The network for 'defense response to virus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

defense response to virus

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

NameDescriptionProbabilityFunc Analog Organism
STAT1signal transducer and activator of transcription 1, 91kDa1.000
IFI44interferon-induced protein 441.000
PLSCR1phospholipid scramblase 11.000
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.999
SP110SP110 nuclear body protein0.999
IFIT3interferon-induced protein with tetratricopeptide repeats 30.999
BCL2B-cell CLL/lymphoma 20.998
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.998
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.997
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.997
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.997
MX2myxovirus (influenza virus) resistance 2 (mouse)0.996
OASL2'-5'-oligoadenylate synthetase-like0.993
SP100SP100 nuclear antigen0.993
MYD88myeloid differentiation primary response gene (88)0.992
IFI44Linterferon-induced protein 44-like0.985
ISG15ISG15 ubiquitin-like modifier0.982
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.981
IRF7interferon regulatory factor 70.978
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.977
PARP12poly (ADP-ribose) polymerase family, member 120.964
IFIH1interferon induced with helicase C domain 10.962
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.958
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.953
TRIM22tripartite motif containing 220.951
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.946
SAMD9sterile alpha motif domain containing 90.940
XAF1XIAP associated factor 10.936
BCL2L11BCL2-like 11 (apoptosis facilitator)0.928
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.925
IFIT2interferon-induced protein with tetratricopeptide repeats 20.919
IFI16interferon, gamma-inducible protein 160.911
IFIT1interferon-induced protein with tetratricopeptide repeats 10.909
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.904
IFIT5interferon-induced protein with tetratricopeptide repeats 50.894
CASP8caspase 8, apoptosis-related cysteine peptidase0.881
IFITM1interferon induced transmembrane protein 1 (9-27)0.876
PTPN6protein tyrosine phosphatase, non-receptor type 60.846
HERC5hect domain and RLD 50.824
SAMD9Lsterile alpha motif domain containing 9-like0.819
TRIM21tripartite motif containing 210.794
CCR1chemokine (C-C motif) receptor 10.787
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.772
MAP3K14mitogen-activated protein kinase kinase kinase 140.762
DTX3Ldeltex 3-like (Drosophila)0.757
NMIN-myc (and STAT) interactor0.755
IL4Rinterleukin 4 receptor0.755
CXCL10chemokine (C-X-C motif) ligand 100.751
PMLpromyelocytic leukemia0.750
PTPN1protein tyrosine phosphatase, non-receptor type 10.750
EPSTI1epithelial stromal interaction 1 (breast)0.738
TYMPthymidine phosphorylase0.725
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.716
BCL2L1BCL2-like 10.716
IFI35interferon-induced protein 350.710
PILRApaired immunoglobin-like type 2 receptor alpha0.705
PARP9poly (ADP-ribose) polymerase family, member 90.689
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.671
IFI6interferon, alpha-inducible protein 60.668
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.626
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.617
MAVSmitochondrial antiviral signaling protein0.605
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.567
CHUKconserved helix-loop-helix ubiquitous kinase0.560
UBE2L6ubiquitin-conjugating enzyme E2L 60.557
IL23Ainterleukin 23, alpha subunit p190.549
GBP1guanylate binding protein 1, interferon-inducible0.546
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.532
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.531
BAK1BCL2-antagonist/killer 10.517
BADBCL2-associated agonist of cell death0.501
CXCL11chemokine (C-X-C motif) ligand 110.490
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.477
MED15mediator complex subunit 150.476
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.465
SMURF2SMAD specific E3 ubiquitin protein ligase 20.461
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.456
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.438
C19orf66chromosome 19 open reading frame 660.397
IRF9interferon regulatory factor 90.381
IL15RAinterleukin 15 receptor, alpha0.375
TICAM2toll-like receptor adaptor molecule 20.373
NLRC4NLR family, CARD domain containing 40.368
INSRinsulin receptor0.363
SMAD4SMAD family member 40.346
SIGLEC7sialic acid binding Ig-like lectin 70.335
RSAD2radical S-adenosyl methionine domain containing 20.314
IRF1interferon regulatory factor 10.302
RTP4receptor (chemosensory) transporter protein 40.289
RIPK2receptor-interacting serine-threonine kinase 20.280
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.279
APOL6apolipoprotein L, 60.279
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.276
IRF2interferon regulatory factor 20.268
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.267
RNF11ring finger protein 110.266
HK3hexokinase 3 (white cell)0.265
TRIM5tripartite motif containing 50.262
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.257
CYBBcytochrome b-245, beta polypeptide0.254
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nod1nucleotide-binding oligomerization domain containing 10.220
il6stinterleukin 6 signal transducer0.162
pycardPYD and CARD domain containing0.118
il7rinterleukin 7 receptor0.106
caspacaspase a0.095
capns1bcalpain, small subunit 1 b0.054
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.044
mmp9matrix metalloproteinase 90.042
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.038
lrmplymphoid-restricted membrane protein0.034
tlr21toll-like receptor 210.031
nos2anitric oxide synthase 2a, inducible0.030
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.030
LOC557072caspase recruitment domain-containing protein 11-like0.029
crfa31.2IL-4RA-like protein 20.029
dhfrdihydrofolate reductase0.028
stc1lstanniocalcin 1, like0.022
tfe3atranscription factor binding to IGHM enhancer 3a0.021
il12bbinterleukin 12B, b0.020
prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a0.018
tyrobpTYRO protein tyrosine kinase binding protein0.018
sec24cSEC24 family, member C (S. cerevisiae)0.018
LOC555739serine/threonine-protein kinase LMTK1-like0.017
traf6TNF receptor-associated factor 60.017
irf3interferon regulatory factor 30.016
hectd1HECT domain containing 10.016
wipi2WD repeat domain, phosphoinositide interacting 20.015
sult3st2sulfotransferase family 3, cytosolic sulfotransferase 20.015
pnrc2proline-rich nuclear receptor coactivator 20.015
tlr2toll-like receptor 20.015
cd8aCD8 antigen, alpha polypeptide0.015
eomesbeomesodermin homolog b0.015
gmfgglia maturation factor, gamma0.015
stat1asignal transduction and activation of transcription 1a0.015
ifng1-2interferon, gamma 1-20.014
ube2hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)0.014
cd40lgCD40 ligand0.013
il4rinterleukin 4 receptor0.013
wnt5awingless-type MMTV integration site family, member 5a0.013
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.013
usp4ubiquitin specific protease 4 (proto-oncogene)0.013
cnot3aCCR4-NOT transcription complex, subunit 3a0.013
pkzprotein kinase containing Z-DNA binding domains0.013
grnagranulin a0.013
tfe3btranscription factor binding to IGHM enhancer 3b0.013
atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.012
spon2aspondin 2a, extracellular matrix protein0.012
cd247lCD247 antigen like0.012
slc14a2solute carrier family 14 (urea transporter), member 20.012
relv-rel reticuloendotheliosis viral oncogene homolog0.012
c1qccomplement component 1, q subcomponent, C chain0.012
tbx21T-box 210.012
nitr4anovel immune-type receptor 4a0.011
cxcr3.2chemokine (C-X-C motif) receptor 3.20.011
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.011
kpna4karyopherin alpha 4 (importin alpha 3)0.011
dkk3ldickkopf homolog 3 like (Xenopus laevis)0.011
rbm22RNA binding motif protein 220.011
grhl1grainyhead-like 1 (Drosophila)0.011
cd247CD247 antigen0.010
casc3cancer susceptibility candidate 30.010
tmem38atransmembrane protein 38A0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DreddDeath related ced-3/Nedd2-like protein0.931
ird5immune response deficient 50.904
BG4CG12297 gene product from transcript CG12297-RA0.901
PGRP-SAPeptidoglycan recognition protein SA0.838
imdimmune deficiency0.824
18w18 wheeler0.788
grassGram-positive Specific Serine protease0.784
DptBDiptericin B0.757
PGRP-LCPeptidoglycan recognition protein LC0.732
PGRP-SDCG7496 gene product from transcript CG7496-RA0.637
Toll-7CG8595 gene product from transcript CG8595-RA0.544
Sema-1bCG6446 gene product from transcript CG6446-RA0.510
PGRP-LBPeptidoglycan recognition protein LB0.484
Myd88CG2078 gene product from transcript CG2078-RA0.462
IceCG7788 gene product from transcript CG7788-RA0.439
CG32185CG32185 gene product from transcript CG32185-RA0.401
Mpk2CG5475 gene product from transcript CG5475-RB0.279
pirkpoor Imd response upon knock-in0.243
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.235
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.228
Atg18Autophagy-specific gene 180.218
Adf1Adh transcription factor 10.210
Toll-6CG7250 gene product from transcript CG7250-RA0.196
SPESpatzle-Processing Enzyme0.191
Atg5Autophagy-specific gene 50.165
ird1immune response deficient 10.163
CG16718CG16718 gene product from transcript CG16718-RA0.162
p38bCG7393 gene product from transcript CG7393-RA0.140
Tak1TGF-beta activated kinase 10.130
Nrx-IVNeurexin IV0.128
AGO2Argonaute 20.123
CG7611CG7611 gene product from transcript CG7611-RJ0.118
Uba1Ubiquitin activating enzyme 10.113
Tsc1CG6147 gene product from transcript CG6147-RA0.106
Mt2Methyltransferase 20.103
Atg13Autophagy-specific gene 130.100
upd2unpaired 20.100
Atg9Autophagy-specific gene 90.097
HsfHeat shock factor0.088
eaterCG6124 gene product from transcript CG6124-RB0.083
CG18594CG18594 gene product from transcript CG18594-RA0.081
Sox14Sox box protein 140.080
Traf6TNF-receptor-associated factor 60.077
eIF6CG17611 gene product from transcript CG17611-RA0.070
PGRP-LFPeptidoglycan recognition protein LF0.065
CG13641CG13641 gene product from transcript CG13641-RA0.065
Atg1Autophagy-specific gene 10.065
PvrPDGF- and VEGF-receptor related0.063
IrcImmune-regulated catalase0.056
drkdownstream of receptor kinase0.055
r2d2CG7138 gene product from transcript CG7138-RB0.054
CG15917CG15917 gene product from transcript CG15917-RA0.052
NcNedd2-like caspase0.050
Spn1Serine protease inhibitor 10.048
p120ctnAdherens junction protein p1200.045
Mekk1CG7717 gene product from transcript CG7717-RB0.045
modSPmodular serine protease0.042
Rrp42CG8395 gene product from transcript CG8395-RA0.041
CG6664CG6664 gene product from transcript CG6664-RC0.038
Sp7Serine protease 70.037
spiritSerine Protease Immune Response Integrator0.036
pashapartner of drosha0.035
CG10650CG10650 gene product from transcript CG10650-RA0.035
CG17107CG17107 gene product from transcript CG17107-RA0.034
CG9184CG9184 gene product from transcript CG9184-RB0.032
SaraSmad anchor for receptor activation0.032
EphrinCG1862 gene product from transcript CG1862-RA0.032
PGRP-SB1CG9681 gene product from transcript CG9681-RA0.031
Tsp42EfTetraspanin 42Ef0.031
PtenCG5671 gene product from transcript CG5671-RB0.031
Ube3aUbiquitin protein ligase E3A0.031
EDTPEgg-derived tyrosine phosphatase0.030
GNBP3Gram-negative bacteria binding protein 30.029
bratbrain tumor0.028
DuoxDual oxidase0.026
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase0.997
Gbp7guanylate binding protein 70.995
Trim30atripartite motif-containing 30A0.992
Casp1caspase 10.989
Stat3signal transducer and activator of transcription 30.980
Ikzf1IKAROS family zinc finger 10.977
Irf7interferon regulatory factor 70.972
Tnftumor necrosis factor0.968
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.961
Tlr4toll-like receptor 40.959
Uba7ubiquitin-like modifier activating enzyme 70.958
Usp18ubiquitin specific peptidase 180.955
Irf9interferon regulatory factor 90.951
Rsad2radical S-adenosyl methionine domain containing 20.930
Gbp3guanylate binding protein 30.928
Oasl22'-5' oligoadenylate synthetase-like 20.925
Stat1signal transducer and activator of transcription 10.922
Gbp2guanylate binding protein 20.917
Trim21tripartite motif-containing 210.914
Ccl4chemokine (C-C motif) ligand 40.911
Ikbkginhibitor of kappaB kinase gamma0.908
Parp14poly (ADP-ribose) polymerase family, member 140.898
Myd88myeloid differentiation primary response gene 880.892
Igtpinterferon gamma induced GTPase0.872
Ifi44interferon-induced protein 440.859
Irgm1immunity-related GTPase family M member 10.859
Il2rginterleukin 2 receptor, gamma chain0.854
Mndalmyeloid nuclear differentiation antigen like0.848
PycardPYD and CARD domain containing0.833
Il10interleukin 100.830
Iigp1interferon inducible GTPase 10.814
Zbp1Z-DNA binding protein 10.813
Irf1interferon regulatory factor 10.810
Map3k14mitogen-activated protein kinase kinase kinase 140.802
Cd4CD4 antigen0.798
Rtp4receptor transporter protein 40.793
FasFas (TNF receptor superfamily member 6)0.788
Irgm2immunity-related GTPase family M member 20.784
Mx1myxovirus (influenza virus) resistance 10.775
Map3k8mitogen-activated protein kinase kinase kinase 80.762
Ccr2chemokine (C-C motif) receptor 20.746
Trim30dtripartite motif-containing 30D0.743
Oas32'-5' oligoadenylate synthetase 30.718
Cxcl10chemokine (C-X-C motif) ligand 100.709
Ccl2chemokine (C-C motif) ligand 20.678
Gbp6guanylate binding protein 60.675
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.642
Mx2myxovirus (influenza virus) resistance 20.629
Ifitm3interferon induced transmembrane protein 30.617
Il2rbinterleukin 2 receptor, beta chain0.606
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.602
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.572
Sp100nuclear antigen Sp1000.558
Il1binterleukin 1 beta0.556
Oas22'-5' oligoadenylate synthetase 20.552
Gbp5guanylate binding protein 50.548
Aim2absent in melanoma 20.538
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.529
Il1r1interleukin 1 receptor, type I0.523
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.515
Stat5asignal transducer and activator of transcription 5A0.510
Slfn2schlafen 20.501
Cd274CD274 antigen0.500
Ifit3interferon-induced protein with tetratricopeptide repeats 30.496
Bcl3B-cell leukemia/lymphoma 30.481
Ube2l6ubiquitin-conjugating enzyme E2L 60.475
Tor3atorsin family 3, member A0.474
Ifit1interferon-induced protein with tetratricopeptide repeats 10.470
Ltalymphotoxin A0.468
BtkBruton agammaglobulinemia tyrosine kinase0.465
Cd180CD180 antigen0.463
Pyhin1pyrin and HIN domain family, member 10.462
Lcklymphocyte protein tyrosine kinase0.456
Ifi47interferon gamma inducible protein 470.455
Sfpi1SFFV proviral integration 10.451
Birc3baculoviral IAP repeat-containing 30.445
Samd9lsterile alpha motif domain containing 9-like0.444
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.441
Ifit2interferon-induced protein with tetratricopeptide repeats 20.430
FynFyn proto-oncogene0.427
Herc6hect domain and RLD 60.389
Lyz2lysozyme 20.381
Lcp2lymphocyte cytosolic protein 20.381
Mavsmitochondrial antiviral signaling protein0.378
Il12binterleukin 12b0.377
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.374
Gbp10guanylate-binding protein 100.373
Tgtp2T-cell specific GTPase 20.369
Trim34atripartite motif-containing 34A0.366
Slfn8schlafen 80.364
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.360
BC006779cDNA sequence BC0067790.360
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.355
S1pr2sphingosine-1-phosphate receptor 20.353
Mcl1myeloid cell leukemia sequence 10.331
Socs3suppressor of cytokine signaling 30.326
Slfn4schlafen 40.320
Ifi203interferon activated gene 2030.311
Foxp3forkhead box P30.302
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.300
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Casp1caspase 10.094
Sellselectin L0.078
Ptprcprotein tyrosine phosphatase, receptor type, C0.072
Cybbcytochrome b-245, beta polypeptide0.064
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.063
Klrd1killer cell lectin-like receptor, subfamily D, member 10.059
Ccl5chemokine (C-C motif) ligand 50.048
Il1binterleukin 1 beta0.044
RT1-EC2RT1 class Ib, locus EC20.042
Nkg7natural killer cell group 7 sequence0.041
Cxcl10chemokine (C-X-C motif) ligand 100.039
Hckhemopoietic cell kinase0.039
Clec9aC-type lectin domain family 9, member a0.035
Cd53Cd53 molecule0.032
Gzmkgranzyme K0.029
Igsf6immunoglobulin superfamily, member 60.029
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.028
Ifit3interferon-induced protein with tetratricopeptide repeats 30.027
LOC100364500RT1 class I, locus CE11-like0.025
Apol3apolipoprotein L, 30.023
Aif1allograft inflammatory factor 10.023
Gbp2guanylate binding protein 20.023
Il2rbinterleukin 2 receptor, beta0.022
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.021
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.020
Il7rinterleukin 7 receptor0.019
Ncr1natural cytotoxicity triggering receptor 10.018
Tlr4toll-like receptor 40.018
Cxcl9chemokine (C-X-C motif) ligand 90.018
Socs3suppressor of cytokine signaling 30.017
Mx1myxovirus (influenza virus) resistance 10.017
Wipf1WAS/WASL interacting protein family, member 10.017
Clec4a3C-type lectin domain family 4, member a30.017
Cnr2cannabinoid receptor 2 (macrophage)0.016
Arhgap4Rho GTPase activating protein 40.016
Calcrcalcitonin receptor0.016
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.015
Vcam1vascular cell adhesion molecule 10.015
Cxcl16chemokine (C-X-C motif) ligand 160.015
Ly86lymphocyte antigen 860.014
Cd38CD38 molecule0.014
Ptafrplatelet-activating factor receptor0.013
TcrbT-cell receptor beta chain0.013
Ccr5chemokine (C-C motif) receptor 50.012
Ptpn6protein tyrosine phosphatase, non-receptor type 60.012
RT1-S3RT1 class Ib, locus S30.012
Cd86CD86 molecule0.011
Adam17ADAM metallopeptidase domain 170.011
Ccl4chemokine (C-C motif) ligand 40.011
Ctshcathepsin H0.011
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.011
Tnftumor necrosis factor (TNF superfamily, member 2)0.011
Bin2bridging integrator 20.010
Icam1intercellular adhesion molecule 10.010
Cd247Cd247 molecule0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism