The network for 'negative regulation of cellular metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.847
let-502Protein LET-5020.771
vab-3Protein VAB-30.619
unc-37Protein UNC-370.552
pha-4Protein PHA-40.542
lin-53Protein LIN-530.421
nhr-67Protein NHR-670.385
snr-2Protein SNR-20.369
rad-26Protein RAD-260.340
elt-6Protein ELT-60.320
gld-1Protein GLD-10.319
hlh-2Protein HLH-20.312
his-1Protein HIS-10.283
his-5Protein HIS-50.272
mab-5Protein MAB-50.244
mat-3Protein MAT-30.237
egl-27Protein EGL-270.232
hcp-3Protein HCP-30.218
mls-2Protein MLS-20.211
his-16Protein HIS-160.207
his-3Protein HIS-30.206
cacn-1Protein CACN-10.204
pop-1Protein POP-10.203
ceh-20Protein CEH-200.199
F39B2.1Protein F39B2.10.195
his-64Protein HIS-640.189
cids-2Protein CIDS-20.187
pgl-1Protein PGL-10.187
zip-7Protein ZIP-70.177
pry-1Protein PRY-10.176
lin-11Protein LIN-110.175
his-45Protein HIS-450.174
his-31Protein HIS-310.160
pes-1Protein PES-10.157
eor-1Protein EOR-10.152
egl-15Protein EGL-150.148
mes-4Protein MES-40.148
fkh-2Protein FKH-20.147
CELE_C12D8.1Protein C12D8.10.146
mex-5Protein MEX-50.144
unc-62Protein UNC-620.141
fkb-6Protein FKB-60.138
his-61Protein HIS-610.138
egl-44Protein EGL-440.137
rsp-1Protein RSP-10.136
nhr-2Protein NHR-20.136
his-42Protein HIS-420.135
mut-16Protein MUT-160.134
F48A11.4Protein F48A11.40.130
scc-1Protein SCC-10.128
ucr-2.3Protein UCR-2.30.128
pqn-44Protein PQN-440.128
aap-1Protein AAP-10.127
gpd-4Protein GPD-40.126
eat-4Protein EAT-40.122
ifc-2Protein IFC-20.120
H43E16.1Protein H43E16.10.119
lin-66Protein LIN-660.119
spc-1Protein SPC-10.119
inx-13Protein INX-130.118
hmg-1.1Protein HMG-1.10.117
spd-5Protein SPD-50.117
tam-1Protein TAM-10.113
tag-319Protein TAG-3190.113
ubq-1Protein UBQ-10.110
teg-4Protein TEG-40.110
Y17G7B.20Protein Y17G7B.200.110
aph-2Protein APH-20.110
eya-1Protein EYA-10.109
vbh-1Protein VBH-10.109
szy-20Protein SZY-200.108
egl-13Protein EGL-130.108
M01A8.2Protein M01A8.20.108
ulp-2Protein ULP-20.107
egl-46Protein EGL-460.107
unc-85Protein UNC-850.107
his-51Protein HIS-510.107
hbl-1Protein HBL-10.107
hum-5Protein HUM-50.106
CELE_F19F10.9Protein F19F10.90.106
his-52Protein HIS-520.106
ZC53.1Protein ZC53.10.105
unc-52Protein UNC-520.105
alp-1Protein ALP-10.104
F46C8.3Protein F46C8.30.104
his-29Protein HIS-290.104
hlh-11Protein HLH-110.103
inx-3Protein INX-30.103
mcm-4Protein MCM-40.102
peb-1Protein PEB-10.102
npp-4Protein NPP-40.101
fbf-2Protein FBF-20.101
F22B3.4Protein F22B3.40.101
isw-1Protein ISW-10.100
T28C6.7Protein T28C6.70.100
dpy-22Protein DPY-220.100
his-15Protein HIS-150.098
smk-1Protein SMK-10.098
sea-2Protein SEA-20.098
tbx-8Protein TBX-80.098
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin0.949
pcnaproliferating cell nuclear antigen0.849
gata6GATA-binding protein 60.810
dlx2adistal-less homeobox gene 2a0.715
runx1runt-related transcription factor 10.674
sox9bSRY-box containing gene 9b0.649
her1hairy-related 10.627
runx2brunt-related transcription factor 2b0.623
wnt2bbwingless-type MMTV integration site family, member 2Bb0.605
gscgoosecoid0.602
cdh1cadherin 1, epithelial0.602
tbx6T-box gene 60.559
piwil1piwi-like 1 (Drosophila)0.550
bmp2bbone morphogenetic protein 2b0.525
fgf3fibroblast growth factor 30.487
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.452
nrg2aneuregulin 2a0.439
lef1lymphocyte enhancer binding factor 10.434
aldh1a2aldehyde dehydrogenase 1 family, member A20.410
lmx1b.1LIM homeobox transcription factor 1, beta 10.403
otpborthopedia homolog b0.396
pdlim7PDZ and LIM domain 70.377
twist3twist30.371
tac1tachykinin 10.358
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.352
pax8paired box gene 80.352
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.348
dctdopachrome tautomerase0.345
esr1estrogen receptor 10.341
mab21l2mab-21-like 20.339
fzd7afrizzled homolog 7a0.336
axin2axin 2 (conductin, axil)0.325
lhx1aLIM homeobox 1a0.321
snai1bsnail homolog 1b (Drosophila)0.318
dlx5adistal-less homeobox gene 5a0.318
dusp6dual specificity phosphatase 60.317
inspreproinsulin0.316
sox19aSRY-box containing gene 19a0.296
socs3asuppressor of cytokine signaling 3a0.293
pitx2paired-like homeodomain transcription factor 20.285
vcanaversican a0.275
rarabretinoic acid receptor, alpha b0.275
per2period homolog 2 (Drosophila)0.273
sox2SRY-box containing gene 20.266
klf4Kruppel-like factor 40.264
hes6hairy and enhancer of split 6 (Drosophila)0.260
nkx2.5NK2 transcription factor related 50.255
whsc1Wolf-Hirschhorn syndrome candidate 10.251
tbx2bT-box 2b0.250
cnr1cannabinoid receptor 10.249
ccnb1cyclin B10.244
traf4atnf receptor-associated factor 4a0.244
hnf1baHNF1 homeobox Ba0.238
tgif1TGFB-induced factor homeobox 10.235
fzd8afrizzled homolog 8a0.231
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.226
pea3ETS-domain transcription factor pea30.226
sall1asal-like 1a (Drosophila)0.224
etv5bets variant 5b0.222
spry4sprouty (Drosophila) homolog 40.220
cry1acryptochrome 1a0.216
msh6mutS homolog 6 (E. coli)0.216
jag2jagged 20.215
pou3f3bPOU class 3 homeobox 3b0.213
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.212
fzd7bfrizzled homolog 7b0.207
hp1bp3heterochromatin protein 1, binding protein 30.206
ctnnb1catenin (cadherin-associated protein), beta 10.199
hoxb1bhomeo box B1b0.199
dmbx1adiencephalon/mesencephalon homeobox 1a0.198
prox1prospero-related homeobox gene 10.198
gro1groucho 10.198
eomesaeomesodermin homolog a0.195
sox4aSRY-box containing gene 4a0.191
ef1aelongation factor 1-alpha0.189
hmx1H6 homeo box 10.188
olfm2olfactomedin 20.183
tomm40translocase of outer mitochondrial membrane 40 homolog (yeast)0.182
setdb1aSET domain, bifurcated 1a0.182
pou3f2POU class 3 homeobox 20.179
bhlhe22basic helix-loop-helix family, member e220.176
ephb3aeph receptor B3a0.175
zgc:77155zgc:771550.175
hoxa13ahomeo box A13a0.172
dbx1adeveloping brain homeobox 1a0.170
hhexhematopoietically expressed homeobox0.169
vdravitamin D receptor a0.169
wnt5bwingless-type MMTV integration site family, member 5b0.166
kdrlkinase insert domain receptor like0.164
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.163
nap1l1nucleosome assembly protein 1, like 10.162
gli1GLI-Kruppel family member 10.162
gata5GATA-binding protein 50.161
fgf17fibroblast growth factor 170.152
xirp2axin actin-binding repeat containing 2a0.152
ripply1ripply10.152
pitx3paired-like homeodomain transcription factor 30.150
hk1hexokinase 10.149
zff9zinc finger protein 90.148
neo1neogenin 10.148
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
NNotch0.999
saxsaxophone0.998
IswiImitation SWI0.998
hephemipterous0.996
MadMothers against dpp0.996
Su(var)205Suppressor of variegation 2050.995
drkdownstream of receptor kinase0.995
BEAF-32Boundary element-associated factor of 32kD0.995
Su(H)Suppressor of Hairless0.994
shishibire0.994
Snr1Snf5-related 10.992
InRInsulin-like receptor0.992
CycBCyclin B0.989
CtBPC-terminal Binding Protein0.988
lwrlesswright0.988
atoatonal0.985
tkvthickveins0.982
PtenCG5671 gene product from transcript CG5671-RB0.973
slmbsupernumerary limbs0.973
Fmr1CG6203 gene product from transcript CG6203-RC0.973
shnschnurri0.969
rinrasputin0.968
CTCFCG8591 gene product from transcript CG8591-RA0.968
pr-set7CG3307 gene product from transcript CG3307-RC0.964
Adf1Adh transcription factor 10.961
hbhunchback0.957
HLHm7E(spl) region transcript m70.956
dncdunce0.956
p53CG33336 gene product from transcript CG33336-RB0.954
brmbrahma0.952
E(spl)Enhancer of split0.952
CkIIalphaCasein kinase II alpha subunit0.951
bcdbicoid0.949
EgfrEpidermal growth factor receptor0.949
trxtrithorax0.948
Tip60CG6121 gene product from transcript CG6121-RA0.947
bratbrain tumor0.946
rlrolled0.945
Pi3K92ECG4141 gene product from transcript CG4141-RB0.942
D1D1 chromosomal protein0.941
dcodiscs overgrown0.941
cicubitus interruptus0.941
Mpk2CG5475 gene product from transcript CG5475-RB0.940
ash2absent, small, or homeotic discs 20.940
Ras85DRas oncogene at 85D0.939
Uba2Smt3 activating enzyme 20.938
Akt1CG4006 gene product from transcript CG4006-RA0.937
Pp1-87BProtein phosphatase 1 at 87B0.934
smt3CG4494 gene product from transcript CG4494-RA0.932
enengrailed0.929
Tm1Tropomyosin 10.927
kaykayak0.919
Sir2CG5216 gene product from transcript CG5216-RA0.911
CycACyclin A0.910
Src64BSrc oncogene at 64B0.909
abd-Aabdominal A0.903
ebiCG4063 gene product from transcript CG4063-RA0.901
Vap-33-1CG5014 gene product from transcript CG5014-RB0.893
sxcsuper sex combs0.890
loqsloquacious0.884
PcPolycomb0.881
UbxUltrabithorax0.879
dacdachshund0.879
snostrawberry notch0.877
stysprouty0.874
simsingle-minded0.871
His2AvHistone H2A variant0.866
Mob2CG11711 gene product from transcript CG11711-RC0.858
DrefDNA replication-related element factor0.853
E(var)3-9Enhancer of variegation 3-90.852
nmonemo0.852
PclPolycomblike0.852
Bap60Brahma associated protein 60kD0.850
fufused0.849
Pka-C1cAMP-dependent protein kinase 10.846
jumujumeau0.844
nejnejire0.843
reptreptin0.842
eyeyeless0.835
stgstring0.834
waplwings apart-like0.833
putpunt0.832
thrthree rows0.826
SceSex combs extra0.825
smosmoothened0.820
prdpaired0.817
rapretina aberrant in pattern0.811
SnapSoluble NSF attachment protein0.807
rprreaper0.806
UbqnUbiquilin0.806
p38bCG7393 gene product from transcript CG7393-RA0.803
ScmSex comb on midleg0.799
CycECyclin E0.798
tshteashirt0.797
JraJun-related antigen0.796
myoglianinCG1838 gene product from transcript CG1838-RD0.795
CG14667CG14667 gene product from transcript CG14667-RA0.794
Suv4-20CG13363 gene product from transcript CG13363-RA0.791
S6kRPS6-p70-protein kinase0.788
ThorCG8846 gene product from transcript CG8846-RA0.786
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.796
Nedd4neural precursor cell expressed, developmentally down-regulated 40.666
Hspb1heat shock protein 10.562
Jak2Janus kinase 20.543
FosFBJ osteosarcoma oncogene0.524
Cd9CD9 molecule0.524
Egr1early growth response 10.506
JunJun oncogene0.499
Stip1stress-induced phosphoprotein 10.499
Cav1caveolin 1, caveolae protein0.497
Ptmsparathymosin0.480
Siah1aseven in absentia 1A0.475
Tgfbr2transforming growth factor, beta receptor II0.475
Klf9Kruppel-like factor 90.414
Nfianuclear factor I/A0.413
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.401
Hspa1aheat shock 70kD protein 1A0.401
Nfibnuclear factor I/B0.398
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.394
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.385
Trim47tripartite motif-containing 470.383
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.378
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.375
Metmet proto-oncogene0.375
Pgam1phosphoglycerate mutase 1 (brain)0.365
Dusp1dual specificity phosphatase 10.365
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.365
Dynll1dynein light chain LC8-type 10.363
Eif4heukaryotic translation initiation factor 4H0.361
Calcrlcalcitonin receptor-like0.361
Casp2caspase 20.360
Smad7SMAD family member 70.356
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.350
Svs4seminal vesicle secretory protein 40.346
Arf6ADP-ribosylation factor 60.344
Id3inhibitor of DNA binding 30.344
Hdac2histone deacetylase 20.343
Zfp36zinc finger protein 360.340
Socs3suppressor of cytokine signaling 30.340
Errfi1ERBB receptor feedback inhibitor 10.337
Plb1phospholipase B10.337
RorbRAR-related orphan receptor B0.334
Homer3homer homolog 3 (Drosophila)0.332
Btg2BTG family, member 20.322
Foxi2forkhead box I20.322
Lgals3lectin, galactoside-binding, soluble, 30.319
Scaf1SR-related CTD-associated factor 10.318
Tcfe2atranscription factor E2a0.317
Gja1gap junction protein, alpha 10.316
DbpD site of albumin promoter (albumin D-box) binding protein0.315
Fgfr1Fibroblast growth factor receptor 10.314
Synposynaptopodin0.314
Adra2badrenergic, alpha-2B-, receptor0.312
Ldhalactate dehydrogenase A0.311
Irs1insulin receptor substrate 10.306
Nek9NIMA (never in mitosis gene a)- related kinase 90.305
S100a8S100 calcium binding protein A80.304
Gsk3bglycogen synthase kinase 3 beta0.304
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.302
Itgamintegrin, alpha M0.302
Sfrs1splicing factor, arginine/serine-rich 10.301
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.295
Klf4Kruppel-like factor 4 (gut)0.295
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.293
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.291
Myo1bmyosin Ib0.291
Nfyanuclear transcription factor-Y alpha0.288
Dlg1discs, large homolog 1 (Drosophila)0.287
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.281
Dchs1dachsous 1 (Drosophila)0.279
Amhanti-Mullerian hormone0.278
Hes1hairy and enhancer of split 1 (Drosophila)0.278
Prss3protease, serine, 30.278
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.278
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.276
Adam10ADAM metallopeptidase domain 100.274
Ubtfupstream binding transcription factor, RNA polymerase I0.273
Ifitm3interferon induced transmembrane protein 30.271
Adcy4adenylate cyclase 40.271
Mybl2myeloblastosis oncogene-like 20.267
Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.267
Klrg1killer cell lectin-like receptor subfamily G, member 10.263
Cd44Cd44 molecule0.260
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.256
Cckarcholecystokinin A receptor0.256
Ascl1achaete-scute complex homolog 1 (Drosophila)0.255
Klf2Kruppel-like factor 2 (lung)0.254
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.252
Klf6Kruppel-like factor 60.250
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.250
Rhobras homolog gene family, member B0.249
Adora2aadenosine A2a receptor0.248
Tspotranslocator protein0.248
Nrp1neuropilin 10.245
Capgcapping protein (actin filament), gelsolin-like0.244
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.243
Jak1Janus kinase 10.241
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.238
Runx1runt-related transcription factor 10.237
Fgfr2fibroblast growth factor receptor 20.235
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
HHF1Hhf1p1.000
RPD3Rpd3p0.992
GLC7Glc7p0.990
SIN3Sin3p0.988
SIR2Sir2p0.977
SIR4Sir4p0.966
SIN4Sin4p0.954
SIC1Sic1p0.952
BBC1Bbc1p0.943
HOG1Hog1p0.941
RIF1Rif1p0.926
RTS1Rts1p0.888
SIR3Sir3p0.888
HDA1Hda1p0.881
CYC8Cyc8p0.861
RAP1Rap1p0.850
SUM1Sum1p0.847
ADR1Adr1p0.847
BCK1Bck1p0.823
RTF1Rtf1p0.822
SPT16Spt16p0.775
SDS3Sds3p0.764
CDC25Cdc25p0.762
GCN1Gcn1p0.761
CCR4Ccr4p0.760
CDC55Cdc55p0.733
YAK1Yak1p0.723
CKA2Cka2p0.706
ROX3Rox3p0.700
MRC1Mrc1p0.698
GSY2Gsy2p0.697
HDA2Hda2p0.694
RTT106Rtt106p0.693
CSE2Cse2p0.691
SSN3Ssn3p0.689
ORC2Orc2p0.688
FUS3Fus3p0.686
URE2Ure2p0.681
SNF1Snf1p0.679
VID22Vid22p0.675
ORC5Orc5p0.668
ISW2Isw2p0.665
SNT1Snt1p0.665
KSP1Ksp1p0.658
CTI6Cti6p0.658
DED1Ded1p0.657
SET1Set1p0.656
BRE2Bre2p0.647
SMC6Smc6p0.643
CBF2Cbf2p0.640
GAL11Gal11p0.639
RCO1Rco1p0.637
PDS1Pds1p0.637
SAP30Sap30p0.630
STE7Ste7p0.625
HTB2Htb2p0.617
HHT1Hht1p0.613
VPS21Vps21p0.606
HST1Hst1p0.604
PAP2Pap2p0.603
SMT3Smt3p0.602
SHO1Sho1p0.601
GSY1Gsy1p0.594
PPH21Pph21p0.593
UME6Ume6p0.591
RSC2Rsc2p0.587
RAD53Rad53p0.585
ORC3Orc3p0.584
CDC28Cdc28p0.579
GCS1Gcs1p0.575
SSN8Ssn8p0.574
ORC1Orc1p0.564
BUB3Bub3p0.562
CTF18Ctf18p0.561
ASF1Asf1p0.559
GLN3Gln3p0.557
TOM1Tom1p0.554
YCS4Ycs4p0.554
PIL1Pil1p0.552
CHL1Chl1p0.552
GBP2Gbp2p0.548
PLC1Plc1p0.543
VPS36Vps36p0.539
RIM101Rim101p0.537
NMD2Nmd2p0.536
EAF3Eaf3p0.535
HAA1Haa1p0.534
PGD1Pgd1p0.528
HHF2Hhf2p0.524
SRB2Srb2p0.514
CIN8Cin8p0.513
RLF2Rlf2p0.512
STN1Stn1p0.512
MET4Met4p0.511
CLB5Clb5p0.510
SPT5Spt5p0.504
UBP8Ubp8p0.502
ZDS2Zds2p0.498
RXT2Rxt2p0.497
RAD9Rad9p0.497