The network for 'purine nucleobase metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

purine nucleobase metabolic process

The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

NameDescriptionProbabilityFunc Analog Organism
WDYHV1WDYHV motif containing 10.066
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.064
IL1RAPinterleukin 1 receptor accessory protein0.058
MARSmethionyl-tRNA synthetase0.057
SARSseryl-tRNA synthetase0.046
YARStyrosyl-tRNA synthetase0.034
MCM2minichromosome maintenance complex component 20.031
IL8interleukin 80.027
PRTFDC1phosphoribosyl transferase domain containing 10.027
TRIB3tribbles homolog 3 (Drosophila)0.026
GMPSguanine monphosphate synthetase0.025
TARSthreonyl-tRNA synthetase0.024
CASP4caspase 4, apoptosis-related cysteine peptidase0.023
PRDX4peroxiredoxin 40.022
AARSalanyl-tRNA synthetase0.021
GARSglycyl-tRNA synthetase0.021
IL1R1interleukin 1 receptor, type I0.019
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG3011CG3011 gene product from transcript CG3011-RA0.158
vvermilion0.033
CG11089CG11089 gene product from transcript CG11089-RD0.031
Hex-CHexokinase C0.025
PgdPhosphogluconate dehydrogenase0.016
CG3590CG3590 gene product from transcript CG3590-RA0.012
SpdSSpermidine Synthase0.011
AdhAlcohol dehydrogenase0.011
CG11255CG11255 gene product from transcript CG11255-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ren1renin 1 structural0.193
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.180
Hif1ahypoxia inducible factor 1, alpha subunit0.140
Gja1gap junction protein, alpha 10.093
Shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.066
Psmd14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.063
Spp1secreted phosphoprotein 10.055
Pgls6-phosphogluconolactonase0.051
Rb1retinoblastoma 10.045
Itgb1integrin beta 1 (fibronectin receptor beta)0.043
Slc25a5solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 50.037
Phgdh3-phosphoglycerate dehydrogenase0.032
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.032
Atad3aATPase family, AAA domain containing 3A0.030
Aqp2aquaporin 20.029
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.024
Pdcd6programmed cell death 60.024
Ltb4r1leukotriene B4 receptor 10.023
Galegalactose-4-epimerase, UDP0.022
BC048355cDNA sequence BC0483550.022
Agtr1aangiotensin II receptor, type 1a0.021
Ptgs2prostaglandin-endoperoxide synthase 20.020
Shkbp1Sh3kbp1 binding protein 10.020
Apcadenomatosis polyposis coli0.019
Umpsuridine monophosphate synthetase0.019
Bcap29B-cell receptor-associated protein 290.018
Ctnnb1catenin (cadherin associated protein), beta 10.017
Cpsf3lcleavage and polyadenylation specific factor 3-like0.017
RoraRAR-related orphan receptor alpha0.017
Gpr172bG protein-coupled receptor 172B0.017
Ptpn11protein tyrosine phosphatase, non-receptor type 110.016
Psapprosaposin0.016
Vmp1vacuole membrane protein 10.016
Ptenphosphatase and tensin homolog0.015
Pno1partner of NOB1 homolog (S. cerevisiae)0.014
Ube2cubiquitin-conjugating enzyme E2C0.014
Rcc1regulator of chromosome condensation 10.014
Mpzl2myelin protein zero-like 20.014
Prelid1PRELI domain containing 10.014
Psma4proteasome (prosome, macropain) subunit, alpha type 40.014
Dazap1DAZ associated protein 10.013
Psat1phosphoserine aminotransferase 10.013
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.013
NadkNAD kinase0.013
Vdac2voltage-dependent anion channel 20.013
Mybl2myeloblastosis oncogene-like 20.013
Taf9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.013
Rbm3RNA binding motif protein 30.012
Fam108afamily with sequence similarity 108, member A0.012
Fpgsfolylpolyglutamyl synthetase0.012
Pgk1phosphoglycerate kinase 10.012
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.012
Cdt1chromatin licensing and DNA replication factor 10.012
Mifmacrophage migration inhibitory factor0.012
Elovl1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 10.011
Gpx1glutathione peroxidase 10.011
Ptrh1peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)0.011
Unguracil DNA glycosylase0.011
E2f1E2F transcription factor 10.011
Psmg4proteasome (prosome, macropain) assembly chaperone 40.011
Slc19a1solute carrier family 19 (sodium/hydrogen exchanger), member 10.011
Eif5aeukaryotic translation initiation factor 5A0.011
Cmpk1cytidine monophosphate (UMP-CMP) kinase 10.011
Aprtadenine phosphoribosyl transferase0.011
Il18rapinterleukin 18 receptor accessory protein0.011
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.011
Hey2hairy/enhancer-of-split related with YRPW motif 20.011
Slc12a1solute carrier family 12, member 10.011
Rrp9RRP9, small subunit (SSU) processome component, homolog (yeast)0.010
Ccne1cyclin E10.010
Ccl22chemokine (C-C motif) ligand 220.010
Smyd5SET and MYND domain containing 50.010
Terttelomerase reverse transcriptase0.010
Capza2capping protein (actin filament) muscle Z-line, alpha 20.010
Trp53transformation related protein 530.010
Mdm2transformed mouse 3T3 cell double minute 20.010
Atp6v1c1ATPase, H+ transporting, lysosomal V1 subunit C10.010
Pgdphosphogluconate dehydrogenase0.010
Rps6ka1ribosomal protein S6 kinase polypeptide 10.010
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.010
Pgam1phosphoglycerate mutase 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rcn2reticulocalbin 2, EF-hand calcium binding domain0.064
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.052
RragaRas-related GTP binding A0.051
RabggtbRab geranylgeranyltransferase, beta subunit0.049
Mrps14mitochondrial ribosomal protein S140.039
Fam92a1family with sequence similarity 92, member A10.030
Dhfrdihydrofolate reductase0.025
Rangap1RAN GTPase activating protein 10.022
CnbpCCHC-type zinc finger, nucleic acid binding protein0.020
Cse1lCSE1 chromosome segregation 1-like (yeast)0.019
Rbbp7retinoblastoma binding protein 70.019
Hspd1heat shock protein 1 (chaperonin)0.019
Cycscytochrome c, somatic0.018
Cxcl2chemokine (C-X-C motif) ligand 20.018
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.017
Tfpitissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.016
Cd53Cd53 molecule0.016
Sumo1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.015
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.015
Tnni2troponin I type 2 (skeletal, fast)0.014
RT1-DaRT1 class II, locus Da0.014
Tsr2TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)0.014
Nae1NEDD8 activating enzyme E1 subunit 10.014
Aldh4a1aldehyde dehydrogenase 4 family, member A10.013
Tomm20translocase of outer mitochondrial membrane 20 homolog (yeast)0.013
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.013
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.012
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.012
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.012
Pole4polymerase (DNA-directed), epsilon 4 (p12 subunit)0.012
Mycmyelocytomatosis oncogene0.012
RGD1311703similar to sid2057p0.011
Ccl3chemokine (C-C motif) ligand 30.011
Gucy1b3guanylate cyclase 1, soluble, beta 30.011
Eif4eeukaryotic translation initiation factor 4E0.011
Bpnt13'(2'), 5'-bisphosphate nucleotidase 10.011
Cfl2cofilin 2, muscle0.011
Slc2a1solute carrier family 2 (facilitated glucose transporter), member 10.010
Slfn2schlafen 20.010
Pdhbpyruvate dehydrogenase (lipoamide) beta0.010
Srgnserglycin0.010
S100a9S100 calcium binding protein A90.010
Lcn2lipocalin 20.010
Wdr77WD repeat domain 770.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ADE1Ade1p0.048
ADE12Ade12p0.039
ADE17Ade17p0.021
CLN1Cln1p0.017
SHM2Shm2p0.016
APT2Apt2p0.015
SPG3Spg3p0.015
ADE2Ade2p0.013
APT1Apt1p0.012
ADE5,7Ade5,7p0.012
MDE1Mde1p0.010