The network for 'lens development in camera type eye' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lens development in camera type eye

The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

NameDescriptionProbabilityFunc Analog Organism
SP1Sp1 transcription factor0.984
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.976
SMAD2SMAD family member 20.967
ENGendoglin0.948
SMAD4SMAD family member 40.936
SMAD3SMAD family member 30.927
FGF1fibroblast growth factor 1 (acidic)0.867
EP300E1A binding protein p3000.790
FN1fibronectin 10.759
TJP1tight junction protein 1 (zona occludens 1)0.738
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.674
PBX1pre-B-cell leukemia homeobox 10.666
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.484
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.465
MDM2Mdm2 p53 binding protein homolog (mouse)0.452
HNF4Ahepatocyte nuclear factor 4, alpha0.403
TGFB1transforming growth factor, beta 10.402
CAV1caveolin 1, caveolae protein, 22kDa0.396
RB1retinoblastoma 10.390
SCHIP1schwannomin interacting protein 10.384
SKILSKI-like oncogene0.383
TGFBR1transforming growth factor, beta receptor 10.380
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.375
FGFR1fibroblast growth factor receptor 10.347
BCL9B-cell CLL/lymphoma 90.337
YY1YY1 transcription factor0.334
CRYBB2crystallin, beta B20.326
FSTL1follistatin-like 10.325
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.315
TP53tumor protein p530.303
EFNA1ephrin-A10.273
HIPK2homeodomain interacting protein kinase 20.248
TACC1transforming, acidic coiled-coil containing protein 10.246
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.246
HDAC1histone deacetylase 10.243
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.236
RASSF5Ras association (RalGDS/AF-6) domain family member 50.235
CLSPNclaspin0.227
TGFB3transforming growth factor, beta 30.221
BTRCbeta-transducin repeat containing0.208
PVRL4poliovirus receptor-related 40.208
ZFYVE9zinc finger, FYVE domain containing 90.191
HCFC1host cell factor C1 (VP16-accessory protein)0.184
CTGFconnective tissue growth factor0.183
FGF10fibroblast growth factor 100.182
HTThuntingtin0.176
SREBF2sterol regulatory element binding transcription factor 20.155
PVRL3poliovirus receptor-related 30.154
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.151
SKIv-ski sarcoma viral oncogene homolog (avian)0.149
PXNpaxillin0.144
NCOR1nuclear receptor corepressor 10.138
SIN3ASIN3 homolog A, transcription regulator (yeast)0.133
PTPN11protein tyrosine phosphatase, non-receptor type 110.128
SIRT2sirtuin 20.123
MEIS2Meis homeobox 20.123
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.120
DAXXdeath-domain associated protein0.120
GAB1GRB2-associated binding protein 10.118
CREBBPCREB binding protein0.118
RUNX1runt-related transcription factor 10.117
SMAD7SMAD family member 70.114
MAKmale germ cell-associated kinase0.111
FLNAfilamin A, alpha0.106
RAD23ARAD23 homolog A (S. cerevisiae)0.100
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.099
CREB1cAMP responsive element binding protein 10.096
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.093
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.088
NRP1neuropilin 10.086
EPAS1endothelial PAS domain protein 10.086
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.084
BCRbreakpoint cluster region0.083
FKBP1AFK506 binding protein 1A, 12kDa0.083
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.083
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.082
FBLN1fibulin 10.076
PMLpromyelocytic leukemia0.076
TRIM28tripartite motif containing 280.074
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.074
NFYAnuclear transcription factor Y, alpha0.074
SOX2SRY (sex determining region Y)-box 20.071
CRYBB3crystallin, beta B30.070
UHRF2ubiquitin-like with PHD and ring finger domains 20.069
KRT8keratin 80.069
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.067
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.066
SMAD1SMAD family member 10.066
MAFBv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.066
THBS1thrombospondin 10.065
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.063
SALL2sal-like 2 (Drosophila)0.062
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.062
STK4serine/threonine kinase 40.061
CSNK1Dcasein kinase 1, delta0.061
FYNFYN oncogene related to SRC, FGR, YES0.060
KCTD1potassium channel tetramerisation domain containing 10.060
CDK6cyclin-dependent kinase 60.058
POGZpogo transposable element with ZNF domain0.058
FGF7fibroblast growth factor 70.056
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
crygmxl2crystallin, gamma MX, like 20.842
dlcdeltaC0.715
foxe3forkhead box E30.610
cryba4crystallin, beta A40.583
pax6bpaired box gene 6b0.552
foxa2forkhead box A20.552
bmp2bbone morphogenetic protein 2b0.473
dnmt4DNA (cytosine-5-)-methyltransferase 40.432
mab21l2mab-21-like 20.423
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.400
crygm3crystallin, gamma M30.393
pax6apaired box gene 6a0.380
cdh2cadherin 2, neuronal0.378
crygm6crystallin, gamma M60.314
pxnpaxillin0.303
crygm1crystallin, gamma M10.300
otx1borthodenticle homolog 1b0.294
scinlascinderin like a0.279
ascl1aachaete-scute complex-like 1a (Drosophila)0.274
crygm2fcrystallin, gamma M2f0.258
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.255
mdkamidkine-related growth factor0.253
fstafollistatin a0.250
myod1myogenic differentiation 10.234
shhasonic hedgehog a0.212
tp63tumor protein p630.211
notch1anotch homolog 1a0.204
rx2retinal homeobox gene 20.195
crygn1crystallin, gamma N10.193
fgfr2fibroblast growth factor receptor 20.191
gdf6agrowth differentiation factor 6a0.184
crygm2d11crystallin, gamma M2d110.184
emx3empty spiracles homeobox 30.183
rx1retinal homeobox gene 10.182
pea3ETS-domain transcription factor pea30.180
lamb1alaminin, beta 1a0.173
unc5bunc-5 homolog B (C. elegans)0.172
cryaacrystallin, alpha A0.163
six2asine oculis-related homeobox 2a0.159
pitx2paired-like homeodomain transcription factor 20.158
crygm2d2crystallin, gamma M2d20.151
otx2orthodenticle homolog 20.141
her6hairy-related 60.137
sox2SRY-box containing gene 20.136
dnmt6DNA (cytosine-5-)-methyltransferase 60.135
crygm2acrystallin, gamma M2a0.125
lama2laminin, alpha 20.123
cryba2acrystallin, beta A2a0.122
foxi3bforkhead box I3b0.122
crygm4crystallin, gamma M40.121
nr2e1nuclear receptor subfamily 2, group E, member 10.120
crygmxcrystallin, gamma MX0.115
foxi1forkhead box I10.113
bocbrother of CDO0.112
vsx2visual system homeobox 20.109
neurog1neurogenin 10.108
fgfr4fibroblast growth factor receptor 40.106
crygm2bcrystallin, gamma M2b0.106
cryabacrystallin, alpha B, a0.103
jag1bjagged 1b0.103
aqp10baquaporin 10b0.103
zgc:171792zgc:1717920.101
crygm7crystallin, gamma M70.101
crygs1crystallin, gamma S10.096
crygm2d8crystallin, gamma M2d80.096
crestincrestin0.093
mipbmajor intrinsic protein of lens fiber b0.092
cx55.5connexin 55.50.089
lama5laminin, alpha 50.088
crygm2d10crystallin, gamma M2d100.088
crabp2acellular retinoic acid binding protein 2, a0.088
extl3exostoses (multiple)-like 30.086
notch3notch homolog 30.085
edn1endothelin 10.083
trpm7transient receptor potential cation channel, subfamily M, member 70.083
crygm2d16crystallin, gamma M2d160.082
gata2aGATA-binding protein 2a0.080
crygm2d7crystallin, gamma M2d70.079
sema3aasemaphorin 3aa0.077
irx1biroquois homeobox protein 1, b0.077
disp1dispatched homolog 1 (Drosophila)0.077
crygmxl1crystallin, gamma MX, like 10.076
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.075
crygn2crystallin, gamma N20.074
crygm2d15crystallin, gamma M2d150.073
fgf3fibroblast growth factor 30.071
grifingalectin related inter-fiber protein0.070
nr2f5nuclear receptor subfamily 2, group F, member 50.070
msxdmuscle segment homeobox D0.066
coe2coe20.065
nr2f6bnuclear receptor subfamily 2, group F, member 6b0.064
ebf3early B-cell factor 30.064
fgfrl1afibroblast growth factor receptor-like 1a0.063
cryba2bcrystallin, beta A2b0.063
fgfr3fibroblast growth factor receptor 30.060
dnmt8DNA (cytosine-5-)-methyltransferase 80.059
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.059
fn1fibronectin 10.059
pitx3paired-like homeodomain transcription factor 30.058
emx2empty spiracles homeobox 20.057
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ntf3neurotrophin 30.996
Shhsonic hedgehog0.986
Smad4MAD homolog 4 (Drosophila)0.983
Bmp4bone morphogenetic protein 40.982
Pax6paired box gene 60.981
Pax3paired box gene 30.980
Smad3MAD homolog 3 (Drosophila)0.976
Pbx1pre B-cell leukemia transcription factor 10.968
Nodalnodal0.964
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.958
Gata4GATA binding protein 40.954
Ptpn11protein tyrosine phosphatase, non-receptor type 110.954
Hand2heart and neural crest derivatives expressed transcript 20.942
Isl1ISL1 transcription factor, LIM/homeodomain0.936
Otx2orthodenticle homolog 2 (Drosophila)0.925
Gli3GLI-Kruppel family member GLI30.921
Bmpr1abone morphogenetic protein receptor, type 1A0.920
Tcfap2atranscription factor AP-2, alpha0.900
Hoxd13homeobox D130.887
Fgf8fibroblast growth factor 80.861
Pitx2paired-like homeodomain transcription factor 20.824
Smad1MAD homolog 1 (Drosophila)0.789
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.786
Foxf1aforkhead box F1a0.781
Pou3f3POU domain, class 3, transcription factor 30.775
Gata6GATA binding protein 60.768
Eya1eyes absent 1 homolog (Drosophila)0.753
Foxh1forkhead box H10.752
Epha2Eph receptor A20.727
Gbx2gastrulation brain homeobox 20.708
Grb2growth factor receptor bound protein 20.705
Atoh7atonal homolog 7 (Drosophila)0.705
Hand1heart and neural crest derivatives expressed transcript 10.704
Dok1docking protein 10.694
Sox2SRY-box containing gene 20.692
Apcadenomatosis polyposis coli0.681
Tbx3T-box 30.674
Pax2paired box gene 20.668
Fgfr2fibroblast growth factor receptor 20.649
Zic3zinc finger protein of the cerebellum 30.647
Trp53transformation related protein 530.645
Ptenphosphatase and tensin homolog0.639
Foxg1forkhead box G10.627
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.600
Crygdcrystallin, gamma D0.593
Fstfollistatin0.576
Smad6MAD homolog 6 (Drosophila)0.562
Ror1receptor tyrosine kinase-like orphan receptor 10.562
Sox9SRY-box containing gene 90.558
Sox4SRY-box containing gene 40.548
Krt14keratin 140.530
Hmx1H6 homeobox 10.527
Tgfbr2transforming growth factor, beta receptor II0.517
Retret proto-oncogene0.480
Lgals7lectin, galactose binding, soluble 70.476
Shc1src homology 2 domain-containing transforming protein C10.476
Fzd7frizzled homolog 7 (Drosophila)0.474
Jag1jagged 10.470
Ptk7PTK7 protein tyrosine kinase 70.469
Ephb2Eph receptor B20.466
Cryaacrystallin, alpha A0.464
Tgfb2transforming growth factor, beta 20.454
Engendoglin0.450
Foxc1forkhead box C10.448
Msx2homeobox, msh-like 20.446
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.409
Acvr1activin A receptor, type 10.400
Pou4f2POU domain, class 4, transcription factor 20.395
Axin1axin 10.390
Nf1neurofibromatosis 10.389
Hes1hairy and enhancer of split 1 (Drosophila)0.381
Ptk2PTK2 protein tyrosine kinase 20.376
UncxUNC homeobox0.360
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.359
Neurod1neurogenic differentiation 10.353
Snai1snail homolog 1 (Drosophila)0.344
Prph2peripherin 20.341
Hdac1histone deacetylase 10.324
Gata3GATA binding protein 30.324
Fgf3fibroblast growth factor 30.321
Krt7keratin 70.319
Prphperipherin0.316
Dkk1dickkopf homolog 1 (Xenopus laevis)0.301
Myl7myosin, light polypeptide 7, regulatory0.297
Klf3Kruppel-like factor 3 (basic)0.296
Smad2MAD homolog 2 (Drosophila)0.296
Sox1SRY-box containing gene 10.289
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.283
Efna2ephrin A20.282
Arid1aAT rich interactive domain 1A (SWI-like)0.279
Hoxb4homeobox B40.274
Inpp5dinositol polyphosphate-5-phosphatase D0.273
Yap1yes-associated protein 10.270
Krt8keratin 80.269
Pitx3paired-like homeodomain transcription factor 30.269
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.268
Tcfap2btranscription factor AP-2 beta0.266
Pkp1plakophilin 10.263
Tbx2T-box 20.263
Sox11SRY-box containing gene 110.262
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.857
Tgfbr2transforming growth factor, beta receptor II0.175
Castcalpastatin0.173
Crygccrystallin, gamma C0.154
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.139
Adam10ADAM metallopeptidase domain 100.132
Crygbcrystallin, gamma B0.113
Cryba1crystallin, beta A10.108
Lepleptin0.107
Ptprcprotein tyrosine phosphatase, receptor type, C0.101
Anxa1annexin A10.095
Mipmajor intrinsic protein of lens fiber0.094
Lim2lens intrinsic membrane protein 20.090
Crybb3crystallin, beta B30.085
Tubb5tubulin, beta 50.081
Anxa2annexin A20.078
Foxe3forkhead box E30.073
Bmpr1abone morphogenetic protein receptor, type IA0.070
Cdk2cyclin dependent kinase 20.069
Mep1ameprin 1 alpha0.067
Pax4paired box 40.066
Psen1presenilin 10.066
Gpr182G protein-coupled receptor 1820.064
Trim28tripartite motif-containing 280.063
Nek9NIMA (never in mitosis gene a)- related kinase 90.062
Id3inhibitor of DNA binding 30.060
Bgnbiglycan0.059
Vipr1vasoactive intestinal peptide receptor 10.058
Sp1Sp1 transcription factor0.056
Jundjun D proto-oncogene0.053
Top2btopoisomerase (DNA) II beta0.053
Lbrlamin B receptor0.053
Olr1701olfactory receptor 17010.052
Vimvimentin0.052
Aanatarylalkylamine N-acetyltransferase0.051
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.050
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.049
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.049
Mef2dmyocyte enhancer factor 2D0.047
Dynlt1dynein light chain Tctex-type 10.047
Acracrosin0.043
Crybb1crystallin, beta B10.043
Accn3amiloride-sensitive cation channel 30.043
Adam17ADAM metallopeptidase domain 170.040
Loxlysyl oxidase0.039
Vcanversican0.039
Akr1c14aldo-keto reductase family 1, member C140.038
Mpeg1macrophage expressed 10.038
Arpc1bactin related protein 2/3 complex, subunit 1B0.038
Jak1Janus kinase 10.038
Msnmoesin0.038
Olr1469olfactory receptor Olr14690.037
Hist1h1ahistone cluster 1, H1a0.037
Myh9myosin, heavy chain 9, non-muscle0.037
Zfxzinc finger protein X-linked0.036
Myo1bmyosin Ib0.036
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.036
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.036
Nat1N-acetyltransferase 10.035
Col9a1collagen, type IX, alpha 10.035
Cpceruloplasmin0.034
Ucnurocortin0.033
Aebp1AE binding protein 10.033
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.033
Cald1caldesmon 10.033
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.033
Atxn1ataxin 10.031
Ubtfupstream binding transcription factor, RNA polymerase I0.030
Tcfe2atranscription factor E2a0.030
Myh13myosin, heavy chain 13, skeletal muscle0.029
Foxd3forkhead box D30.029
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.029
Tcf12transcription factor 120.028
Anxa5annexin A50.028
Enpp6ectonucleotide pyrophosphatase/phosphodiesterase 60.026
Hist1h1dhistone cluster 1, H1d0.026
Ahraryl hydrocarbon receptor0.026
Dab2disabled homolog 2 (Drosophila)0.026
Tlr4toll-like receptor 40.026
Prdm2PR domain containing 2, with ZNF domain0.026
Casp4caspase 4, apoptosis-related cysteine peptidase0.025
RestRE1-silencing transcription factor0.025
Pax8paired box 80.025
A3galt2alpha 1,3-galactosyltransferase 20.024
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.024
RGD1308958similar to chromosome 9 open reading frame 50.024
Stat5bsignal transducer and activator of transcription 5B0.023
Lhx9LIM homeobox 90.023
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.023
Homer3homer homolog 3 (Drosophila)0.023
Cdc23CDC23 (cell division cycle 23, yeast, homolog)0.022
Ush1cUsher syndrome 1C homolog (human)0.022
Grifingalectin-related inter-fiber protein0.022
Adrb1adrenergic, beta-1-, receptor0.022
Hmgb2high mobility group box 20.021
Bmp15bone morphogenetic protein 150.021
Chd4chromodomain helicase DNA binding protein 40.021
Timp1TIMP metallopeptidase inhibitor 10.021
Celcarboxyl ester lipase0.020
Prim2primase, DNA, polypeptide 20.020
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism