The network for 'cartilage development involved in endochondral bone morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cartilage development involved in endochondral bone morphogenesis

The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.

NameDescriptionProbabilityFunc Analog Organism
RXRAretinoid X receptor, alpha0.999
POU5F1POU class 5 homeobox 10.974
NOTCH1notch 10.933
PAX3paired box 30.836
TGFB1transforming growth factor, beta 10.817
NOTCH3notch 30.776
MED25mediator complex subunit 250.670
TGFB3transforming growth factor, beta 30.543
WWP2WW domain containing E3 ubiquitin protein ligase 20.518
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.497
VEGFAvascular endothelial growth factor A0.424
PTPRBprotein tyrosine phosphatase, receptor type, B0.424
NRP1neuropilin 10.395
FN1fibronectin 10.367
SMAD7SMAD family member 70.346
PTPN3protein tyrosine phosphatase, non-receptor type 30.295
JAG1jagged 10.280
CREBBPCREB binding protein0.280
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.247
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.236
FSTL1follistatin-like 10.219
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.215
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.174
NCOA1nuclear receptor coactivator 10.166
IGFBP3insulin-like growth factor binding protein 30.162
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.144
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.143
COL1A2collagen, type I, alpha 20.141
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.129
NOTCH2notch 20.128
MEOX2mesenchyme homeobox 20.124
COL4A1collagen, type IV, alpha 10.115
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.109
SOX2SRY (sex determining region Y)-box 20.102
PTPN2protein tyrosine phosphatase, non-receptor type 20.098
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.097
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.097
FOXD3forkhead box D30.093
HMGA1high mobility group AT-hook 10.092
DLL1delta-like 1 (Drosophila)0.088
SPOPspeckle-type POZ protein0.086
ITGB1BP2integrin beta 1 binding protein (melusin) 20.084
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.081
NOTCH2NLnotch 2 N-terminal like0.080
PIAS1protein inhibitor of activated STAT, 10.080
COL6A1collagen, type VI, alpha 10.077
FOXG1forkhead box G10.075
HOXA10homeobox A100.074
RXRBretinoid X receptor, beta0.071
PTPN9protein tyrosine phosphatase, non-receptor type 90.067
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.067
BMP1bone morphogenetic protein 10.067
PDGFAplatelet-derived growth factor alpha polypeptide0.064
TGFBR1transforming growth factor, beta receptor 10.064
ADAM11ADAM metallopeptidase domain 110.063
LOXlysyl oxidase0.062
CDH5cadherin 5, type 2 (vascular endothelium)0.061
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.059
COL3A1collagen, type III, alpha 10.057
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.054
QKIquaking homolog, KH domain RNA binding (mouse)0.051
COL5A1collagen, type V, alpha 10.050
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.049
COL7A1collagen, type VII, alpha 10.049
MARCKSL1MARCKS-like 10.046
SOCS2suppressor of cytokine signaling 20.046
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.044
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.043
RXRGretinoid X receptor, gamma0.042
FGFR1fibroblast growth factor receptor 10.041
NID2nidogen 2 (osteonidogen)0.041
STC1stanniocalcin 10.041
AXIN1axin 10.040
FBLN2fibulin 20.039
HOXD13homeobox D130.039
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.039
MMP16matrix metallopeptidase 16 (membrane-inserted)0.038
MAML1mastermind-like 1 (Drosophila)0.036
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.036
DUSP7dual specificity phosphatase 70.036
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.034
PGRMC1progesterone receptor membrane component 10.033
KANK2KN motif and ankyrin repeat domains 20.033
KHSRPKH-type splicing regulatory protein0.033
MSX1msh homeobox 10.032
IGFBP5insulin-like growth factor binding protein 50.032
INSRinsulin receptor0.031
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.031
TWIST1twist homolog 1 (Drosophila)0.031
POU3F2POU class 3 homeobox 20.031
COL11A1collagen, type XI, alpha 10.029
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.028
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.028
INHBBinhibin, beta B0.028
PTHLHparathyroid hormone-like hormone0.027
SMAD4SMAD family member 40.026
ARID1AAT rich interactive domain 1A (SWI-like)0.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch1anotch homolog 1a0.952
sox9aSRY-box containing gene 9a0.831
foxi1forkhead box I10.826
gli2aGLI-Kruppel family member GLI2a0.755
jag1bjagged 1b0.740
col5a1procollagen, type V, alpha 10.682
sox10SRY-box containing gene 100.438
prdm1aPR domain containing 1a, with ZNF domain0.342
eya1eyes absent homolog 10.322
ghragrowth hormone receptor a0.274
runx3runt-related transcription factor 30.270
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.234
foxi3aforkhead box I3a0.232
tp63tumor protein p630.227
col2a1acollagen type II, alpha-1a0.211
tfe3btranscription factor binding to IGHM enhancer 3b0.179
myf5myogenic factor 50.160
col9a3collagen, type IX, alpha 30.145
rbp4retinol binding protein 4, plasma0.144
foxa1forkhead box A10.121
hoxa2bhomeo box A2b0.120
col1a2collagen, type I, alpha 20.117
hey1hairy/enhancer-of-split related with YRPW motif 10.117
foxd3forkhead box D30.116
jag2jagged 20.097
shhasonic hedgehog a0.093
efnb2aephrin B2a0.087
gdf6agrowth differentiation factor 6a0.084
vwfvon Willebrand factor0.083
six4bsine oculis homeobox homolog 4b0.082
foxc1aforkhead box C1a0.082
ihhbIndian hedgehog homolog b0.079
cdx4caudal type homeo box transcription factor 40.069
hoxd10ahomeo box D10a0.068
ctgfconnective tissue growth factor0.067
hapln1ahyaluronan and proteoglycan link protein 1a0.065
tbx24T-box 240.064
lmx1b.1LIM homeobox transcription factor 1, beta 10.063
col12a1collagen, type XII, alpha 10.058
nkx3.2NK3 homeobox 20.056
raraaretinoic acid receptor, alpha a0.056
satb2SATB homeobox 20.055
gbx1gastrulation brain homeobox 10.054
hoxa10bhomeo box A10b0.053
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.049
snai2snail homolog 2 (Drosophila)0.048
hoxd12ahomeo box D12a0.045
edn1endothelin 10.045
pitx3paired-like homeodomain transcription factor 30.044
col1a1acollagen, type I, alpha 1a0.043
wnt11wingless-type MMTV integration site family, member 110.042
col5a2lcollagen, type V, alpha 2-like0.041
barx1BarH-like homeobox 10.040
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.038
mab21l2mab-21-like 20.037
lhx1bLIM homeobox 1b0.037
atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.037
foxi3bforkhead box I3b0.037
il17rdinterleukin 17 receptor D0.036
pax8paired box gene 80.035
notch3notch homolog 30.035
nr2f5nuclear receptor subfamily 2, group F, member 50.033
ascl1aachaete-scute complex-like 1a (Drosophila)0.033
myod1myogenic differentiation 10.032
gbx2gastrulation brain homeo box 20.032
hoxb2ahomeo box B2a0.031
col11a1acollagen, type XI, alpha 1a0.030
matn4matrilin 40.030
hoxb5ahomeo box B5a0.030
col10a1collagen, type X, alpha 10.026
hoxd13ahomeo box D13a0.025
postnperiostin, osteoblast specific factor0.024
alx4baristaless-like homeobox 4b0.023
pdgfaaplatelet-derived growth factor alpha a0.023
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.023
barx2BarH-like homeobox 20.023
plod3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 30.022
tead3aTEA domain family member 3 a0.022
notch2notch homolog 20.021
fgfrl1afibroblast growth factor receptor-like 1a0.021
ghrbgrowth hormone receptor b0.021
hoxb3ahomeo box B3a0.020
dlx3bdistal-less homeobox gene 3b0.020
hoxa4ahomeo box A4a0.020
hoxa9bhomeo box A9b0.020
rxrgaretinoid x receptor, gamma a0.019
disp1dispatched homolog 1 (Drosophila)0.018
fgf3fibroblast growth factor 30.018
angptl2angiopoietin-like 20.018
bmp7bbone morphogenetic protein 7b0.018
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 11.000
Tgfbr2transforming growth factor, beta receptor II0.999
Fgfr2fibroblast growth factor receptor 20.999
Tgfb2transforming growth factor, beta 20.998
Gli2GLI-Kruppel family member GLI20.997
Fgfr1fibroblast growth factor receptor 10.996
Foxc1forkhead box C10.996
Bmp4bone morphogenetic protein 40.995
Nos3nitric oxide synthase 3, endothelial cell0.992
Shhsonic hedgehog0.992
Gli3GLI-Kruppel family member GLI30.988
Fbn1fibrillin 10.984
Prrx1paired related homeobox 10.982
Ror2receptor tyrosine kinase-like orphan receptor 20.977
Fgfr3fibroblast growth factor receptor 30.975
Sox9SRY-box containing gene 90.971
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.967
Fgf8fibroblast growth factor 80.944
Rargretinoic acid receptor, gamma0.935
Pax3paired box gene 30.930
Col11a1collagen, type XI, alpha 10.927
Twist2twist homolog 2 (Drosophila)0.926
Esr1estrogen receptor 1 (alpha)0.926
Pkd1polycystic kidney disease 1 homolog0.922
Runx2runt related transcription factor 20.876
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.871
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.870
Prrx2paired related homeobox 20.857
Acvr1activin A receptor, type 10.821
Col2a1collagen, type II, alpha 10.817
Hoxd11homeobox D110.811
Rxraretinoid X receptor alpha0.798
Smosmoothened homolog (Drosophila)0.796
Pthlhparathyroid hormone-like peptide0.791
Loxlysyl oxidase0.776
Meox2mesenchyme homeobox 20.775
Col1a2collagen, type I, alpha 20.752
Foxc2forkhead box C20.725
Hoxa11homeobox A110.718
Dlx5distal-less homeobox 50.711
Col3a1collagen, type III, alpha 10.705
Col5a2collagen, type V, alpha 20.705
Vegfavascular endothelial growth factor A0.669
Hand2heart and neural crest derivatives expressed transcript 20.651
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.637
Tbx1T-box 10.633
Rararetinoic acid receptor, alpha0.596
Smad3MAD homolog 3 (Drosophila)0.595
Col16a1collagen, type XVI, alpha 10.577
Msx1homeobox, msh-like 10.571
Col6a2collagen, type VI, alpha 20.568
Npr2natriuretic peptide receptor 20.553
Tcfap2atranscription factor AP-2, alpha0.539
Gata4GATA binding protein 40.528
Ctnnb1catenin (cadherin associated protein), beta 10.515
Eya1eyes absent 1 homolog (Drosophila)0.507
Ctskcathepsin K0.497
Apcadenomatosis polyposis coli0.445
Bmpr1abone morphogenetic protein receptor, type 1A0.439
Irs2insulin receptor substrate 20.431
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.420
Pitx2paired-like homeodomain transcription factor 20.414
Pax2paired box gene 20.399
Egfrepidermal growth factor receptor0.394
Col5a1collagen, type V, alpha 10.373
Bmp7bone morphogenetic protein 70.372
Ptenphosphatase and tensin homolog0.371
Smad7MAD homolog 7 (Drosophila)0.340
Hoxa3homeobox A30.331
Ltbp2latent transforming growth factor beta binding protein 20.327
Tgfbr1transforming growth factor, beta receptor I0.318
Hspg2perlecan (heparan sulfate proteoglycan 2)0.302
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.290
Grem1gremlin 10.283
Mmp2matrix metallopeptidase 20.262
Kiss1KiSS-1 metastasis-suppressor0.262
Tbx15T-box 150.262
Thbs2thrombospondin 20.254
Rspo2R-spondin 2 homolog (Xenopus laevis)0.243
Hoxa1homeobox A10.224
Ptpn11protein tyrosine phosphatase, non-receptor type 110.219
Wisp1WNT1 inducible signaling pathway protein 10.210
Smad4MAD homolog 4 (Drosophila)0.205
Col6a1collagen, type VI, alpha 10.202
Hoxb3homeobox B30.199
Fgfrl1fibroblast growth factor receptor-like 10.186
Ednraendothelin receptor type A0.183
Jag1jagged 10.183
Msx2homeobox, msh-like 20.178
Notch1Notch gene homolog 1 (Drosophila)0.177
Fbn2fibrillin 20.177
Twist1twist homolog 1 (Drosophila)0.174
Dlx2distal-less homeobox 20.173
Bmp5bone morphogenetic protein 50.166
Fstl1follistatin-like 10.165
Fgf9fibroblast growth factor 90.164
En1engrailed 10.163
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col3a1collagen, type III, alpha 10.994
Col1a1collagen, type I, alpha 10.992
Col1a2collagen, type I, alpha 20.963
Col5a1collagen, type V, alpha 10.925
Fstl1follistatin-like 10.668
Col12a1collagen, type XII, alpha 10.565
Col5a2collagen, type V, alpha 20.497
Postnperiostin, osteoblast specific factor0.350
Fbn1fibrillin 10.289
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.189
Col6a2collagen, type VI, alpha 20.169
Loxl1lysyl oxidase-like 10.128
Col14a1collagen, type XIV, alpha 10.095
Col15a1collagen, type XV, alpha 10.090
Ccdc80coiled-coil domain containing 800.063
Col4a5collagen, type IV, alpha 50.055
Pcolceprocollagen C-endopeptidase enhancer0.052
Col4a1collagen, type IV, alpha 10.051
Rcn3reticulocalbin 3, EF-hand calcium binding domain0.043
Loxlysyl oxidase0.040
Miamelanoma inhibitory activity0.032
Srpxsushi-repeat-containing protein, X-linked0.032
Dab2disabled homolog 2 (Drosophila)0.031
Fndc1fibronectin type III domain containing 10.030
Leprel2leprecan-like 20.029
Ggcxgamma-glutamyl carboxylase0.028
Prl8a2prolactin family 8, subfamily a, member 20.027
Fn1fibronectin 10.027
Capn6calpain 60.022
Msx1msh homeobox 10.020
Col9a2collagen, type IX, alpha 20.020
Lamc1laminin, gamma 10.020
Cpzcarboxypeptidase Z0.020
Mmp23matrix metallopeptidase 230.019
Nid2nidogen 20.019
Tgfb3transforming growth factor, beta 30.018
Mfap4microfibrillar-associated protein 40.018
Scarf2scavenger receptor class F, member 20.017
Myl9myosin, light chain 9, regulatory0.017
Col9a1collagen, type IX, alpha 10.017
Col11a2collagen, type XI, alpha 20.017
Fkbp10FK506 binding protein 100.016
Agtr1aangiotensin II receptor, type 1a0.016
Adkadenosine kinase0.015
Col2a1collagen, type II, alpha 10.015
Cercamcerebral endothelial cell adhesion molecule0.015
Gna12guanine nucleotide binding protein (G protein) alpha 120.015
Ibspintegrin-binding sialoprotein0.015
Fbln5fibulin 50.015
Ctskcathepsin K0.014
Rxraretinoid X receptor alpha0.014
Slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.014
Syngr2synaptogyrin 20.014
Suv420h2suppressor of variegation 4-20 homolog 2 (Drosophila)0.014
Nr2f2nuclear receptor subfamily 2, group F, member 20.013
Lect1leukocyte cell derived chemotaxin 10.013
Tnctenascin C0.013
Bmp1bone morphogenetic protein 10.013
Dnm3dynamin 30.013
Chiachitinase, acidic0.012
Rhojras homolog gene family, member J0.012
Megf6multiple EGF-like-domains 60.012
P4ha1prolyl 4-hydroxylase, alpha polypeptide I0.012
Arhgap28Rho GTPase activating protein 280.012
Maged2melanoma antigen, family D, 20.012
Ng23Ng23 protein0.012
Znf692zinc finger protein 6920.012
C1qtnf6C1q and tumor necrosis factor related protein 60.012
Sox10SRY (sex determining region Y)-box 100.011
Adrb1adrenergic, beta-1-, receptor0.011
Pthlhparathyroid hormone-like hormone0.011
Pxdnperoxidasin homolog (Drosophila)0.011
Fzd2frizzled homolog 2 (Drosophila)0.011
Ptpn12protein tyrosine phosphatase, non-receptor type 120.011
Stx3syntaxin 30.010
Clcn2chloride channel 20.010
Kcnh6potassium voltage-gated channel, subfamily H (eag-related), member 60.010
Cishcytokine inducible SH2-containing protein0.010
C1qtnf5C1q and tumor necrosis factor related protein 50.010
Col11a1collagen, type XI, alpha 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism