The network for 'ossification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

NameDescriptionProbabilityFunc Analog Organism
COL1A1collagen, type I, alpha 10.999
FN1fibronectin 10.997
FHL2four and a half LIM domains 20.980
MMP14matrix metallopeptidase 14 (membrane-inserted)0.967
SMAD4SMAD family member 40.964
COL6A1collagen, type VI, alpha 10.935
FBLN1fibulin 10.934
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.932
CCR5chemokine (C-C motif) receptor 50.926
SMAD2SMAD family member 20.919
COL1A2collagen, type I, alpha 20.896
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.877
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.839
COL3A1collagen, type III, alpha 10.824
FBN1fibrillin 10.799
HIPK2homeodomain interacting protein kinase 20.797
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.747
SKILSKI-like oncogene0.735
JUNjun proto-oncogene0.714
EGR1early growth response 10.705
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.705
PRKD2protein kinase D20.695
DDR2discoidin domain receptor tyrosine kinase 20.695
BMP1bone morphogenetic protein 10.692
CCL5chemokine (C-C motif) ligand 50.685
HNRNPKheterogeneous nuclear ribonucleoprotein K0.683
COL5A1collagen, type V, alpha 10.673
BCAR1breast cancer anti-estrogen resistance 10.651
COL4A1collagen, type IV, alpha 10.646
THBS1thrombospondin 10.615
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.578
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.574
EFTUD2elongation factor Tu GTP binding domain containing 20.573
IFITM3interferon induced transmembrane protein 3 (1-8U)0.566
COL4A2collagen, type IV, alpha 20.564
SMAD7SMAD family member 70.557
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.556
AXIN1axin 10.540
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.530
GSK3Bglycogen synthase kinase 3 beta0.530
IGFBP5insulin-like growth factor binding protein 50.528
IFITM1interferon induced transmembrane protein 1 (9-27)0.510
FGF1fibroblast growth factor 1 (acidic)0.507
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.477
SFRP1secreted frizzled-related protein 10.475
IFITM2interferon induced transmembrane protein 2 (1-8D)0.469
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.451
TP53tumor protein p530.445
RXRAretinoid X receptor, alpha0.443
COL6A2collagen, type VI, alpha 20.442
TGFB3transforming growth factor, beta 30.438
MDM2Mdm2 p53 binding protein homolog (mouse)0.428
NCOR2nuclear receptor corepressor 20.426
RCN3reticulocalbin 3, EF-hand calcium binding domain0.417
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.411
SMAD9SMAD family member 90.410
POU3F2POU class 3 homeobox 20.409
BMP2bone morphogenetic protein 20.407
NOTCH1notch 10.391
MXRA5matrix-remodelling associated 50.388
ZHX1zinc fingers and homeoboxes 10.384
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.383
ADAM12ADAM metallopeptidase domain 120.383
FLNAfilamin A, alpha0.377
PTK2PTK2 protein tyrosine kinase 20.376
RUNX1runt-related transcription factor 10.368
RPL18Aribosomal protein L18a0.367
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.367
PRELPproline/arginine-rich end leucine-rich repeat protein0.366
TGFB1transforming growth factor, beta 10.361
TM4SF1transmembrane 4 L six family member 10.360
JAG1jagged 10.355
SUFUsuppressor of fused homolog (Drosophila)0.354
SMAD3SMAD family member 30.345
PTGISprostaglandin I2 (prostacyclin) synthase0.341
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.339
NOTCH3notch 30.338
POSTNperiostin, osteoblast specific factor0.314
LTBP2latent transforming growth factor beta binding protein 20.313
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.309
FKBP1AFK506 binding protein 1A, 12kDa0.307
PECAM1platelet/endothelial cell adhesion molecule0.306
FOXF2forkhead box F20.304
THBS2thrombospondin 20.303
SOCS3suppressor of cytokine signaling 30.302
PLXND1plexin D10.299
NCOR1nuclear receptor corepressor 10.296
SERPINH1serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)0.294
PTCH1patched 10.287
ATF3activating transcription factor 30.285
FZD1frizzled homolog 1 (Drosophila)0.280
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.276
MRC2mannose receptor, C type 20.269
CCL2chemokine (C-C motif) ligand 20.263
FBLN2fibulin 20.262
LAMB1laminin, beta 10.262
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
col1a2collagen, type I, alpha 20.984
wnt5bwingless-type MMTV integration site family, member 5b0.969
sox9bSRY-box containing gene 9b0.969
bmp2bbone morphogenetic protein 2b0.955
sox9aSRY-box containing gene 9a0.741
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.678
pitx3paired-like homeodomain transcription factor 30.648
myod1myogenic differentiation 10.606
runx2brunt-related transcription factor 2b0.515
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.450
col10a1collagen, type X, alpha 10.445
nf1aneurofibromin 1a0.416
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.414
runx2arunt-related transcription factor 2a0.408
col1a1acollagen, type I, alpha 1a0.388
tbx1T-box 10.387
sparcsecreted acidic cysteine rich glycoprotein0.386
spry4sprouty (Drosophila) homolog 40.382
bocbrother of CDO0.349
col5a1procollagen, type V, alpha 10.347
wlswntless homolog (Drosophila)0.320
col5a2lcollagen, type V, alpha 2-like0.298
mmp15bmatrix metallopeptidase 15b0.297
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.297
osr1odd-skipped related 1 (Drosophila)0.294
fgf8afibroblast growth factor 8 a0.285
ihhaIndian hedgehog homolog a0.276
xylt1xylosyltransferase 10.259
tcf7transcription factor 7 (T-cell specific, HMG-box)0.257
shhasonic hedgehog a0.253
smosmoothened homolog (Drosophila)0.251
mmp2matrix metalloproteinase 20.248
fn1fibronectin 10.227
hspa12bheat shock protein 12B0.222
satb2SATB homeobox 20.220
ctsl1bcathepsin L, 1 b0.216
wif1wnt inhibitory factor 10.207
dlx4adistal-less homeobox gene 4a0.205
dachadachshund a0.191
wnt10awingless-type MMTV integration site family, member 10a0.185
tgfbitransforming growth factor, beta-induced0.179
col2a1acollagen type II, alpha-1a0.175
igf1rbinsulin-like growth factor 1b receptor0.154
ctgfconnective tissue growth factor0.152
smad5MAD homolog 5 (Drosophila)0.151
notch3notch homolog 30.151
ldb2aLIM-domain binding factor 2a0.123
dlx3bdistal-less homeobox gene 3b0.121
cdh1cadherin 1, epithelial0.118
efnb2aephrin B2a0.118
myf6myogenic factor 60.115
matn4matrilin 40.113
sulf1sulfatase 10.107
pitx2paired-like homeodomain transcription factor 20.101
epha4aeph receptor A4a0.100
fgfr3fibroblast growth factor receptor 30.100
apoebapolipoprotein Eb0.100
kdrlkinase insert domain receptor like0.098
fgf4fibroblast growth factor 40.093
wnt3wingless-type MMTV integration site family, member 30.089
bmp3bone morphogenetic protein 30.089
edn1endothelin 10.088
six1bsine oculis homeobox homolog 1b0.087
tlr3toll-like receptor 30.087
dag1dystroglycan 10.086
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.086
thrbthyroid hormone receptor beta0.085
runx3runt-related transcription factor 30.084
smad1MAD homolog 1 (Drosophila)0.083
tll1tolloid-like 10.083
egr2bearly growth response 2b0.078
ptgs2aprostaglandin-endoperoxide synthase 2a0.078
bmp1abone morphogenetic protein 1a0.078
kdelr2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 20.076
lef1lymphocyte enhancer binding factor 10.071
fstl1bfollistatin-like 1b0.071
fgf17fibroblast growth factor 170.069
col27a1acollagen, type XXVII, alpha 1a0.068
sox11bSRY-box containing gene 11b0.068
runx1runt-related transcription factor 10.068
stc1lstanniocalcin 1, like0.067
dlx2adistal-less homeobox gene 2a0.067
bmperBMP binding endothelial regulator0.067
ptch2patched 20.064
gli1GLI-Kruppel family member 10.060
aldobaldolase b, fructose-bisphosphate0.060
cmybtranscription factor cmyb0.057
aldh1a3aldehyde dehydrogenase 1 family, member A30.057
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.056
sufusuppressor of fused homolog (Drosophila)0.056
acvr1lactivin A receptor, type I like0.056
gli2aGLI-Kruppel family member GLI2a0.055
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr3fibroblast growth factor receptor 31.000
Fgfr1fibroblast growth factor receptor 10.999
Tgfb2transforming growth factor, beta 20.997
Ptenphosphatase and tensin homolog0.995
Fgfr2fibroblast growth factor receptor 20.994
Bmp4bone morphogenetic protein 40.993
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.993
Col1a1collagen, type I, alpha 10.992
Bcl2B-cell leukemia/lymphoma 20.990
Pax2paired box gene 20.989
Ctnnb1catenin (cadherin associated protein), beta 10.989
Gli3GLI-Kruppel family member GLI30.989
Smad6MAD homolog 6 (Drosophila)0.988
Ror2receptor tyrosine kinase-like orphan receptor 20.985
Gli2GLI-Kruppel family member GLI20.984
Trp53transformation related protein 530.982
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.974
Prrx2paired related homeobox 20.967
Notch1Notch gene homolog 1 (Drosophila)0.965
Smosmoothened homolog (Drosophila)0.959
Notch2Notch gene homolog 2 (Drosophila)0.955
Bmpr1abone morphogenetic protein receptor, type 1A0.951
Pthlhparathyroid hormone-like peptide0.949
Fgf10fibroblast growth factor 100.944
Msx1homeobox, msh-like 10.942
Gdnfglial cell line derived neurotrophic factor0.942
Twist2twist homolog 2 (Drosophila)0.938
Prrx1paired related homeobox 10.932
Runx2runt related transcription factor 20.931
Vdrvitamin D receptor0.930
Tgfb1i1transforming growth factor beta 1 induced transcript 10.926
Rargretinoic acid receptor, gamma0.925
Gata4GATA binding protein 40.921
Retret proto-oncogene0.907
Grb10growth factor receptor bound protein 100.903
Col2a1collagen, type II, alpha 10.903
Smad3MAD homolog 3 (Drosophila)0.895
Leprleptin receptor0.894
Col1a2collagen, type I, alpha 20.888
Pax9paired box gene 90.886
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.884
Npr2natriuretic peptide receptor 20.874
Fzd2frizzled homolog 2 (Drosophila)0.871
Shhsonic hedgehog0.871
Neurog3neurogenin 30.865
Nf1neurofibromatosis 10.847
Bmp7bone morphogenetic protein 70.842
Pax3paired box gene 30.842
Dlx5distal-less homeobox 50.840
Vegfavascular endothelial growth factor A0.837
Col6a2collagen, type VI, alpha 20.836
Sp1trans-acting transcription factor 10.833
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.823
Leprel2leprecan-like 20.817
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.814
Sfrp2secreted frizzled-related protein 20.809
Gata6GATA binding protein 60.808
Notch3Notch gene homolog 3 (Drosophila)0.802
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.786
Eya1eyes absent 1 homolog (Drosophila)0.785
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.782
Mef2dmyocyte enhancer factor 2D0.782
Efnb2ephrin B20.779
Gpc3glypican 30.777
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.777
Ptgs2prostaglandin-endoperoxide synthase 20.773
Nos3nitric oxide synthase 3, endothelial cell0.771
Ascl1achaete-scute complex homolog 1 (Drosophila)0.771
Mfap2microfibrillar-associated protein 20.769
Ltbp2latent transforming growth factor beta binding protein 20.765
Gas1growth arrest specific 10.765
Efnb1ephrin B10.759
Pbx1pre B-cell leukemia transcription factor 10.751
Foxc1forkhead box C10.750
Ednraendothelin receptor type A0.743
Mrc2mannose receptor, C type 20.741
Ltblymphotoxin B0.734
Pcolceprocollagen C-endopeptidase enhancer protein0.729
Platplasminogen activator, tissue0.727
Efsembryonal Fyn-associated substrate0.726
Hspg2perlecan (heparan sulfate proteoglycan 2)0.725
Tbx2T-box 20.721
Fzd1frizzled homolog 1 (Drosophila)0.721
Loxl1lysyl oxidase-like 10.712
Fgf3fibroblast growth factor 30.712
Bmp2bone morphogenetic protein 20.704
Myod1myogenic differentiation 10.689
Col11a1collagen, type XI, alpha 10.686
Col6a1collagen, type VI, alpha 10.683
Tbx5T-box 50.683
Tbx3T-box 30.680
Wnt4wingless-related MMTV integration site 40.677
Arandrogen receptor0.677
Hic1hypermethylated in cancer 10.674
Pitx3paired-like homeodomain transcription factor 30.669
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.667
Hes1hairy and enhancer of split 1 (Drosophila)0.666
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.434
Sycp1synaptonemal complex protein 10.365
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.308
C1qtnf6C1q and tumor necrosis factor related protein 60.253
Prrx1paired related homeobox 10.244
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.233
Igfbp5insulin-like growth factor binding protein 50.227
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.218
Col5a2collagen, type V, alpha 20.216
Crtapcartilage associated protein0.205
Capn6calpain 60.199
Crisp1cysteine-rich secretory protein 10.198
Loxlysyl oxidase0.197
Hapln1hyaluronan and proteoglycan link protein 10.195
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.192
Col5a1collagen, type V, alpha 10.192
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.192
Igfbp3insulin-like growth factor binding protein 30.192
Col12a1collagen, type XII, alpha 10.187
Col3a1collagen, type III, alpha 10.182
Phkg1phosphorylase kinase, gamma 10.181
Itpr2inositol 1,4,5-triphosphate receptor, type 20.174
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.173
Calcrcalcitonin receptor0.165
Col1a2collagen, type I, alpha 20.165
Srpxsushi-repeat-containing protein, X-linked0.156
Folh1folate hydrolase 10.153
Scn9asodium channel, voltage-gated, type IX, alpha0.151
Bcl2B-cell CLL/lymphoma 20.149
Fgf10fibroblast growth factor 100.142
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.138
Mmp13matrix metallopeptidase 130.136
Il2rainterleukin 2 receptor, alpha0.135
Enpp6ectonucleotide pyrophosphatase/phosphodiesterase 60.131
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.126
Tas2r126taste receptor, type 2, member 1260.125
Slc34a1solute carrier family 34 (sodium phosphate), member 10.123
Prss1protease, serine, 1 (trypsin 1)0.119
Ptpn14protein tyrosine phosphatase, non-receptor type 140.118
Tgfb2transforming growth factor, beta 20.117
Galntl1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 10.112
Glycam1glycosylation dependent cell adhesion molecule 10.109
Hspa1lheat shock protein 1-like0.107
Fn1fibronectin 10.106
Sstr1somatostatin receptor 10.104
Gng7guanine nucleotide binding protein (G protein), gamma 70.103
Olr1500olfactory receptor 15000.103
Accn3amiloride-sensitive cation channel 30.101
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.100
Agtr1aangiotensin II receptor, type 1a0.100
Mmp3matrix metallopeptidase 30.098
Arcactivity-regulated cytoskeleton-associated protein0.098
LOC312273Trypsin V-A0.095
Sfrp4secreted frizzled-related protein 40.095
Gfra1GDNF family receptor alpha 10.093
Sostdc1sclerostin domain containing 10.093
Prol1proline rich, lacrimal 10.092
Nr2f2nuclear receptor subfamily 2, group F, member 20.092
Six1SIX homeobox 10.092
Mafbv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.091
Padi2peptidyl arginine deiminase, type II0.091
Vom1r105vomeronasal 1 receptor 1050.089
Dchs1dachsous 1 (Drosophila)0.088
Has2hyaluronan synthase 20.087
Necab1N-terminal EF-hand calcium binding protein 10.086
Mas1MAS1 oncogene0.086
Mmp10matrix metallopeptidase 100.086
Hoxb8homeo box B80.086
Uoxurate oxidase0.085
Plagl1pleiomorphic adenoma gene-like 10.084
Serpinb12serpin peptidase inhibitor, clade B (ovalbumin), member 120.084
Rgs8regulator of G-protein signaling 80.083
Gpr12G protein-coupled receptor 120.083
Fam38bfamily with sequence similarity 38, member B0.082
Acrv1acrosomal vesicle protein 10.082
Asb9ankyrin repeat and SOCS box-containing 90.081
LOC679840similar to germinal histone H4 gene0.080
Csf3colony stimulating factor 3 (granulocyte)0.079
Sod3superoxide dismutase 3, extracellular0.078
Plxdc2plexin domain containing 20.078
Spta1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.078
Olr1496olfactory receptor 14960.077
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.076
Nkx6-1NK6 homeobox 10.076
Reg3aregenerating islet-derived 3 alpha0.075
FevFEV (ETS oncogene family)0.075
Nr4a3nuclear receptor subfamily 4, group A, member 30.075
Loxl1lysyl oxidase-like 10.074
Arhgap28Rho GTPase activating protein 280.074
Vom2r40vomeronasal 2 receptor, 400.073
Nedd4neural precursor cell expressed, developmentally down-regulated 40.073
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism