The network for 'limbic system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

limbic system development

The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory.

NameDescriptionProbabilityFunc Analog Organism
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.996
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.979
ESR1estrogen receptor 10.968
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.918
UBR1ubiquitin protein ligase E3 component n-recognin 10.913
HDAC1histone deacetylase 10.905
FGF1fibroblast growth factor 1 (acidic)0.902
FGF10fibroblast growth factor 100.891
CASP9caspase 9, apoptosis-related cysteine peptidase0.880
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.857
SCHIP1schwannomin interacting protein 10.857
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.856
QKIquaking homolog, KH domain RNA binding (mouse)0.847
CRHR1corticotropin releasing hormone receptor 10.846
TSC2tuberous sclerosis 20.840
NCOA1nuclear receptor coactivator 10.831
CRHcorticotropin releasing hormone0.817
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.799
USP46ubiquitin specific peptidase 460.777
DLG4discs, large homolog 4 (Drosophila)0.771
VEGFAvascular endothelial growth factor A0.734
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.715
SOX10SRY (sex determining region Y)-box 100.697
BCL2L1BCL2-like 10.695
NR4A1nuclear receptor subfamily 4, group A, member 10.644
ADORA2Aadenosine A2a receptor0.635
PAX3paired box 30.610
APAF1apoptotic peptidase activating factor 10.607
ATXN1ataxin 10.564
MYOD1myogenic differentiation 10.563
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.553
GSK3Bglycogen synthase kinase 3 beta0.498
BCL2B-cell CLL/lymphoma 20.454
MKL1megakaryoblastic leukemia (translocation) 10.428
NR4A2nuclear receptor subfamily 4, group A, member 20.424
PAX8paired box 80.415
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.405
RXRAretinoid X receptor, alpha0.404
PPP5Cprotein phosphatase 5, catalytic subunit0.401
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.398
SCRIBscribbled homolog (Drosophila)0.396
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.387
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.376
HNF4Ahepatocyte nuclear factor 4, alpha0.363
XIAPX-linked inhibitor of apoptosis0.361
NCOR2nuclear receptor corepressor 20.356
BAK1BCL2-antagonist/killer 10.341
NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 10.311
PMLpromyelocytic leukemia0.309
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.309
RPL18Aribosomal protein L18a0.279
CASP7caspase 7, apoptosis-related cysteine peptidase0.262
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.250
ALKanaplastic lymphoma receptor tyrosine kinase0.244
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.242
MED25mediator complex subunit 250.238
FGF7fibroblast growth factor 70.231
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.230
PDX1pancreatic and duodenal homeobox 10.230
WWOXWW domain containing oxidoreductase0.229
FGFR1fibroblast growth factor receptor 10.227
TP53tumor protein p530.224
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.223
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.215
SPOPspeckle-type POZ protein0.213
BCL2L11BCL2-like 11 (apoptosis facilitator)0.211
MDM4Mdm4 p53 binding protein homolog (mouse)0.210
LPLlipoprotein lipase0.200
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.199
AXIN1axin 10.193
RAB3GAP2RAB3 GTPase activating protein subunit 2 (non-catalytic)0.190
LRP6low density lipoprotein receptor-related protein 60.184
NEDD4neural precursor cell expressed, developmentally down-regulated 40.176
CELF3CUGBP, Elav-like family member 30.176
CDK5cyclin-dependent kinase 50.175
MYOGmyogenin (myogenic factor 4)0.174
RNF144Bring finger protein 144B0.173
FEZ1fasciculation and elongation protein zeta 1 (zygin I)0.169
HDAC2histone deacetylase 20.162
MYLK2myosin light chain kinase 20.159
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.158
PAX6paired box 60.157
CLIP1CAP-GLY domain containing linker protein 10.156
TRIP12thyroid hormone receptor interactor 120.155
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.153
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.153
NUMBLnumb homolog (Drosophila)-like0.152
NCOA3nuclear receptor coactivator 30.152
LHX3LIM homeobox 30.152
RBPMSRNA binding protein with multiple splicing0.151
SOX11SRY (sex determining region Y)-box 110.150
FGF2fibroblast growth factor 2 (basic)0.146
FOXG1forkhead box G10.144
HDAC3histone deacetylase 30.138
SPRR2Asmall proline-rich protein 2A0.133
BIDBH3 interacting domain death agonist0.132
EP300E1A binding protein p3000.131
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.130
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ascl1aachaete-scute complex-like 1a (Drosophila)0.906
fgf3fibroblast growth factor 30.797
otpaorthopedia homolog a0.763
fezf2FEZ family zinc finger 20.732
dbx1adeveloping brain homeobox 1a0.721
lhx2bLIM homeobox 2b0.695
wnt8bwingless-type MMTV integration site family, member 8b0.694
barhl2BarH-like 20.657
gli1GLI-Kruppel family member 10.591
lef1lymphocyte enhancer binding factor 10.589
spry4sprouty (Drosophila) homolog 40.560
dlx1adistal-less homeobox gene 1a0.536
foxp2forkhead box P20.527
otx1borthodenticle homolog 1b0.523
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.497
wnt2bbwingless-type MMTV integration site family, member 2Bb0.493
lfnglunatic fringe homolog0.485
ndr2nodal-related 20.471
wnt3awingless-type MMTV integration site family, member 3A0.457
robo3roundabout homolog 30.357
hoxd4ahomeo box D4a0.350
efnb2aephrin B2a0.318
wnt10awingless-type MMTV integration site family, member 10a0.295
lmo3LIM domain only 30.295
zbtb4zinc finger and BTB domain containing 40.288
nrp1aneuropilin 1a0.279
dlx2adistal-less homeobox gene 2a0.271
shhasonic hedgehog a0.265
sox2SRY-box containing gene 20.256
gli3GLI-Kruppel family member GLI30.246
prox1prospero-related homeobox gene 10.242
arxaristaless related homeobox0.240
wnt9bwingless-type MMTV integration site family, member 9B0.220
itgavintegrin, alpha V0.197
sim1asingle-minded homolog 1a (Drosophila)0.194
fgfr3fibroblast growth factor receptor 30.192
ndr1nodal-related 10.185
fgf8afibroblast growth factor 8 a0.184
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.172
emx2empty spiracles homeobox 20.168
drd2ldopamine receptor D2 like0.166
foxd3forkhead box D30.162
hmgb1ahigh-mobility group box 1a0.162
vdravitamin D receptor a0.157
pax6apaired box gene 6a0.155
fabp7afatty acid binding protein 7, brain, a0.150
wnt1wingless-type MMTV integration site family, member 10.146
nr2e1nuclear receptor subfamily 2, group E, member 10.145
pou5f1POU domain, class 5, transcription factor 10.142
zic1zic family member 1 (odd-paired homolog, Drosophila)0.142
gng3guanine nucleotide binding protein (G protein), gamma 30.137
bdnfbrain-derived neurotrophic factor0.133
tal1T-cell acute lymphocytic leukemia 10.123
cdx4caudal type homeo box transcription factor 40.119
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.118
fzd7afrizzled homolog 7a0.112
wnt7bawingless-type MMTV integration site family, member 7Ba0.111
sox11bSRY-box containing gene 11b0.103
pitx3paired-like homeodomain transcription factor 30.101
cdh6cadherin 60.101
tbx1T-box 10.101
sox3SRY-box containing gene 30.101
runx1runt-related transcription factor 10.100
foxh1forkhead box H10.099
adcyap1r1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I0.099
map2k4amitogen-activated protein kinase kinase 4a0.098
axin2axin 2 (conductin, axil)0.096
dlx6adistal-less homeobox gene 6a0.093
sncbsynuclein, beta0.090
lhx5LIM homeobox 50.089
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.085
rarabretinoic acid receptor, alpha b0.084
mibmind bomb0.083
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.079
hnf1baHNF1 homeobox Ba0.077
hs3st3b1aheparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a0.076
sox21bSRY-box containing gene 21 b0.075
wnt7aawingless-type MMTV integration site family, member 7Aa0.072
ift88intraflagellar transport 88 homolog0.072
mapk1mitogen-activated protein kinase 10.072
cdh2cadherin 2, neuronal0.072
adarb1adenosine deaminase, RNA-specific, B10.071
otx2orthodenticle homolog 20.071
flhfloating head0.070
nr2e3nuclear receptor subfamily 2, group E, member 30.069
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.068
wnt2wingless-type MMTV integration site family member 20.068
pou3f1POU class 3 homeobox 10.067
pax7apaired box gene 7a0.066
adcyap1badenylate cyclase activating polypeptide 1b0.066
nrp2aneuropilin 2a0.064
lhx1aLIM homeobox 1a0.064
rx3retinal homeobox gene 30.062
nr4a2bnuclear receptor subfamily 4, group A, member 2b0.061
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)1.000
Sox2SRY-box containing gene 21.000
Shhsonic hedgehog1.000
Pax3paired box gene 30.999
Fgf10fibroblast growth factor 100.999
Pax2paired box gene 20.997
Isl1ISL1 transcription factor, LIM/homeodomain0.996
Pax6paired box gene 60.996
Gli3GLI-Kruppel family member GLI30.996
Hand1heart and neural crest derivatives expressed transcript 10.995
Ascl1achaete-scute complex homolog 1 (Drosophila)0.992
Msx1homeobox, msh-like 10.992
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.991
Rarbretinoic acid receptor, beta0.991
Hand2heart and neural crest derivatives expressed transcript 20.986
Fgf8fibroblast growth factor 80.986
Sox11SRY-box containing gene 110.984
Emx1empty spiracles homolog 1 (Drosophila)0.983
Lhx1LIM homeobox protein 10.983
Fgfr1fibroblast growth factor receptor 10.977
Eya1eyes absent 1 homolog (Drosophila)0.970
Dab1disabled homolog 1 (Drosophila)0.970
Dlx5distal-less homeobox 50.969
Foxg1forkhead box G10.967
Neurod1neurogenic differentiation 10.964
Sox3SRY-box containing gene 30.963
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.962
Hoxd13homeobox D130.960
Lef1lymphoid enhancer binding factor 10.958
Pitx1paired-like homeodomain transcription factor 10.951
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.950
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.936
Alx4aristaless-like homeobox 40.934
Hoxa13homeobox A130.918
Ctnnb1catenin (cadherin associated protein), beta 10.915
Lhx3LIM homeobox protein 30.908
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.907
Gscgoosecoid homeobox0.906
Prrx1paired related homeobox 10.899
Pitx2paired-like homeodomain transcription factor 20.898
Msx2homeobox, msh-like 20.889
Trp53transformation related protein 530.873
Hmx3H6 homeobox 30.871
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.862
Insm1insulinoma-associated 10.856
Hoxa1homeobox A10.849
Id1inhibitor of DNA binding 10.848
Fgfr2fibroblast growth factor receptor 20.846
Hoxd11homeobox D110.846
Wnt6wingless-related MMTV integration site 60.839
Dlx1distal-less homeobox 10.838
Hoxa11homeobox A110.831
Rargretinoic acid receptor, gamma0.828
Hes1hairy and enhancer of split 1 (Drosophila)0.820
Hoxa2homeobox A20.817
Sall3sal-like 3 (Drosophila)0.803
Gli2GLI-Kruppel family member GLI20.802
Wnt3awingless-related MMTV integration site 3A0.793
Cdx2caudal type homeobox 20.792
Neurog3neurogenin 30.790
Pou3f3POU domain, class 3, transcription factor 30.790
Hoxb1homeobox B10.788
Tlx3T-cell leukemia, homeobox 30.777
Hes5hairy and enhancer of split 5 (Drosophila)0.776
Bdnfbrain derived neurotrophic factor0.775
Pax9paired box gene 90.775
Lhx5LIM homeobox protein 50.762
Efnb2ephrin B20.752
Pax8paired box gene 80.741
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.738
Wnt1wingless-related MMTV integration site 10.736
Zic3zinc finger protein of the cerebellum 30.735
Phox2bpaired-like homeobox 2b0.710
Fgf5fibroblast growth factor 50.709
Pbx1pre B-cell leukemia transcription factor 10.708
Gbx2gastrulation brain homeobox 20.707
Bmp7bone morphogenetic protein 70.705
Neurog2neurogenin 20.697
Hoxd3homeobox D30.693
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.692
Bbs4Bardet-Biedl syndrome 4 (human)0.687
Emx2empty spiracles homolog 2 (Drosophila)0.686
Lmx1bLIM homeobox transcription factor 1 beta0.683
Epha4Eph receptor A40.680
Foxh1forkhead box H10.667
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.664
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.651
Rararetinoic acid receptor, alpha0.651
En1engrailed 10.625
Drd2dopamine receptor D20.622
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.615
Sim1single-minded homolog 1 (Drosophila)0.613
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.610
Cdh6cadherin 60.610
Mmp24matrix metallopeptidase 240.610
Zic1zinc finger protein of the cerebellum 10.609
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cckbrcholecystokinin B receptor0.320
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.275
Crhbpcorticotropin releasing hormone binding protein0.274
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.251
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.218
Egr3early growth response 30.206
Tgfbr2transforming growth factor, beta receptor II0.181
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.161
Dlg4discs, large homolog 4 (Drosophila)0.150
Npy5rneuropeptide Y receptor Y50.138
Nr4a2nuclear receptor subfamily 4, group A, member 20.137
Lgals3lectin, galactoside-binding, soluble, 30.118
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.115
Adra2cadrenergic, alpha-2C-, receptor0.115
Shank1SH3 and multiple ankyrin repeat domains 10.114
Anxa2annexin A20.111
Nr5a2nuclear receptor subfamily 5, group A, member 20.106
Gng7guanine nucleotide binding protein (G protein), gamma 70.101
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.100
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.098
DbpD site of albumin promoter (albumin D-box) binding protein0.097
Bmp6bone morphogenetic protein 60.095
Arandrogen receptor0.094
Neurod2neurogenic differentiation 20.093
Pax6paired box 60.089
S100a10S100 calcium binding protein A100.087
Ptprcprotein tyrosine phosphatase, receptor type, C0.086
Svs4seminal vesicle secretory protein 40.086
Rup2urinary protein 20.085
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.084
Myo1dmyosin ID0.084
Nat1N-acetyltransferase 10.080
Aqp4aquaporin 40.078
Trhr2thyrotropin releasing hormone receptor 20.077
Prlhrprolactin releasing hormone receptor0.076
Nkx6-1NK6 homeobox 10.076
Acrv1acrosomal vesicle protein 10.075
Drd1adopamine receptor D1A0.073
Atxn1ataxin 10.073
Cnksr2connector enhancer of kinase suppressor of Ras 20.072
Ghsrgrowth hormone secretagogue receptor0.072
Arnt2aryl hydrocarbon receptor nuclear translocator 20.071
Actr2ARP2 actin-related protein 2 homolog (yeast)0.070
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.069
Tlr4toll-like receptor 40.068
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.066
Tacr3tachykinin receptor 30.065
Sfrp4secreted frizzled-related protein 40.064
Chrnecholinergic receptor, nicotinic, epsilon0.063
Cgm4carcinoembryonic antigen gene family 40.060
Olr1493olfactory receptor gene Olr14930.060
Chrm1cholinergic receptor, muscarinic 10.060
Iappislet amyloid polypeptide0.059
Akr1c14aldo-keto reductase family 1, member C140.059
Ucp1uncoupling protein 1 (mitochondrial, proton carrier)0.059
Rims1regulating synaptic membrane exocytosis 10.059
Kcnt1potassium channel, subfamily T, member 10.059
Grm1glutamate receptor, metabotropic 10.059
Chrna7cholinergic receptor, nicotinic, alpha 70.059
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.057
Anxa1annexin A10.057
Adora3adenosine A3 receptor0.057
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.057
Ube2d4ubiquitin-conjugating enzyme E2D 40.056
Itpr2inositol 1,4,5-triphosphate receptor, type 20.056
Cysscystatin S0.055
Nr1d2nuclear receptor subfamily 1, group D, member 20.055
Ghrhgrowth hormone releasing hormone0.055
Lrrc7leucine rich repeat containing 70.055
Gfra2GDNF family receptor alpha 20.055
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.053
Anxa5annexin A50.053
Impg2interphotoreceptor matrix proteoglycan 20.052
Cd38CD38 molecule0.050
Gtf2igeneral transcription factor II I0.050
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.049
Vipvasoactive intestinal peptide0.049
Jak2Janus kinase 20.049
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.049
S100a6S100 calcium binding protein A60.049
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.048
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.048
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.048
Vcsa1variable coding sequence A10.048
Hrh2histamine receptor H 20.048
Foxj1forkhead box J10.048
Rxrgretinoid X receptor gamma0.047
Gja4gap junction protein, alpha 40.046
Akap5A kinase (PRKA) anchor protein 50.046
Klrg1killer cell lectin-like receptor subfamily G, member 10.046
Prkg2protein kinase, cGMP-dependent, type II0.045
Vom1r97vomeronasal 1 receptor 970.045
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.045
Ppypancreatic polypeptide0.045
Il15interleukin 150.044
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism