The network for 'regulation of heart growth' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of heart growth

Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
FGFR1fibroblast growth factor receptor 10.998
FGF1fibroblast growth factor 1 (acidic)0.997
TBX5T-box 50.997
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.992
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.984
YY1YY1 transcription factor0.965
FGF10fibroblast growth factor 100.916
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.915
EP300E1A binding protein p3000.841
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.827
JAG1jagged 10.776
RUVBL2RuvB-like 2 (E. coli)0.743
NOTCH1notch 10.723
TGFB3transforming growth factor, beta 30.634
HDAC4histone deacetylase 40.622
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.486
FGF2fibroblast growth factor 2 (basic)0.477
MAML1mastermind-like 1 (Drosophila)0.477
TP53tumor protein p530.449
TTRtransthyretin0.403
DVL3dishevelled, dsh homolog 3 (Drosophila)0.386
WWOXWW domain containing oxidoreductase0.382
SATB2SATB homeobox 20.353
GATA4GATA binding protein 40.352
HNF4Ahepatocyte nuclear factor 4, alpha0.332
STK3serine/threonine kinase 30.322
KRT5keratin 50.308
YAP1Yes-associated protein 10.283
PLCG1phospholipase C, gamma 10.268
ATXN1Lataxin 1-like0.262
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.213
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.212
MEF2Amyocyte enhancer factor 2A0.203
FGF7fibroblast growth factor 70.203
CABLES1Cdk5 and Abl enzyme substrate 10.194
NEDD4neural precursor cell expressed, developmentally down-regulated 40.185
SPENspen homolog, transcriptional regulator (Drosophila)0.182
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.178
NOTCH3notch 30.166
SIRT1sirtuin 10.163
TGFB1transforming growth factor, beta 10.154
HDAC9histone deacetylase 90.148
AXIN1axin 10.146
DCNdecorin0.143
INO80EINO80 complex subunit E0.141
NR5A2nuclear receptor subfamily 5, group A, member 20.128
BMP7bone morphogenetic protein 70.126
CDK2cyclin-dependent kinase 20.120
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.117
AHRaryl hydrocarbon receptor0.113
NCOA1nuclear receptor coactivator 10.113
KLF13Kruppel-like factor 130.107
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.106
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.100
STK4serine/threonine kinase 40.100
BMP2bone morphogenetic protein 20.099
FRS2fibroblast growth factor receptor substrate 20.097
RASSF5Ras association (RalGDS/AF-6) domain family member 50.097
SNW1SNW domain containing 10.094
MDM2Mdm2 p53 binding protein homolog (mouse)0.092
CREBBPCREB binding protein0.089
EGR1early growth response 10.088
KAT2BK(lysine) acetyltransferase 2B0.087
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.074
TNS4tensin 40.070
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.070
KRT6Ckeratin 6C0.070
PTPN14protein tyrosine phosphatase, non-receptor type 140.068
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.067
SEC16ASEC16 homolog A (S. cerevisiae)0.066
TP73tumor protein p730.066
C20orf20chromosome 20 open reading frame 200.065
RUNX1runt-related transcription factor 10.063
FGF8fibroblast growth factor 8 (androgen-induced)0.061
FGFR3fibroblast growth factor receptor 30.060
QKIquaking homolog, KH domain RNA binding (mouse)0.060
CTBP2C-terminal binding protein 20.059
S1PR5sphingosine-1-phosphate receptor 50.059
DLG2discs, large homolog 2 (Drosophila)0.059
DPCDdeleted in primary ciliary dyskinesia homolog (mouse)0.059
NRP1neuropilin 10.057
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.057
NOSTRINnitric oxide synthase trafficker0.056
FSTL1follistatin-like 10.056
SMAD7SMAD family member 70.056
SHC1SHC (Src homology 2 domain containing) transforming protein 10.055
PHLDA1pleckstrin homology-like domain, family A, member 10.055
APPamyloid beta (A4) precursor protein0.054
NOTCH2notch 20.053
DLG3discs, large homolog 3 (Drosophila)0.052
TCF4transcription factor 40.051
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.051
AMOTL1angiomotin like 10.051
CDC20cell division cycle 20 homolog (S. cerevisiae)0.050
HIPK2homeodomain interacting protein kinase 20.049
TBX1T-box 10.048
VPS72vacuolar protein sorting 72 homolog (S. cerevisiae)0.048
DMAP1DNA methyltransferase 1 associated protein 10.048
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.046
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.914
tbx1T-box 10.876
pdlim7PDZ and LIM domain 70.823
hey2hairy/enhancer-of-split related with YRPW motif 20.684
has2hyaluronan synthase 20.600
mef2cbmyocyte enhancer factor 2cb0.592
gli1GLI-Kruppel family member 10.535
sema3aasemaphorin 3aa0.533
fgfr1afibroblast growth factor receptor 1a0.514
smyhc1slow myosin heavy chain 10.436
wt1awilms tumor 1a0.423
foxa3forkhead box A30.395
fli1afriend leukemia integration 1a0.385
wnt2bbwingless-type MMTV integration site family, member 2Bb0.378
pax2apaired box gene 2a0.365
foxj1aforkhead box J1a0.343
gata5GATA-binding protein 50.332
bmp4bone morphogenetic protein 40.327
aldh1a2aldehyde dehydrogenase 1 family, member A20.317
tbx20T-box 200.277
pitx3paired-like homeodomain transcription factor 30.270
hnf1baHNF1 homeobox Ba0.264
rxrabretinoid x receptor, alpha b0.257
nkx2.5NK2 transcription factor related 50.257
kif23kinesin family member 230.247
tbx2bT-box 2b0.241
tnni1btroponin I, skeletal, slow b0.238
smyd1bSET and MYND domain containing 1b0.222
grem2gremlin 2, cysteine knot superfamily0.219
etv2ets variant gene 20.206
tnnc1btroponin C type 1b (slow)0.203
coblcordon-bleu homolog (mouse)0.197
tnni1altroponin I, skeletal, slow like0.195
diexfdigestive organ expansion factor homolog0.184
lhx2bLIM homeobox 2b0.178
foxn4forkhead box N40.177
myod1myogenic differentiation 10.176
gata6GATA-binding protein 60.173
hsp90a.1heat shock protein 90-alpha 10.172
mef2camyocyte enhancer factor 2ca0.171
eng2aengrailed 2a0.164
lppLIM domain containing preferred translocation partner in lipoma0.163
fstafollistatin a0.153
grnbgranulin b0.148
lef1lymphocyte enhancer binding factor 10.148
rfx2regulatory factor X, 2 (influences HLA class II expression)0.144
fabp11afatty acid binding protein 11a0.137
nppanatriuretic peptide precursor A0.137
wlswntless homolog (Drosophila)0.137
thtyrosine hydroxylase0.135
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.135
aplnrbapelin receptor b0.135
igf1rbinsulin-like growth factor 1b receptor0.135
ihhaIndian hedgehog homolog a0.133
prox1prospero-related homeobox gene 10.132
klf4aKruppel-like transcription factor 4a0.130
gpiaglucose phosphate isomerase a0.129
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.128
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.128
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.126
pdlim3bPDZ and LIM domain 3b0.125
snrpcsmall nuclear ribonucleoprotein polypeptide C0.120
tbx18T-box 180.119
tp73tumor protein p730.118
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.118
rbpms2RNA binding protein with multiple splicing 20.115
gdnfglial cell derived neurotrophic factor0.114
six1bsine oculis homeobox homolog 1b0.113
myf6myogenic factor 60.113
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.112
rbm24aRNA binding motif protein 24a0.108
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.108
tal1T-cell acute lymphocytic leukemia 10.107
eng1aengrailed 1a0.107
ahi1Abelson helper integration site 10.105
hand2heart and neural crest derivatives expressed transcript 20.104
hspa12bheat shock protein 12B0.103
spsb1splA/ryanodine receptor domain and SOCS box containing 10.102
dnmt8DNA (cytosine-5-)-methyltransferase 80.099
emx3empty spiracles homeobox 30.096
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.092
zbtb4zinc finger and BTB domain containing 40.092
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.089
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.088
aurkbaurora kinase B0.087
sox9bSRY-box containing gene 9b0.085
cdh5cadherin 50.085
ruvbl1RuvB-like 1 (E. coli)0.084
gapdhglyceraldehyde-3-phosphate dehydrogenase0.084
mbpmyelin basic protein0.084
trpv4transient receptor potential cation channel, subfamily V, member 40.083
tfebtranscription factor EB0.082
jag1bjagged 1b0.081
myl7myosin, light polypeptide 7, regulatory0.079
myogmyogenin0.079
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.077
podxlpodocalyxin-like0.076
plk1polo-like kinase 1 (Drosophila)0.073
rhouaras homolog gene family, member Ua0.072
ttnatitin a0.072
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Pax2paired box gene 20.996
Gli3GLI-Kruppel family member GLI30.995
Gli2GLI-Kruppel family member GLI20.993
Hand2heart and neural crest derivatives expressed transcript 20.992
Gata4GATA binding protein 40.989
Fgf8fibroblast growth factor 80.982
Nognoggin0.976
Foxc2forkhead box C20.971
Foxc1forkhead box C10.962
Tbx3T-box 30.961
Ntf3neurotrophin 30.958
Pax3paired box gene 30.957
Hoxa1homeobox A10.956
Tbx5T-box 50.935
Pitx2paired-like homeodomain transcription factor 20.928
Bmp4bone morphogenetic protein 40.927
Trp63transformation related protein 630.909
Lhx1LIM homeobox protein 10.878
Ror2receptor tyrosine kinase-like orphan receptor 20.874
Tbx1T-box 10.851
Sox9SRY-box containing gene 90.834
Rxraretinoid X receptor alpha0.823
Retret proto-oncogene0.819
Otx2orthodenticle homolog 2 (Drosophila)0.818
Hoxa13homeobox A130.794
Fgfr3fibroblast growth factor receptor 30.792
Itgb1integrin beta 1 (fibronectin receptor beta)0.776
Hand1heart and neural crest derivatives expressed transcript 10.772
Zfpm2zinc finger protein, multitype 20.742
Ptpn11protein tyrosine phosphatase, non-receptor type 110.737
Jag1jagged 10.730
Notch2Notch gene homolog 2 (Drosophila)0.729
Notch1Notch gene homolog 1 (Drosophila)0.721
Sox2SRY-box containing gene 20.701
Tbrachyury0.693
Apcadenomatosis polyposis coli0.683
Nos3nitric oxide synthase 3, endothelial cell0.672
Tbx2T-box 20.661
Tcf21transcription factor 210.643
Meox2mesenchyme homeobox 20.641
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.596
Zeb1zinc finger E-box binding homeobox 10.592
Vangl2vang-like 2 (van gogh, Drosophila)0.567
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.561
Dll4delta-like 4 (Drosophila)0.556
Pitx1paired-like homeodomain transcription factor 10.556
Fgf10fibroblast growth factor 100.547
Efnb2ephrin B20.541
Bmp5bone morphogenetic protein 50.526
Wnt3awingless-related MMTV integration site 3A0.525
Lef1lymphoid enhancer binding factor 10.523
Wt1Wilms tumor 1 homolog0.522
Pthlhparathyroid hormone-like peptide0.483
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.472
Scn5asodium channel, voltage-gated, type V, alpha0.453
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.447
Gdnfglial cell line derived neurotrophic factor0.447
Nkx2-1NK2 homeobox 10.438
Ctnnb1catenin (cadherin associated protein), beta 10.437
Shesrc homology 2 domain-containing transforming protein E0.433
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.417
Foxf1aforkhead box F1a0.417
Lmx1aLIM homeobox transcription factor 1 alpha0.399
Nodalnodal0.394
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.390
Twist2twist homolog 2 (Drosophila)0.372
Smad6MAD homolog 6 (Drosophila)0.360
Ptenphosphatase and tensin homolog0.357
Isl1ISL1 transcription factor, LIM/homeodomain0.351
Hoxd13homeobox D130.344
Hmx3H6 homeobox 30.342
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.340
Gata6GATA binding protein 60.317
Chd7chromodomain helicase DNA binding protein 70.317
En1engrailed 10.314
Gja5gap junction protein, alpha 50.311
Fgf15fibroblast growth factor 150.309
Hey2hairy/enhancer-of-split related with YRPW motif 20.306
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.305
Pou5f1POU domain, class 5, transcription factor 10.303
Cdx2caudal type homeobox 20.301
Bmp7bone morphogenetic protein 70.298
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.294
Wnt11wingless-related MMTV integration site 110.289
Nr5a1nuclear receptor subfamily 5, group A, member 10.288
Rbpjlrecombination signal binding protein for immunoglobulin kappa J region-like0.288
Fgf18fibroblast growth factor 180.284
Gata3GATA binding protein 30.276
Phox2bpaired-like homeobox 2b0.271
Itga3integrin alpha 30.267
Pcsk5proprotein convertase subtilisin/kexin type 50.265
Mef2cmyocyte enhancer factor 2C0.252
Vegfavascular endothelial growth factor A0.248
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.246
Bcl2B-cell leukemia/lymphoma 20.238
Socs1suppressor of cytokine signaling 10.235
Emx2empty spiracles homolog 2 (Drosophila)0.235
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.317
Cdkn3cyclin-dependent kinase inhibitor 30.137
Cav2caveolin 20.134
Acat3acetyl-Coenzyme A acetyltransferase 30.112
Top2atopoisomerase (DNA) II alpha0.087
Cald1caldesmon 10.073
Ube2cubiquitin-conjugating enzyme E2C0.070
Timp3TIMP metallopeptidase inhibitor 30.063
Nos3nitric oxide synthase 3, endothelial cell0.062
Pdcphosducin0.060
Gja3gap junction protein, alpha 30.051
Insig1insulin induced gene 10.051
Nrg1neuregulin 10.049
Prl8a2prolactin family 8, subfamily a, member 20.047
Kif2ckinesin family member 2C0.045
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.045
Traf4af1TRAF4 associated factor 10.044
Nek9NIMA (never in mitosis gene a)- related kinase 90.043
Ednraendothelin receptor type A0.042
Crybb2crystallin, beta B20.038
Phkg1phosphorylase kinase, gamma 10.036
Syt8synaptotagmin VIII0.036
Strnstriatin, calmodulin binding protein0.033
Ccnb1cyclin B10.031
Kcng2potassium voltage-gated channel, subfamily G, member 20.029
Tnni1troponin I type 1 (skeletal, slow)0.028
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.028
Notch2Notch homolog 2 (Drosophila)0.028
Dctn3dynactin 30.027
Fgf14fibroblast growth factor 140.026
Pttg1pituitary tumor-transforming 10.026
Col4a4collagen, type IV, alpha 40.026
Tpc1808tropic 18080.025
Htr65-hydroxytryptamine (serotonin) receptor 60.025
Ap2s1adaptor-related protein complex 2, sigma 1 subunit0.024
Dmddystrophin0.024
Pecam1platelet/endothelial cell adhesion molecule 10.024
Sgp158proline-rich glycoprotein (sgp158)0.023
Ahraryl hydrocarbon receptor0.023
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.022
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.022
LOC100362824caveolin 2-like0.022
Muskmuscle, skeletal, receptor tyrosine kinase0.022
Nusap1nucleolar and spindle associated protein 10.021
Gja4gap junction protein, alpha 40.020
Dlg4discs, large homolog 4 (Drosophila)0.020
Ccnb2cyclin B20.020
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.019
Prrx1paired related homeobox 10.019
Grik3glutamate receptor, ionotropic, kainate 30.019
Prkcaprotein kinase C, alpha0.019
Emp1epithelial membrane protein 10.018
Il2rainterleukin 2 receptor, alpha0.018
Synposynaptopodin0.018
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.018
Cdh6cadherin 60.018
Lamc1laminin, gamma 10.018
RGD1564327similar to integrin alpha 80.018
Smad7SMAD family member 70.017
Olr287olfactory receptor 2870.017
Cks2CDC28 protein kinase regulatory subunit 20.017
Fgf16fibroblast growth factor 160.017
Cyp51cytochrome P450, family 510.017
Hspb2heat shock protein beta 20.016
Depdc1DEP domain containing 10.016
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.016
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.016
Ngfnerve growth factor (beta polypeptide)0.016
KitlgKIT ligand0.016
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.016
LOC286980putative pheromone receptor (Go-VN13B)0.016
Nedd4neural precursor cell expressed, developmentally down-regulated 40.015
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.015
Fgf5fibroblast growth factor 50.015
Myo1dmyosin ID0.015
Itpr2inositol 1,4,5-triphosphate receptor, type 20.015
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.015
Fdft1farnesyl diphosphate farnesyl transferase 10.015
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.015
Prp15proline-rich protein 150.015
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.015
Lim2lens intrinsic membrane protein 20.015
Sox17SRY (sex determining region Y)-box 170.014
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.014
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.014
Vom2r27vomeronasal 2 receptor, 270.014
Opn1swopsin 1 (cone pigments), short-wave-sensitive0.014
Tmem97transmembrane protein 970.014
Ier5immediate early response 50.014
Ckmcreatine kinase, muscle0.014
Reg3aregenerating islet-derived 3 alpha0.014
Igfbp5insulin-like growth factor binding protein 50.014
Prkchprotein kinase C, eta0.014
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.013
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.013
Adamts13ADAM metallopeptidase with thrombospondin type 1 motif, 130.013
Znf483zinc finger protein 4830.013
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.013
Slc1a6solute carrier family 1 (high affinity aspartate/glutamate transporter), member 60.013
Tacr2tachykinin receptor 20.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism