The network for 'establishment or maintenance of cytoskeleton polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment or maintenance of cytoskeleton polarity

Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.

NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)1.000
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide1.000
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide1.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
SFNstratifin0.999
EIF4A3eukaryotic translation initiation factor 4A30.998
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.998
GSK3Bglycogen synthase kinase 3 beta0.996
APCadenomatous polyposis coli0.996
OCRLoculocerebrorenal syndrome of Lowe0.996
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.993
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.982
PRKCZprotein kinase C, zeta0.978
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.978
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.976
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.975
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.974
HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B10.969
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.966
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.956
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.953
RHOAras homolog gene family, member A0.931
ARHGAP1Rho GTPase activating protein 10.922
MAPRE1microtubule-associated protein, RP/EB family, member 10.919
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.887
HNRNPKheterogeneous nuclear ribonucleoprotein K0.879
CLIP1CAP-GLY domain containing linker protein 10.783
HNRNPFheterogeneous nuclear ribonucleoprotein F0.766
MAPRE2microtubule-associated protein, RP/EB family, member 20.758
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.744
CDC25Bcell division cycle 25 homolog B (S. pombe)0.737
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.719
AKAP11A kinase (PRKA) anchor protein 110.695
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.639
PRKCIprotein kinase C, iota0.623
KEAP1kelch-like ECH-associated protein 10.618
STRADASTE20-related kinase adaptor alpha0.597
KIF5Bkinesin family member 5B0.537
MAPRE3microtubule-associated protein, RP/EB family, member 30.526
AKAP9A kinase (PRKA) anchor protein (yotiao) 90.525
CHN2chimerin (chimaerin) 20.519
NCF2neutrophil cytosolic factor 20.510
PTBP2polypyrimidine tract binding protein 20.491
KIFAP3kinesin-associated protein 30.457
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.450
PRR5proline rich 5 (renal)0.446
MARK2MAP/microtubule affinity-regulating kinase 20.441
MAPTmicrotubule-associated protein tau0.441
RANBP2RAN binding protein 20.438
YBX1Y box binding protein 10.433
SH3RF3SH3 domain containing ring finger 30.432
DCAF7DDB1 and CUL4 associated factor 70.423
SETSET nuclear oncogene0.416
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.396
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.387
TACC3transforming, acidic coiled-coil containing protein 30.384
LMO2LIM domain only 2 (rhombotin-like 1)0.383
PCBP1poly(rC) binding protein 10.371
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.370
AKT1S1AKT1 substrate 1 (proline-rich)0.369
HMGA1high mobility group AT-hook 10.369
HNRNPA1heterogeneous nuclear ribonucleoprotein A10.352
NINninein (GSK3B interacting protein)0.348
SRPK1SRSF protein kinase 10.347
XIAPX-linked inhibitor of apoptosis0.327
KIF1Bkinesin family member 1B0.323
RAB11FIP1RAB11 family interacting protein 1 (class I)0.319
CBFBcore-binding factor, beta subunit0.313
HDAC4histone deacetylase 40.313
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.313
CTDP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 10.304
HNRNPRheterogeneous nuclear ribonucleoprotein R0.291
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.290
SRSF2serine/arginine-rich splicing factor 20.281
CLASP2cytoplasmic linker associated protein 20.277
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.276
CALM1calmodulin 1 (phosphorylase kinase, delta)0.269
RAB11FIP2RAB11 family interacting protein 2 (class I)0.263
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.261
HNRNPA0heterogeneous nuclear ribonucleoprotein A00.238
SORBS3sorbin and SH3 domain containing 30.227
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.225
HNRNPA3heterogeneous nuclear ribonucleoprotein A30.217
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.214
STAU1staufen, RNA binding protein, homolog 1 (Drosophila)0.213
STK4serine/threonine kinase 40.205
ADAMTSL4ADAMTS-like 40.202
SYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting protein0.189
JUPjunction plakoglobin0.187
SRPK2SRSF protein kinase 20.186
TPX2TPX2, microtubule-associated, homolog (Xenopus laevis)0.183
NCKAP1NCK-associated protein 10.183
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.180
AKT2v-akt murine thymoma viral oncogene homolog 20.175
BADBCL2-associated agonist of cell death0.174
RAP1GDS1RAP1, GTP-GDP dissociation stimulator 10.174
PKP3plakophilin 30.169
ITGB4integrin, beta 40.166
RAB14RAB14, member RAS oncogene family0.163
LAD1ladinin 10.156
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
bazbazooka0.990
Dhc64CDynein heavy chain 64C0.962
Lis-1Lissencephaly-10.948
sqhspaghetti squash0.927
Cdc42CG12530 gene product from transcript CG12530-RA0.924
rokRho-kinase0.887
Eb1CG3265 gene product from transcript CG3265-RF0.823
Rab5Rab-protein 50.695
miminus0.677
sqdsquid0.670
LamLamin0.609
oskoskar0.588
par-6CG5884 gene product from transcript CG5884-RA0.553
Src64BSrc oncogene at 64B0.550
cactcactus0.546
shgshotgun0.528
par-1CG8201 gene product from transcript CG8201-RA0.488
BicDBicaudal D0.460
gishgilgamesh0.448
jarjaguar0.358
orboo18 RNA-binding protein0.329
spn-FCG12114 gene product from transcript CG12114-RA0.319
aPKCatypical protein kinase C0.292
Atx2Ataxin-20.290
vasvasa0.278
dpdumpy0.270
chicchickadee0.267
msnmisshapen0.254
ovoCG6824 gene product from transcript CG6824-RE0.254
grkgurken0.250
capucappuccino0.238
klarklarsicht0.238
Pak3CG14895 gene product from transcript CG14895-RA0.231
wlswntless0.221
AblAbl tyrosine kinase0.214
trctricornered0.213
Arp66BActin-related protein 66B0.211
snsinged0.191
staistathmin0.189
rinrasputin0.185
Kap3Kinesin associated protein 30.179
scbscab0.170
lkb1CG9374 gene product from transcript CG9374-RJ0.166
cpacapping protein alpha0.162
dshdishevelled0.160
Pi3K21BCG2699 gene product from transcript CG2699-RA0.153
Tm1Tropomyosin 10.153
Ras64BRas oncogene at 64B0.143
BicCBicaudal C0.137
ensensconsin0.135
fs(1)Nfemale sterile (1) Nasrat0.134
DlicDynein light intermediate chain0.133
MntCG13316 gene product from transcript CG13316-RD0.128
sec5CG8843 gene product from transcript CG8843-RA0.124
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.121
Klp64DKinesin-like protein at 64D0.115
Top1Topoisomerase 10.115
GdiGDP dissociation inhibitor0.114
Apc2Adenomatous polyposis coli tumor suppressor homolog 20.111
Vrp1Verprolin 10.110
eaeaster0.107
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.105
Klp10ACG1453 gene product from transcript CG1453-RA0.104
Sop2Suppressor of profilin 20.101
spirspire0.100
saxsaxophone0.100
tacctransforming acidic coiled-coil protein0.099
Fs(2)KetFemale sterile (2) Ketel0.098
kugkugelei0.098
PknProtein kinase related to protein kinase N0.094
nufnuclear fallout0.094
RalaRas-related protein0.093
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.092
rasraspberry0.091
wunwunen0.090
armarmadillo0.090
belbelle0.088
otkoff-track0.088
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.087
pucpuckered0.087
Cdc27CG8610 gene product from transcript CG8610-RA0.086
VangVan Gogh0.084
toctoucan0.084
armiarmitage0.083
liclicorne0.081
sds22CG5851 gene product from transcript CG5851-RA0.080
nebnebbish0.079
pumpumilio0.076
katanin-60katanin 600.073
Rac1CG2248 gene product from transcript CG2248-RA0.073
Rho1CG8416 gene product from transcript CG8416-RB0.071
vihvihar0.071
JraJun-related antigen0.070
Upf2CG2253 gene product from transcript CG2253-RA0.070
Nup154Nucleoporin 1540.070
exuexuperantia0.069
AGO3Argonaute 30.068
sharkSrc homology 2, ankyrin repeat, tyrosine kinase0.068
ttktramtrack0.066
flrflare0.065
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide1.000
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
Kif3akinesin family member 3A0.908
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.900
Smad4MAD homolog 4 (Drosophila)0.881
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.853
Raver2ribonucleoprotein, PTB-binding 20.852
Rac1RAS-related C3 botulinum substrate 10.850
Vhlvon Hippel-Lindau tumor suppressor0.850
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.773
RictorRPTOR independent companion of MTOR, complex 20.771
Stx12syntaxin 120.698
Snrpd1small nuclear ribonucleoprotein D10.680
Mtpnmyotrophin0.647
Bicd2bicaudal D homolog 2 (Drosophila)0.635
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.612
Jarid2jumonji, AT rich interactive domain 20.607
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.603
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.587
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.581
Ctnnb1catenin (cadherin associated protein), beta 10.574
Apcadenomatosis polyposis coli0.551
Csnk1a1casein kinase 1, alpha 10.544
Lrrk2leucine-rich repeat kinase 20.544
Dync1i2dynein cytoplasmic 1 intermediate chain 20.515
Fusfusion, derived from t(12;16) malignant liposarcoma (human)0.467
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.451
Kif3bkinesin family member 3B0.434
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.429
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.420
Ezh1enhancer of zeste homolog 1 (Drosophila)0.407
Gsk3bglycogen synthase kinase 3 beta0.388
Vapavesicle-associated membrane protein, associated protein A0.381
Ap2b1adaptor-related protein complex 2, beta 1 subunit0.359
Smad3MAD homolog 3 (Drosophila)0.336
Actr3ARP3 actin-related protein 3 homolog (yeast)0.322
Rpgrip1lRpgrip1-like0.310
Rptorregulatory associated protein of MTOR, complex 10.309
Nptnneuroplastin0.308
Stat5asignal transducer and activator of transcription 5A0.287
Ccdc64coiled-coil domain containing 640.286
Mapre1microtubule-associated protein, RP/EB family, member 10.276
Ncoa2nuclear receptor coactivator 20.273
Sfnstratifin0.267
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.260
Prkceprotein kinase C, epsilon0.250
Capza2capping protein (actin filament) muscle Z-line, alpha 20.237
Pfn2profilin 20.237
Thbs1thrombospondin 10.235
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.225
Wdr1WD repeat domain 10.217
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.206
Kif5ckinesin family member 5C0.200
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.200
Spna2spectrin alpha 20.200
Ttc7tetratricopeptide repeat domain 70.197
Kifap3kinesin-associated protein 30.183
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.182
Rtn4reticulon 40.179
Hif1ahypoxia inducible factor 1, alpha subunit0.178
Mapkap1mitogen-activated protein kinase associated protein 10.176
Gja1gap junction protein, alpha 10.175
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.172
Ctnnd1catenin (cadherin associated protein), delta 10.172
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.171
Rab1RAB1, member RAS oncogene family0.170
U2af2U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 20.169
Lmnalamin A0.168
Bmpr1abone morphogenetic protein receptor, type 1A0.165
Dstndestrin0.162
Cltcclathrin, heavy polypeptide (Hc)0.158
Msh2mutS homolog 2 (E. coli)0.158
Aplp2amyloid beta (A4) precursor-like protein 20.152
Msnmoesin0.151
Raver1ribonucleoprotein, PTB-binding 10.150
Ppargperoxisome proliferator activated receptor gamma0.146
Lama5laminin, alpha 50.142
Dnajc5DnaJ (Hsp40) homolog, subfamily C, member 50.140
Trp63transformation related protein 630.139
Klc1kinesin light chain 10.138
Itgb1integrin beta 1 (fibronectin receptor beta)0.135
Pa2g4proliferation-associated 2G40.134
Hnrnpa1heterogeneous nuclear ribonucleoprotein A10.132
Arf4ADP-ribosylation factor 40.130
Snx6sorting nexin 60.130
Stxbp1syntaxin binding protein 10.128
Cyfip1cytoplasmic FMR1 interacting protein 10.127
Serinc1serine incorporator 10.125
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.123
Smad1MAD homolog 1 (Drosophila)0.122
Macf1microtubule-actin crosslinking factor 10.121
Lmnb1lamin B10.121
Nf2neurofibromatosis 20.117
Rab10RAB10, member RAS oncogene family0.116
Fkbp1aFK506 binding protein 1a0.116
Gna13guanine nucleotide binding protein, alpha 130.114
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.113
Impad1inositol monophosphatase domain containing 10.113
Clic4chloride intracellular channel 4 (mitochondrial)0.110
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.110
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
TOR2Tor2p0.567
SLM1Slm1p0.485
YPK1Ypk1p0.423
TSC11Tsc11p0.409
SLM2Slm2p0.337
AVO1Avo1p0.167
RHO1Rho1p0.129
MOB1Mob1p0.077
ROM2Rom2p0.075
TOR1Tor1p0.056
BIT2Bit2p0.044
DBF20Dbf20p0.041
PEF1Pef1p0.040
LST8Lst8p0.031
YER064Chypothetical protein0.030
MSS4Mss4p0.028
SGE1Sge1p0.028
MOB2Mob2p0.027
RDI1Rdi1p0.026
BIT61Bit61p0.022
TCO89Tco89p0.022
PRS2Prs2p0.022
SRD1Srd1p0.021
TAO3Tao3p0.021
BIG1Big1p0.020
GYL1Gyl1p0.020
SHE2She2p0.019
YLR162Whypothetical protein0.019
LEU2Leu2p0.018
YLR264C-Ahypothetical protein0.018
YOL038C-Ahypothetical protein0.017
KRE9Kre9p0.017
MER1Mer1p0.017
KIC1Kic1p0.017
ARP10Arp10p0.016
THG1Thg1p0.016
YLR042Chypothetical protein0.015
HLJ1Hlj1p0.015
MF(ALPHA)2Mf(alpha)2p0.015
URA3Ura3p0.015
YIL151Chypothetical protein0.014
SPL2Spl2p0.014
YIR035Chypothetical protein0.014
YMR295Chypothetical protein0.014
YNL058Chypothetical protein0.014
IML1Iml1p0.014
TSC3Tsc3p0.013
YAR068Whypothetical protein0.013
YFR039Chypothetical protein0.013
CHA1Cha1p0.013
ARO10Aro10p0.013
YLR108Chypothetical protein0.013
CUP1-1Cup1-1p0.013
HXT3Hxt3p0.013
ATP6Atp6p0.013
YCH1Ych1p0.013
ARG8Arg8p0.013
RIO2Rio2p0.013
MF(ALPHA)1Mf(alpha)1p0.013
YBR013Chypothetical protein0.013
UPS3Ups3p0.012
CRP1Crp1p0.012
AUA1Aua1p0.012
SEC72Sec72p0.012
CPD1Cpd1p0.012
ZPS1Zps1p0.012
DIC1Dic1p0.012
SWC7Swc7p0.012
OPT2Opt2p0.012
HPF1Hpf1p0.012
PFS1Pfs1p0.012
SCM4Scm4p0.012
YPR157Whypothetical protein0.012
REE1Ree1p0.012
MYO1Myo1p0.011
YJL181Whypothetical protein0.011
RHO4Rho4p0.011
INN1Inn1p0.011
SRX1Srx1p0.011
PCL9Pcl9p0.011
YOL013W-Ahypothetical protein0.011
DUR1,2Dur1,2p0.011
SWT1Swt1p0.011
IZH4Izh4p0.011
ARO9Aro9p0.011
AQY2Aqy2p0.011
SKS1Sks1p0.011
BNA4Bna4p0.011
MSB4Msb4p0.011
ERT1Ert1p0.011
ICS2Ics2p0.011
DUR3Dur3p0.011
FMT1Fmt1p0.011
ALT2Alt2p0.010
CDC15Cdc15p0.010
YKR075Chypothetical protein0.010
YLL053Chypothetical protein0.010
NCE103Nce103p0.010
RNP1Rnp1p0.010
YJL218Whypothetical protein0.010