The network for 'response to activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to activity

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.

NameDescriptionProbabilityFunc Analog Organism
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.981
SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 20.958
SULT1A4sulfotransferase family, cytosolic, 1A, phenol-preferring, member 40.928
IL1R1interleukin 1 receptor, type I0.847
UHRF1ubiquitin-like with PHD and ring finger domains 10.799
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.729
NOSTRINnitric oxide synthase trafficker0.705
TNNI1troponin I type 1 (skeletal, slow)0.635
ESR1estrogen receptor 10.552
NCF4neutrophil cytosolic factor 4, 40kDa0.517
LY96lymphocyte antigen 960.511
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.485
IL1Binterleukin 1, beta0.479
PPARGperoxisome proliferator-activated receptor gamma0.458
PLAURplasminogen activator, urokinase receptor0.421
VAC14Vac14 homolog (S. cerevisiae)0.384
CCR5chemokine (C-C motif) receptor 50.363
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.333
PRDX1peroxiredoxin 10.333
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.330
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.320
ENGendoglin0.315
NGFnerve growth factor (beta polypeptide)0.311
PPP5Cprotein phosphatase 5, catalytic subunit0.275
ESRRGestrogen-related receptor gamma0.265
S100BS100 calcium binding protein B0.262
MYLK2myosin light chain kinase 20.260
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.248
TRIM63tripartite motif containing 630.244
TTNtitin0.237
TICAM2toll-like receptor adaptor molecule 20.234
NRIP1nuclear receptor interacting protein 10.231
MYD88myeloid differentiation primary response gene (88)0.211
CDK2cyclin-dependent kinase 20.205
VHLvon Hippel-Lindau tumor suppressor0.194
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.189
RIPK2receptor-interacting serine-threonine kinase 20.182
IL10RAinterleukin 10 receptor, alpha0.181
EGLN1egl nine homolog 1 (C. elegans)0.177
NCOA1nuclear receptor coactivator 10.159
SRGNserglycin0.159
HNF4Ahepatocyte nuclear factor 4, alpha0.152
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.146
THBS1thrombospondin 10.145
IRS2insulin receptor substrate 20.138
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.134
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.133
TNNT2troponin T type 2 (cardiac)0.131
SRFserum response factor (c-fos serum response element-binding transcription factor)0.130
PLATplasminogen activator, tissue0.127
TGFB1transforming growth factor, beta 10.122
ARNTaryl hydrocarbon receptor nuclear translocator0.120
TIMP2TIMP metallopeptidase inhibitor 20.120
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.116
TNNT3troponin T type 3 (skeletal, fast)0.107
HDAC1histone deacetylase 10.105
SH3RF1SH3 domain containing ring finger 10.104
FGFR1fibroblast growth factor receptor 10.104
IL1RAPinterleukin 1 receptor accessory protein0.098
CTBP1C-terminal binding protein 10.093
A2Malpha-2-macroglobulin0.091
ITGA6integrin, alpha 60.084
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.077
TRIM43tripartite motif containing 430.076
IL1R2interleukin 1 receptor, type II0.073
SREBF2sterol regulatory element binding transcription factor 20.072
TLR2toll-like receptor 20.072
RXRAretinoid X receptor, alpha0.071
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.062
KANK2KN motif and ankyrin repeat domains 20.060
TTRtransthyretin0.060
EGLN3egl nine homolog 3 (C. elegans)0.060
PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit0.058
PGAM2phosphoglycerate mutase 2 (muscle)0.058
IL8interleukin 80.057
EEDembryonic ectoderm development0.055
CCL20chemokine (C-C motif) ligand 200.053
EZH2enhancer of zeste homolog 2 (Drosophila)0.053
ICAM1intercellular adhesion molecule 10.052
KAT2BK(lysine) acetyltransferase 2B0.051
RARAretinoic acid receptor, alpha0.051
PXMP2peroxisomal membrane protein 2, 22kDa0.050
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.049
CCL2chemokine (C-C motif) ligand 20.049
DNMT1DNA (cytosine-5-)-methyltransferase 10.049
MYH7myosin, heavy chain 7, cardiac muscle, beta0.048
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.047
COX6A2cytochrome c oxidase subunit VIa polypeptide 20.046
TNNI2troponin I type 2 (skeletal, fast)0.046
PRDM1PR domain containing 1, with ZNF domain0.046
LTKleukocyte receptor tyrosine kinase0.046
SGCAsarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)0.046
SUZ12suppressor of zeste 12 homolog (Drosophila)0.045
PRDX6peroxiredoxin 60.045
TIMP1TIMP metallopeptidase inhibitor 10.045
TNFAIP2tumor necrosis factor, alpha-induced protein 20.045
ACTN2actinin, alpha 20.043
MTA3metastasis associated 1 family, member 30.043
AQP7aquaporin 70.042
CYB5Acytochrome b5 type A (microsomal)0.042
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myhz2myosin, heavy polypeptide 2, fast muscle specific0.636
myod1myogenic differentiation 10.349
tnni1altroponin I, skeletal, slow like0.181
actn3aactinin alpha 3a0.137
tnnc1btroponin C type 1b (slow)0.111
actn3bactinin alpha 3b0.090
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.082
smyhc1slow myosin heavy chain 10.080
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.076
smyd1bSET and MYND domain containing 1b0.070
smyhc2slow myosin heavy chain 20.068
myogmyogenin0.064
tnnt3btroponin T3b, skeletal, fast0.062
fabp11afatty acid binding protein 11a0.058
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.055
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.051
itgb1aintegrin, beta 1a0.051
tnnt1troponin T1, skeletal, slow0.043
cav1caveolin 10.040
tnni2a.4troponin I, skeletal, fast 2a.40.040
srfserum response factor0.038
tnfatumor necrosis factor a (TNF superfamily, member 2)0.034
tnni1btroponin I, skeletal, slow b0.031
zgc:56466zgc:564660.030
vdravitamin D receptor a0.029
th2tyrosine hydroxylase 20.028
stc1lstanniocalcin 1, like0.028
grifingalectin related inter-fiber protein0.026
gstalglutathione S-transferase, alpha-like0.026
si:rp71-39b20.7si:rp71-39b20.70.026
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.022
six1bsine oculis homeobox homolog 1b0.021
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.021
sult2st2sulfotransferase family 2, cytosolic sulfotransferase 20.020
igf1rbinsulin-like growth factor 1b receptor0.020
actc1aactin, alpha, cardiac muscle 1a0.020
zgc:66286zgc:662860.019
inhainhibin, alpha0.019
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.019
actn2actinin, alpha 20.019
slc26a3solute carrier family 26, member 30.019
tpmaalpha-tropomyosin0.019
park7parkinson disease (autosomal recessive, early onset) 70.018
pacsin3protein kinase C and casein kinase substrate in neurons 30.018
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.018
sod1superoxide dismutase 1, soluble0.018
hspb11heat shock protein, alpha-crystallin-related, b110.017
igf2ainsulin-like growth factor 2a0.017
zgc:112986zgc:1129860.017
LOC569128hypothetical protein LOC5691280.016
hsp90a.1heat shock protein 90-alpha 10.016
scn4aasodium channel, voltage-gated, type IV, alpha, a0.016
mef2dmyocyte enhancer factor 2d0.015
ryr2aryanodine receptor 2a (cardiac)0.015
mstnamyostatin a0.015
mstnbmyostatin b0.015
xirp2axin actin-binding repeat containing 2a0.015
LOC100000934hypothetical protein LOC1000009340.015
insrbinsulin receptor b0.014
dnajb13DnaJ (Hsp40) related, subfamily B, member 130.014
esr1estrogen receptor 10.014
zgc:64114zgc:641140.013
il1binterleukin 1, beta and interleukin 1, beta0.013
lbx2ladybird homeobox homolog 2 (Drosophila)0.013
zgc:101797zgc:1017970.013
zgc:110373zgc:1103730.013
cx39.9connexin 39.90.012
itgb1b.1integrin, beta 1b.10.012
mylz2myosin, light polypeptide 2, skeletal muscle0.012
ryr1bryanodine receptor 1b (skeletal)0.012
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.012
ncoa1nuclear receptor coactivator 10.011
il6stinterleukin 6 signal transducer0.011
zgc:101782zgc:1017820.011
cx32.3connexin 32.30.011
mxi1max interacting protein0.011
adrb2aadrenergic receptor, beta 2a0.011
nos2anitric oxide synthase 2a, inducible0.011
hspb9heat shock protein, alpha-crystallin-related, 90.011
hprt1hypoxanthine phosphoribosyltransferase 10.011
acp5bacid phosphatase 5b, tartrate resistant0.011
nr0b1nuclear receptor subfamily 0, group B, member 10.011
il8interleukin 80.011
aldh7a1aldehyde dehydrogenase 7 family, member A10.011
gdf9growth differentiation factor 90.011
tshbthyroid stimulating hormone, beta subunit0.011
igfbp1binsulin-like growth factor binding protein 1b0.010
zgc:112056zgc:1120560.010
furinbfurin (paired basic amino acid cleaving enzyme) b0.010
mapk7mitogen-activated protein kinase 70.010
tp53bp2tumor protein p53 binding protein, 20.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nos1nitric oxide synthase 1, neuronal0.700
Leprleptin receptor0.539
Lepleptin0.507
Fbn1fibrillin 10.458
Ptgs2prostaglandin-endoperoxide synthase 20.221
Mybphmyosin binding protein H0.157
Bglapbone gamma carboxyglutamate protein0.145
Ttntitin0.139
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.132
Tlr2toll-like receptor 20.131
Nos3nitric oxide synthase 3, endothelial cell0.107
Mmp9matrix metallopeptidase 90.105
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.091
Umoduromodulin0.090
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.088
Vdrvitamin D receptor0.087
Cav1caveolin 1, caveolae protein0.081
Tnni2troponin I, skeletal, fast 20.077
Actn3actinin alpha 30.069
Arandrogen receptor0.067
Slc12a1solute carrier family 12, member 10.065
Vegfavascular endothelial growth factor A0.064
Lyz2lysozyme 20.061
Esr1estrogen receptor 1 (alpha)0.061
Hbb-b1hemoglobin, beta adult major chain0.060
Hrchistidine rich calcium binding protein0.057
Nrapnebulin-related anchoring protein0.056
Ptpn11protein tyrosine phosphatase, non-receptor type 110.054
Agtr2angiotensin II receptor, type 20.054
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.052
Tnnc2troponin C2, fast0.050
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.042
Tnnt3troponin T3, skeletal, fast0.039
Ren1renin 1 structural0.039
Tgfb1transforming growth factor, beta 10.038
Eporerythropoietin receptor0.035
Agtr1aangiotensin II receptor, type 1a0.035
Il10interleukin 100.035
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.031
Col1a1collagen, type I, alpha 10.030
Cacng1calcium channel, voltage-dependent, gamma subunit 10.030
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.029
Insrinsulin receptor0.028
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.028
Egln1EGL nine homolog 1 (C. elegans)0.026
Apoeapolipoprotein E0.026
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.026
Nos2nitric oxide synthase 2, inducible0.025
Myl3myosin, light polypeptide 30.025
Myoz1myozenin 10.024
Nr3c1nuclear receptor subfamily 3, group C, member 10.024
Ldb3LIM domain binding 30.024
Ckmcreatine kinase, muscle0.023
Ckmt2creatine kinase, mitochondrial 20.023
Myod1myogenic differentiation 10.022
Ghrgrowth hormone receptor0.022
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.022
Il1r1interleukin 1 receptor, type I0.022
Art1ADP-ribosyltransferase 10.021
Pthlhparathyroid hormone-like peptide0.021
Irak4interleukin-1 receptor-associated kinase 40.021
Sim1single-minded homolog 1 (Drosophila)0.020
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.020
Hif1ahypoxia inducible factor 1, alpha subunit0.020
Ccl2chemokine (C-C motif) ligand 20.020
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.019
Cav3caveolin 30.019
Spp1secreted phosphoprotein 10.019
Casq1calsequestrin 10.018
Vhlvon Hippel-Lindau tumor suppressor0.018
AxlAXL receptor tyrosine kinase0.018
Myf6myogenic factor 60.018
Tcaptitin-cap0.018
Npr2natriuretic peptide receptor 20.017
Xirp1xin actin-binding repeat containing 10.017
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.017
Tlr4toll-like receptor 40.017
Cox8bcytochrome c oxidase, subunit VIIIb0.017
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.016
Myh4myosin, heavy polypeptide 4, skeletal muscle0.016
Myom2myomesin 20.016
Gckglucokinase0.016
Hprthypoxanthine guanine phosphoribosyl transferase0.015
Tbx15T-box 150.014
Ryr1ryanodine receptor 1, skeletal muscle0.014
Cdh15cadherin 150.014
Fgf6fibroblast growth factor 60.014
Ppargperoxisome proliferator activated receptor gamma0.014
Pvalbparvalbumin0.014
Npy1rneuropeptide Y receptor Y10.013
Fbxo32F-box protein 320.013
Cks1bCDC28 protein kinase 1b0.013
Casp4caspase 4, apoptosis-related cysteine peptidase0.013
Timp4tissue inhibitor of metalloproteinase 40.013
Vav3vav 3 oncogene0.012
Cd44CD44 antigen0.012
Csrp3cysteine and glycine-rich protein 30.012
Il6interleukin 60.012
Fstfollistatin0.012
Plgplasminogen0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.108
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.108
Ccl4chemokine (C-C motif) ligand 40.081
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.072
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.069
Tgthyroglobulin0.068
Csf3colony stimulating factor 3 (granulocyte)0.062
Dnase1l3deoxyribonuclease 1-like 30.060
LOC286992peptide HP (rs14)0.056
Serpina4serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 40.054
Gckrglucokinase (hexokinase 4) regulator0.053
Il6interleukin 60.053
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.050
AhnakAHNAK nucleoprotein0.049
Mmp3matrix metallopeptidase 30.049
Hist1h1ahistone cluster 1, H1a0.049
Xcl1chemokine (C motif) ligand 10.048
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.047
Utrnutrophin0.046
Slco2b1solute carrier organic anion transporter family, member 2b10.044
Il1binterleukin 1 beta0.044
Lect1leukocyte cell derived chemotaxin 10.044
Ces1ccarboxylesterase 1C0.044
Sult2a2sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 20.044
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.044
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.043
Ube2d4ubiquitin-conjugating enzyme E2D 40.043
Clcn5chloride channel 50.043
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.043
Pitx3paired-like homeodomain 30.042
Cxcl10chemokine (C-X-C motif) ligand 100.042
Fshbfollicle stimulating hormone, beta polypeptide0.041
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.041
Albalbumin0.041
Bdkrb2bradykinin receptor B20.040
Mmp10matrix metallopeptidase 100.040
Dact3dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)0.039
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.039
Pyypeptide YY (mapped)0.039
Gipgastric inhibitory polypeptide0.039
C9complement component 90.038
Ccl3chemokine (C-C motif) ligand 30.038
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.037
Csf1colony stimulating factor 1 (macrophage)0.036
Ccr1chemokine (C-C motif) receptor 10.036
Sftpa1surfactant protein A10.036
Ccl2chemokine (C-C motif) ligand 20.036
Orm1orosomucoid 10.036
Arpp21cAMP-regulated phosphoprotein 210.036
Rup2urinary protein 20.036
Il1ainterleukin 1 alpha0.035
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.035
Cd4Cd4 molecule0.035
Myo1cmyosin IC0.034
Ccl20chemokine (C-C motif) ligand 200.034
Agtr1aangiotensin II receptor, type 1a0.034
Il1rninterleukin 1 receptor antagonist0.034
Guca2aguanylate cyclase activator 2a (guanylin)0.034
C8bcomplement component 8, beta polypeptide0.034
Ccr3chemokine (C-C motif) receptor 30.034
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.033
Apcsamyloid P component, serum0.033
Cela1chymotrypsin-like elastase family, member 10.033
Hpxhemopexin0.033
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.033
Rab1bRAB1B, member RAS oncogene family0.033
Olfml2bolfactomedin-like 2B0.033
Psgb1pregnancy-specific beta 1-glycoprotein0.033
Ednrbendothelin receptor type B0.033
Pgcprogastricsin (pepsinogen C)0.033
Apoa5apolipoprotein A-V0.033
Shank1SH3 and multiple ankyrin repeat domains 10.033
Lbplipopolysaccharide binding protein0.033
Slc22a1solute carrier family 22 (organic cation transporter), member 10.032
Clic4chloride intracellular channel 40.032
Ednraendothelin receptor type A0.032
Il1rl1interleukin 1 receptor-like 10.032
Plcb2phospholipase C, beta 20.032
Hist1h2bahistone cluster 1, H2ba0.032
Gnrhrgonadotropin releasing hormone receptor0.032
Tfpi2tissue factor pathway inhibitor 20.031
Adrb2adrenergic, beta-2-, receptor, surface0.031
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.031
Nr5a2nuclear receptor subfamily 5, group A, member 20.031
Ifnginterferon gamma0.031
Fosl1fos-like antigen 10.031
LOC286980putative pheromone receptor (Go-VN13B)0.030
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.030
Mmp9matrix metallopeptidase 90.030
Loxl1lysyl oxidase-like 10.030
Ahsgalpha-2-HS-glycoprotein0.030
Kcnd3potassium voltage-gated channel, Shal-related subfamily, member 30.030
Ccl11chemokine (C-C motif) ligand 110.030
Aqp8aquaporin 80.030
LOC300024similar to Ly6-B antigen gene0.030
Ccl7chemokine (C-C motif) ligand 70.030
Scn9asodium channel, voltage-gated, type IX, alpha0.029
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.029
Tnnc2troponin C type 2 (fast)0.029
Flt1FMS-related tyrosine kinase 10.029
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism