The network for 'regulation of protein homodimerization activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein homodimerization activity

Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FHL2four and a half LIM domains 20.999
TRAF2TNF receptor-associated factor 20.946
PXNpaxillin0.358
CD40CD40 molecule, TNF receptor superfamily member 50.340
BCL2L1BCL2-like 10.282
FN1fibronectin 10.278
BCL2L11BCL2-like 11 (apoptosis facilitator)0.257
TRAF3TNF receptor-associated factor 30.246
PDIA3protein disulfide isomerase family A, member 30.220
PTPRCprotein tyrosine phosphatase, receptor type, C0.197
ZNF420zinc finger protein 4200.176
ENGendoglin0.169
TRAF1TNF receptor-associated factor 10.143
BCL2B-cell CLL/lymphoma 20.142
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.134
TRADDTNFRSF1A-associated via death domain0.109
TICAM2toll-like receptor adaptor molecule 20.097
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.095
SMURF1SMAD specific E3 ubiquitin protein ligase 10.091
SMAD1SMAD family member 10.077
IRAK2interleukin-1 receptor-associated kinase 20.067
BADBCL2-associated agonist of cell death0.061
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.058
ZNF84zinc finger protein 840.051
ZNF585Azinc finger protein 585A0.050
RIPK2receptor-interacting serine-threonine kinase 20.044
CD63CD63 molecule0.042
ZNF432zinc finger protein 4320.041
ITGA6integrin, alpha 60.037
FHL3four and a half LIM domains 30.032
ZNF260zinc finger protein 2600.029
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.027
NUMBLnumb homolog (Drosophila)-like0.026
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.024
CD9CD9 molecule0.021
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.021
ZMYND11zinc finger, MYND-type containing 110.019
ITGB4integrin, beta 40.019
RNR2l-rRNA0.019
TRAF6TNF receptor-associated factor 60.019
ZNF623zinc finger protein 6230.018
MAP4K4mitogen-activated protein kinase kinase kinase kinase 40.017
FLNAfilamin A, alpha0.017
ARF6ADP-ribosylation factor 60.016
ZNF140zinc finger protein 1400.016
RNF144Bring finger protein 144B0.015
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.015
ARandrogen receptor0.015
HDAC9histone deacetylase 90.014
TRAF5TNF receptor-associated factor 50.014
SOD1superoxide dismutase 1, soluble0.014
BIRC3baculoviral IAP repeat containing 30.013
TLR4toll-like receptor 40.013
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.012
ZNF12zinc finger protein 120.012
ZNF512Bzinc finger protein 512B0.012
HDAC4histone deacetylase 40.011
ITGA7integrin, alpha 70.011
ZNF571zinc finger protein 5710.011
BIRC2baculoviral IAP repeat containing 20.011
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Klc1kinesin light chain 10.965
Tlr4toll-like receptor 40.493
Bcl2B-cell leukemia/lymphoma 20.350
Myd88myeloid differentiation primary response gene 880.287
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.211
Mef2cmyocyte enhancer factor 2C0.151
Hdac4histone deacetylase 40.146
Mapk8mitogen-activated protein kinase 80.142
Tnfaip3tumor necrosis factor, alpha-induced protein 30.119
Bak1BCL2-antagonist/killer 10.067
Hdac5histone deacetylase 50.065
Retret proto-oncogene0.054
Hdac7histone deacetylase 70.054
Mef2amyocyte enhancer factor 2A0.054
Mef2dmyocyte enhancer factor 2D0.044
Vegfavascular endothelial growth factor A0.038
Lystlysosomal trafficking regulator0.033
CblbCasitas B-lineage lymphoma b0.031
Zeb2zinc finger E-box binding homeobox 20.029
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.026
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.024
Nrg1neuregulin 10.021
Rrm2bribonucleotide reductase M2 B (TP53 inducible)0.020
Map3k8mitogen-activated protein kinase kinase kinase 80.018
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.018
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.018
Arf6ADP-ribosylation factor 60.018
Fgfr2fibroblast growth factor receptor 20.018
Pbx1pre B-cell leukemia transcription factor 10.016
Klf7Kruppel-like factor 7 (ubiquitous)0.015
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.014
Birc3baculoviral IAP repeat-containing 30.014
Hivep2human immunodeficiency virus type I enhancer binding protein 20.013
Qkquaking0.013
Sox4SRY-box containing gene 40.013
Cd14CD14 antigen0.013
Smad3MAD homolog 3 (Drosophila)0.013
St3gal2ST3 beta-galactoside alpha-2,3-sialyltransferase 20.013
Ehd4EH-domain containing 40.012
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.012
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.012
Kif1bkinesin family member 1B0.012
Gucy1b3guanylate cyclase 1, soluble, beta 30.012
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.012
Nf1neurofibromatosis 10.012
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.012
Traf6TNF receptor-associated factor 60.012
Commd4COMM domain containing 40.011
Kif5ckinesin family member 5C0.011
Zbtb20zinc finger and BTB domain containing 200.011
NansN-acetylneuraminic acid synthase (sialic acid synthase)0.011
Map3k5mitogen-activated protein kinase kinase kinase 50.010
Ehd3EH-domain containing 30.010
Tcf4transcription factor 40.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Crhr1corticotropin releasing hormone receptor 10.084
Dhx40DEAH (Asp-Glu-Ala-His) box polypeptide 400.044
Gjd2gap junction protein, delta 20.041
Fam65afamily with sequence similarity 65, member A0.037
Trhrthyrotropin releasing hormone receptor0.036
Akap14A kinase (PRKA) anchor protein 140.031
Pparaperoxisome proliferator activated receptor alpha0.022
RGD1562618similar to RIKEN cDNA 6030419C18 gene0.021
Pax8paired box 80.019
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.018
Cckarcholecystokinin A receptor0.017
Ppypancreatic polypeptide0.017
Ttc33tetratricopeptide repeat domain 330.015
LOC100359879RIKEN cDNA A830041P22-like0.015
Zp3zona pellucida glycoprotein 3 (sperm receptor)0.014
Accn2amiloride-sensitive cation channel 2, neuronal0.013
Lhx1LIM homeobox 10.012
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.011
Eporerythropoietin receptor0.011
Slc1a6solute carrier family 1 (high affinity aspartate/glutamate transporter), member 60.011
Irf2interferon regulatory factor 20.011
Tmem106btransmembrane protein 106B0.011
Phkg1phosphorylase kinase, gamma 10.011
Mpp3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)0.011
Vps35vacuolar protein sorting 35 homolog (S. cerevisiae)0.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism