The network for 'tumor necrosis factor mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tumor necrosis factor mediated signaling pathway

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
BCAR1breast cancer anti-estrogen resistance 10.898
PTPN1protein tyrosine phosphatase, non-receptor type 10.808
TRADDTNFRSF1A-associated via death domain0.744
C1QAcomplement component 1, q subcomponent, A chain0.488
CFLARCASP8 and FADD-like apoptosis regulator0.463
ZNF43zinc finger protein 430.457
TRAF1TNF receptor-associated factor 10.302
TRAF2TNF receptor-associated factor 20.294
CASP8caspase 8, apoptosis-related cysteine peptidase0.159
ZNF253zinc finger protein 2530.149
TRAF5TNF receptor-associated factor 50.134
INADLInaD-like (Drosophila)0.131
STAT1signal transducer and activator of transcription 1, 91kDa0.124
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.122
IL4Rinterleukin 4 receptor0.115
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.112
TRAF3TNF receptor-associated factor 30.111
TRAF6TNF receptor-associated factor 60.110
JAK2Janus kinase 20.094
CAV1caveolin 1, caveolae protein, 22kDa0.094
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.087
IFNAR2interferon (alpha, beta and omega) receptor 20.075
ZNF273zinc finger protein 2730.072
CD40CD40 molecule, TNF receptor superfamily member 50.071
ZNF85zinc finger protein 850.071
IRAK1interleukin-1 receptor-associated kinase 10.068
C1QCcomplement component 1, q subcomponent, C chain0.064
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.064
ZNF675zinc finger protein 6750.064
SOCS3suppressor of cytokine signaling 30.061
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.060
ZNF708zinc finger protein 7080.053
KRT8keratin 80.052
CASP10caspase 10, apoptosis-related cysteine peptidase0.049
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.046
MAP3K14mitogen-activated protein kinase kinase kinase 140.044
IFNAR1interferon (alpha, beta and omega) receptor 10.043
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.040
IRAK2interleukin-1 receptor-associated kinase 20.038
ZNF91zinc finger protein 910.037
RNF31ring finger protein 310.037
INSRinsulin receptor0.035
ZNF680zinc finger protein 6800.035
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.034
ZNF254zinc finger protein 2540.033
ZNF93zinc finger protein 930.029
GHRgrowth hormone receptor0.026
ZNF746zinc finger protein 7460.026
APOC1apolipoprotein C-I0.026
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.026
IL12RB2interleukin 12 receptor, beta 20.025
NLRC4NLR family, CARD domain containing 40.025
C1QBcomplement component 1, q subcomponent, B chain0.025
TMEM173transmembrane protein 1730.025
FADDFas (TNFRSF6)-associated via death domain0.025
IFNGR1interferon gamma receptor 10.024
FYNFYN oncogene related to SRC, FGR, YES0.024
CREBBPCREB binding protein0.024
LCATlecithin-cholesterol acyltransferase0.024
IL2RBinterleukin 2 receptor, beta0.023
FASFas (TNF receptor superfamily, member 6)0.022
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.022
NMIN-myc (and STAT) interactor0.021
ZNF107zinc finger protein 1070.021
PMLpromyelocytic leukemia0.020
STAT5Asignal transducer and activator of transcription 5A0.020
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.018
MEFVMediterranean fever0.018
BIRC3baculoviral IAP repeat containing 30.018
ZNF430zinc finger protein 4300.017
SOCS1suppressor of cytokine signaling 10.016
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.016
ZNF117zinc finger protein 1170.016
TOX4TOX high mobility group box family member 40.015
ZMYND11zinc finger, MYND-type containing 110.015
IRF9interferon regulatory factor 90.015
EPORerythropoietin receptor0.015
STAT2signal transducer and activator of transcription 2, 113kDa0.015
SH2B1SH2B adaptor protein 10.014
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.014
NUMBLnumb homolog (Drosophila)-like0.014
ZNF92zinc finger protein 920.014
LIMD1LIM domains containing 10.013
DAXXdeath-domain associated protein0.013
TNFRSF9tumor necrosis factor receptor superfamily, member 90.013
CAPN1calpain 1, (mu/I) large subunit0.013
GRB10growth factor receptor-bound protein 100.012
TNFSF14tumor necrosis factor (ligand) superfamily, member 140.012
PDCD6IPprogrammed cell death 6 interacting protein0.012
MATKmegakaryocyte-associated tyrosine kinase0.012
CLTCclathrin, heavy chain (Hc)0.011
TRAF3IP2TRAF3 interacting protein 20.011
IL2RGinterleukin 2 receptor, gamma0.011
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.011
ITKIL2-inducible T-cell kinase0.011
STAP2signal transducing adaptor family member 20.010
TNFAIP3tumor necrosis factor, alpha-induced protein 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.999
Ighimmunoglobulin heavy chain complex0.995
Ifnginterferon gamma0.948
Myd88myeloid differentiation primary response gene 880.947
Map3k14mitogen-activated protein kinase kinase kinase 140.943
Ltalymphotoxin A0.935
Cd19CD19 antigen0.897
Cd40CD40 antigen0.839
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.835
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.803
Stat3signal transducer and activator of transcription 30.742
FasFas (TNF receptor superfamily member 6)0.717
Krt8keratin 80.717
Krt6akeratin 6A0.692
Tlr4toll-like receptor 40.674
Traf6TNF receptor-associated factor 60.646
Pkp1plakophilin 10.618
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.609
Tnfaip3tumor necrosis factor, alpha-induced protein 30.496
Krt17keratin 170.490
Krt5keratin 50.448
Ikbkginhibitor of kappaB kinase gamma0.429
Il1r1interleukin 1 receptor, type I0.419
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.410
Krt33bkeratin 33B0.373
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.312
Gbp5guanylate binding protein 50.310
Ltblymphotoxin B0.303
Krt19keratin 190.292
Krt18keratin 180.273
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.266
Wnt10awingless related MMTV integration site 10a0.238
Csf1colony stimulating factor 1 (macrophage)0.216
Il4interleukin 40.215
Map3k7mitogen-activated protein kinase kinase kinase 70.209
Lyz2lysozyme 20.206
Traf2TNF receptor-associated factor 20.204
Socs1suppressor of cytokine signaling 10.195
Cd44CD44 antigen0.182
Sprr1asmall proline-rich protein 1A0.169
Casp4caspase 4, apoptosis-related cysteine peptidase0.168
Krt86keratin 860.163
Krtap8-1keratin associated protein 8-10.160
Il10interleukin 100.155
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.153
Psapl1prosaposin-like 10.151
Prf1perforin 1 (pore forming protein)0.144
Il7interleukin 70.142
Tff1trefoil factor 10.130
Bcl3B-cell leukemia/lymphoma 30.125
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.122
Icosinducible T-cell co-stimulator0.117
Il6interleukin 60.117
Ccl2chemokine (C-C motif) ligand 20.115
Ptgs2prostaglandin-endoperoxide synthase 20.114
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.100
Birc3baculoviral IAP repeat-containing 30.098
Bcl6B-cell leukemia/lymphoma 60.097
Krt71keratin 710.092
Krt7keratin 70.092
Ticam1toll-like receptor adaptor molecule 10.091
Syt8synaptotagmin VIII0.082
Krt27keratin 270.082
Ikbkbinhibitor of kappaB kinase beta0.082
Krtap3-1keratin associated protein 3-10.080
Nlrp3NLR family, pyrin domain containing 30.080
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.077
Krtap5-1keratin associated protein 5-10.076
Krt33akeratin 33A0.075
Il6stinterleukin 6 signal transducer0.074
Il22interleukin 220.074
Rnf31ring finger protein 310.069
5430421N21RikRIKEN cDNA 5430421N21 gene0.068
Tnfrsf18tumor necrosis factor receptor superfamily, member 180.063
Krt84keratin 840.061
Nos2nitric oxide synthase 2, inducible0.059
Cxcr5chemokine (C-X-C motif) receptor 50.058
Irak1interleukin-1 receptor-associated kinase 10.058
Alox12earachidonate lipoxygenase, epidermal0.057
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.057
Apoeapolipoprotein E0.055
Dlx3distal-less homeobox 30.052
Slurp1secreted Ly6/Plaur domain containing 10.050
Asprv1aspartic peptidase, retroviral-like 10.048
Mavsmitochondrial antiviral signaling protein0.048
S100a3S100 calcium binding protein A30.048
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.048
Krt4keratin 40.044
Krt14keratin 140.043
Stat6signal transducer and activator of transcription 60.043
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.041
Krt13keratin 130.038
Lgals7lectin, galactose binding, soluble 70.038
Il2interleukin 20.038
Ccl4chemokine (C-C motif) ligand 40.037
Cd40lgCD40 ligand0.037
Casp14caspase 140.036
Krt31keratin 310.036
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Krt18keratin 180.730
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.503
Tnftumor necrosis factor (TNF superfamily, member 2)0.439
Stat3signal transducer and activator of transcription 30.282
Lrp10low-density lipoprotein receptor-related protein 100.266
Il2rainterleukin 2 receptor, alpha0.163
Il6interleukin 60.154
Il1binterleukin 1 beta0.117
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.115
Icam1intercellular adhesion molecule 10.114
Arl5cADP-ribosylation factor-like 5C0.112
Cxcl10chemokine (C-X-C motif) ligand 100.107
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.096
Clec9aC-type lectin domain family 9, member a0.094
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.091
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.085
Ptafrplatelet-activating factor receptor0.082
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.082
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.076
Il4rainterleukin 4 receptor, alpha0.073
Arid5aAT rich interactive domain 5A (Mrf1 like)0.073
Adora2aadenosine A2a receptor0.071
LOC686323similar to thyroid receptor-interacting protein 60.069
Bcl3B-cell CLL/lymphoma 30.068
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.067
Ier3immediate early response 30.064
Ccl3chemokine (C-C motif) ligand 30.060
Hmox1heme oxygenase (decycling) 10.060
Il13ra1interleukin 13 receptor, alpha 10.060
Neurl3neuralized homolog 3 (Drosophila)0.058
Ripk3receptor-interacting serine-threonine kinase 30.057
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.056
Litaflipopolysaccharide-induced TNF factor0.055
Socs3suppressor of cytokine signaling 30.054
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.051
Ccl22chemokine (C-C motif) ligand 220.050
Cxcl2chemokine (C-X-C motif) ligand 20.049
Mvpmajor vault protein0.049
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.047
Ccl20chemokine (C-C motif) ligand 200.047
Clptm1cleft lip and palate associated transmembrane protein 10.046
Il1ainterleukin 1 alpha0.046
Selpselectin P0.045
Ptger4prostaglandin E receptor 4 (subtype EP4)0.043
Ninj1ninjurin 10.043
Lmnalamin A0.042
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.042
Gzmkgranzyme K0.041
Il1rl1interleukin 1 receptor-like 10.039
Eedembryonic ectoderm development0.038
Cd2Cd2 molecule0.038
Gpx2glutathione peroxidase 20.038
Tgm1transglutaminase 1, K polypeptide0.038
Calcbcalcitonin-related polypeptide, beta0.037
Birc3baculoviral IAP repeat-containing 30.037
Myd88myeloid differentiation primary response gene 880.037
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.037
Irak3interleukin-1 receptor-associated kinase 30.036
Bcl7cB-cell CLL/lymphoma 7C0.036
Fosl1fos-like antigen 10.035
Sellselectin L0.035
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.034
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.034
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.034
LOC100361706lambda-chain C1-region-like0.033
Socs5suppressor of cytokine signaling 50.033
Plxnb2plexin B20.033
Slc39a1solute carrier family 39 (zinc transporter), member 10.033
Ptger2prostaglandin E receptor 2 (subtype EP2)0.032
Runx1runt-related transcription factor 10.031
Lst1leukocyte specific transcript 10.031
Vps37cvacuolar protein sorting 37 homolog C (S. cerevisiae)0.031
Hivep2human immunodeficiency virus type I enhancer binding protein 20.031
Ccl4chemokine (C-C motif) ligand 40.031
Cd247Cd247 molecule0.031
Ptbp1polypyrimidine tract binding protein 10.031
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.029
Mt2Ametallothionein 2A0.029
Nrg1neuregulin 10.029
Fosl2fos-like antigen 20.029
Ripk2receptor-interacting serine-threonine kinase 20.028
Trim47tripartite motif-containing 470.028
S100gS100 calcium binding protein G0.027
Npepl1aminopeptidase-like 10.027
P2ry2purinergic receptor P2Y, G-protein coupled, 20.026
Ubdubiquitin D0.026
Sbno2strawberry notch homolog 2 (Drosophila)0.026
Hbegfheparin-binding EGF-like growth factor0.025
Vat1vesicle amine transport protein 1 homolog (T californica)0.025
Il6stinterleukin 6 signal transducer0.024
RGD1559588similar to cell surface receptor FDFACT0.024
TcrbT-cell receptor beta chain0.024
Epha2Eph receptor A20.023
Il7interleukin 70.023
Mmp8matrix metallopeptidase 80.023
Zc3h11azinc finger CCCH-type containing 11A0.023
Rrbp1ribosome binding protein 10.023
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism