The network for 'system process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.998
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.998
DLG4discs, large homolog 4 (Drosophila)0.994
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.987
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.986
EGFRepidermal growth factor receptor0.984
FLNAfilamin A, alpha0.983
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.982
PSEN1presenilin 10.981
SHC1SHC (Src homology 2 domain containing) transforming protein 10.980
YAP1Yes-associated protein 10.972
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.971
APPamyloid beta (A4) precursor protein0.969
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.963
FYNFYN oncogene related to SRC, FGR, YES0.960
SMAD2SMAD family member 20.955
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.949
FHL2four and a half LIM domains 20.947
GSK3Bglycogen synthase kinase 3 beta0.932
ILKintegrin-linked kinase0.931
ATF2activating transcription factor 20.929
JUPjunction plakoglobin0.924
FGFR2fibroblast growth factor receptor 20.924
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.922
CRYABcrystallin, alpha B0.921
PTPN1protein tyrosine phosphatase, non-receptor type 10.920
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.908
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.898
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.895
TNNI1troponin I type 1 (skeletal, slow)0.889
CASP8caspase 8, apoptosis-related cysteine peptidase0.881
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.880
MAPTmicrotubule-associated protein tau0.875
NCOA3nuclear receptor coactivator 30.874
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.873
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.871
NCOR2nuclear receptor corepressor 20.854
ACTN2actinin, alpha 20.832
SRFserum response factor (c-fos serum response element-binding transcription factor)0.831
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.827
CRHR1corticotropin releasing hormone receptor 10.823
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.821
CRYBB2crystallin, beta B20.821
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.808
TRIM63tripartite motif containing 630.796
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.796
NRP1neuropilin 10.795
MAPK1mitogen-activated protein kinase 10.793
JAG1jagged 10.793
HNF4Ahepatocyte nuclear factor 4, alpha0.786
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.786
FGFR1fibroblast growth factor receptor 10.784
QKIquaking homolog, KH domain RNA binding (mouse)0.781
LRRK2leucine-rich repeat kinase 20.779
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.779
DRD2dopamine receptor D20.775
FGF1fibroblast growth factor 1 (acidic)0.771
AHSA1AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)0.771
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.764
CCKBRcholecystokinin B receptor0.763
FN1fibronectin 10.762
TGFB1transforming growth factor, beta 10.759
MYOD1myogenic differentiation 10.757
NCAM1neural cell adhesion molecule 10.755
CRYBB1crystallin, beta B10.754
HSPB1heat shock 27kDa protein 10.754
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.751
PKM2pyruvate kinase, muscle0.748
JUNjun proto-oncogene0.737
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.736
NCOR1nuclear receptor corepressor 10.731
HLA-Fmajor histocompatibility complex, class I, F0.729
HSPB8heat shock 22kDa protein 80.725
TNRC6Atrinucleotide repeat containing 6A0.720
NTRK3neurotrophic tyrosine kinase, receptor, type 30.719
LBX1ladybird homeobox 10.719
RARAretinoic acid receptor, alpha0.716
HLA-Amajor histocompatibility complex, class I, A0.712
TEKTEK tyrosine kinase, endothelial0.712
C1QAcomplement component 1, q subcomponent, A chain0.710
CHRNA4cholinergic receptor, nicotinic, alpha 40.710
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.710
CALCAcalcitonin-related polypeptide alpha0.707
UBR5ubiquitin protein ligase E3 component n-recognin 50.704
MEF2Cmyocyte enhancer factor 2C0.702
DLGAP2discs, large (Drosophila) homolog-associated protein 20.697
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.693
ZFYVE9zinc finger, FYVE domain containing 90.682
PTENphosphatase and tensin homolog0.681
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.681
CRYBB3crystallin, beta B30.679
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.674
HTR45-hydroxytryptamine (serotonin) receptor 40.669
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.667
PAX8paired box 80.659
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
atn-1Protein ATN-10.847
pha-4Protein PHA-40.770
unc-9Protein UNC-90.724
pkg-1Protein PKG-10.651
sup-12Protein SUP-120.609
egl-18Protein EGL-180.523
inx-15Protein INX-150.504
rig-6Protein RIG-60.478
goa-1Protein GOA-10.475
unc-27Protein UNC-270.467
syg-1Protein SYG-10.462
egl-13Protein EGL-130.455
odr-3Protein ODR-30.449
lag-1Protein LAG-10.436
alx-1Protein ALX-10.424
nlg-1Protein NLG-10.403
flt-1Protein FLT-10.385
myo-3Protein MYO-30.381
daf-11Protein DAF-110.379
unc-43Protein UNC-430.378
glp-1Protein GLP-10.374
egl-27Protein EGL-270.358
unc-32Protein UNC-320.350
lev-11Protein LEV-110.349
mig-5Protein MIG-50.347
eps-8Protein EPS-80.346
vab-8Protein VAB-80.331
ipp-5Protein IPP-50.329
inx-1Protein INX-10.324
plc-3Protein PLC-30.316
vab-3Protein VAB-30.304
egl-15Protein EGL-150.301
che-2Protein CHE-20.297
pkn-1Protein PKN-10.294
gld-1Protein GLD-10.293
T25F10.6Protein T25F10.60.292
unc-73Protein UNC-730.282
pkc-2Protein PKC-20.281
msp-78Protein MSP-780.280
zyx-1Protein ZYX-10.278
unc-104Protein UNC-1040.271
hum-4Protein HUM-40.271
lin-36Protein LIN-360.270
tni-1Protein TNI-10.266
efn-2Protein EFN-20.256
vab-10Protein VAB-100.254
Y40C5A.1Protein Y40C5A.10.242
lin-11Protein LIN-110.242
pal-1Protein PAL-10.241
tax-6Protein TAX-60.239
CELE_Y37A1B.17Protein Y37A1B.170.231
pkc-1Protein PKC-10.230
bar-1Protein BAR-10.227
uig-1Protein UIG-10.226
ida-1Protein IDA-10.226
hif-1Protein HIF-10.225
Y44E3A.6Protein Y44E3A.60.224
eat-4Protein EAT-40.223
msp-77Protein MSP-770.220
pat-3Protein PAT-30.220
wrk-1Protein WRK-10.219
unc-38Protein UNC-380.216
osm-5Protein OSM-50.214
brp-1Protein BRP-10.212
abts-1Protein ABTS-10.210
msp-76Protein MSP-760.210
lbp-7Protein LBP-70.209
daf-12Protein DAF-120.206
pdfr-1Protein PDFR-10.204
lin-15AProtein LIN-15A0.202
unc-95Protein UNC-950.201
let-60Protein LET-600.201
nhr-69Protein NHR-690.201
mig-38Protein MIG-380.201
aap-1Protein AAP-10.200
H43E16.1Protein H43E16.10.191
pmk-1Protein PMK-10.191
mpz-2Protein MPZ-20.189
nhr-2Protein NHR-20.187
egl-46Protein EGL-460.186
C54E4.2Protein C54E4.20.186
inx-13Protein INX-130.185
C46C11.3Protein C46C11.30.185
ahr-1Protein AHR-10.184
T28B4.1Protein T28B4.10.182
unc-7Protein UNC-70.177
pxf-1Protein PXF-10.176
hlh-2Protein HLH-20.173
gei-18Protein GEI-180.171
epi-1Protein EPI-10.171
add-1Protein ADD-10.171
par-1Protein PAR-10.171
let-23Protein LET-230.170
egl-36Protein EGL-360.170
ceh-6Protein CEH-60.167
pes-7Protein PES-70.167
unc-89Protein UNC-890.167
twk-18Protein TWK-180.164
msp-63Protein MSP-630.164
itr-1Protein ITR-10.163
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.980
notch1anotch homolog 1a0.954
shhasonic hedgehog a0.945
plcg1phospholipase C, gamma 10.931
cdh23cadherin-like 230.929
cx43connexin 430.926
lama2laminin, alpha 20.923
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.901
her6hairy-related 60.861
tnnt2atroponin T2a, cardiac0.770
lama4laminin, alpha 40.769
lhx2bLIM homeobox 2b0.756
sox10SRY-box containing gene 100.744
muskmuscle, skeletal, receptor tyrosine kinase0.734
crb2acrumbs homolog 2a0.731
hnf1baHNF1 homeobox Ba0.731
dag1dystroglycan 10.729
ascl1aachaete-scute complex-like 1a (Drosophila)0.703
hsp90a.1heat shock protein 90-alpha 10.701
mylz2myosin, light polypeptide 2, skeletal muscle0.697
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.692
myf5myogenic factor 50.685
ptch1patched 10.684
gli1GLI-Kruppel family member 10.681
prnprs3prion protein, related sequence 30.675
unc45bunc-45 homolog B (C. elegans)0.675
leprleptin receptor0.673
smyd1bSET and MYND domain containing 1b0.667
lmx1b.1LIM homeobox transcription factor 1, beta 10.651
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.650
neurodneurogenic differentiation0.641
sh3gl1bSH3-domain GRB2-like 1b0.641
ndr2nodal-related 20.637
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.625
hey2hairy/enhancer-of-split related with YRPW motif 20.623
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.610
sema3aasemaphorin 3aa0.605
rag1recombination activating gene 10.605
prdm1aPR domain containing 1a, with ZNF domain0.592
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.583
pdgfaaplatelet-derived growth factor alpha a0.583
myod1myogenic differentiation 10.582
igf1insulin-like growth factor 10.580
fgfr3fibroblast growth factor receptor 30.575
gapdhglyceraldehyde-3-phosphate dehydrogenase0.572
tnnc1atroponin C type 1a (slow)0.571
egr1early growth response 10.571
ywhag13-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 10.564
opn4lopsin 4, like0.558
tnni1btroponin I, skeletal, slow b0.558
scn12absodium channel, voltage gated, type XII, alpha b0.538
tnnc1btroponin C type 1b (slow)0.535
thtyrosine hydroxylase0.535
ndrg4N-myc downstream regulated gene 40.533
her15.1hairy and enhancer of split-related 15.10.531
nf1aneurofibromin 1a0.528
scn8aasodium channel, voltage-gated, type VIII, alpha a0.520
evx1even-skipped homeobox 10.515
tbx1T-box 10.513
atp1a3aATPase, Na+/K+ transporting, alpha 3a polypeptide0.510
atoh7atonal homolog 70.502
tie1endothelium-specific receptor tyrosine kinase 10.502
actc1aactin, alpha, cardiac muscle 1a0.501
ttnatitin a0.497
wt1awilms tumor 1a0.497
wnt2bawingless-type MMTV integration site family, member 2Ba0.489
efnb2aephrin B2a0.487
fezf2FEZ family zinc finger 20.484
kif17kinesin family member 170.474
foxn4forkhead box N40.471
gria2bglutamate receptor, ionotropic, AMPA 2b0.469
sncgbsynuclein, gamma b (breast cancer-specific protein 1)0.464
lef1lymphocyte enhancer binding factor 10.462
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.462
fabp7afatty acid binding protein 7, brain, a0.462
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.460
foxh1forkhead box H10.454
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.451
lhx1aLIM homeobox 1a0.445
ptmaaprothymosin, alpha a0.441
ttnbtitin b0.440
actn1actinin, alpha 10.435
dzip1DAZ interacting protein 10.430
vmhcventricular myosin heavy chain0.429
mibmind bomb0.428
fzd7bfrizzled homolog 7b0.425
mpzmyelin protein zero0.419
sall1asal-like 1a (Drosophila)0.417
arnt2aryl hydrocarbon receptor nuclear translocator 20.417
myhz2myosin, heavy polypeptide 2, fast muscle specific0.416
krt18keratin 180.415
pax7apaired box gene 7a0.411
epb41l5erythrocyte membrane protein band 4.1 like 50.406
klf4aKruppel-like transcription factor 4a0.401
fgfr1afibroblast growth factor receptor 1a0.395
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism