The network for 'positive regulation of insulin like growth factor receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of insulin like growth factor receptor signaling pathway

Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.

NameDescriptionProbabilityFunc Analog Organism
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.978
CTNND1catenin (cadherin-associated protein), delta 10.963
INSRinsulin receptor0.961
GH1growth hormone 10.958
IGF2Rinsulin-like growth factor 2 receptor0.908
DSG2desmoglein 20.890
GRB10growth factor receptor-bound protein 100.822
PTPN1protein tyrosine phosphatase, non-receptor type 10.809
CSHL1chorionic somatomammotropin hormone-like 10.782
CSH2chorionic somatomammotropin hormone 20.750
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.660
GH2growth hormone 20.649
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.611
ITGB1BP3integrin beta 1 binding protein 30.579
ADAM12ADAM metallopeptidase domain 120.538
DCNdecorin0.537
FZD1frizzled homolog 1 (Drosophila)0.502
IGFBP5insulin-like growth factor binding protein 50.459
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.453
JUPjunction plakoglobin0.417
IRS1insulin receptor substrate 10.367
DSPdesmoplakin0.320
COL1A1collagen, type I, alpha 10.274
IRS2insulin receptor substrate 20.253
MDM2Mdm2 p53 binding protein homolog (mouse)0.248
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.217
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.208
TFtransferrin0.206
FGF18fibroblast growth factor 180.203
FOXO1forkhead box O10.201
PTPRJprotein tyrosine phosphatase, receptor type, J0.194
JAK2Janus kinase 20.189
FAF1Fas (TNFRSF6) associated factor 10.164
SFRP1secreted frizzled-related protein 10.163
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.137
LRP6low density lipoprotein receptor-related protein 60.133
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 10.127
TGFAtransforming growth factor, alpha0.120
IHHIndian hedgehog0.118
KRT14keratin 140.107
MMP11matrix metallopeptidase 11 (stromelysin 3)0.095
PTGISprostaglandin I2 (prostacyclin) synthase0.093
LBX1ladybird homeobox 10.093
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.090
RAXretina and anterior neural fold homeobox0.088
FGF3fibroblast growth factor 30.087
WNT1wingless-type MMTV integration site family, member 10.087
NOVnephroblastoma overexpressed gene0.083
FGF8fibroblast growth factor 8 (androgen-induced)0.077
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.075
IGF2insulin-like growth factor 2 (somatomedin A)0.074
FZD8frizzled homolog 8 (Drosophila)0.072
WNT3wingless-type MMTV integration site family, member 30.071
WNT6wingless-type MMTV integration site family, member 60.070
IGFBP2insulin-like growth factor binding protein 2, 36kDa0.068
STAT5Bsignal transducer and activator of transcription 5B0.068
CXCL14chemokine (C-X-C motif) ligand 140.066
RHBGRh family, B glycoprotein (gene/pseudogene)0.064
IGF1Rinsulin-like growth factor 1 receptor0.064
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.064
PTGER1prostaglandin E receptor 1 (subtype EP1), 42kDa0.063
TCF4transcription factor 40.063
HOXC8homeobox C80.063
TP73tumor protein p730.062
PSEN1presenilin 10.059
PKP2plakophilin 20.059
CHRNA4cholinergic receptor, nicotinic, alpha 40.059
KRT5keratin 50.057
KREMEN2kringle containing transmembrane protein 20.057
G6PCglucose-6-phosphatase, catalytic subunit0.057
IRX4iroquois homeobox 40.055
HS3ST6heparan sulfate (glucosamine) 3-O-sulfotransferase 60.054
JPH3junctophilin 30.054
HSPG2heparan sulfate proteoglycan 20.054
NDRG1N-myc downstream regulated 10.053
FRMD5FERM domain containing 50.053
FOXD3forkhead box D30.053
PLCG1phospholipase C, gamma 10.052
S1PR5sphingosine-1-phosphate receptor 50.052
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.051
SOX21SRY (sex determining region Y)-box 210.051
FBXO11F-box protein 110.049
WIF1WNT inhibitory factor 10.049
ARVCFarmadillo repeat gene deleted in velocardiofacial syndrome0.049
ADRA1Dadrenergic, alpha-1D-, receptor0.048
CRELD2cysteine-rich with EGF-like domains 20.048
HOXB1homeobox B10.048
POU4F3POU class 4 homeobox 30.047
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.046
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.046
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.046
NBL1neuroblastoma, suppression of tumorigenicity 10.045
THtyrosine hydroxylase0.045
NEUROG2neurogenin 20.045
SOX1SRY (sex determining region Y)-box 10.045
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.045
PKP3plakophilin 30.044
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.043
SLC18A3solute carrier family 18 (vesicular acetylcholine), member 30.043
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.043
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
NNotch0.232
wgwingless0.060
Aos1CG12276 gene product from transcript CG12276-RA0.028
CG6610CG6610 gene product from transcript CG6610-RA0.015
SmFSmall ribonucleoprotein particle protein SmF0.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Esr1estrogen receptor 1 (alpha)0.738
Trp63transformation related protein 630.708
Ptenphosphatase and tensin homolog0.689
Trp73transformation related protein 730.508
Trp53transformation related protein 530.470
Emx2empty spiracles homolog 2 (Drosophila)0.256
Ghrgrowth hormone receptor0.213
Fgfr2fibroblast growth factor receptor 20.182
Ift57intraflagellar transport 57 homolog (Chlamydomonas)0.153
Wnt3awingless-related MMTV integration site 3A0.152
Col1a1collagen, type I, alpha 10.119
FcgrtFc receptor, IgG, alpha chain transporter0.101
Emx1empty spiracles homolog 1 (Drosophila)0.096
BrafBraf transforming gene0.092
Ltbp4latent transforming growth factor beta binding protein 40.078
Lrp1low density lipoprotein receptor-related protein 10.078
Arandrogen receptor0.060
Foxo1forkhead box O10.057
Apcadenomatosis polyposis coli0.057
Sfnstratifin0.056
Apoeapolipoprotein E0.056
Lef1lymphoid enhancer binding factor 10.052
Ahraryl-hydrocarbon receptor0.052
Prlrprolactin receptor0.051
CblCasitas B-lineage lymphoma0.050
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.046
Fshrfollicle stimulating hormone receptor0.045
Aebp1AE binding protein 10.045
Otx1orthodenticle homolog 1 (Drosophila)0.045
Otx2orthodenticle homolog 2 (Drosophila)0.044
Huwe1HECT, UBA and WWE domain containing 10.043
Cdkn2acyclin-dependent kinase inhibitor 2A0.040
Pthlhparathyroid hormone-like peptide0.038
Yap1yes-associated protein 10.036
Rargretinoic acid receptor, gamma0.035
RictorRPTOR independent companion of MTOR, complex 20.034
Prelpproline arginine-rich end leucine-rich repeat0.032
Hoxa13homeobox A130.032
Rxraretinoid X receptor alpha0.032
Tenc1tensin like C1 domain-containing phosphatase0.032
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.030
Nbl1neuroblastoma, suppression of tumorigenicity 10.030
Pitx2paired-like homeodomain transcription factor 20.029
Dcndecorin0.028
Stat5asignal transducer and activator of transcription 5A0.025
Nos1nitric oxide synthase 1, neuronal0.024
Ift81intraflagellar transport 81 homolog (Chlamydomonas)0.024
Rararetinoic acid receptor, alpha0.024
Gdf10growth differentiation factor 100.024
Timp1tissue inhibitor of metalloproteinase 10.023
Fgfr1fibroblast growth factor receptor 10.023
Slc16a2solute carrier family 16 (monocarboxylic acid transporters), member 20.023
Mdm4transformed mouse 3T3 cell double minute 40.022
Lcorligand dependent nuclear receptor corepressor0.022
Tnxbtenascin XB0.022
Tbx3T-box 30.021
Kitkit oncogene0.021
Smad3MAD homolog 3 (Drosophila)0.020
Pgrprogesterone receptor0.020
Thbs3thrombospondin 30.019
Pou2f1POU domain, class 2, transcription factor 10.018
Insrinsulin receptor0.018
Tcfap2ctranscription factor AP-2, gamma0.018
Pkd1polycystic kidney disease 1 homolog0.018
AxlAXL receptor tyrosine kinase0.018
Pax6paired box gene 60.018
Hhathedgehog acyltransferase0.017
Fzd8frizzled homolog 8 (Drosophila)0.017
Pikfyvephosphoinositide kinase, FYVE finger containing0.017
Tyro3TYRO3 protein tyrosine kinase 30.017
En2engrailed 20.017
Zbtb37zinc finger and BTB domain containing 370.017
Dkk1dickkopf homolog 1 (Xenopus laevis)0.016
Smoc1SPARC related modular calcium binding 10.016
Gas1growth arrest specific 10.016
Cdx2caudal type homeobox 20.016
Gli3GLI-Kruppel family member GLI30.016
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.016
Cep110centrosomal protein 1100.016
Ramp2receptor (calcitonin) activity modifying protein 20.015
Mycl1v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)0.015
Nf1neurofibromatosis 10.015
Rasip1Ras interacting protein 10.015
Fxyd1FXYD domain-containing ion transport regulator 10.014
Chst8carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 80.014
Lrp6low density lipoprotein receptor-related protein 60.014
Igf2insulin-like growth factor 20.014
Tgfb1i1transforming growth factor beta 1 induced transcript 10.014
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.014
Lamb2laminin, beta 20.014
Amhr2anti-Mullerian hormone type 2 receptor0.013
Ncor2nuclear receptor co-repressor 20.013
Lamc2laminin, gamma 20.013
Hspg2perlecan (heparan sulfate proteoglycan 2)0.013
Emp2epithelial membrane protein 20.013
Fbln2fibulin 20.013
Zfp280dzinc finger protein 280D0.012
Sall4sal-like 4 (Drosophila)0.012
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.012
Nr6a1nuclear receptor subfamily 6, group A, member 10.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism