The network for 'kinin cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

kinin cascade

A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.

NameDescriptionProbabilityFunc Analog Organism
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11.000
PLAURplasminogen activator, urokinase receptor1.000
PLATplasminogen activator, tissue0.986
METmet proto-oncogene (hepatocyte growth factor receptor)0.983
PLAUplasminogen activator, urokinase0.969
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.856
APOHapolipoprotein H (beta-2-glycoprotein I)0.734
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.506
KNG1kininogen 10.303
IL8interleukin 80.259
TNCtenascin C0.246
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.234
NPC2Niemann-Pick disease, type C20.215
IGFALSinsulin-like growth factor binding protein, acid labile subunit0.192
SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.182
SPHK1sphingosine kinase 10.153
ORM1orosomucoid 10.103
SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 20.095
C8Acomplement component 8, alpha polypeptide0.085
FOSL1FOS-like antigen 10.084
EMP1epithelial membrane protein 10.080
FGBfibrinogen beta chain0.077
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.075
TNFAIP6tumor necrosis factor, alpha-induced protein 60.073
GCGRglucagon receptor0.063
ITIH2inter-alpha (globulin) inhibitor H20.056
RDH16retinol dehydrogenase 16 (all-trans)0.051
LPAlipoprotein, Lp(a)0.051
PDGFCplatelet derived growth factor C0.051
C9complement component 90.050
MASP2mannan-binding lectin serine peptidase 20.050
GCKRglucokinase (hexokinase 4) regulator0.048
PHLDA1pleckstrin homology-like domain, family A, member 10.043
INHBAinhibin, beta A0.042
THBS1thrombospondin 10.042
SPP2secreted phosphoprotein 2, 24kDa0.042
MMP14matrix metallopeptidase 14 (membrane-inserted)0.042
CRPC-reactive protein, pentraxin-related0.041
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.041
CPN1carboxypeptidase N, polypeptide 10.041
TIMP1TIMP metallopeptidase inhibitor 10.040
TFR2transferrin receptor 20.040
APOBapolipoprotein B (including Ag(x) antigen)0.039
BHMTbetaine--homocysteine S-methyltransferase0.038
ITIH1inter-alpha (globulin) inhibitor H10.038
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.037
C4BPBcomplement component 4 binding protein, beta0.035
F2coagulation factor II (thrombin)0.034
PROZprotein Z, vitamin K-dependent plasma glycoprotein0.034
OSMRoncostatin M receptor0.031
PROCprotein C (inactivator of coagulation factors Va and VIIIa)0.030
FTCDformiminotransferase cyclodeaminase0.030
SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 20.029
ALDOBaldolase B, fructose-bisphosphate0.029
ANGPTL4angiopoietin-like 40.027
LIPClipase, hepatic0.027
APOFapolipoprotein F0.026
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.026
SAA4serum amyloid A4, constitutive0.026
F11coagulation factor XI0.025
SLC22A1solute carrier family 22 (organic cation transporter), member 10.024
PRODH2proline dehydrogenase (oxidase) 20.024
AGXTalanine-glyoxylate aminotransferase0.024
HAAO3-hydroxyanthranilate 3,4-dioxygenase0.023
GJB1gap junction protein, beta 1, 32kDa0.022
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 60.022
S100A2S100 calcium binding protein A20.021
HNF4Ahepatocyte nuclear factor 4, alpha0.020
SERPIND1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.020
CXCL3chemokine (C-X-C motif) ligand 30.020
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.019
PVRpoliovirus receptor0.019
TUBB6tubulin, beta 60.019
ECM1extracellular matrix protein 10.019
IL1Binterleukin 1, beta0.018
C8Bcomplement component 8, beta polypeptide0.018
EPHA2EPH receptor A20.018
RANBP9RAN binding protein 90.017
CD44CD44 molecule (Indian blood group)0.017
GBA3glucosidase, beta, acid 3 (cytosolic)0.017
ITIH3inter-alpha (globulin) inhibitor H30.016
HABP2hyaluronan binding protein 20.016
F10coagulation factor X0.016
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.015
CHST11carbohydrate (chondroitin 4) sulfotransferase 110.015
AMBPalpha-1-microglobulin/bikunin precursor0.015
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.015
PDLIM4PDZ and LIM domain 40.015
FAPfibroblast activation protein, alpha0.015
CPB2carboxypeptidase B2 (plasma)0.015
CYR61cysteine-rich, angiogenic inducer, 610.014
LTA4Hleukotriene A4 hydrolase0.014
PROCRprotein C receptor, endothelial0.014
GPRC5AG protein-coupled receptor, family C, group 5, member A0.013
RAB17RAB17, member RAS oncogene family0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Klk1b5kallikrein 1-related peptidase b51.000
Klk1b26kallikrein 1-related petidase b260.999
Klk1b1kallikrein 1-related peptidase b10.998
Klk1kallikrein 10.998
Klk1b8kallikrein 1-related peptidase b80.996
Klk1b11kallikrein 1-related peptidase b110.991
Klk1b21kallikrein 1-related peptidase b210.986
Klk1b9kallikrein 1-related peptidase b90.880
Klk1b3kallikrein 1-related peptidase b30.840
Klk1b24kallikrein 1-related peptidase b240.835
Klk1b27kallikrein 1-related peptidase b270.761
Klk1b16kallikrein 1-related peptidase b160.729
Klk1b4kallikrein 1-related pepidase b40.676
Egfbp2epidermal growth factor binding protein type B0.546
Cela2achymotrypsin-like elastase family, member 2A0.101
Tff2trefoil factor 2 (spasmolytic protein 1)0.090
Smr3asubmaxillary gland androgen regulated protein 3A0.076
Try5trypsin 50.056
Zg16zymogen granule protein 160.046
Sprr1bsmall proline-rich protein 1B0.044
Ctrb1chymotrypsinogen B10.044
5430421N21RikRIKEN cDNA 5430421N21 gene0.040
Expiextracellular proteinase inhibitor0.031
Dmbt1deleted in malignant brain tumors 10.029
Lcn4lipocalin 40.025
Dnase1deoxyribonuclease I0.025
Nr0b2nuclear receptor subfamily 0, group B, member 20.022
Tal2T-cell acute lymphocytic leukemia 20.021
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.021
Krtap8-2keratin associated protein 8-20.020
Cuzd1CUB and zona pellucida-like domains 10.019
Klk1b22kallikrein 1-related peptidase b220.019
Prss3protease, serine, 30.018
Hgdhomogentisate 1, 2-dioxygenase0.018
Tssk2testis-specific serine kinase 20.017
Tnp2transition protein 20.015
Hesx1homeobox gene expressed in ES cells0.013
Utf1undifferentiated embryonic cell transcription factor 10.013
Krt17keratin 170.012
Ctsgcathepsin G0.012
Prl7a1prolactin family 7, subfamily a, member 10.011
1700019N19RikRIKEN cDNA 1700019N19 gene0.010
Reg2regenerating islet-derived 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism