The network for 'protein kinase b signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein kinase b signaling

A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.

NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.995
EGFRepidermal growth factor receptor0.995
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.981
FYNFYN oncogene related to SRC, FGR, YES0.978
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.975
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.970
SH3KBP1SH3-domain kinase binding protein 10.920
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.893
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.856
TEKTEK tyrosine kinase, endothelial0.855
SYKspleen tyrosine kinase0.683
GRB2growth factor receptor-bound protein 20.681
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.680
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.659
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.632
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.593
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.562
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.493
SHC1SHC (Src homology 2 domain containing) transforming protein 10.468
IGF1Rinsulin-like growth factor 1 receptor0.450
WASLWiskott-Aldrich syndrome-like0.418
SH2D4ASH2 domain containing 4A0.412
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.397
PTK2PTK2 protein tyrosine kinase 20.377
LATlinker for activation of T cells0.350
IL1R1interleukin 1 receptor, type I0.333
CALM1calmodulin 1 (phosphorylase kinase, delta)0.309
FGFR1fibroblast growth factor receptor 10.306
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.282
BCAR1breast cancer anti-estrogen resistance 10.280
HCKhemopoietic cell kinase0.275
WIPF1WAS/WASL interacting protein family, member 10.274
STK4serine/threonine kinase 40.274
TAL1T-cell acute lymphocytic leukemia 10.268
FKBP1AFK506 binding protein 1A, 12kDa0.257
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.252
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.247
IL8interleukin 80.228
PTPN1protein tyrosine phosphatase, non-receptor type 10.221
PDCD6IPprogrammed cell death 6 interacting protein0.217
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.208
SPRR2Asmall proline-rich protein 2A0.206
CCR5chemokine (C-C motif) receptor 50.200
BMP2bone morphogenetic protein 20.191
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.191
ADRB1adrenergic, beta-1-, receptor0.191
CXCL2chemokine (C-X-C motif) ligand 20.184
MPDZmultiple PDZ domain protein0.182
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.179
GAB1GRB2-associated binding protein 10.177
GUCY2Cguanylate cyclase 2C (heat stable enterotoxin receptor)0.177
MAPK8mitogen-activated protein kinase 80.171
CCL2chemokine (C-C motif) ligand 20.171
ZNF746zinc finger protein 7460.169
GHRgrowth hormone receptor0.167
HDAC6histone deacetylase 60.167
CCL4chemokine (C-C motif) ligand 40.165
IRS1insulin receptor substrate 10.164
SMAD7SMAD family member 70.160
PTENphosphatase and tensin homolog0.160
ARRB1arrestin, beta 10.155
IL6interleukin 6 (interferon, beta 2)0.153
FGAfibrinogen alpha chain0.152
BCRbreakpoint cluster region0.152
CXCL3chemokine (C-X-C motif) ligand 30.149
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.149
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.147
MTORmechanistic target of rapamycin (serine/threonine kinase)0.144
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.143
CCL20chemokine (C-C motif) ligand 200.141
ILKintegrin-linked kinase0.140
CXCL9chemokine (C-X-C motif) ligand 90.126
PTPN12protein tyrosine phosphatase, non-receptor type 120.125
CTNND1catenin (cadherin-associated protein), delta 10.125
NRP1neuropilin 10.124
INSRinsulin receptor0.124
NCK1NCK adaptor protein 10.119
GOPCgolgi-associated PDZ and coiled-coil motif containing0.117
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.114
PRKCAprotein kinase C, alpha0.108
RICTORRPTOR independent companion of MTOR, complex 20.107
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.107
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.101
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.098
ANGPT2angiopoietin 20.097
CCL8chemokine (C-C motif) ligand 80.097
PDE4DIPphosphodiesterase 4D interacting protein0.096
SNX9sorting nexin 90.095
GRB10growth factor receptor-bound protein 100.095
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.093
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.091
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.090
LCKlymphocyte-specific protein tyrosine kinase0.089
DLG4discs, large homolog 4 (Drosophila)0.087
ADORA2Aadenosine A2a receptor0.086
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.084
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tp53bp2tumor protein p53 binding protein, 20.581
igf1rbinsulin-like growth factor 1b receptor0.531
stc1lstanniocalcin 1, like0.206
ptk2.1protein tyrosine kinase 2a0.190
jag1bjagged 1b0.139
mmp9matrix metalloproteinase 90.128
igf1insulin-like growth factor 10.104
vdravitamin D receptor a0.091
rag1recombination activating gene 10.089
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.088
zbtb4zinc finger and BTB domain containing 40.088
tp73tumor protein p730.082
pomt2protein-O-mannosyltransferase 20.079
il1binterleukin 1, beta and interleukin 1, beta0.072
ncf1neutrophil cytosolic factor 10.072
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.067
drd2adopamine receptor D2a0.066
fn1fibronectin 10.062
srfserum response factor0.062
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.058
runx2brunt-related transcription factor 2b0.054
btg2B-cell translocation gene 20.053
igfbp2binsulin-like growth factor binding protein 2b0.052
furinbfurin (paired basic amino acid cleaving enzyme) b0.051
pomt1protein-O-mannosyltransferase 10.051
ifnphi1interferon phi 10.050
LOC567965rho GTPase-activating protein 7-like0.048
slc4a2asolute carrier family 4, anion exchanger, member 2a0.047
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.046
fgf8afibroblast growth factor 8 a0.044
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.042
ghragrowth hormone receptor a0.039
ocrloculocerebrorenal syndrome of Lowe0.038
evx1even-skipped homeobox 10.037
fxr2fragile X mental retardation, autosomal homolog 20.037
trpv6transient receptor potential cation channel, subfamily V, member 60.034
nrg2aneuregulin 2a0.034
emp2epithelial membrane protein 20.034
ca10acarbonic anhydrase Xa0.032
fabp11afatty acid binding protein 11a0.031
scn1asodium channel, voltage-gated, type I, alpha0.031
vegfaavascular endothelial growth factor Aa0.031
igf2ainsulin-like growth factor 2a0.030
insrainsulin receptor a0.030
ctgfconnective tissue growth factor0.029
arntl1aaryl hydrocarbon receptor nuclear translocator-like 1a0.029
LOC100534970hypothetical protein LOC1005349700.028
flt4fms-related tyrosine kinase 40.027
dag1dystroglycan 10.026
ahctf1AT hook containing transcription factor 10.026
igf2binsulin-like growth factor 2b0.025
colec11collectin sub-family member 110.025
eng2aengrailed 2a0.024
tpm3tropomyosin 30.024
igf1rainsulin-like growth factor 1a receptor0.024
pdgfaaplatelet-derived growth factor alpha a0.024
kal1aKallmann syndrome 1a sequence0.024
psen1presenilin 10.024
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.024
nr1h5nuclear receptor subfamily 1, group H, member 50.024
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.023
rc3rabconnectin 30.023
wt1bwilms tumor 1b0.023
tnfatumor necrosis factor a (TNF superfamily, member 2)0.023
pax7apaired box gene 7a0.023
il8interleukin 80.022
nadl1.2neural adhesion molecule L1.20.022
fgf4fibroblast growth factor 40.022
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.022
jupjunction plakoglobin0.021
sulf1sulfatase 10.021
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.021
ptgs1prostaglandin-endoperoxide synthase 10.021
ptprfprotein tyrosine phosphatase, receptor type, F0.020
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.020
tlr3toll-like receptor 30.020
mbtps1membrane-bound transcription factor protease, site 10.020
fbln4fibulin 40.020
ncam2neural cell adhesion molecule 20.020
kif5bbkinesin family member 5B, b0.020
mapk1mitogen-activated protein kinase 10.019
ppip5k1diphosphoinositol pentakisphosphate kinase 10.019
insrbinsulin receptor b0.019
ripk2receptor-interacting serine-threonine kinase 20.019
foxc1aforkhead box C1a0.019
odc1ornithine decarboxylase 10.018
LOC565839tumor necrosis factor alpha-induced protein 2-like0.018
stmn2bstathmin-like 2b0.018
skianuclear oncoprotein skia0.018
hlxb9lahomeo box HB9 like a0.018
trim55atripartite motif-containing 55a0.017
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.298
Akt1CG4006 gene product from transcript CG4006-RA0.040
S6kRPS6-p70-protein kinase0.031
EndoGIEndonuclease G inhibitor0.029
norpAno receptor potential A0.028
SsdpSequence-specific single-stranded DNA-binding protein0.027
Sema-1aCG18405 gene product from transcript CG18405-RD0.026
myoglianinCG1838 gene product from transcript CG1838-RD0.023
Pk61CProtein kinase 61C0.023
SmoxSmad on X0.022
sosine oculis0.021
Snap25Synapse protein 250.020
ThorCG8846 gene product from transcript CG8846-RA0.019
CG3004CG3004 gene product from transcript CG3004-RA0.019
PtenCG5671 gene product from transcript CG5671-RB0.019
CG9510CG9510 gene product from transcript CG9510-RC0.019
Fak56DFocal Adhesion Kinase0.018
G-oalpha47AG protein oalpha 47A0.018
reporeversed polarity0.017
rostrolling stone0.017
Gyc76CGuanylyl cyclase at 76C0.017
CspCysteine string protein0.016
CdsACDP diglyceride synthetase0.016
HcfHost cell factor0.016
RagACG11968 gene product from transcript CG11968-RA0.016
ninaBneither inactivation nor afterpotential B0.016
hipkhomeodomain interacting protein kinase0.015
GstE6Glutathione S transferase E60.015
ninaAneither inactivation nor afterpotential A0.015
inaDinactivation no afterpotential D0.015
katanin-60katanin 600.015
CG8090CG8090 gene product from transcript CG8090-RB0.014
ATP7CG1886 gene product from transcript CG1886-RB0.014
RhebCG1081 gene product from transcript CG1081-RA0.014
ImpL2Ecdysone-inducible gene L20.014
Atg18Autophagy-specific gene 180.013
Socs36ESuppressor of cytokine signaling at 36E0.013
CG32528CG32528 gene product from transcript CG32528-RA0.013
Ank2Ankyrin 20.013
yip2yippee interacting protein 20.013
rolsrolling pebbles0.013
Gr28bGustatory receptor 28b0.013
CG17826CG17826 gene product from transcript CG17826-RA0.013
LaLa autoantigen-like0.013
CG11581CG11581 gene product from transcript CG11581-RA0.013
CG42629CG42629 gene product from transcript CG42629-RB0.013
LamCLamin C0.013
mRpS30mitochondrial ribosomal protein S300.013
Spn27ASerpin 27A0.013
Sir2CG5216 gene product from transcript CG5216-RA0.013
witwishful thinking0.013
swshort wing0.012
slboslow border cells0.012
NFATNFAT homolog0.012
par-1CG8201 gene product from transcript CG8201-RA0.012
CG31176CG31176 gene product from transcript CG31176-RA0.012
Vps4Vacuolar protein sorting 40.012
CG9436CG9436 gene product from transcript CG9436-RA0.012
CG9339CG9339 gene product from transcript CG9339-RG0.012
AdoRAdenosine receptor0.012
plexBplexin B0.012
trptransient receptor potential0.012
RhoGAP92BCG4755 gene product from transcript CG4755-RA0.012
AcCoASAcetyl Coenzyme A synthase0.012
Adgf-AAdenosine deaminase-related growth factor A0.012
LnkCG17367 gene product from transcript CG17367-RC0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grb2growth factor receptor bound protein 20.990
Fgfr2fibroblast growth factor receptor 20.979
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.932
Egfrepidermal growth factor receptor0.920
Insrinsulin receptor0.917
Ptpn11protein tyrosine phosphatase, non-receptor type 110.886
CblCasitas B-lineage lymphoma0.876
Ghrgrowth hormone receptor0.825
Apoeapolipoprotein E0.807
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.791
Apcadenomatosis polyposis coli0.759
Rb1retinoblastoma 10.756
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.754
Ptenphosphatase and tensin homolog0.742
Tnftumor necrosis factor0.698
Cd40CD40 antigen0.697
Bdnfbrain derived neurotrophic factor0.687
AxlAXL receptor tyrosine kinase0.670
Nos1nitric oxide synthase 1, neuronal0.669
Fgf3fibroblast growth factor 30.662
Slc34a1solute carrier family 34 (sodium phosphate), member 10.657
Sox2SRY-box containing gene 20.646
Nf1neurofibromatosis 10.634
Retret proto-oncogene0.630
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.625
Nr3c1nuclear receptor subfamily 3, group C, member 10.624
Ltalymphotoxin A0.617
Cd44CD44 antigen0.592
Cxcl13chemokine (C-X-C motif) ligand 130.582
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.574
Esr1estrogen receptor 1 (alpha)0.551
Ccr1chemokine (C-C motif) receptor 10.536
Ntf3neurotrophin 30.531
Grb10growth factor receptor bound protein 100.529
Mup10major urinary protein 100.519
Htra3HtrA serine peptidase 30.494
Lmnalamin A0.493
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.490
Shhsonic hedgehog0.489
Cav1caveolin 1, caveolae protein0.465
Pbx1pre B-cell leukemia transcription factor 10.465
Nos2nitric oxide synthase 2, inducible0.462
Gab1growth factor receptor bound protein 2-associated protein 10.450
Ccl4chemokine (C-C motif) ligand 40.449
Ifnginterferon gamma0.444
Atoh7atonal homolog 7 (Drosophila)0.437
Fgfr1fibroblast growth factor receptor 10.437
Leprleptin receptor0.427
Phox2apaired-like homeobox 2a0.421
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.404
Spry4sprouty homolog 4 (Drosophila)0.404
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.384
Parvaparvin, alpha0.383
Fzd1frizzled homolog 1 (Drosophila)0.383
Socs1suppressor of cytokine signaling 10.381
Isl1ISL1 transcription factor, LIM/homeodomain0.377
Meox2mesenchyme homeobox 20.375
Ednraendothelin receptor type A0.375
Tyro3TYRO3 protein tyrosine kinase 30.375
Smad3MAD homolog 3 (Drosophila)0.372
Rbl2retinoblastoma-like 20.367
Ctnnb1catenin (cadherin associated protein), beta 10.341
Itgb1integrin beta 1 (fibronectin receptor beta)0.340
Oc90otoconin 900.338
Arrb1arrestin, beta 10.337
Arrb2arrestin, beta 20.335
C3ar1complement component 3a receptor 10.330
Adam17a disintegrin and metallopeptidase domain 170.325
LOC100048884novel member of the major urinary protein (Mup) gene family0.324
Map3k14mitogen-activated protein kinase kinase kinase 140.323
Sox4SRY-box containing gene 40.322
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.319
Icosinducible T-cell co-stimulator0.316
Plcg1phospholipase C, gamma 10.304
Wnt5awingless-related MMTV integration site 5A0.302
BtkBruton agammaglobulinemia tyrosine kinase0.301
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.297
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.296
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.291
Tenc1tensin like C1 domain-containing phosphatase0.288
Utf1undifferentiated embryonic cell transcription factor 10.283
Il10interleukin 100.272
Crhr1corticotropin releasing hormone receptor 10.270
Pax3paired box gene 30.267
Timp3tissue inhibitor of metalloproteinase 30.266
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.262
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.258
Vangl2vang-like 2 (van gogh, Drosophila)0.256
Pou3f3POU domain, class 3, transcription factor 30.255
Bmp4bone morphogenetic protein 40.254
Eya1eyes absent 1 homolog (Drosophila)0.254
Prop1paired like homeodomain factor 10.254
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.247
Mgat3mannoside acetylglucosaminyltransferase 30.246
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.244
Prlrprolactin receptor0.244
C1qacomplement component 1, q subcomponent, alpha polypeptide0.242
BrafBraf transforming gene0.240
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor (TNF superfamily, member 2)0.024
Ddr1discoidin domain receptor tyrosine kinase 10.019
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.018
Il1ainterleukin 1 alpha0.016
Ptgs2prostaglandin-endoperoxide synthase 20.015
Ccr5chemokine (C-C motif) receptor 50.014
DbpD site of albumin promoter (albumin D-box) binding protein0.014
Ralgdsral guanine nucleotide dissociation stimulator0.013
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.010
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.010
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism