The network for 'negative regulation of transcription factor import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transcription factor import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.

NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.413
FBXW11F-box and WD repeat domain containing 110.363
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.246
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.223
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.207
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.152
ZNF420zinc finger protein 4200.107
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.078
BTRCbeta-transducin repeat containing0.077
PMLpromyelocytic leukemia0.075
CHUKconserved helix-loop-helix ubiquitous kinase0.072
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.070
MDM2Mdm2 p53 binding protein homolog (mouse)0.070
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.067
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.065
CREBBPCREB binding protein0.064
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.059
C3orf15chromosome 3 open reading frame 150.056
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.054
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.043
ZNF260zinc finger protein 2600.042
BBS10Bardet-Biedl syndrome 100.041
CKAP5cytoskeleton associated protein 50.041
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.040
CASP8caspase 8, apoptosis-related cysteine peptidase0.039
NCOA6nuclear receptor coactivator 60.038
ZNF84zinc finger protein 840.037
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.033
HIPK3homeodomain interacting protein kinase 30.032
FASFas (TNF receptor superfamily, member 6)0.030
ZNF432zinc finger protein 4320.030
BCL3B-cell CLL/lymphoma 30.029
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.029
MAP2K5mitogen-activated protein kinase kinase 50.027
DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 20.027
RANBP3RAN binding protein 30.027
AXIN1axin 10.026
GRB10growth factor receptor-bound protein 100.025
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.025
PSEN2presenilin 2 (Alzheimer disease 4)0.025
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.024
SKP1S-phase kinase-associated protein 10.024
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.024
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.023
IRS2insulin receptor substrate 20.023
SNAI1snail homolog 1 (Drosophila)0.022
ZNF585Azinc finger protein 585A0.022
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.022
RARAretinoic acid receptor, alpha0.021
ACTN1actinin, alpha 10.020
DYRK4dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 40.020
ZNF529zinc finger protein 5290.020
IRS1insulin receptor substrate 10.019
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.019
MAP3K3mitogen-activated protein kinase kinase kinase 30.018
SMAD3SMAD family member 30.017
PRKCZprotein kinase C, zeta0.016
ZNF140zinc finger protein 1400.016
LZTS2leucine zipper, putative tumor suppressor 20.016
STX8syntaxin 80.016
GLI1GLI family zinc finger 10.015
PEX26peroxisomal biogenesis factor 260.015
FLNBfilamin B, beta0.014
MAP3K14mitogen-activated protein kinase kinase kinase 140.014
CUL1cullin 10.014
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.014
NCOR2nuclear receptor corepressor 20.014
ZNF571zinc finger protein 5710.014
RPTORregulatory associated protein of MTOR, complex 10.014
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.013
ZNF12zinc finger protein 120.013
SMAD1SMAD family member 10.013
PJA2praja ring finger 20.013
SETD7SET domain containing (lysine methyltransferase) 70.012
ZNF304zinc finger protein 3040.012
NPLOC4nuclear protein localization 4 homolog (S. cerevisiae)0.012
CFLARCASP8 and FADD-like apoptosis regulator0.012
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.012
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.012
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.012
GSK3Bglycogen synthase kinase 3 beta0.011
NEDD4neural precursor cell expressed, developmentally down-regulated 40.011
RB1retinoblastoma 10.011
RCN3reticulocalbin 3, EF-hand calcium binding domain0.011
ZNF623zinc finger protein 6230.011
ZNF567zinc finger protein 5670.011
ZNF189zinc finger protein 1890.010
ZNF83zinc finger protein 830.010
LATS1LATS, large tumor suppressor, homolog 1 (Drosophila)0.010
FBXW2F-box and WD repeat domain containing 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG6610CG6610 gene product from transcript CG6610-RA0.044
Prp8pre-mRNA processing factor 80.038
ebiCG4063 gene product from transcript CG4063-RA0.038
RpII215RNA polymerase II 215kD subunit0.035
CG1677CG1677 gene product from transcript CG1677-RB0.035
Klp61FKinesin-like protein at 61F0.031
SmFSmall ribonucleoprotein particle protein SmF0.030
Caf1Chromatin assembly factor 1 subunit0.028
Tom20Translocase of outer membrane 200.027
LSm7CG13277 gene product from transcript CG13277-RA0.025
mod(mdg4)modifier of mdg40.023
CG12079CG12079 gene product from transcript CG12079-RA0.023
CG12155CG12155 gene product from transcript CG12155-RA0.022
EgfrEpidermal growth factor receptor0.022
CG4281CG4281 gene product from transcript CG4281-RA0.021
CG14464CG14464 gene product from transcript CG14464-RC0.020
CG13220CG13220 gene product from transcript CG13220-RA0.020
CG11267CG11267 gene product from transcript CG11267-RA0.019
Prp19CG5519 gene product from transcript CG5519-RA0.019
az2CG1605 gene product from transcript CG1605-RA0.018
CG14671CG14671 gene product from transcript CG14671-RA0.017
Rcd5Reduction in Cnn dots 50.017
CG11985CG11985 gene product from transcript CG11985-RA0.016
SF2CG6987 gene product from transcript CG6987-RA0.016
CG9172CG9172 gene product from transcript CG9172-RA0.016
CG2807CG2807 gene product from transcript CG2807-RA0.016
CG7372CG7372 gene product from transcript CG7372-RA0.016
CG3887CG3887 gene product from transcript CG3887-RA0.016
RnpS1RNA-binding protein S10.016
zf30CZinc finger protein 30C0.015
Cpsf160Cleavage and polyadenylation specificity factor 1600.015
CG3683CG3683 gene product from transcript CG3683-RC0.015
Su(fu)Suppressor of fused0.015
gemininCG3183 gene product from transcript CG3183-RA0.015
CG12299CG12299 gene product from transcript CG12299-RA0.015
Rpb11CG6840 gene product from transcript CG6840-RA0.014
aspabnormal spindle0.014
CG13993CG13993 gene product from transcript CG13993-RA0.014
Fcp1CG12252 gene product from transcript CG12252-RA0.014
CG18292CG18292 gene product from transcript CG18292-RA0.014
XNPCG4548 gene product from transcript CG4548-RA0.014
Prosbeta5Proteasome beta5 subunit0.014
RPA2Replication protein A20.013
Rpb10CG13628 gene product from transcript CG13628-RA0.013
Nurf-38Nucleosome remodeling factor - 38kD0.013
CG11858CG11858 gene product from transcript CG11858-RA0.013
bafbarrier to autointegration factor0.013
CG11107CG11107 gene product from transcript CG11107-RA0.013
CG10664CG10664 gene product from transcript CG10664-RB0.013
SsrpStructure specific recognition protein0.013
CG13472CG13472 gene product from transcript CG13472-RA0.013
osaCG7467 gene product from transcript CG7467-RD0.013
Bap170Brahma associated protein 170kD0.013
TorTarget of rapamycin0.013
PdswCG8844 gene product from transcript CG8844-RA0.013
RanGapRan GTPase activating protein0.012
CG9350CG9350 gene product from transcript CG9350-RA0.012
ND23NADH:ubiquinone reductase 23kD subunit precursor0.012
PompCG9324 gene product from transcript CG9324-RA0.012
MED22Mediator complex subunit 220.012
CG8386CG8386 gene product from transcript CG8386-RA0.012
CG9548CG9548 gene product from transcript CG9548-RA0.012
stmAstambha A0.012
CycECyclin E0.012
Prosbeta2Proteasome beta2 subunit0.012
levyCG17280 gene product from transcript CG17280-RA0.012
msd1mitotic spindle density 10.012
Trn-SRTransportin-Serine/Arginine rich0.012
CoVaCytochrome c oxidase subunit Va0.011
CG6020CG6020 gene product from transcript CG6020-RA0.011
ublubiquitin like0.011
CG2021CG2021 gene product from transcript CG2021-RA0.011
E2f2E2F transcription factor 20.011
poloCG12306 gene product from transcript CG12306-RA0.011
Fas2Fasciclin 20.011
Cbp20cap binding protein 200.011
Grip128CG9201 gene product from transcript CG9201-RB0.011
thrthree rows0.011
CG11970CG11970 gene product from transcript CG11970-RA0.011
mRpL50mitochondrial ribosomal protein L500.011
Vha36CG8186 gene product from transcript CG8186-RA0.011
CG2862CG2862 gene product from transcript CG2862-RA0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.949
Ptenphosphatase and tensin homolog0.639
Apcadenomatosis polyposis coli0.375
Ctnnb1catenin (cadherin associated protein), beta 10.298
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.225
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.184
Rxraretinoid X receptor alpha0.183
Rargretinoic acid receptor, gamma0.154
Per1period homolog 1 (Drosophila)0.142
Rararetinoic acid receptor, alpha0.135
Fgfr1fibroblast growth factor receptor 10.096
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.086
Mapkap1mitogen-activated protein kinase associated protein 10.085
Sap18Sin3-associated polypeptide 180.083
Grb10growth factor receptor bound protein 100.058
Bcl3B-cell leukemia/lymphoma 30.053
Stat3signal transducer and activator of transcription 30.052
Ece1endothelin converting enzyme 10.052
Trp63transformation related protein 630.048
Esr1estrogen receptor 1 (alpha)0.047
Notch2Notch gene homolog 2 (Drosophila)0.045
Cdkn1bcyclin-dependent kinase inhibitor 1B0.044
Bcl2B-cell leukemia/lymphoma 20.044
Il6stinterleukin 6 signal transducer0.042
Apoeapolipoprotein E0.039
FasFas (TNF receptor superfamily member 6)0.037
Ikbkbinhibitor of kappaB kinase beta0.036
Rnf115ring finger protein 1150.036
Psen1presenilin 10.036
Ncoa3nuclear receptor coactivator 30.034
Fgfr2fibroblast growth factor receptor 20.034
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.033
Tnftumor necrosis factor0.033
Ptpn11protein tyrosine phosphatase, non-receptor type 110.029
Axin1axin 10.028
Pkd1polycystic kidney disease 1 homolog0.027
Ppargperoxisome proliferator activated receptor gamma0.026
Thrathyroid hormone receptor alpha0.025
Pbx1pre B-cell leukemia transcription factor 10.025
Rptorregulatory associated protein of MTOR, complex 10.025
Meox2mesenchyme homeobox 20.024
Mdm2transformed mouse 3T3 cell double minute 20.021
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.021
Ptch1patched homolog 10.021
Flot2flotillin 20.020
Cdh23cadherin 23 (otocadherin)0.020
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.019
Igbp1immunoglobulin (CD79A) binding protein 10.019
Pias1protein inhibitor of activated STAT 10.018
DbpD site albumin promoter binding protein0.018
Card11caspase recruitment domain family, member 110.017
Lrp6low density lipoprotein receptor-related protein 60.017
Slc12a6solute carrier family 12, member 60.017
Tgfb1transforming growth factor, beta 10.017
Sox9SRY-box containing gene 90.016
Kitlkit ligand0.016
Vhlvon Hippel-Lindau tumor suppressor0.016
Socs3suppressor of cytokine signaling 30.016
Atp6v0eATPase, H+ transporting, lysosomal V0 subunit E0.016
Telo2TEL2, telomere maintenance 2, homolog (S. cerevisiae)0.016
Cys1cystin 10.015
Ghrgrowth hormone receptor0.015
Megf8multiple EGF-like-domains 80.015
Prf1perforin 1 (pore forming protein)0.015
Rnh1ribonuclease/angiogenin inhibitor 10.015
Bcl6B-cell leukemia/lymphoma 60.014
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.014
Rab5aRAB5A, member RAS oncogene family0.013
Lrp5low density lipoprotein receptor-related protein 50.013
Gli2GLI-Kruppel family member GLI20.013
Duox2dual oxidase 20.013
Cstbcystatin B0.013
Ubr3ubiquitin protein ligase E3 component n-recognin 30.013
Tefthyrotroph embryonic factor0.013
Kitkit oncogene0.013
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.013
WwoxWW domain-containing oxidoreductase0.013
Thrbthyroid hormone receptor beta0.012
RictorRPTOR independent companion of MTOR, complex 20.012
Lgals3lectin, galactose binding, soluble 30.012
Yap1yes-associated protein 10.012
Siah2seven in absentia 20.012
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.012
Bicc1bicaudal C homolog 1 (Drosophila)0.012
Smosmoothened homolog (Drosophila)0.012
BrafBraf transforming gene0.012
Anxa7annexin A70.012
Leprleptin receptor0.012
Dusp1dual specificity phosphatase 10.012
Stat6signal transducer and activator of transcription 60.011
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.011
Gbaglucosidase, beta, acid0.011
Chd7chromodomain helicase DNA binding protein 70.011
Cav1caveolin 1, caveolae protein0.010
Sqstm1sequestosome 10.010
Nr1d2nuclear receptor subfamily 1, group D, member 20.010
Mlst8MTOR associated protein, LST8 homolog (S. cerevisiae)0.010
Chmp2achromatin modifying protein 2A0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism