The network for 'lymphocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lymphocyte differentiation

The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.

NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.998
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.948
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.810
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.810
EGFRepidermal growth factor receptor0.802
B2Mbeta-2-microglobulin0.757
LATlinker for activation of T cells0.741
RUNX1runt-related transcription factor 10.690
HLA-Gmajor histocompatibility complex, class I, G0.687
NCOR2nuclear receptor corepressor 20.677
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.623
PMLpromyelocytic leukemia0.556
NOTCH1notch 10.547
GRB2growth factor receptor-bound protein 20.534
PTPN1protein tyrosine phosphatase, non-receptor type 10.528
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.474
IL4Rinterleukin 4 receptor0.463
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.461
SHC1SHC (Src homology 2 domain containing) transforming protein 10.454
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.441
SIN3ASIN3 homolog A, transcription regulator (yeast)0.438
HLA-Amajor histocompatibility complex, class I, A0.395
HLA-Bmajor histocompatibility complex, class I, B0.394
PTPN6protein tyrosine phosphatase, non-receptor type 60.384
PLCG1phospholipase C, gamma 10.383
TGIF1TGFB-induced factor homeobox 10.377
TAL1T-cell acute lymphocytic leukemia 10.371
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.357
HLA-Cmajor histocompatibility complex, class I, C0.355
ESR1estrogen receptor 10.355
ZFYVE9zinc finger, FYVE domain containing 90.348
TP53tumor protein p530.345
PPARAperoxisome proliferator-activated receptor alpha0.333
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.282
HCKhemopoietic cell kinase0.261
VAV1vav 1 guanine nucleotide exchange factor0.251
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.250
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.248
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.237
HLA-Fmajor histocompatibility complex, class I, F0.234
CDK6cyclin-dependent kinase 60.206
BIRC3baculoviral IAP repeat containing 30.201
CD247CD247 molecule0.200
NOTCH3notch 30.199
NCOR1nuclear receptor corepressor 10.190
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.181
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.179
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.174
FYNFYN oncogene related to SRC, FGR, YES0.170
NR0B1nuclear receptor subfamily 0, group B, member 10.168
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.165
SLASrc-like-adaptor0.157
HLA-Emajor histocompatibility complex, class I, E0.154
CTBP2C-terminal binding protein 20.150
IL2RGinterleukin 2 receptor, gamma0.149
NR4A1nuclear receptor subfamily 4, group A, member 10.148
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.145
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.144
CD86CD86 molecule0.143
CCR7chemokine (C-C motif) receptor 70.142
ICAM1intercellular adhesion molecule 10.139
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.137
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.131
SYKspleen tyrosine kinase0.129
DLG1discs, large homolog 1 (Drosophila)0.124
GRB7growth factor receptor-bound protein 70.123
APLFaprataxin and PNKP like factor0.122
GHRgrowth hormone receptor0.118
PILRApaired immunoglobin-like type 2 receptor alpha0.107
CD80CD80 molecule0.103
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.101
IRF4interferon regulatory factor 40.101
FOSFBJ murine osteosarcoma viral oncogene homolog0.099
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.098
CXCR4chemokine (C-X-C motif) receptor 40.097
RUNX3runt-related transcription factor 30.097
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.097
SMAD2SMAD family member 20.095
CTBP1C-terminal binding protein 10.092
RXRAretinoid X receptor, alpha0.091
BMPR1Abone morphogenetic protein receptor, type IA0.086
HIPK2homeodomain interacting protein kinase 20.083
TCF12transcription factor 120.082
CD3DCD3d molecule, delta (CD3-TCR complex)0.081
IL2RBinterleukin 2 receptor, beta0.081
CASP8caspase 8, apoptosis-related cysteine peptidase0.080
SOCS3suppressor of cytokine signaling 30.079
PTPRCprotein tyrosine phosphatase, receptor type, C0.079
IL4interleukin 40.077
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.075
CD8ACD8a molecule0.074
BIDBH3 interacting domain death agonist0.074
ITKIL2-inducible T-cell kinase0.073
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.071
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.070
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.070
EP300E1A binding protein p3000.068
CD3GCD3g molecule, gamma (CD3-TCR complex)0.066
BCL2L1BCL2-like 10.065
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.064
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cmybtranscription factor cmyb0.964
ikzf1IKAROS family zinc finger 1 (Ikaros)0.719
bmp2bbone morphogenetic protein 2b0.664
rag1recombination activating gene 10.519
tp53tumor protein p530.495
tcf7transcription factor 7 (T-cell specific, HMG-box)0.445
cdx4caudal type homeo box transcription factor 40.412
bcl2B-cell leukemia/lymphoma 20.394
lcp1lymphocyte cytosolic plastin 10.358
trim33tripartite motif-containing 330.329
runx3runt-related transcription factor 30.317
rspo3R-spondin 3 homolog (Xenopus laevis)0.293
bmperBMP binding endothelial regulator0.289
il7rinterleukin 7 receptor0.286
flhfloating head0.259
slc30a7solute carrier family 30 (zinc transporter), member 70.231
ccnd1cyclin D10.225
gata1aGATA binding protein 1a0.224
chdchordin0.203
lef1lymphocyte enhancer binding factor 10.200
tbx1T-box 10.195
coblcordon-bleu homolog (mouse)0.192
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.188
spns2spinster homolog 2 (Drosophila)0.185
wnt8awingless-type MMTV integration site family, member 8a0.184
dlcdeltaC0.173
runx1runt-related transcription factor 10.171
nrp2bneuropilin 2b0.166
hoxa2bhomeo box A2b0.158
zgc:64115zgc:641150.152
runx2arunt-related transcription factor 2a0.149
coro1acoronin, actin binding protein, 1A0.136
fgf3fibroblast growth factor 30.134
fzd5frizzled homolog 50.124
kitakit receptor a0.120
anxa11aannexin A11a0.119
smoc2secreted modular calcium binding protein 20.114
fgf4fibroblast growth factor 40.112
mmp9matrix metalloproteinase 90.111
rad21RAD21 homolog (S. pombe)0.100
id1inhibitor of DNA binding 10.095
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.095
egr2bearly growth response 2b0.095
restRE1-silencing transcription factor0.082
cd247lCD247 antigen like0.082
ncor1nuclear receptor co-repressor 10.081
tgfb3transforming growth factor, beta 30.078
rpl23aribosomal protein L23a0.077
dnmt4DNA (cytosine-5-)-methyltransferase 40.076
pdlim3aPDZ and LIM domain 3a0.075
shhbsonic hedgehog b0.072
tal1T-cell acute lymphocytic leukemia 10.071
pax5paired box gene 50.070
elk4ELK4, ETS-domain protein0.070
jag1bjagged 1b0.069
dlddeltaD0.067
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.065
pcdh18bprotocadherin 18b0.056
lfnglunatic fringe homolog0.055
rag2recombination activating gene 20.055
krt5keratin 50.055
fzd8afrizzled homolog 8a0.054
dnttdeoxynucleotidyltransferase, terminal0.054
gscgoosecoid0.053
tp63tumor protein p630.051
lmx1b.1LIM homeobox transcription factor 1, beta 10.051
nme2b.1non-metastatic cells 2b.1, protein (NM23B) expressed in0.049
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.047
cxcr4bchemokine (C-X-C motif), receptor 4b0.044
gfi1.1growth factor independent 1.10.043
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.043
mycamyelocytomatosis oncogene a0.043
znf703zinc finger protein 7030.042
tfe3atranscription factor binding to IGHM enhancer 3a0.042
tbx2bT-box 2b0.041
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.039
alkanaplastic lymphoma kinase (Ki-1)0.036
sfrp5secreted frizzled-related protein 50.036
eomesbeomesodermin homolog b0.033
rargaretinoic acid receptor gamma a0.032
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.031
pdcd2programmed cell death 20.030
gata3GATA-binding protein 30.029
msxbmuscle segment homeobox B0.028
baxabcl2-associated X protein, a0.028
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.028
rpl7aribosomal protein L7a0.027
mitfamicrophthalmia-associated transcription factor a0.027
tfectranscription factor EC0.027
rhoabras homolog gene family, member Ab0.026
crip2cysteine-rich protein 20.026
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.026
hlxb9lahomeo box HB9 like a0.026
fn1fibronectin 10.024
dusp6dual specificity phosphatase 60.024
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.024
zgc:123327zgc:1233270.024
zbtb4zinc finger and BTB domain containing 40.024
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.024
capns1bcalpain, small subunit 1 b0.024
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 11.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Ptenphosphatase and tensin homolog1.000
Ighimmunoglobulin heavy chain complex1.000
Gli2GLI-Kruppel family member GLI21.000
Gli3GLI-Kruppel family member GLI30.999
Cd19CD19 antigen0.997
Sox2SRY-box containing gene 20.997
Pax2paired box gene 20.997
Socs1suppressor of cytokine signaling 10.996
Map3k14mitogen-activated protein kinase kinase kinase 140.996
Sox9SRY-box containing gene 90.996
FasFas (TNF receptor superfamily member 6)0.996
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.995
Fgfr2fibroblast growth factor receptor 20.995
Trp53transformation related protein 530.995
Tnftumor necrosis factor0.995
Runx1runt related transcription factor 10.993
Stat3signal transducer and activator of transcription 30.992
Bcl2B-cell leukemia/lymphoma 20.992
Ctnnb1catenin (cadherin associated protein), beta 10.992
Cd40CD40 antigen0.992
Tgfb1transforming growth factor, beta 10.991
Cdkn1bcyclin-dependent kinase inhibitor 1B0.989
Jak2Janus kinase 20.989
Lcklymphocyte protein tyrosine kinase0.989
Fgfr1fibroblast growth factor receptor 10.989
Ltalymphotoxin A0.988
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.988
Ntf3neurotrophin 30.986
Icosinducible T-cell co-stimulator0.985
Shhsonic hedgehog0.980
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.978
Emx1empty spiracles homolog 1 (Drosophila)0.977
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.973
Tnfaip3tumor necrosis factor, alpha-induced protein 30.973
Nf1neurofibromatosis 10.968
Tcf3transcription factor 30.968
Ptprcprotein tyrosine phosphatase, receptor type, C0.959
Zeb1zinc finger E-box binding homeobox 10.959
Notch1Notch gene homolog 1 (Drosophila)0.959
Ptf1apancreas specific transcription factor, 1a0.958
Smad4MAD homolog 4 (Drosophila)0.957
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.956
Bmi1Bmi1 polycomb ring finger oncogene0.956
Rnf2ring finger protein 20.955
Jag1jagged 10.952
Hes1hairy and enhancer of split 1 (Drosophila)0.950
Foxc1forkhead box C10.947
Hoxa1homeobox A10.947
Pax6paired box gene 60.945
Dll1delta-like 1 (Drosophila)0.944
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.942
Latlinker for activation of T cells0.939
Hic1hypermethylated in cancer 10.938
Ptpn11protein tyrosine phosphatase, non-receptor type 110.936
Hoxd13homeobox D130.931
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.930
Batfbasic leucine zipper transcription factor, ATF-like0.929
Rb1retinoblastoma 10.929
Ltblymphotoxin B0.929
Eya1eyes absent 1 homolog (Drosophila)0.928
Cd22CD22 antigen0.927
Sfpi1SFFV proviral integration 10.926
Irf8interferon regulatory factor 80.926
Efnb2ephrin B20.919
Rargretinoic acid receptor, gamma0.919
Csf1colony stimulating factor 1 (macrophage)0.918
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.915
Apcadenomatosis polyposis coli0.915
Pbx1pre B-cell leukemia transcription factor 10.914
Irf4interferon regulatory factor 40.913
Ccr6chemokine (C-C motif) receptor 60.911
Il2rbinterleukin 2 receptor, beta chain0.907
Bmp4bone morphogenetic protein 40.906
Irf5interferon regulatory factor 50.906
Fzd8frizzled homolog 8 (Drosophila)0.906
Arandrogen receptor0.905
Vangl2vang-like 2 (van gogh, Drosophila)0.894
Bcl6B-cell leukemia/lymphoma 60.891
Il2interleukin 20.887
Foxp3forkhead box P30.884
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.883
Pdcd1programmed cell death 10.881
TcrbT-cell receptor beta chain0.879
Ror2receptor tyrosine kinase-like orphan receptor 20.878
Gata3GATA binding protein 30.873
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.871
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.865
RybpRING1 and YY1 binding protein0.864
Onecut1one cut domain, family member 10.863
Esr1estrogen receptor 1 (alpha)0.857
Twist2twist homolog 2 (Drosophila)0.855
AxlAXL receptor tyrosine kinase0.851
Hoxa11homeobox A110.851
Ccl2chemokine (C-C motif) ligand 20.850
FynFyn proto-oncogene0.849
Leprleptin receptor0.846
H2-Aahistocompatibility 2, class II antigen A, alpha0.842
Itgb1integrin beta 1 (fibronectin receptor beta)0.839
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.364
RT1-BaRT1 class II, locus Ba0.254
Cd247Cd247 molecule0.134
Cd37CD37 molecule0.126
TcrbT-cell receptor beta chain0.072
RT1-Db1RT1 class II, locus Db10.068
Cd2Cd2 molecule0.067
Igh-6immunoglobulin heavy chain 60.033
Cd5Cd5 molecule0.032
Cfpcomplement factor properdin0.030
Stat4signal transducer and activator of transcription 40.029
Map4k1mitogen activated protein kinase kinase kinase kinase 10.028
Gpsm3G-protein signaling modulator 3 (AGS3-like, C. elegans)0.025
Bin2bridging integrator 20.025
Il2rbinterleukin 2 receptor, beta0.021
Lyz2lysozyme 20.019
Ptger4prostaglandin E receptor 4 (subtype EP4)0.017
Laptm5lysosomal protein transmembrane 50.016
Stat6signal transducer and activator of transcription 60.015
Cd3gCD3 molecule, gamma0.015
Plcg2phospholipase C, gamma 20.015
Tgfbr2transforming growth factor, beta receptor II0.014
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.014
RT1-DMbRT1 class II, locus DMb0.013
Cd4Cd4 molecule0.013
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.012
Ccr5chemokine (C-C motif) receptor 50.012
RT1-BbRT1 class II, locus Bb0.012
Creb1cAMP responsive element binding protein 10.012
Arhgap4Rho GTPase activating protein 40.012
Ccl5chemokine (C-C motif) ligand 50.011
Cd3eCD3 molecule, epsilon0.011
Lilrb3lleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like0.011
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.011
Spnsialophorin0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism