The network for 'positive regulation of myeloid cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of myeloid cell differentiation

Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
BIRC3baculoviral IAP repeat containing 30.997
CREBBPCREB binding protein0.991
TAL1T-cell acute lymphocytic leukemia 10.985
CCR5chemokine (C-C motif) receptor 50.982
CFLARCASP8 and FADD-like apoptosis regulator0.979
RUNX1runt-related transcription factor 10.971
BIRC2baculoviral IAP repeat containing 20.970
XIAPX-linked inhibitor of apoptosis0.967
CASP8caspase 8, apoptosis-related cysteine peptidase0.911
TRAF1TNF receptor-associated factor 10.911
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.877
NOTCH1notch 10.841
CASP3caspase 3, apoptosis-related cysteine peptidase0.821
FASFas (TNF receptor superfamily, member 6)0.794
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.792
RIPK2receptor-interacting serine-threonine kinase 20.780
IL8interleukin 80.759
TRAF3TNF receptor-associated factor 30.753
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.733
IL2RBinterleukin 2 receptor, beta0.721
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.670
FASLGFas ligand (TNF superfamily, member 6)0.651
JUNjun proto-oncogene0.646
SMAD2SMAD family member 20.638
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.628
FADDFas (TNFRSF6)-associated via death domain0.607
CXCL2chemokine (C-X-C motif) ligand 20.593
HSPA1Aheat shock 70kDa protein 1A0.548
HOXB5homeobox B50.494
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.423
SETD8SET domain containing (lysine methyltransferase) 80.414
KAT2BK(lysine) acetyltransferase 2B0.399
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.393
FKBP1AFK506 binding protein 1A, 12kDa0.385
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.373
SH2D4ASH2 domain containing 4A0.369
HSPA1Bheat shock 70kDa protein 1B0.365
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.355
IL1Binterleukin 1, beta0.352
TNFAIP3tumor necrosis factor, alpha-induced protein 30.351
IFNGinterferon, gamma0.346
CASP10caspase 10, apoptosis-related cysteine peptidase0.330
MDM2Mdm2 p53 binding protein homolog (mouse)0.312
HOXA5homeobox A50.310
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.309
RIPK3receptor-interacting serine-threonine kinase 30.306
BMP2bone morphogenetic protein 20.303
NCOA6nuclear receptor coactivator 60.289
ATF2activating transcription factor 20.288
IL23Ainterleukin 23, alpha subunit p190.278
DAXXdeath-domain associated protein0.276
APAF1apoptotic peptidase activating factor 10.273
CCL20chemokine (C-C motif) ligand 200.266
SMAD7SMAD family member 70.257
SP1Sp1 transcription factor0.256
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.250
CASP7caspase 7, apoptosis-related cysteine peptidase0.249
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.246
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.236
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.229
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.215
CCR2chemokine (C-C motif) receptor 20.203
NCOA1nuclear receptor coactivator 10.203
TGFB1transforming growth factor, beta 10.195
CCL4chemokine (C-C motif) ligand 40.192
CXCL3chemokine (C-X-C motif) ligand 30.182
CASP9caspase 9, apoptosis-related cysteine peptidase0.172
SMAD4SMAD family member 40.169
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.165
JAG1jagged 10.165
CXCL9chemokine (C-X-C motif) ligand 90.162
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.162
ZMYND11zinc finger, MYND-type containing 110.157
ARandrogen receptor0.152
CCL5chemokine (C-C motif) ligand 50.150
BBS10Bardet-Biedl syndrome 100.149
CTBP1C-terminal binding protein 10.147
HDAC6histone deacetylase 60.144
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.143
CXCL5chemokine (C-X-C motif) ligand 50.140
HOXA10homeobox A100.137
SMURF1SMAD specific E3 ubiquitin protein ligase 10.134
CD40CD40 molecule, TNF receptor superfamily member 50.130
GATA1GATA binding protein 1 (globin transcription factor 1)0.127
CCL8chemokine (C-C motif) ligand 80.125
HOXB6homeobox B60.122
ACVR1activin A receptor, type I0.119
SLAMF1signaling lymphocytic activation molecule family member 10.118
USP18ubiquitin specific peptidase 180.111
MAGEA11melanoma antigen family A, 110.105
BMPR1Abone morphogenetic protein receptor, type IA0.104
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.103
NOTCH3notch 30.101
HMG20Ahigh mobility group 20A0.100
SMAD1SMAD family member 10.095
HOXB3homeobox B30.095
TCF12transcription factor 120.094
CD2CD2 molecule0.093
JUPjunction plakoglobin0.091
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.090
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tal1T-cell acute lymphocytic leukemia 10.983
mpxmyeloid-specific peroxidase0.835
cmybtranscription factor cmyb0.739
hmgb1ahigh-mobility group box 1a0.562
gata1aGATA binding protein 1a0.539
lmo2LIM domain only 2 (rhombotin-like 1)0.419
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.402
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.396
brd4bromodomain containing 40.395
hmgb2ahigh-mobility group box 2a0.271
atf3activating transcription factor 30.266
ltkleukocyte tyrosine kinase0.266
notch3notch homolog 30.255
hoxd4ahomeo box D4a0.247
slc4a1asolute carrier family 4, anion exchanger, member 1a0.246
runx1runt-related transcription factor 10.244
hmgb3ahigh-mobility group box 3a0.239
socs3asuppressor of cytokine signaling 3a0.232
copebcore promoter element binding protein0.228
trpm7transient receptor potential cation channel, subfamily M, member 70.225
cfl2lcofilin 2, like0.205
si:dkeyp-22b2.3si:dkeyp-22b2.30.204
wu:fv91b12wu:fv91b120.197
acvr2bactivin receptor IIb0.184
klf2aKruppel-like factor 2a0.166
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.131
jag1bjagged 1b0.127
gata3GATA-binding protein 30.117
plcg1phospholipase C, gamma 10.113
scinlbscinderin like b0.111
gria4bglutamate receptor, ionotropic, AMPA 4b0.110
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.107
inhainhibin, alpha0.105
mycamyelocytomatosis oncogene a0.102
junbljun B proto-oncogene, like0.100
fli1afriend leukemia integration 1a0.098
cdk10cyclin-dependent kinase 100.097
pmelapremelanosome protein a0.096
mmrn2amultimerin 2a0.096
cpla2cytosolic phospholipase a20.089
mitfamicrophthalmia-associated transcription factor a0.088
si:ch211-173o4.2si:ch211-173o4.20.088
ptk6aPTK6 protein tyrosine kinase 6a0.088
sfswapsplicing factor, suppressor of white-apricot homolog (Drosophila)0.087
junbjun B proto-oncogene0.086
esyt3extended synaptotagmin-like protein 30.086
cahzcarbonic anhydrase0.085
egr2bearly growth response 2b0.085
midnmidnolin0.082
sf3b1splicing factor 3b, subunit 10.080
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.080
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.080
angptl1angiopoietin-like 10.078
hhiphedgehog interacting protein0.077
trim33tripartite motif-containing 330.077
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.076
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.075
fasFas (TNF receptor superfamily, member 6)0.074
alas2aminolevulinate, delta-, synthetase 20.073
trim71tripartite motif-containing 710.073
tgfb3transforming growth factor, beta 30.071
socs1suppressor of cytokine signaling 10.070
dusp5dual specificity phosphatase 50.070
lyzlysozyme0.069
cry1acryptochrome 1a0.069
acsl3aacyl-CoA synthetase long-chain family member 3a0.066
tlr3toll-like receptor 30.064
lppLIM domain containing preferred translocation partner in lipoma0.064
foxd3forkhead box D30.063
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.063
nf1aneurofibromin 1a0.063
irak4interleukin-1 receptor-associated kinase 40.063
gdf6agrowth differentiation factor 6a0.062
mef2amyocyte enhancer factor 2a0.062
paqr8progestin and adipoQ receptor family member VIII0.060
paqr7bprogestin and adipoQ receptor family member VII, b0.060
gria3bglutamate receptor, ionotrophic, AMPA 3b0.059
inhbaainhibin, beta Aa0.057
sox10SRY-box containing gene 100.057
csf1racolony stimulating factor 1 receptor, a0.057
kdm1alysine (K)-specific demethylase 1a0.056
sult1st4sulfotransferase family 1, cytosolic sulfotransferase 40.056
hoxb3ahomeo box B3a0.056
h2afvlH2A histone family, member V, like0.056
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.056
pax7apaired box gene 7a0.055
rad54bRAD54 homolog B (S. cerevisiae)0.055
mmp15amatrix metallopeptidase 15a0.054
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.054
metmet proto-oncogene (hepatocyte growth factor receptor)0.054
ccnd1cyclin D10.054
gdf9growth differentiation factor 90.054
zeb2azinc finger E-box binding homeobox 2a0.053
iclp1invariant chain-like protein 10.052
dynlrb1dynein, light chain, roadblock-type 10.051
zbtb4zinc finger and BTB domain containing 40.051
ednrb1endothelin receptor B0.050
zgc:110340zgc:1103400.050
hoxb5bhomeo box B5b0.050
pnp4apurine nucleoside phosphorylase 4a0.050
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 10.949
Mapk14mitogen-activated protein kinase 140.933
Tnftumor necrosis factor0.878
Notch1Notch gene homolog 1 (Drosophila)0.868
Ldb3LIM domain binding 30.821
Ighimmunoglobulin heavy chain complex0.805
JunJun oncogene0.774
Nos3nitric oxide synthase 3, endothelial cell0.728
Csf1colony stimulating factor 1 (macrophage)0.706
Tgfb1transforming growth factor, beta 10.705
Leprleptin receptor0.695
Emx1empty spiracles homolog 1 (Drosophila)0.657
Trp53transformation related protein 530.652
Ascl1achaete-scute complex homolog 1 (Drosophila)0.646
Gata1GATA binding protein 10.635
Gata4GATA binding protein 40.632
Smad3MAD homolog 3 (Drosophila)0.616
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.606
Rb1retinoblastoma 10.602
Ptf1apancreas specific transcription factor, 1a0.579
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.563
Tlr4toll-like receptor 40.557
Stat1signal transducer and activator of transcription 10.504
Stat3signal transducer and activator of transcription 30.487
Id1inhibitor of DNA binding 10.468
Hes1hairy and enhancer of split 1 (Drosophila)0.465
Ptgs2prostaglandin-endoperoxide synthase 20.459
Cav1caveolin 1, caveolae protein0.426
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.394
Otporthopedia homolog (Drosophila)0.385
Ltblymphotoxin B0.384
Notch2Notch gene homolog 2 (Drosophila)0.368
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.365
Psen1presenilin 10.352
Dll1delta-like 1 (Drosophila)0.352
Hand1heart and neural crest derivatives expressed transcript 10.343
Tcf3transcription factor 30.336
Irf9interferon regulatory factor 90.323
Ptpn11protein tyrosine phosphatase, non-receptor type 110.319
Tnfaip3tumor necrosis factor, alpha-induced protein 30.315
Eporerythropoietin receptor0.315
Neurod1neurogenic differentiation 10.312
Kitkit oncogene0.295
Snai1snail homolog 1 (Drosophila)0.292
FosFBJ osteosarcoma oncogene0.291
Cdkn1bcyclin-dependent kinase inhibitor 1B0.268
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.255
Sall3sal-like 3 (Drosophila)0.254
Neurog2neurogenin 20.253
Itgb2integrin beta 20.238
Ctnnb1catenin (cadherin associated protein), beta 10.237
Nr3c1nuclear receptor subfamily 3, group C, member 10.232
Id3inhibitor of DNA binding 30.231
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.225
Ncoa3nuclear receptor coactivator 30.223
BtkBruton agammaglobulinemia tyrosine kinase0.218
Rbl1retinoblastoma-like 1 (p107)0.213
Ptpn6protein tyrosine phosphatase, non-receptor type 60.200
Ptenphosphatase and tensin homolog0.196
Ppargperoxisome proliferator activated receptor gamma0.195
Trp73transformation related protein 730.192
S1pr2sphingosine-1-phosphate receptor 20.190
Tal1T-cell acute lymphocytic leukemia 10.188
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.186
Rbl2retinoblastoma-like 20.182
Fgd1FYVE, RhoGEF and PH domain containing 10.180
Usp18ubiquitin specific peptidase 180.174
Sox11SRY-box containing gene 110.168
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.167
Pitx1paired-like homeodomain transcription factor 10.159
Sox2SRY-box containing gene 20.158
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.154
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.153
Tcf4transcription factor 40.150
Otx2orthodenticle homolog 2 (Drosophila)0.148
Foxf1aforkhead box F1a0.146
Egr1early growth response 10.144
Fli1Friend leukemia integration 10.144
Foxo1forkhead box O10.142
Smad4MAD homolog 4 (Drosophila)0.142
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.141
Cd44CD44 antigen0.138
Hand2heart and neural crest derivatives expressed transcript 20.137
Lhx3LIM homeobox protein 30.136
Inhbainhibin beta-A0.128
Map3k14mitogen-activated protein kinase kinase kinase 140.127
Hoxa1homeobox A10.123
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.122
Socs1suppressor of cytokine signaling 10.122
Il2rginterleukin 2 receptor, gamma chain0.119
Plaurplasminogen activator, urokinase receptor0.119
Stat5bsignal transducer and activator of transcription 5B0.118
Itgalintegrin alpha L0.117
Ahraryl-hydrocarbon receptor0.115
Gata2GATA binding protein 20.114
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.113
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.112
WrnWerner syndrome homolog (human)0.109
Efnb2ephrin B20.109
FasFas (TNF receptor superfamily member 6)0.107
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Atf3activating transcription factor 30.404
Junbjun B proto-oncogene0.200
Dusp1dual specificity phosphatase 10.165
Klf4Kruppel-like factor 4 (gut)0.107
Egr1early growth response 10.097
Btg2BTG family, member 20.046
Il2rbinterleukin 2 receptor, beta0.041
Ccl4chemokine (C-C motif) ligand 40.033
Egr2early growth response 20.033
Fcn1ficolin (collagen/fibrinogen domain containing) 10.033
Guca2aguanylate cyclase activator 2a (guanylin)0.026
Mmp3matrix metallopeptidase 30.025
Ier2immediate early response 20.024
Cd247Cd247 molecule0.024
Nr4a1nuclear receptor subfamily 4, group A, member 10.023
Il1binterleukin 1 beta0.021
Plauplasminogen activator, urokinase0.020
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.019
Errfi1ERBB receptor feedback inhibitor 10.017
Ccl3chemokine (C-C motif) ligand 30.016
Prf1perforin 1 (pore forming protein)0.015
Prss22protease, serine, 220.015
Rassf5Ras association (RalGDS/AF-6) domain family member 50.015
Ptprcprotein tyrosine phosphatase, receptor type, C0.015
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.014
Casp2caspase 20.014
Kdrkinase insert domain receptor0.014
Cd86CD86 molecule0.013
Klrd1killer cell lectin-like receptor, subfamily D, member 10.013
Casp3caspase 30.013
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.013
Adora2aadenosine A2a receptor0.013
Slasrc-like adaptor0.012
Mylk2myosin light chain kinase 20.012
FosFBJ osteosarcoma oncogene0.012
Smad1SMAD family member 10.012
Il8rbinterleukin 8 receptor, beta0.012
Hmgb1high mobility group box 10.012
Tgfbr3transforming growth factor, beta receptor III0.011
Gzmkgranzyme K0.011
Gfi1growth factor independent 1 transcription repressor0.011
Hspa1aheat shock 70kD protein 1A0.010
Nfibnuclear factor I/B0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism