox2SRY-box containing gene 20.803
Il6stinterleukin 6 signal transducer0.800
Emx2empty spiracles homolog 2 (Drosophila)0.796
Efna1ephrin A10.792
Ptpn11protein tyrosine phosphatase, non-receptor type 110.786
Hes1hairy and enhancer of split 1 (Drosophila)0.781
Prrx2paired related homeobox 20.777
Pthlhparathyroid hormone-like peptide0.771
Sall4sal-like 4 (Drosophila)0.771
Foxa2forkhead box A20.767
Hif3ahypoxia inducible factor 3, alpha subunit0.766
Hand2heart and neural crest derivatives expressed transcript 20.761
Ctnnb1catenin (cadherin associated protein), beta 10.761
Htr75-hydroxytryptamine (serotonin) receptor 70.760
Adra2badrenergic receptor, alpha 2b0.756
Hoxa10homeobox A100.756
Bmpr1abone morphogenetic protein receptor, type 1A0.755
Zic3zinc finger protein of the cerebellum 30.752
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Metmet proto-oncogene0.639
Ccr2chemokine (C-C motif) receptor 20.526
Fgfr2fibroblast growth factor receptor 20.513
Edn1endothelin 10.455
Egr2early growth response 20.437
Flt1FMS-related tyrosine kinase 10.421
Id3inhibitor of DNA binding 30.402
Pecam1platelet/endothelial cell adhesion molecule 10.369
Ccl2chemokine (C-C motif) ligand 20.369
Il9rinterleukin 9 receptor0.356
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.352
Il8rbinterleukin 8 receptor, beta0.345
Itgamintegrin, alpha M0.322
Tacr1tachykinin receptor 10.313
Csf1colony stimulating factor 1 (macrophage)0.310
Mmp3matrix metallopeptidase 30.303
TekTEK tyrosine kinase, endothelial0.292
Mmp10matrix metallopeptidase 100.267
Ccl4chemokine (C-C motif) ligand 40.266
Cxcl2chemokine (C-X-C motif) ligand 20.262
Cdh5cadherin 50.243
Cd4Cd4 molecule0.242
Egr1early growth response 10.229
Trim47tripartite motif-containing 470.209
Plxnd1plexin D10.200
Ptafrplatelet-activating factor receptor0.194
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.188
Cmklr1chemokine-like receptor 10.186
Il1r1interleukin 1 receptor, type I0.180
Cpa3carboxypeptidase A3, mast cell0.170
Otx1orthodenticle homeobox 10.170
Hspa1aheat shock 70kD protein 1A0.166
Kdrkinase insert domain receptor0.165
Gzmkgranzyme K0.159
Ngfnerve growth factor (beta polypeptide)0.157
GperG protein-coupled estrogen receptor 10.156
Slc6a18solute carrier family 6, member 180.156
Il4interleukin 40.154
Elk3ELK3, ETS-domain protein0.150
LOC60591calcium-activated potassium channel beta subunit0.150
Cxcr5chemokine (C-X-C motif) receptor 50.149
Dusp1dual specificity phosphatase 10.148
Arl5cADP-ribosylation factor-like 5C0.142
Egr3early growth response 30.142
Arhgef15Rho guanine nucleotide exchange factor (GEF) 150.141
Galgalanin prepropeptide0.140
Il6interleukin 60.137
Pfn1profilin 10.135
Cd200r1CD200 receptor 10.132
Mbl1mannose-binding lectin (protein A) 10.128
Epas1endothelial PAS domain protein 10.128
Twist2twist homolog 2 (Drosophila)0.127
Igfbp5insulin-like growth factor binding protein 50.127
Orm1orosomucoid 10.125
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.124
Adora2aadenosine A2a receptor0.122
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.121
Smgbneonatal submandibular gland protein B0.121
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.120
Meox2mesenchyme homeobox 20.120
Mmp12matrix metallopeptidase 120.118
Egfl7EGF-like-domain, multiple 70.115
Rhobras homolog gene family, member B0.115
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.115
Apoa2apolipoprotein A-II0.114
Reg1aregenerating islet-derived 1 alpha0.113
Prrx1paired related homeobox 10.113
Socs3suppressor of cytokine signaling 30.110
GraspGRP1 (general receptor for phosphoinositides 1)-associated scaffold protein0.110
Calcrlcalcitonin receptor-like0.109
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.108
Adam7ADAM metallopeptidase domain 70.107
Has2hyaluronan synthase 20.106
Itga6integrin, alpha 60.106
Nfe2l2nuclear factor, erythroid derived 2, like 20.105
Sellselectin L0.104
Stc1stanniocalcin 10.103
Ccl3chemokine (C-C motif) ligand 30.102
Tas2r126taste receptor, type 2, member 1260.101
Smad1SMAD family member 10.100
Cd80Cd80 molecule0.100
Gata2GATA binding protein 20.099
Il1rl1interleukin 1 receptor-like 10.098
Iappislet amyloid polypeptide0.098
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.097
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.096
Cyyr1cysteine/tyrosine-rich 10.094
Col12a1collagen, type XII, alpha 10.094
Pmfbp1polyamine modulated factor 1 binding protein 10.092
Ccr5chemokine (C-C motif) receptor 50.092
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.092
Gucy2dguanylate cyclase 2d0.091
Mmp13matrix metallopeptidase 130.090
JunJun oncogene0.089
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism