The network for 'lymphocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lymphocyte activation

A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.

NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
SYKspleen tyrosine kinase1.000
PTPN6protein tyrosine phosphatase, non-receptor type 60.998
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.995
EGFRepidermal growth factor receptor0.994
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.992
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.989
CCL5chemokine (C-C motif) ligand 50.986
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.983
SHC1SHC (Src homology 2 domain containing) transforming protein 10.983
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.983
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.974
LCKlymphocyte-specific protein tyrosine kinase0.971
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.968
TNFAIP3tumor necrosis factor, alpha-induced protein 30.959
CD247CD247 molecule0.944
IL2RBinterleukin 2 receptor, beta0.943
IL2RGinterleukin 2 receptor, gamma0.930
PTPRCprotein tyrosine phosphatase, receptor type, C0.927
GRB2growth factor receptor-bound protein 20.926
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.926
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.916
IRF4interferon regulatory factor 40.912
BCL2B-cell CLL/lymphoma 20.911
PLCG1phospholipase C, gamma 10.904
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.901
ITKIL2-inducible T-cell kinase0.862
RB1retinoblastoma 10.856
FGFR2fibroblast growth factor receptor 20.854
SOCS3suppressor of cytokine signaling 30.853
RUNX1runt-related transcription factor 10.846
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.834
PTPN1protein tyrosine phosphatase, non-receptor type 10.813
ICAM1intercellular adhesion molecule 10.812
CCR5chemokine (C-C motif) receptor 50.812
IRAK1interleukin-1 receptor-associated kinase 10.805
IL1R1interleukin 1 receptor, type I0.804
BRCA1breast cancer 1, early onset0.799
CCR7chemokine (C-C motif) receptor 70.790
BIRC3baculoviral IAP repeat containing 30.789
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.783
SH2D1ASH2 domain containing 1A0.765
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.763
HCKhemopoietic cell kinase0.749
IL10RAinterleukin 10 receptor, alpha0.748
GRB7growth factor receptor-bound protein 70.745
NOTCH1notch 10.744
PSEN1presenilin 10.739
CD2CD2 molecule0.738
SLASrc-like-adaptor0.730
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.730
CCL22chemokine (C-C motif) ligand 220.715
NKG7natural killer cell group 7 sequence0.714
TRAF1TNF receptor-associated factor 10.707
BCL2L1BCL2-like 10.705
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.679
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.674
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.669
FASFas (TNF receptor superfamily, member 6)0.666
EP300E1A binding protein p3000.647
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.644
FLNAfilamin A, alpha0.643
NCOR2nuclear receptor corepressor 20.643
FGFR1fibroblast growth factor receptor 10.637
HLA-DMBmajor histocompatibility complex, class II, DM beta0.637
IL4Rinterleukin 4 receptor0.630
CD86CD86 molecule0.625
CDK6cyclin-dependent kinase 60.619
TRAF3IP3TRAF3 interacting protein 30.612
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.610
INSRinsulin receptor0.604
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.592
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.585
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.584
SMAD7SMAD family member 70.579
FASLGFas ligand (TNF superfamily, member 6)0.573
MS4A1membrane-spanning 4-domains, subfamily A, member 10.572
VAV1vav 1 guanine nucleotide exchange factor0.563
LTAlymphotoxin alpha (TNF superfamily, member 1)0.561
CCL4chemokine (C-C motif) ligand 40.557
SASH3SAM and SH3 domain containing 30.552
BTN3A3butyrophilin, subfamily 3, member A30.542
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.539
MYD88myeloid differentiation primary response gene (88)0.534
SIRT1sirtuin 10.534
TGIF1TGFB-induced factor homeobox 10.531
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.530
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.530
UBASH3Bubiquitin associated and SH3 domain containing B0.527
CD3GCD3g molecule, gamma (CD3-TCR complex)0.517
STAT4signal transducer and activator of transcription 40.511
TNFRSF9tumor necrosis factor receptor superfamily, member 90.497
CXCL10chemokine (C-X-C motif) ligand 100.493
TYROBPTYRO protein tyrosine kinase binding protein0.492
HLA-Fmajor histocompatibility complex, class I, F0.488
SLAMF1signaling lymphocytic activation molecule family member 10.483
DLG1discs, large homolog 1 (Drosophila)0.482
SH3BP2SH3-domain binding protein 20.481
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.479
CD6CD6 molecule0.478
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ikzf1IKAROS family zinc finger 1 (Ikaros)0.386
fgf3fibroblast growth factor 30.331
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.320
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.308
fgf8afibroblast growth factor 8 a0.253
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.233
egr2bearly growth response 2b0.222
mmp9matrix metalloproteinase 90.197
hspa5heat shock protein 50.176
cdx4caudal type homeo box transcription factor 40.160
fgfr1bfibroblast growth factor receptor 1b0.155
runx2arunt-related transcription factor 2a0.124
gata1aGATA binding protein 1a0.123
cxcr4bchemokine (C-X-C motif), receptor 4b0.098
rspo3R-spondin 3 homolog (Xenopus laevis)0.097
dlcdeltaC0.091
tp63tumor protein p630.088
il7rinterleukin 7 receptor0.076
sfrp5secreted frizzled-related protein 50.075
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.068
cd63Cd63 antigen0.058
kitakit receptor a0.055
nap1l1nucleosome assembly protein 1, like 10.048
runx3runt-related transcription factor 30.045
tp53tumor protein p530.045
lcp1lymphocyte cytosolic plastin 10.043
csrp1acysteine and glycine-rich protein 1a0.043
epha4aeph receptor A4a0.042
tbx1T-box 10.040
lmo4aLIM domain only 4a0.040
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.039
nrp2bneuropilin 2b0.037
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.037
capns1bcalpain, small subunit 1 b0.036
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.036
elk4ELK4, ETS-domain protein0.035
cmybtranscription factor cmyb0.033
pglyrp5peptidoglycan recognition protein 50.033
bmp2bbone morphogenetic protein 2b0.032
cxcr4achemokine (C-X-C motif) receptor 4a0.032
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.031
cbfbcore-binding factor, beta subunit0.030
dlddeltaD0.028
cldneclaudin e0.028
tlr2toll-like receptor 20.028
hspa9heat shock protein 90.028
wnt1wingless-type MMTV integration site family, member 10.027
zgc:64115zgc:641150.027
sb:cb472sb:cb4720.027
zgc:64051zgc:640510.026
crip2cysteine-rich protein 20.026
anxa1aannexin A1a0.025
rpl7aribosomal protein L7a0.025
lft1lefty10.025
odc1ornithine decarboxylase 10.025
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.024
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.024
twist1atwist1a0.024
si:ch211-215h6.2si:ch211-215h6.20.024
zfp36l1azinc finger protein 36, C3H type-like 1a0.023
fzd8afrizzled homolog 8a0.023
wnt3wingless-type MMTV integration site family, member 30.023
plagl2pleiomorphic adenoma gene-like 20.022
spry2sprouty homolog 20.022
si:dkey-27i16.2si:dkey-27i16.20.022
coro1acoronin, actin binding protein, 1A0.022
pcdh18bprotocadherin 18b0.021
btkBruton agammaglobulinemia tyrosine kinase0.021
irx7iroquois homeobox protein 70.021
foxa2forkhead box A20.020
rykreceptor-like tyrosine kinase0.020
chdchordin0.020
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.020
pola2polymerase (DNA directed), alpha 20.020
impdh1binosine 5'-phosphate dehydrogenase 1b0.020
tlr3toll-like receptor 30.019
raraaretinoic acid receptor, alpha a0.019
zgc:56039zgc:560390.019
ccnd1cyclin D10.019
axin2axin 2 (conductin, axil)0.018
rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.018
dag1dystroglycan 10.018
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.018
mycamyelocytomatosis oncogene a0.018
cd8aCD8 antigen, alpha polypeptide0.018
mt2metallothionein 20.018
camk2g1calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 10.018
rpl23aribosomal protein L23a0.018
her1hairy-related 10.018
osr1odd-skipped related 1 (Drosophila)0.017
pfn1profilin 10.017
lef1lymphocyte enhancer binding factor 10.016
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.016
tnfatumor necrosis factor a (TNF superfamily, member 2)0.016
LOC100003514protein kinase C alpha type-like0.016
otx1borthodenticle homolog 1b0.016
rtn1areticulon 1a0.016
dnmt4DNA (cytosine-5-)-methyltransferase 40.016
pax5paired box gene 50.016
efna2ephrin A20.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-BaRT1 class II, locus Ba0.777
Cd247Cd247 molecule0.761
RT1-DaRT1 class II, locus Da0.720
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.700
Ptafrplatelet-activating factor receptor0.658
Cd2Cd2 molecule0.646
Gzmkgranzyme K0.599
Anxa2annexin A20.531
Il1binterleukin 1 beta0.502
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.498
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.405
Cd5Cd5 molecule0.403
Arhgap4Rho GTPase activating protein 40.358
Ptprcprotein tyrosine phosphatase, receptor type, C0.350
Ccr5chemokine (C-C motif) receptor 50.334
Lcp2lymphocyte cytosolic protein 20.324
Laptm5lysosomal protein transmembrane 50.300
Bin2bridging integrator 20.275
Cd37CD37 molecule0.263
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.222
Mvpmajor vault protein0.218
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.213
Sellselectin L0.204
Plcg2phospholipase C, gamma 20.198
Ptger4prostaglandin E receptor 4 (subtype EP4)0.189
Ciitaclass II, major histocompatibility complex, transactivator0.188
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.184
Rassf5Ras association (RalGDS/AF-6) domain family member 50.182
Cd86CD86 molecule0.180
Cd3gCD3 molecule, gamma0.173
Spnsialophorin0.172
Ccl5chemokine (C-C motif) ligand 50.162
Il10interleukin 100.149
Prf1perforin 1 (pore forming protein)0.142
Csf1colony stimulating factor 1 (macrophage)0.141
Nkg7natural killer cell group 7 sequence0.141
Fgfr2fibroblast growth factor receptor 20.139
Ctsl1cathepsin L10.138
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.138
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.133
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.133
Ccr2chemokine (C-C motif) receptor 20.132
Il2rbinterleukin 2 receptor, beta0.132
Casp1caspase 10.131
Reg3gregenerating islet-derived 3 gamma0.131
Cxcr4chemokine (C-X-C motif) receptor 40.130
Cxcr3chemokine (C-X-C motif) receptor 30.129
Il2rainterleukin 2 receptor, alpha0.127
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.126
Cd4Cd4 molecule0.125
Clec9aC-type lectin domain family 9, member a0.122
RT1-Db1RT1 class II, locus Db10.121
Slfn2schlafen 20.115
Syt8synaptotagmin VIII0.115
Il6stinterleukin 6 signal transducer0.112
Ptger2prostaglandin E receptor 2 (subtype EP2)0.107
Inpp5dinositol polyphosphate-5-phosphatase D0.106
Gimap4GTPase, IMAP family member 40.106
Ly86lymphocyte antigen 860.104
Creb1cAMP responsive element binding protein 10.102
Hckhemopoietic cell kinase0.098
Il1r1interleukin 1 receptor, type I0.096
Myo1fmyosin IF0.093
Gfra2GDNF family receptor alpha 20.093
Ctsbcathepsin B0.090
Gpr114G protein-coupled receptor 1140.090
Lypd3Ly6/Plaur domain containing 30.088
Lyz2lysozyme 20.087
Hspe1heat shock protein 1 (chaperonin 10)0.086
Acvr1bactivin A receptor, type IB0.085
Ccl4chemokine (C-C motif) ligand 40.083
RGD1559588similar to cell surface receptor FDFACT0.082
Prss27protease, serine 270.080
Mmp10matrix metallopeptidase 100.078
Inhbeinhibin beta E0.077
Hcsthematopoietic cell signal transducer0.077
Cmtm3CKLF-like MARVEL transmembrane domain containing 30.076
Itgadintegrin, alpha D0.076
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.076
Vcam1vascular cell adhesion molecule 10.073
Plekpleckstrin0.071
Pde3aphosphodiesterase 3A, cGMP inhibited0.071
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.070
Il18interleukin 180.069
Sh2d2aSH2 domain protein 2A0.069
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.069
Slc28a3solute carrier family 28 (sodium-coupled nucleoside transporter), member 30.069
Il1rninterleukin 1 receptor antagonist0.069
Gckrglucokinase (hexokinase 4) regulator0.069
Mylk2myosin light chain kinase 20.069
Nos3nitric oxide synthase 3, endothelial cell0.068
Cfpcomplement factor properdin0.068
Zbp1Z-DNA binding protein 10.068
Calcrcalcitonin receptor0.067
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.066
Atp2a3ATPase, Ca++ transporting, ubiquitous0.066
FcrlaFc receptor-like A0.066
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.064
Map4k1mitogen activated protein kinase kinase kinase kinase 10.063
Gata6GATA binding protein 60.063
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism