The network for 'tetrapyrrole biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tetrapyrrole biosynthetic process

The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

NameDescriptionProbabilityFunc Analog Organism
SPTA1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.995
SPTBspectrin, beta, erythrocytic0.948
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.699
ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.297
ANK1ankyrin 1, erythrocytic0.158
RHAGRh-associated glycoprotein0.096
COX5Acytochrome c oxidase subunit Va0.061
PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.053
URODuroporphyrinogen decarboxylase0.047
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.046
ATP5OATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.030
PCBD2pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 20.027
OXA1Loxidase (cytochrome c) assembly 1-like0.024
EEF2eukaryotic translation elongation factor 20.023
TKTtransketolase0.022
SLC25A6solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 60.021
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.020
CHD3chromodomain helicase DNA binding protein 30.017
CLN3ceroid-lipofuscinosis, neuronal 30.016
RHDRh blood group, D antigen0.016
UQCRC2ubiquinol-cytochrome c reductase core protein II0.015
FAF1Fas (TNFRSF6) associated factor 10.014
SND1staphylococcal nuclease and tudor domain containing 10.014
MYL6Bmyosin, light chain 6B, alkali, smooth muscle and non-muscle0.014
ERP29endoplasmic reticulum protein 290.013
AKR7A2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)0.012
ECHS1enoyl CoA hydratase, short chain, 1, mitochondrial0.012
HNF1BHNF1 homeobox B0.012
QARSglutaminyl-tRNA synthetase0.012
SDHBsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.011
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.011
HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit0.011
ATPAF1ATP synthase mitochondrial F1 complex assembly factor 10.011
C1orf50chromosome 1 open reading frame 500.011
ASMTLacetylserotonin O-methyltransferase-like0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tfr1atransferrin receptor 1a0.853
alas2aminolevulinate, delta-, synthetase 20.850
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.745
fechferrochelatase0.715
urosuroporphyrinogen III synthase0.707
slc4a1asolute carrier family 4, anion exchanger, member 1a0.409
klfdKruppel-like factor d0.320
ppoxprotoporphyrinogen oxidase0.219
uroduroporphyrinogen decarboxylase0.136
slc25a37solute carrier family 25, member 370.134
hmbsbhydroxymethylbilane synthase, b0.123
hbbe2hemoglobin beta embryonic-20.114
gata1aGATA binding protein 1a0.112
glrx5glutaredoxin 5 homolog (S. cerevisiae)0.071
iba57IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)0.065
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.046
hdrhematopoietic death receptor0.044
sptbspectrin, beta, erythrocytic0.038
slc25a39solute carrier family 25, member 390.026
tspotranslocator protein0.025
nt5c2l15'-nucleotidase, cytosolic II, like 10.024
slc20a1asolute carrier family 20, member 1a0.022
slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.021
hbbe3hemoglobin beta embryonic-30.020
hbae3hemoglobin alpha embryonic-30.017
prcpprolylcarboxypeptidase (angiotensinase C)0.017
map2k4amitogen-activated protein kinase kinase 4a0.016
nfe2nuclear factor, erythroid-derived 20.015
slc43a3asolute carrier family 43, member 3a0.014
bdh23-hydroxybutyrate dehydrogenase, type 20.014
si:dkeyp-94b4.2si:dkeyp-94b4.20.014
trim2atripartite motif-containing 2a0.013
ssr1signal sequence receptor, alpha0.013
si:dkeyp-84f11.5si:dkeyp-84f11.50.012
zgc:158288zgc:1582880.012
zgc:123327zgc:1233270.012
atpif1ATPase inhibitory factor 10.012
fzd5frizzled homolog 50.012
scarb1scavenger receptor class B, member 10.012
tmod4tropomodulin 4 (muscle)0.011
glipr2GLI pathogenesis-related 20.011
si:dkey-48j7.5si:dkey-48j7.50.011
si:dkey-246k9.1si:dkey-246k9.10.011
palb2partner and localizer of BRCA20.011
pdap1pdgfa associated protein 10.011
zgc:112089zgc:1120890.011
LOC797097PLAC8-like protein 1-like0.011
st3gal4ST3 beta-galactoside alpha-2,3-sialyltransferase 40.011
lmo2LIM domain only 2 (rhombotin-like 1)0.011
hibadha3-hydroxyisobutyrate dehydrogenase a0.010
cox17COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)0.010
zgc:110091zgc:1100910.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Spna1spectrin alpha 10.997
Ank1ankyrin 1, erythroid0.997
Hbb-b1hemoglobin, beta adult major chain0.991
Spnb1spectrin beta 10.978
Hbb-b2hemoglobin, beta adult minor chain0.889
Slc4a1solute carrier family 4 (anion exchanger), member 10.818
Add2adducin 2 (beta)0.696
Exoc6exocyst complex component 60.535
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.344
Klf1Kruppel-like factor 1 (erythroid)0.332
Ahspalpha hemoglobin stabilizing protein0.271
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.150
Epb4.1erythrocyte protein band 4.10.149
Pklrpyruvate kinase liver and red blood cell0.132
Hmbshydroxymethylbilane synthase0.125
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.104
Hba-a2hemoglobin alpha, adult chain 20.077
Fechferrochelatase0.068
Tmprss6transmembrane serine protease 60.066
Eporerythropoietin receptor0.055
Urosuroporphyrinogen III synthase0.043
Ttc7tetratricopeptide repeat domain 70.040
Beta-shemoglobin subunit beta-1-like0.029
Glrx5glutaredoxin 5 homolog (S. cerevisiae)0.025
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.024
Hfehemochromatosis0.023
Cd59bCD59b antigen0.022
Taldo1transaldolase 10.021
Gypaglycophorin A0.020
Macf1microtubule-actin crosslinking factor 10.019
Dync1h1dynein cytoplasmic 1 heavy chain 10.019
Abcb4ATP-binding cassette, sub-family B (MDR/TAP), member 40.019
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.019
Spna2spectrin alpha 20.018
Pnpopyridoxine 5'-phosphate oxidase0.018
Acaa2acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)0.016
Fbxl5F-box and leucine-rich repeat protein 50.016
Hfe2hemochromatosis type 2 (juvenile) (human homolog)0.016
Catcatalase0.015
Aladaminolevulinate, delta-, dehydratase0.015
Sncasynuclein, alpha0.015
Ebpphenylalkylamine Ca2+ antagonist (emopamil) binding protein0.014
Dhrs4dehydrogenase/reductase (SDR family) member 40.014
Cycscytochrome c, somatic0.014
Txnrd2thioredoxin reductase 20.014
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.013
Tfrctransferrin receptor0.013
Kifap3kinesin-associated protein 30.012
Pnpla6patatin-like phospholipase domain containing 60.012
Spnb2spectrin beta 20.012
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.012
Gcdhglutaryl-Coenzyme A dehydrogenase0.011
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.011
Kitlkit ligand0.011
Hk1hexokinase 10.011
Prdx2peroxiredoxin 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hmbshydroxymethylbilane synthase0.828
Uroduroporphyrinogen decarboxylase0.628
Trap1TNF receptor-associated protein 10.553
Mdh1malate dehydrogenase 1, NAD (soluble)0.463
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.211
Akr7a2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)0.170
Aladaminolevulinate, delta-, dehydratase0.161
Oaz1ornithine decarboxylase antizyme 10.139
Mpstmercaptopyruvate sulfurtransferase0.111
Ppoxprotoporphyrinogen oxidase0.073
Sordsorbitol dehydrogenase0.051
Mipepmitochondrial intermediate peptidase0.049
Tstthiosulfate sulfurtransferase0.039
ApehN-acylaminoacyl-peptide hydrolase0.034
Ppifpeptidylprolyl isomerase F0.034
Hspd1heat shock protein 1 (chaperonin)0.033
Grhprglyoxylate reductase/hydroxypyruvate reductase0.027
RGD1308134similar to RIKEN cDNA 1110020A230.027
RGD1311605similar to apoptosis related protein APR-3; p18 protein0.024
Adh5alcohol dehydrogenase 5 (class III), chi polypeptide0.023
Trappc1trafficking protein particle complex 10.022
Ccscopper chaperone for superoxide dismutase0.019
Fechferrochelatase0.019
Tmem14ctransmembrane protein 14C0.018
Uqcrc2ubiquinol cytochrome c reductase core protein 20.017
Mrpl3mitochondrial ribosomal protein L30.016
Mosc2MOCO sulphurase C-terminal domain containing 20.016
Mri1methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)0.016
Cycscytochrome c, somatic0.015
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.014
Pecrperoxisomal trans-2-enoyl-CoA reductase0.012
Hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.011
Tsta3tissue specific transplantation antigen P35B0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MIR1Mir1p0.113
HEM2Hem2p0.103
HEM12Hem12p0.038
MNP1Mnp1p0.031
CYC1Cyc1p0.026
MET3Met3p0.024
NDE1Nde1p0.023
PMI40Pmi40p0.022
LEU5Leu5p0.022
SUL2Sul2p0.021
PDI1Pdi1p0.021
COX4Cox4p0.020
MDH1Mdh1p0.020
SRD1Srd1p0.019
NAM9Nam9p0.018
HEM3Hem3p0.018
CPD1Cpd1p0.018
YNL190Whypothetical protein0.018
YLR264C-Ahypothetical protein0.018
ALE1Ale1p0.017
ERG9Erg9p0.017
BIO2Bio2p0.017
AVT7Avt7p0.017
ARP10Arp10p0.017
ANB1Anb1p0.017
ARG8Arg8p0.017
AIM38Aim38p0.017
YOL038C-Ahypothetical protein0.016
COX18Cox18p0.016
YLR162Whypothetical protein0.016
SPL2Spl2p0.016
LEU2Leu2p0.016
MET16Met16p0.016
ADH2Adh2p0.016
OPT2Opt2p0.016
ALD6Ald6p0.015
PCP1Pcp1p0.015
SCT1Sct1p0.015
SWC7Swc7p0.015
MET14Met14p0.015
CUP1-1Cup1-1p0.015
COX5BCox5bp0.015
MET5Met5p0.015
MER1Mer1p0.015
BAP3Bap3p0.015
COX2Cox2p0.015
ZPS1Zps1p0.015
ADE8Ade8p0.015
SCM4Scm4p0.015
UPS3Ups3p0.015
YPR157Whypothetical protein0.015
COX9Cox9p0.014
LSB6Lsb6p0.014
YAR068Whypothetical protein0.014
RMD6Rmd6p0.014
TOS6Tos6p0.014
BSC1Bsc1p0.014
HPF1Hpf1p0.014
DIC1Dic1p0.014
COA2Coa2p0.014
YLR042Chypothetical protein0.014
CAM1Cam1p0.013
GLG2Glg2p0.013
MET6Met6p0.013
MTM1Mtm1p0.013
OSH2Osh2p0.013
SEC20Sec20p0.013
YNR014Whypothetical protein0.013
YBR013Chypothetical protein0.013
HOR2Hor2p0.013
HXT3Hxt3p0.013
NAM8Nam8p0.013
MF(ALPHA)2Mf(alpha)2p0.013
AUA1Aua1p0.013
LYS20Lys20p0.013
TOM20Tom20p0.013
YJR120Whypothetical protein0.013
HEM13Hem13p0.012
MRPL3Mrpl3p0.012
GLT1Glt1p0.012
ATP6Atp6p0.012
TIR3Tir3p0.012
FMT1Fmt1p0.012
YOL013W-Ahypothetical protein0.012
ALT2Alt2p0.012
YHR202Whypothetical protein0.012
PDC6Pdc6p0.012
SUT1Sut1p0.012
SCS3Scs3p0.012
YIR035Chypothetical protein0.012
BIO4Bio4p0.012
YGL082Whypothetical protein0.012
ATP23Atp23p0.012
IZH3Izh3p0.012
YJL218Whypothetical protein0.012
MET17Met17p0.012
CAB2Cab2p0.012
YCH1Ych1p0.012
YPL067Chypothetical protein0.012
RNR2Rnr2p0.012