The network for 'response to wounding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to wounding

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FN1fibronectin 11.000
EGFRepidermal growth factor receptor1.000
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.993
CAV1caveolin 1, caveolae protein, 22kDa0.993
PTPN1protein tyrosine phosphatase, non-receptor type 10.985
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.982
JUNjun proto-oncogene0.981
SHC1SHC (Src homology 2 domain containing) transforming protein 10.956
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.940
FLNAfilamin A, alpha0.925
DUSP1dual specificity phosphatase 10.919
APCadenomatous polyposis coli0.893
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.888
THBS1thrombospondin 10.887
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.876
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.870
SYKspleen tyrosine kinase0.866
CTGFconnective tissue growth factor0.862
NRP1neuropilin 10.856
IL1Binterleukin 1, beta0.838
FHL2four and a half LIM domains 20.838
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.837
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.836
SMAD7SMAD family member 70.833
ESR1estrogen receptor 10.828
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.824
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.810
VCAM1vascular cell adhesion molecule 10.795
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.782
ANXA2annexin A20.782
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.780
C3complement component 30.776
FGFR2fibroblast growth factor receptor 20.776
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.771
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.765
RING1ring finger protein 10.762
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.760
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.755
FOSFBJ murine osteosarcoma viral oncogene homolog0.742
S100A4S100 calcium binding protein A40.739
MYH9myosin, heavy chain 9, non-muscle0.728
COL1A1collagen, type I, alpha 10.723
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.716
IL8interleukin 80.715
FGFR1fibroblast growth factor receptor 10.705
MAPK1mitogen-activated protein kinase 10.702
IQGAP1IQ motif containing GTPase activating protein 10.699
TGFB3transforming growth factor, beta 30.681
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.675
PYCARDPYD and CARD domain containing0.669
CXCL2chemokine (C-X-C motif) ligand 20.668
S100BS100 calcium binding protein B0.666
MAP3K7mitogen-activated protein kinase kinase kinase 70.658
ARRB1arrestin, beta 10.657
HDAC1histone deacetylase 10.656
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.656
C1Scomplement component 1, s subcomponent0.642
PRKCAprotein kinase C, alpha0.637
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.637
PCGF2polycomb group ring finger 20.625
NCF2neutrophil cytosolic factor 20.623
CRYABcrystallin, alpha B0.621
MAPK8mitogen-activated protein kinase 80.619
SOCS3suppressor of cytokine signaling 30.609
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.605
PTGISprostaglandin I2 (prostacyclin) synthase0.604
CXCL12chemokine (C-X-C motif) ligand 120.600
NCF1neutrophil cytosolic factor 10.587
SP1Sp1 transcription factor0.582
PLAURplasminogen activator, urokinase receptor0.578
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.571
NCOR2nuclear receptor corepressor 20.537
VEGFAvascular endothelial growth factor A0.532
PTPN11protein tyrosine phosphatase, non-receptor type 110.529
POU5F1POU class 5 homeobox 10.527
CTNND1catenin (cadherin-associated protein), delta 10.525
CCR5chemokine (C-C motif) receptor 50.524
FGAfibrinogen alpha chain0.521
INSRinsulin receptor0.521
JAG1jagged 10.520
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.520
ANXA1annexin A10.519
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.514
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.512
IGFBP5insulin-like growth factor binding protein 50.507
RGS2regulator of G-protein signaling 2, 24kDa0.507
TEKTEK tyrosine kinase, endothelial0.500
TNFtumor necrosis factor0.499
GRB2growth factor receptor-bound protein 20.495
NCF4neutrophil cytosolic factor 4, 40kDa0.487
FBLN1fibulin 10.479
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.478
COL6A1collagen, type VI, alpha 10.472
FASFas (TNF receptor superfamily, member 6)0.472
PLAUplasminogen activator, urokinase0.468
ILKintegrin-linked kinase0.467
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
let-60Protein LET-600.790
hlh-2Protein HLH-20.533
unc-43Protein UNC-430.451
egl-18Protein EGL-180.402
bar-1Protein BAR-10.381
plc-1Protein PLC-10.367
ttyh-1Protein TTYH-10.346
cnd-1Protein CND-10.338
nhr-67Protein NHR-670.329
itr-1Protein ITR-10.323
egl-44Protein EGL-440.289
sta-1Protein STA-10.284
let-23Protein LET-230.284
pha-4Protein PHA-40.268
ina-1Protein INA-10.262
sel-8Protein SEL-80.258
epi-1Protein EPI-10.235
C09E8.1Protein C09E8.10.230
hmg-1.2Protein HMG-1.20.205
mig-15Protein MIG-150.199
pmk-1Protein PMK-10.199
R90.1Protein R90.10.198
cpr-4Protein CPR-40.196
twk-18Protein TWK-180.193
egl-8Protein EGL-80.192
F48F7.6Protein F48F7.60.176
lin-17Protein LIN-170.176
W07G4.5Protein W07G4.50.173
unc-96Protein UNC-960.173
cat-1Protein CAT-10.169
smp-1Protein SMP-10.169
jmjd-3.1Protein JMJD-3.10.167
egl-27Protein EGL-270.167
pry-1Protein PRY-10.166
sli-1Protein SLI-10.165
K07C11.4Protein K07C11.40.163
apl-1Protein APL-10.162
daf-3Protein DAF-30.158
gsk-3Protein GSK-30.157
Y37A1A.3Protein Y37A1A.30.156
ncl-1Protein NCL-10.151
daf-2Protein DAF-20.150
grd-2Protein GRD-20.150
hum-5Protein HUM-50.149
cat-2Protein CAT-20.147
kin-4Protein KIN-40.147
pde-4Protein PDE-40.146
lam-2Protein LAM-20.146
flh-2Protein FLH-20.146
T19D12.2Protein T19D12.20.146
ceh-36Protein CEH-360.144
unc-115Protein UNC-1150.143
cas-1Protein CAS-10.143
ifg-1Protein IFG-10.141
mab-5Protein MAB-50.137
egl-46Protein EGL-460.136
sax-2Protein SAX-20.135
bli-1Protein BLI-10.135
nhr-153Protein NHR-1530.134
lin-32Protein LIN-320.134
pqn-85Protein PQN-850.134
hnd-1Protein HND-10.134
pdl-1Protein PDL-10.133
ndk-1Protein NDK-10.133
cam-1Protein CAM-10.133
dcr-1Protein DCR-10.132
spc-1Protein SPC-10.130
sma-6Protein SMA-60.130
tba-4Protein TBA-40.129
rskn-2Protein RSKN-20.129
tph-1Protein TPH-10.127
hlh-11Protein HLH-110.127
C34D10.2Protein C34D10.20.125
C53B4.4Protein C53B4.40.125
plc-3Protein PLC-30.125
nhr-32Protein NHR-320.124
lsy-2Protein LSY-20.124
smf-2Protein SMF-20.124
C33G3.4Protein C33G3.40.124
C54E4.2Protein C54E4.20.121
let-756Protein LET-7560.121
T08G11.1Protein T08G11.10.120
C18B2.4Protein C18B2.40.120
mig-2Protein MIG-20.119
zyg-1Protein ZYG-10.118
par-6Protein PAR-60.118
col-111Protein COL-1110.118
sos-1Protein SOS-10.117
F49E2.5Protein F49E2.50.116
R57.1Protein R57.10.115
CELE_Y46G5A.29Protein Y46G5A.290.115
K03E6.7Protein K03E6.70.114
C05C9.1Protein C05C9.10.114
ZK180.6Protein ZK180.60.114
unc-62Protein UNC-620.114
hsr-9Protein HSR-90.114
rps-7Protein RPS-70.114
F52F10.2Protein F52F10.20.113
ksr-1Protein KSR-10.112
nhr-100Protein NHR-1000.112
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
col1a1acollagen, type I, alpha 1a0.915
fgf3fibroblast growth factor 30.901
pitx3paired-like homeodomain transcription factor 30.839
mmp9matrix metalloproteinase 90.793
foxa2forkhead box A20.781
ptf1apancreas specific transcription factor, 1a0.757
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.727
ascl1aachaete-scute complex-like 1a (Drosophila)0.683
col1a2collagen, type I, alpha 20.661
dkk1bdickkopf 1b0.644
efnb2aephrin B2a0.624
wnt10awingless-type MMTV integration site family, member 10a0.607
runx2brunt-related transcription factor 2b0.605
tnfrsfatumor necrosis factor receptor superfamily, member a0.603
shhasonic hedgehog a0.600
anxa1aannexin A1a0.598
fn1fibronectin 10.593
fgfr1afibroblast growth factor receptor 1a0.590
alcambactivated leukocyte cell adhesion molecule b0.573
bocbrother of CDO0.572
bmp2bbone morphogenetic protein 2b0.565
eya1eyes absent homolog 10.550
ihhaIndian hedgehog homolog a0.516
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.511
nkx2.2aNK2 transcription factor related 2a0.509
wnt9awingless-type MMTV integration site family, member 9A0.506
her6hairy-related 60.504
scinlascinderin like a0.500
evx1even-skipped homeobox 10.477
emx3empty spiracles homeobox 30.472
spns2spinster homolog 2 (Drosophila)0.469
atoh1aatonal homolog 1a0.460
egr1early growth response 10.460
fabp2fatty acid binding protein 2, intestinal0.453
ctnnb1catenin (cadherin-associated protein), beta 10.451
tp63tumor protein p630.436
lhx2bLIM homeobox 2b0.431
pdlim4PDZ and LIM domain 40.423
cdh1cadherin 1, epithelial0.411
sulf2sulfatase 20.409
myl9lmyosin, light polypeptide 9, like0.409
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.408
bmp2abone morphogenetic protein 2a0.394
atoh1batonal homolog 1b0.383
wnt3wingless-type MMTV integration site family, member 30.382
tgfbr2transforming growth factor, beta receptor II0.380
socs3asuppressor of cytokine signaling 3a0.370
ca8carbonic anhydrase VIII0.369
sox2SRY-box containing gene 20.368
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.365
myf5myogenic factor 50.364
foxd3forkhead box D30.363
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.363
cd63Cd63 antigen0.362
lcp1lymphocyte cytosolic plastin 10.353
mpxmyeloid-specific peroxidase0.347
plcg1phospholipase C, gamma 10.345
igfbp7insulin-like growth factor binding protein 70.340
efnb3bephrin B3b0.340
fgf8afibroblast growth factor 8 a0.339
sox11aSRY-box containing gene 11a0.338
fzd7afrizzled homolog 7a0.332
ppargperoxisome proliferator activated receptor gamma0.329
tpm4tropomyosin 40.327
lmx1b.1LIM homeobox transcription factor 1, beta 10.323
myod1myogenic differentiation 10.320
fn1bfibronectin 1b0.312
crabp2bcellular retinoic acid binding protein 2, b0.311
nod1nucleotide-binding oligomerization domain containing 10.297
flhfloating head0.295
rap1bRAS related protein 1b0.291
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.290
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.288
tbx2bT-box 2b0.287
dbx1adeveloping brain homeobox 1a0.269
prdm1aPR domain containing 1a, with ZNF domain0.263
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.262
myh11amyosin, heavy polypeptide 11, smooth muscle a0.262
ccnd1cyclin D10.261
igf1rbinsulin-like growth factor 1b receptor0.260
hoxa2bhomeo box A2b0.250
fbn2bfibrillin 2b0.249
plp1aproteolipid protein 1a0.247
runx2arunt-related transcription factor 2a0.244
vcanbversican b0.242
tagln2transgelin 20.241
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.241
ephb4beph receptor B4b0.238
grem2gremlin 2, cysteine knot superfamily0.235
neurog1neurogenin 10.234
tgm2btransglutaminase 2b0.233
cx39.9connexin 39.90.230
cnr1cannabinoid receptor 10.230
bnc2basonuclin 20.230
ctsl1bcathepsin L, 1 b0.226
per2period homolog 2 (Drosophila)0.224
fgf10afibroblast growth factor 10a0.223
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EcREcdysone receptor0.988
EgfrEpidermal growth factor receptor0.985
fz2frizzled 20.642
mbcmyoblast city0.638
l(2)gllethal (2) giant larvae0.632
InRInsulin-like receptor0.569
Akt1CG4006 gene product from transcript CG4006-RA0.494
jebjelly belly0.452
par-1CG8201 gene product from transcript CG8201-RA0.418
Fmr1CG6203 gene product from transcript CG6203-RC0.417
drkdownstream of receptor kinase0.394
sqhspaghetti squash0.388
MarfMitochondrial assembly regulatory factor0.377
eyaeyes absent0.371
Rac1CG2248 gene product from transcript CG2248-RA0.371
PGRP-LCPeptidoglycan recognition protein LC0.369
Act57BActin 57B0.353
Lcp3Larval cuticle protein 30.352
Atg1Autophagy-specific gene 10.344
neuroliginCG13772 gene product from transcript CG13772-RA0.338
ovoCG6824 gene product from transcript CG6824-RE0.331
Rho1CG8416 gene product from transcript CG8416-RB0.325
Adf1Adh transcription factor 10.325
Ptp69DProtein tyrosine phosphatase 69D0.293
Stat92ESignal-transducer and activator of transcription protein at 92E0.289
Lcp2Larval cuticle protein 20.272
Rac2CG8556 gene product from transcript CG8556-RA0.271
unc-13CG2999 gene product from transcript CG2999-RA0.266
mewmultiple edematous wings0.265
emsempty spiracles0.262
PvrPDGF- and VEGF-receptor related0.257
DadDaughters against dpp0.256
Pi3K92ECG4141 gene product from transcript CG4141-RB0.250
LamCLamin C0.237
Rab7Rab-protein 70.235
spensplit ends0.230
TbhTyramine beta hydroxylase0.222
McrMacroglobulin complement-related0.220
Kr-h1Kruppel homolog 10.214
l(2)k16918lethal (2) k169180.205
CG13253CG13253 gene product from transcript CG13253-RB0.204
stcksteamer duck0.203
MP1Melanization Protease 10.197
Sp7Serine protease 70.187
norpAno receptor potential A0.178
Src42ASrc oncogene at 42A0.177
Ulp1CG12359 gene product from transcript CG12359-RA0.176
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.161
Hs6stHeparan sulfate 6-O-sulfotransferase0.155
elavembryonic lethal abnormal vision0.154
Cpr49AeCuticular protein 49Ae0.153
cicubitus interruptus0.151
hydhyperplastic discs0.148
Spn28DSerpin 28D0.148
Tsc1CG6147 gene product from transcript CG6147-RA0.144
GNBP3Gram-negative bacteria binding protein 30.138
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa2annexin A20.899
Arpc1bactin related protein 2/3 complex, subunit 1B0.881
Cd4Cd4 molecule0.862
Cd44Cd44 molecule0.845
Lgals3lectin, galactoside-binding, soluble, 30.836
Postnperiostin, osteoblast specific factor0.830
Ccl2chemokine (C-C motif) ligand 20.811
Pzppregnancy-zone protein0.800
Cd14CD14 molecule0.795
Socs3suppressor of cytokine signaling 30.780
Tagln2transgelin 20.778
Il1binterleukin 1 beta0.776
Jak1Janus kinase 10.762
S100a6S100 calcium binding protein A60.760
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.759
Itgb1integrin, beta 10.752
Marcksmyristoylated alanine rich protein kinase C substrate0.740
Fn1fibronectin 10.735
Atf3activating transcription factor 30.727
Gfapglial fibrillary acidic protein0.719
Timp1TIMP metallopeptidase inhibitor 10.714
Cav1caveolin 1, caveolae protein0.711
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.704
Cd48Cd48 molecule0.688
Anxa4annexin A40.673
Scn10asodium channel, voltage-gated, type X, alpha subunit0.668
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.663
Col1a1collagen, type I, alpha 10.660
Col3a1collagen, type III, alpha 10.653
Lamc1laminin, gamma 10.649
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.642
Tubb5tubulin, beta 50.635
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.629
Fgfr2fibroblast growth factor receptor 20.613
Emp1epithelial membrane protein 10.611
Timp2TIMP metallopeptidase inhibitor 20.605
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.603
Plaurplasminogen activator, urokinase receptor0.598
Pmp22peripheral myelin protein 220.593
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.589
Fosl1fos-like antigen 10.586
Edn1endothelin 10.584
Agtr1aangiotensin II receptor, type 1a0.580
Ripk3receptor-interacting serine-threonine kinase 30.565
Il1ainterleukin 1 alpha0.556
Hand2heart and neural crest derivatives expressed 20.548
Jak2Janus kinase 20.547
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.544
Gstm1glutathione S-transferase mu 10.543
FcgrtFc fragment of IgG, receptor, transporter, alpha0.537
RGD1307396similar to RIKEN cDNA 6330406I150.535
Loxlysyl oxidase0.517
Casp3caspase 30.509
Nfianuclear factor I/A0.508
Gpr83G protein-coupled receptor 830.501
Gucy2fguanylate cyclase 2F0.499
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.499
Fstl1follistatin-like 10.495
Acta2smooth muscle alpha-actin0.491
Tpm4tropomyosin 40.479
Id3inhibitor of DNA binding 30.477
Smad1SMAD family member 10.472
Il1r1interleukin 1 receptor, type I0.467
Col12a1collagen, type XII, alpha 10.461
Myh9myosin, heavy chain 9, non-muscle0.459
S100a4S100 calcium-binding protein A40.458
Pecam1platelet/endothelial cell adhesion molecule 10.454
Oprm1opioid receptor, mu 10.454
Iqgap1IQ motif containing GTPase activating protein 10.446
Fabp1fatty acid binding protein 1, liver0.440
Cxcl10chemokine (C-X-C motif) ligand 100.439
Prrx1paired related homeobox 10.437
Cgaglycoprotein hormones, alpha polypeptide0.436
Casp12caspase 120.428
Apoa5apolipoprotein A-V0.419
Inpp5dinositol polyphosphate-5-phosphatase D0.411
Nefmneurofilament, medium polypeptide0.408
Ppyr1pancreatic polypeptide receptor 10.407
Kcng2potassium voltage-gated channel, subfamily G, member 20.404
Slco2b1solute carrier organic anion transporter family, member 2b10.403
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.402
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.401
P2rx5purinergic receptor P2X, ligand-gated ion channel, 50.399
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.398
Col5a2collagen, type V, alpha 20.396
Anxa1annexin A10.396
Rhovras homolog gene family, member V0.390
Il6interleukin 60.390
Leprleptin receptor0.387
Syt8synaptotagmin VIII0.385
Metmet proto-oncogene0.380
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.376
Flt1FMS-related tyrosine kinase 10.374
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism