The network for 'mononuclear cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mononuclear cell proliferation

The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.

NameDescriptionProbabilityFunc Analog Organism
SYKspleen tyrosine kinase0.996
LCKlymphocyte-specific protein tyrosine kinase0.994
PTPRCprotein tyrosine phosphatase, receptor type, C0.992
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.992
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.991
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.989
BCL2B-cell CLL/lymphoma 20.980
FGFR2fibroblast growth factor receptor 20.967
BIRC3baculoviral IAP repeat containing 30.966
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.959
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.937
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.934
PTPN6protein tyrosine phosphatase, non-receptor type 60.924
IL4Rinterleukin 4 receptor0.906
TRAF1TNF receptor-associated factor 10.899
CD2CD2 molecule0.892
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.881
HLA-Bmajor histocompatibility complex, class I, B0.880
CD80CD80 molecule0.862
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.859
ICAM1intercellular adhesion molecule 10.819
PLCG1phospholipase C, gamma 10.816
HLA-Fmajor histocompatibility complex, class I, F0.800
EGFRepidermal growth factor receptor0.794
BTN3A3butyrophilin, subfamily 3, member A30.789
CTLA4cytotoxic T-lymphocyte-associated protein 40.788
ABI1abl-interactor 10.785
LATlinker for activation of T cells0.770
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.754
CCR7chemokine (C-C motif) receptor 70.749
CD86CD86 molecule0.734
SOCS3suppressor of cytokine signaling 30.734
HLA-Gmajor histocompatibility complex, class I, G0.718
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.710
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.690
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.689
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.686
CASP4caspase 4, apoptosis-related cysteine peptidase0.673
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.665
FYBFYN binding protein0.659
BTN3A2butyrophilin, subfamily 3, member A20.649
CD247CD247 molecule0.609
NCF4neutrophil cytosolic factor 4, 40kDa0.598
HLA-Amajor histocompatibility complex, class I, A0.588
XIAPX-linked inhibitor of apoptosis0.544
CCR5chemokine (C-C motif) receptor 50.542
IRF4interferon regulatory factor 40.542
CCL4chemokine (C-C motif) ligand 40.540
LTAlymphotoxin alpha (TNF superfamily, member 1)0.536
BCL10B-cell CLL/lymphoma 100.533
CD3GCD3g molecule, gamma (CD3-TCR complex)0.525
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.521
IL2RGinterleukin 2 receptor, gamma0.517
SH2D1ASH2 domain containing 1A0.514
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.510
IL2RBinterleukin 2 receptor, beta0.510
HLA-Cmajor histocompatibility complex, class I, C0.504
BCL2L1BCL2-like 10.497
CD52CD52 molecule0.469
TANKTRAF family member-associated NFKB activator0.460
HLA-DPB1major histocompatibility complex, class II, DP beta 10.455
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.454
TNFRSF9tumor necrosis factor receptor superfamily, member 90.447
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.442
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.436
HLA-Emajor histocompatibility complex, class I, E0.434
JAK1Janus kinase 10.428
MYD88myeloid differentiation primary response gene (88)0.422
GRB2growth factor receptor-bound protein 20.412
BTN3A1butyrophilin, subfamily 3, member A10.410
CCL22chemokine (C-C motif) ligand 220.399
FGFR1fibroblast growth factor receptor 10.389
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.385
FGF1fibroblast growth factor 1 (acidic)0.373
VAV1vav 1 guanine nucleotide exchange factor0.370
STAT4signal transducer and activator of transcription 40.367
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.359
BCL2A1BCL2-related protein A10.359
TFF1trefoil factor 10.357
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.354
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.345
SIGLEC7sialic acid binding Ig-like lectin 70.336
BAXBCL2-associated X protein0.336
HCKhemopoietic cell kinase0.335
IFNGinterferon, gamma0.329
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.315
CASP9caspase 9, apoptosis-related cysteine peptidase0.311
RUNX1runt-related transcription factor 10.311
IL1Binterleukin 1, beta0.305
BLNKB-cell linker0.304
CASP8caspase 8, apoptosis-related cysteine peptidase0.298
ACVR1Bactivin A receptor, type IB0.295
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.294
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.294
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.289
CCR1chemokine (C-C motif) receptor 10.288
INSRinsulin receptor0.281
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.276
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf8afibroblast growth factor 8 a0.869
kitakit receptor a0.508
mmp9matrix metalloproteinase 90.480
il6rinterleukin 6 receptor0.435
ptch2patched 20.374
shhasonic hedgehog a0.256
ocrloculocerebrorenal syndrome of Lowe0.235
tlr3toll-like receptor 30.221
aldh1a2aldehyde dehydrogenase 1 family, member A20.221
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.211
foxd3forkhead box D30.205
cdx4caudal type homeo box transcription factor 40.200
tbpTATA box binding protein0.185
tnfatumor necrosis factor a (TNF superfamily, member 2)0.183
bmp1abone morphogenetic protein 1a0.176
gmpsguanine monphosphate synthetase0.164
ahcyS-adenosylhomocysteine hydrolase0.163
stc1lstanniocalcin 1, like0.158
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.153
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.148
il7rinterleukin 7 receptor0.145
sbno2bstrawberry notch homolog 2b0.142
runx2arunt-related transcription factor 2a0.141
LOC100003514protein kinase C alpha type-like0.136
rag1recombination activating gene 10.131
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.126
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.121
mmp15bmatrix metallopeptidase 15b0.120
cdh1cadherin 1, epithelial0.120
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.116
dnttdeoxynucleotidyltransferase, terminal0.114
tmem144btransmembrane protein 144b0.112
ca2carbonic anhydrase II0.111
c1qccomplement component 1, q subcomponent, C chain0.103
alkanaplastic lymphoma kinase (Ki-1)0.102
flhfloating head0.100
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.099
emx2empty spiracles homeobox 20.098
disc1disrupted in schizophrenia 10.096
mt2metallothionein 20.096
igf2binsulin-like growth factor 2b0.095
arrb2barrestin, beta 2b0.091
tlr2toll-like receptor 20.090
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.090
ddr2bdiscoidin domain receptor family, member 2b0.088
kbpkif1-binding protein0.087
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.087
fgf20afibroblast growth factor 20a0.086
myod1myogenic differentiation 10.084
hbaa1hemoglobin alpha adult-10.084
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.083
ptk6aPTK6 protein tyrosine kinase 6a0.082
tlr20atoll-like receptor 20a0.082
phf6PHD finger protein 60.082
cxcr4bchemokine (C-X-C motif), receptor 4b0.082
cpoxcoproporphyrinogen oxidase0.081
ivns1abpainfluenza virus NS1A binding protein a0.081
efna2ephrin A20.081
pitx2paired-like homeodomain transcription factor 20.080
csrp1acysteine and glycine-rich protein 1a0.080
hspa5heat shock protein 50.080
trpm7transient receptor potential cation channel, subfamily M, member 70.079
axin2axin 2 (conductin, axil)0.078
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.073
btr16bloodthirsty-related gene family, member 160.072
LOC555739serine/threonine-protein kinase LMTK1-like0.072
cd40lgCD40 ligand0.071
gpr126G protein-coupled receptor 1260.070
bocbrother of CDO0.070
ahcyl1S-adenosylhomocysteine hydrolase-like 10.070
cmybtranscription factor cmyb0.070
angptl3angiopoietin-like 30.069
epha4aeph receptor A4a0.069
cdh2cadherin 2, neuronal0.068
nap1l1nucleosome assembly protein 1, like 10.068
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.067
cyp1d1cytochrome P450, family 1, subfamily D, polypeptide 10.067
rpl7aribosomal protein L7a0.067
foxa2forkhead box A20.067
dnm2dynamin 20.067
lgals2alectin, galactoside-binding, soluble, 2a0.066
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.066
ripk2receptor-interacting serine-threonine kinase 20.066
csf3rcolony stimulating factor 3 receptor (granulocyte)0.066
bmp2bbone morphogenetic protein 2b0.065
tgfb1atransforming growth factor, beta 1a0.064
pdss1prenyl (decaprenyl) diphosphate synthase, subunit 10.064
foxi2forkhead box I20.064
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.064
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.063
impdh1binosine 5'-phosphate dehydrogenase 1b0.062
dnmt7DNA (cytosine-5-)-methyltransferase 70.062
elovl1belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b0.062
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.908
Cd37CD37 molecule0.785
Hckhemopoietic cell kinase0.599
RT1-Db1RT1 class II, locus Db10.528
RT1-DMbRT1 class II, locus DMb0.382
Ptprcprotein tyrosine phosphatase, receptor type, C0.289
Cd247Cd247 molecule0.196
Cd2Cd2 molecule0.142
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.137
Il1r1interleukin 1 receptor, type I0.135
Ciitaclass II, major histocompatibility complex, transactivator0.134
Bin2bridging integrator 20.131
RT1-BaRT1 class II, locus Ba0.125
Fgfr2fibroblast growth factor receptor 20.120
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.106
Ptpn6protein tyrosine phosphatase, non-receptor type 60.102
Cd44Cd44 molecule0.093
Cd86CD86 molecule0.086
Lcp2lymphocyte cytosolic protein 20.083
Tas2r123taste receptor, type 2, member 1230.080
Cd38CD38 molecule0.080
Il10interleukin 100.074
Plauplasminogen activator, urokinase0.073
Rassf5Ras association (RalGDS/AF-6) domain family member 50.073
Il18interleukin 180.069
Mvpmajor vault protein0.069
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.067
Ptafrplatelet-activating factor receptor0.064
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.063
RT1-DMaRT1 class II, locus DMa0.059
Gpr20G protein-coupled receptor 200.059
Skap2src kinase associated phosphoprotein 20.058
Scn11asodium channel, voltage-gated, type XI, alpha0.058
Ly86lymphocyte antigen 860.057
Anxa2annexin A20.056
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.056
Casp1caspase 10.056
Lcp1lymphocyte cytosolic protein 10.053
Ptger4prostaglandin E receptor 4 (subtype EP4)0.049
Inpp5dinositol polyphosphate-5-phosphatase D0.047
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.045
Tgfbr2transforming growth factor, beta receptor II0.044
Lef1lymphoid enhancer binding factor 10.044
Laptm5lysosomal protein transmembrane 50.043
Ctsscathepsin S0.043
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.042
Cd4Cd4 molecule0.041
Cfpcomplement factor properdin0.041
Cd5Cd5 molecule0.039
Lst1leukocyte specific transcript 10.039
Fcer1gFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.039
Il1binterleukin 1 beta0.038
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.038
Prlhrprolactin releasing hormone receptor0.038
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.038
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.037
Taok1TAO kinase 10.036
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.036
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.035
Icosinducible T-cell co-stimulator0.035
Cd53Cd53 molecule0.034
Cd200r1CD200 receptor 10.033
Zbp1Z-DNA binding protein 10.033
Gzmkgranzyme K0.032
Arhgap4Rho GTPase activating protein 40.032
Fgbfibrinogen beta chain0.032
Nr5a2nuclear receptor subfamily 5, group A, member 20.032
Hrh4histamine receptor H40.032
Mmp10matrix metallopeptidase 100.031
Cntn1contactin 10.031
Adora3adenosine A3 receptor0.030
Metmet proto-oncogene0.030
Reg3bregenerating islet-derived 3 beta0.030
Lilrb3lleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like0.030
Prr13proline rich 130.030
F2rl2coagulation factor II (thrombin) receptor-like 20.029
Gmfgglia maturation factor, gamma0.029
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.029
Serpinb1aserine (or cysteine) proteinase inhibitor, clade B, member 1a0.029
LOC100361706lambda-chain C1-region-like0.029
Tgfbr3transforming growth factor, beta receptor III0.028
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.028
Plcg2phospholipase C, gamma 20.028
Hn1hematological and neurological expressed 10.027
Pmfbp1polyamine modulated factor 1 binding protein 10.027
Gzmbgranzyme B0.026
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.026
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.026
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.026
Arpc1bactin related protein 2/3 complex, subunit 1B0.025
Il4interleukin 40.025
Vav1vav 1 guanine nucleotide exchange factor0.025
Fosl1fos-like antigen 10.025
Il2rbinterleukin 2 receptor, beta0.025
LOC100361571keratin associated protein 1-3-like0.024
Aif1allograft inflammatory factor 10.024
Prrx1paired related homeobox 10.024
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.024
Kcnk10potassium channel, subfamily K, member 100.023
Kcnv1potassium channel, subfamily V, member 10.023
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism