The network for 'blood coagulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

blood coagulation

The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

NameDescriptionProbabilityFunc Analog Organism
TEKTEK tyrosine kinase, endothelial0.991
C1QAcomplement component 1, q subcomponent, A chain0.984
FGAfibrinogen alpha chain0.977
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.977
VEGFAvascular endothelial growth factor A0.957
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.942
FGBfibrinogen beta chain0.932
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.927
TAL1T-cell acute lymphocytic leukemia 10.922
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.910
NCF1neutrophil cytosolic factor 10.884
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.884
ALBalbumin0.882
AXLAXL receptor tyrosine kinase0.873
SNAP23synaptosomal-associated protein, 23kDa0.856
ARRB1arrestin, beta 10.831
MYH9myosin, heavy chain 9, non-muscle0.825
LATlinker for activation of T cells0.824
VCAM1vascular cell adhesion molecule 10.822
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.816
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.815
C1QBcomplement component 1, q subcomponent, B chain0.811
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.807
ACTBactin, beta0.770
CAV1caveolin 1, caveolae protein, 22kDa0.747
COL4A2collagen, type IV, alpha 20.733
FLNAfilamin A, alpha0.726
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.714
FN1fibronectin 10.694
CRYABcrystallin, alpha B0.682
CXCL2chemokine (C-X-C motif) ligand 20.677
RARAretinoic acid receptor, alpha0.670
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.656
GRB7growth factor receptor-bound protein 70.628
SHC1SHC (Src homology 2 domain containing) transforming protein 10.605
IL8interleukin 80.592
F13A1coagulation factor XIII, A1 polypeptide0.577
PLCG1phospholipase C, gamma 10.559
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.557
NRP1neuropilin 10.551
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.548
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.542
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.538
PLATplasminogen activator, tissue0.533
PLAUplasminogen activator, urokinase0.531
CD93CD93 molecule0.519
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.518
PLGplasminogen0.509
MPEG1macrophage expressed 10.507
GP1BAglycoprotein Ib (platelet), alpha polypeptide0.487
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.459
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.443
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.424
VAV1vav 1 guanine nucleotide exchange factor0.423
PF4platelet factor 40.422
TMSB4Xthymosin beta 4, X-linked0.411
METmet proto-oncogene (hepatocyte growth factor receptor)0.410
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.398
CCR2chemokine (C-C motif) receptor 20.395
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.389
HBG2hemoglobin, gamma G0.389
GAS6growth arrest-specific 60.384
NR0B2nuclear receptor subfamily 0, group B, member 20.381
CYBAcytochrome b-245, alpha polypeptide0.380
ACTA2actin, alpha 2, smooth muscle, aorta0.368
CFL1cofilin 1 (non-muscle)0.361
EGFRepidermal growth factor receptor0.356
MYOGmyogenin (myogenic factor 4)0.345
POU5F1POU class 5 homeobox 10.337
VCLvinculin0.331
ILKintegrin-linked kinase0.322
SPINT1serine peptidase inhibitor, Kunitz type 10.313
CRPC-reactive protein, pentraxin-related0.310
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.308
NCF2neutrophil cytosolic factor 20.304
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.302
ACTN1actinin, alpha 10.288
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.287
PTRFpolymerase I and transcript release factor0.287
PTGISprostaglandin I2 (prostacyclin) synthase0.282
KNG1kininogen 10.280
KEAP1kelch-like ECH-associated protein 10.278
MYL6myosin, light chain 6, alkali, smooth muscle and non-muscle0.278
ACTG1actin, gamma 10.274
IL6interleukin 6 (interferon, beta 2)0.270
CXCL3chemokine (C-X-C motif) ligand 30.268
C1QCcomplement component 1, q subcomponent, C chain0.267
PGFplacental growth factor0.267
SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)0.262
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.255
ANXA1annexin A10.251
TENC1tensin like C1 domain containing phosphatase (tensin 2)0.241
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.238
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.232
STAB1stabilin 10.230
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.222
SH3BP2SH3-domain binding protein 20.222
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.221
MYH11myosin, heavy chain 11, smooth muscle0.218
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.215
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ambplalpha-1-microglobulin/bikunin precursor, like0.524
plgplasminogen0.395
zgc:193613zgc:1936130.257
msxdmuscle segment homeobox D0.243
fn1bfibronectin 1b0.202
fgafibrinogen alpha chain0.201
tagln2transgelin 20.194
si:dkey-76b14.4si:dkey-76b14.40.193
c9complement component 90.192
lama5laminin, alpha 50.177
vtnbvitronectin b0.156
mpllmyeloproliferative leukemia virus oncogene, like0.156
unc5bunc-5 homolog B (C. elegans)0.147
ptch2patched 20.138
fggfibrinogen, gamma polypeptide0.137
f5coagulation factor V0.136
foxa2forkhead box A20.131
ef1aelongation factor 1-alpha0.127
dusp6dual specificity phosphatase 60.117
col11a1acollagen, type XI, alpha 1a0.113
zgc:103710zgc:1037100.108
nr1h5nuclear receptor subfamily 1, group H, member 50.107
apomapolipoprotein M0.091
mmp9matrix metalloproteinase 90.087
uoxurate oxidase0.082
krt8keratin 80.080
anxa1aannexin A1a0.079
plekhh1pleckstrin homology domain containing, family H (with MyTH4 domain) member 10.076
fgfrl1afibroblast growth factor receptor-like 1a0.076
agtangiotensinogen0.075
foxa1forkhead box A10.073
fetubfetuin B0.072
igfbp7insulin-like growth factor binding protein 70.072
si:dkeyp-84f11.5si:dkeyp-84f11.50.071
col17a1acollagen, type XVII, alpha 1a0.071
bhmtbetaine-homocysteine methyltransferase0.063
nkx2.3NK2 transcription factor related 30.060
slc20a1asolute carrier family 20, member 1a0.058
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.056
col4a1collagen, type IV, alpha 10.053
hphaptoglobin0.053
msxamuscle segment homeobox A0.053
cpa5carboxypeptidase A50.051
si:dkey-8l13.4si:dkey-8l13.40.050
pdlim1PDZ and LIM domain 1 (elfin)0.049
LOC100000500sclerostin-like0.048
camk2g1calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 10.048
itgb3bintegrin beta 3b0.048
cyp2ad2cytochrome P450, family 2, subfamily AD, polypeptide 20.047
dag1dystroglycan 10.047
smtnlsmoothelin, like0.047
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.046
si:dkeyp-104h9.6si:dkeyp-104h9.60.045
LOC100003514protein kinase C alpha type-like0.045
cpceruloplasmin0.044
wlswntless homolog (Drosophila)0.043
gipgastric inhibitory polypeptide0.041
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.040
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.040
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.040
a1cfapobec1 complementation factor0.039
si:dkeyp-110g5.2si:dkeyp-110g5.20.038
shbgsex hormone binding globulin0.037
zgc:91944zgc:919440.037
bmp2abone morphogenetic protein 2a0.034
sult2st1sulfotransferase family 2, cytosolic sulfotransferase 10.033
itih2inter-alpha (globulin) inhibitor H20.033
pkm2apyruvate kinase, muscle, a0.033
prdm1aPR domain containing 1a, with ZNF domain0.032
aldh8a1aldehyde dehydrogenase 8 family, member A10.032
actn1actinin, alpha 10.031
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.031
lrrc15leucine rich repeat containing 150.031
frem2aFras1 related extracellular matrix protein 2a0.030
surf4lsurfeit gene 4, like0.030
zgc:63947zgc:639470.030
si:dkey-204f11.66si:dkey-204f11.660.029
LOC100002342carboxypeptidase A6-like0.029
bfbcomplement component bfb0.029
tfatransferrin-a0.029
notch2notch homolog 20.029
disp1dispatched homolog 1 (Drosophila)0.028
zgc:195154zgc:1951540.028
sb:cb247sb:cb2470.027
ecm2extracellular matrix protein 2, female organ and adipocyte specific0.027
epha4aeph receptor A4a0.027
jag1ajagged 1a0.026
cfbcomplement factor B0.026
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.026
nfe2nuclear factor, erythroid-derived 20.026
csrnp1bcysteine-serine-rich nuclear protein 1b0.026
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.025
asb8ankyrin repeat and SOCS box-containing 80.025
twist2twist20.024
krt18keratin 180.024
fhlfour and a half LIM domains0.023
bmp2bbone morphogenetic protein 2b0.023
nr6a1anuclear receptor subfamily 6, group A, member 1a0.023
gstalglutathione S-transferase, alpha-like0.023
llgl2lethal giant larvae homolog 2 (Drosophila)0.023
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptgs2prostaglandin-endoperoxide synthase 20.983
Ush1gUsher syndrome 1G homolog (human)0.974
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.958
AxlAXL receptor tyrosine kinase0.946
Ptprcprotein tyrosine phosphatase, receptor type, C0.946
Itgb2integrin beta 20.940
Gp5glycoprotein 5 (platelet)0.923
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.920
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.913
LOC100503041PDZ domain-containing protein 7-like0.894
Prkceprotein kinase C, epsilon0.842
Fggfibrinogen gamma chain0.832
Itgb3integrin beta 30.811
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.797
Selpselectin, platelet0.790
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.790
Dlg4discs, large homolog 4 (Drosophila)0.774
Ilkintegrin linked kinase0.764
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.763
Lystlysosomal trafficking regulator0.761
FasFas (TNF receptor superfamily member 6)0.758
Vhlvon Hippel-Lindau tumor suppressor0.750
Ldb3LIM domain binding 30.743
Itgb1integrin beta 1 (fibronectin receptor beta)0.732
Tpm4tropomyosin 40.715
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.712
Cdh23cadherin 23 (otocadherin)0.699
Rab27aRAB27A, member RAS oncogene family0.686
Ceacam2carcinoembryonic antigen-related cell adhesion molecule 20.684
Gp9glycoprotein 9 (platelet)0.682
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.676
S1pr2sphingosine-1-phosphate receptor 20.662
Mutedmuted0.660
Myo7amyosin VIIA0.656
Plgplasminogen0.644
Klklotho0.642
Nos3nitric oxide synthase 3, endothelial cell0.631
C3ar1complement component 3a receptor 10.606
Nfe2l2nuclear factor, erythroid derived 2, like 20.600
Lyl1lymphoblastomic leukemia 10.584
Tln1talin 10.561
WasWiskott-Aldrich syndrome homolog (human)0.551
Pf4platelet factor 40.548
Mplmyeloproliferative leukemia virus oncogene0.545
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.535
Plcd1phospholipase C, delta 10.517
Wnt4wingless-related MMTV integration site 40.508
Lyz2lysozyme 20.508
Gata1GATA binding protein 10.507
F2coagulation factor II0.493
Pldnpallidin0.490
Ppargperoxisome proliferator activated receptor gamma0.475
Smad1MAD homolog 1 (Drosophila)0.472
Cfhcomplement component factor h0.463
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.461
Ncoa3nuclear receptor coactivator 30.455
Myo15myosin XV0.444
Cnn2calponin 20.441
Mertkc-mer proto-oncogene tyrosine kinase0.439
Nr3c1nuclear receptor subfamily 3, group C, member 10.420
Egfrepidermal growth factor receptor0.416
Vimvimentin0.413
Il2rginterleukin 2 receptor, gamma chain0.410
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.409
Mrvi1MRV integration site 10.409
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.402
Vegfavascular endothelial growth factor A0.400
Slc26a5solute carrier family 26, member 50.397
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.394
F2rl2coagulation factor II (thrombin) receptor-like 20.393
Alox5aparachidonate 5-lipoxygenase activating protein0.370
Vav1vav 1 oncogene0.369
Cficomplement component factor i0.366
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.362
Cnocappuccino0.360
Hgfachepatocyte growth factor activator0.359
Bcl2B-cell leukemia/lymphoma 20.359
S1pr3sphingosine-1-phosphate receptor 30.353
Notch2Notch gene homolog 2 (Drosophila)0.351
Eporerythropoietin receptor0.349
Thrbthyroid hormone receptor beta0.348
Ppbppro-platelet basic protein0.344
Procprotein C0.343
Gpr97G protein-coupled receptor 970.339
Gcgrglucagon receptor0.337
Ush1cUsher syndrome 1C homolog (human)0.335
Apoeapolipoprotein E0.334
Taglntransgelin0.333
Fcgr3Fc receptor, IgG, low affinity III0.331
Saa4serum amyloid A 40.327
Sirpasignal-regulatory protein alpha0.326
Itih4inter alpha-trypsin inhibitor, heavy chain 40.323
Ccr2chemokine (C-C motif) receptor 20.318
Leprleptin receptor0.318
Anxa2annexin A20.313
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.313
Pdgfbplatelet derived growth factor, B polypeptide0.313
Tlr4toll-like receptor 40.303
Ikzf1IKAROS family zinc finger 10.302
Hps6Hermansky-Pudlak syndrome 60.301
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa5annexin A50.944
Anxa1annexin A10.853
Vimvimentin0.727
Itgb1integrin, beta 10.684
Acta2smooth muscle alpha-actin0.665
Ifitm3interferon induced transmembrane protein 30.630
Taglntransgelin0.607
AhnakAHNAK nucleoprotein0.555
Actbactin, beta0.491
C1scomplement component 1, s subcomponent0.453
Pzppregnancy-zone protein0.429
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.329
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.321
Hpxhemopexin0.310
Tgm2transglutaminase 2, C polypeptide0.306
Cfbcomplement factor B0.280
Icam1intercellular adhesion molecule 10.264
Arpc1bactin related protein 2/3 complex, subunit 1B0.254
Ahsgalpha-2-HS-glycoprotein0.254
AxlAxl receptor tyrosine kinase0.253
Flnafilamin A, alpha0.253
S100a6S100 calcium binding protein A60.243
Anxa2annexin A20.231
Tpm2tropomyosin 2, beta0.229
Tagln2transgelin 20.221
Cficomplement factor I0.214
Zfp36l1zinc finger protein 36, C3H type-like 10.207
C3complement component 30.197
Cpceruloplasmin0.188
Itih4inter alpha-trypsin inhibitor, heavy chain 40.183
Ctsl1cathepsin L10.173
Mgpmatrix Gla protein0.170
Fn1fibronectin 10.169
MdficMyoD family inhibitor domain containing0.158
Ptafrplatelet-activating factor receptor0.157
Rhocras homolog gene family, member C0.148
Plauplasminogen activator, urokinase0.142
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.142
Inpp5dinositol polyphosphate-5-phosphatase D0.140
Platplasminogen activator, tissue0.135
C1rcomplement component 1, r subcomponent0.133
Pla1aphospholipase A1 member A0.127
B2mbeta-2 microglobulin0.122
Cd151CD151 molecule (Raph blood group)0.118
S100a10S100 calcium binding protein A100.113
Gzmkgranzyme K0.110
Hckhemopoietic cell kinase0.105
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.103
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.102
LOC293989cytochrome P450-like0.099
C5ar1complement component 5a receptor 10.097
Cma1chymase 1, mast cell0.096
Hphaptoglobin0.094
Gcgroup specific component0.087
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.085
S100a4S100 calcium-binding protein A40.083
S100a11S100 calcium binding protein A11 (calizzarin)0.082
C8bcomplement component 8, beta polypeptide0.081
Cd44Cd44 molecule0.079
KitlgKIT ligand0.078
Fgafibrinogen alpha chain0.078
Myadmmyeloid-associated differentiation marker0.076
Slc17a1solute carrier family 17 (sodium phosphate), member 10.075
Capn2calpain 20.073
Iqgap1IQ motif containing GTPase activating protein 10.071
Fabp1fatty acid binding protein 1, liver0.070
Lmnalamin A0.070
Rup2urinary protein 20.066
Kng1kininogen 10.061
Tftransferrin0.060
Fggfibrinogen gamma chain0.058
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.057
Gsngelsolin0.056
Anxa3annexin A30.053
RGD1307396similar to RIKEN cDNA 6330406I150.050
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.050
Ptpn18protein tyrosine phosphatase, non-receptor type 180.049
Tgm1transglutaminase 1, K polypeptide0.048
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.048
Fetubfetuin B0.048
Apohapolipoprotein H (beta-2-glycoprotein I)0.047
Lcp1lymphocyte cytosolic protein 10.047
Clec4fC-type lectin domain family 4, member f0.047
Agtr1aangiotensin II receptor, type 1a0.046
Tlr4toll-like receptor 40.045
Aqp9aquaporin 90.043
TekTEK tyrosine kinase, endothelial0.043
Ptger2prostaglandin E receptor 2 (subtype EP2)0.042
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.042
Pf4platelet factor 40.041
C9complement component 90.040
Ccl4chemokine (C-C motif) ligand 40.040
Azgp1alpha-2-glycoprotein 1, zinc-binding0.040
Lyz2lysozyme 20.040
Lpllipoprotein lipase0.040
Cpb2carboxypeptidase B2 (plasma)0.039
Itm2bintegral membrane protein 2B0.039
Map3k8mitogen-activated protein kinase kinase kinase 80.039
Rgs8regulator of G-protein signaling 80.038
Stx1asyntaxin 1A (brain)0.038
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism