The network for 'positive regulation of actin filament bundle assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of actin filament bundle assembly

Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.

NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)1.000
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)1.000
S100A6S100 calcium binding protein A60.998
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.997
S100A8S100 calcium binding protein A80.983
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.977
S100A11S100 calcium binding protein A110.974
FN1fibronectin 10.969
S100BS100 calcium binding protein B0.968
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.959
RHOAras homolog gene family, member A0.951
S100A9S100 calcium binding protein A90.899
S100A1S100 calcium binding protein A10.890
ARHGAP1Rho GTPase activating protein 10.832
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.815
ANXA2annexin A20.786
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.737
NCF2neutrophil cytosolic factor 20.556
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.541
S100A4S100 calcium binding protein A40.532
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.487
SCHIP1schwannomin interacting protein 10.476
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.442
WIPF1WAS/WASL interacting protein family, member 10.420
MDM2Mdm2 p53 binding protein homolog (mouse)0.406
SORBS3sorbin and SH3 domain containing 30.385
LGALS1lectin, galactoside-binding, soluble, 10.374
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.331
FBLN1fibulin 10.322
PALLDpalladin, cytoskeletal associated protein0.307
CTGFconnective tissue growth factor0.299
EMP3epithelial membrane protein 30.298
PFN1profilin 10.292
SPRY4sprouty homolog 4 (Drosophila)0.281
IQGAP1IQ motif containing GTPase activating protein 10.274
RHOGras homolog gene family, member G (rho G)0.254
UBE2R2ubiquitin-conjugating enzyme E2R 20.248
CD44CD44 molecule (Indian blood group)0.247
TMSB10thymosin beta 100.244
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.210
SEMA6Asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.183
CFL1cofilin 1 (non-muscle)0.173
BAIAP2BAI1-associated protein 20.139
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.123
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.119
CYR61cysteine-rich, angiogenic inducer, 610.111
ACTBactin, beta0.110
FYNFYN oncogene related to SRC, FGR, YES0.110
TAGLN2transgelin 20.109
SPTBN1spectrin, beta, non-erythrocytic 10.108
WASF1WAS protein family, member 10.103
ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDa0.101
AHNAKAHNAK nucleoprotein0.099
MAP3K11mitogen-activated protein kinase kinase kinase 110.097
DLG5discs, large homolog 5 (Drosophila)0.097
LMNAlamin A/C0.094
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.091
TIMP1TIMP metallopeptidase inhibitor 10.088
CAPGcapping protein (actin filament), gelsolin-like0.087
CDK11Bcyclin-dependent kinase 11B0.079
ANXA1annexin A10.077
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.076
ARRB1arrestin, beta 10.076
CDC42EP3CDC42 effector protein (Rho GTPase binding) 30.071
S100A10S100 calcium binding protein A100.071
PLP2proteolipid protein 2 (colonic epithelium-enriched)0.070
SORBS2sorbin and SH3 domain containing 20.069
LCATlecithin-cholesterol acyltransferase0.069
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.067
SMAD2SMAD family member 20.067
LGALS3lectin, galactoside-binding, soluble, 30.066
RAP1ARAP1A, member of RAS oncogene family0.062
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.060
FEM1Bfem-1 homolog b (C. elegans)0.059
APOC1apolipoprotein C-I0.059
BAK1BCL2-antagonist/killer 10.057
MMP14matrix metallopeptidase 14 (membrane-inserted)0.057
ACTN1actinin, alpha 10.057
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.057
AMOTL2angiomotin like 20.057
RAC3ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)0.055
S100PS100 calcium binding protein P0.054
HCKhemopoietic cell kinase0.052
ITSN1intersectin 1 (SH3 domain protein)0.051
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.051
SH3RF3SH3 domain containing ring finger 30.051
FLNAfilamin A, alpha0.050
JUPjunction plakoglobin0.050
INPPL1inositol polyphosphate phosphatase-like 10.049
NCK1NCK adaptor protein 10.049
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Cdc42CG12530 gene product from transcript CG12530-RA0.035
Rac1CG2248 gene product from transcript CG2248-RA0.020
par-1CG8201 gene product from transcript CG8201-RA0.018
Rho1CG8416 gene product from transcript CG8416-RB0.018
Pi3K92ECG4141 gene product from transcript CG4141-RB0.017
sqhspaghetti squash0.014
AblAbl tyrosine kinase0.014
Atg1Autophagy-specific gene 10.012
katanin-60katanin 600.011
plexBplexin B0.011
EphrinCG1862 gene product from transcript CG1862-RA0.011
mbcmyoblast city0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.977
Apcadenomatosis polyposis coli0.960
Rac1RAS-related C3 botulinum substrate 10.954
Efnb2ephrin B20.952
Ephb2Eph receptor B20.906
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.703
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.673
Ephb3Eph receptor B30.453
Gli3GLI-Kruppel family member GLI30.446
Bcl2B-cell leukemia/lymphoma 20.384
Efnb1ephrin B10.379
Rargretinoic acid receptor, gamma0.361
Ptch1patched homolog 10.355
Fgf18fibroblast growth factor 180.348
Wnt3awingless-related MMTV integration site 3A0.328
Wnt4wingless-related MMTV integration site 40.309
Gli2GLI-Kruppel family member GLI20.280
Enahenabled homolog (Drosophila)0.248
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.245
Epha4Eph receptor A40.221
Lhx1LIM homeobox protein 10.221
Fgfr2fibroblast growth factor receptor 20.215
Actbactin, beta0.201
Wdr1WD repeat domain 10.169
Tbx2T-box 20.168
Trp53transformation related protein 530.159
Cdkn1bcyclin-dependent kinase inhibitor 1B0.150
Tead3TEA domain family member 30.147
Hoxa13homeobox A130.142
Nf1neurofibromatosis 10.142
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.142
Trp73transformation related protein 730.136
Vaspvasodilator-stimulated phosphoprotein0.128
Mapkap1mitogen-activated protein kinase associated protein 10.122
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.117
RictorRPTOR independent companion of MTOR, complex 20.114
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.114
Gata5GATA binding protein 50.111
Wnt6wingless-related MMTV integration site 60.110
Fgf10fibroblast growth factor 100.106
Ptenphosphatase and tensin homolog0.103
Zfp651zinc finger protein 6510.102
Amhr2anti-Mullerian hormone type 2 receptor0.101
Smad6MAD homolog 6 (Drosophila)0.095
Dkk1dickkopf homolog 1 (Xenopus laevis)0.093
Celsr2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.093
Efna4ephrin A40.091
Bmp7bone morphogenetic protein 70.091
Dnm1dynamin 10.088
Rnd3Rho family GTPase 30.088
Arhgap1Rho GTPase activating protein 10.087
Vav2vav 2 oncogene0.082
Dmtf1cyclin D binding myb-like transcription factor 10.080
Sox9SRY-box containing gene 90.077
Lmx1aLIM homeobox transcription factor 1 alpha0.076
Hoxd13homeobox D130.073
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.072
Unc5cunc-5 homolog C (C. elegans)0.071
Lrp5low density lipoprotein receptor-related protein 50.069
Kitkit oncogene0.069
Itgb1integrin beta 1 (fibronectin receptor beta)0.069
Bmpr1abone morphogenetic protein receptor, type 1A0.069
Kif5bkinesin family member 5B0.069
Itga3integrin alpha 30.068
Sult5a1sulfotransferase family 5A, member 10.064
Rb1retinoblastoma 10.063
Tmeff2transmembrane protein with EGF-like and two follistatin-like domains 20.062
Rhoaras homolog gene family, member A0.061
Wipf1WAS/WASL interacting protein family, member 10.058
Gli1GLI-Kruppel family member GLI10.057
Npas1neuronal PAS domain protein 10.055
Smurf2SMAD specific E3 ubiquitin protein ligase 20.054
Anxa2annexin A20.054
Sema5asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A0.053
Sema3bsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B0.053
Cdkn2acyclin-dependent kinase inhibitor 2A0.052
Ror2receptor tyrosine kinase-like orphan receptor 20.052
Irs1insulin receptor substrate 10.051
Nckap1NCK-associated protein 10.051
Hspb8heat shock protein 80.051
Lhx9LIM homeobox protein 90.051
Plxna1plexin A10.051
Leprleptin receptor0.051
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.050
Pou3f3POU domain, class 3, transcription factor 30.050
Retret proto-oncogene0.048
BrafBraf transforming gene0.047
Mllt1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.047
Plxna3plexin A30.046
Fzd8frizzled homolog 8 (Drosophila)0.046
Onecut1one cut domain, family member 10.046
Arandrogen receptor0.046
SlkSTE20-like kinase (yeast)0.046
Arpc4actin related protein 2/3 complex, subunit 40.045
Jupjunction plakoglobin0.045
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.045
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.045
Cyr61cysteine rich protein 610.044
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tubb5tubulin, beta 50.017
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.017
Acta2smooth muscle alpha-actin0.016
Arf6ADP-ribosylation factor 60.015
Anxa2annexin A20.015
Myl9myosin, light chain 9, regulatory0.015
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.014
Efhd2EF-hand domain family, member D20.014
Chrna4cholinergic receptor, nicotinic, alpha 40.012
Clic4chloride intracellular channel 40.011
Myh9myosin, heavy chain 9, non-muscle0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism