The network for 'hexose metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hexose metabolic process

The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.

NameDescriptionProbabilityFunc Analog Organism
INSRinsulin receptor0.998
CREBBPCREB binding protein0.997
ESR1estrogen receptor 10.974
NCOA1nuclear receptor coactivator 10.960
RXRAretinoid X receptor, alpha0.928
RARAretinoic acid receptor, alpha0.893
ARandrogen receptor0.765
EP300E1A binding protein p3000.737
MDM2Mdm2 p53 binding protein homolog (mouse)0.715
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.701
KAT2BK(lysine) acetyltransferase 2B0.700
ALDOAaldolase A, fructose-bisphosphate0.700
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.694
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.674
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.659
HIPK2homeodomain interacting protein kinase 20.654
TADA3transcriptional adaptor 30.619
TPI1triosephosphate isomerase 10.617
IRS1insulin receptor substrate 10.549
SIRT1sirtuin 10.463
PGK1phosphoglycerate kinase 10.461
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.461
NCOA3nuclear receptor coactivator 30.460
NCOA6nuclear receptor coactivator 60.451
GRB10growth factor receptor-bound protein 100.413
PRKCZprotein kinase C, zeta0.394
GHRgrowth hormone receptor0.390
PPP4R2protein phosphatase 4, regulatory subunit 20.378
IRS2insulin receptor substrate 20.368
LIN7Blin-7 homolog B (C. elegans)0.357
PTPN1protein tyrosine phosphatase, non-receptor type 10.346
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.344
CREB1cAMP responsive element binding protein 10.329
IGF1Rinsulin-like growth factor 1 receptor0.316
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.301
TTRtransthyretin0.275
GPIglucose-6-phosphate isomerase0.274
TKTtransketolase0.272
SMAD3SMAD family member 30.265
LDHAlactate dehydrogenase A0.244
C1QCcomplement component 1, q subcomponent, C chain0.223
LRRK2leucine-rich repeat kinase 20.219
MED25mediator complex subunit 250.216
NCF1neutrophil cytosolic factor 10.214
GSK3Bglycogen synthase kinase 3 beta0.209
NCOR2nuclear receptor corepressor 20.207
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.195
NOXA1NADPH oxidase activator 10.189
PKM2pyruvate kinase, muscle0.179
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.176
ACACAacetyl-CoA carboxylase alpha0.174
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.169
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.169
HNF4Ahepatocyte nuclear factor 4, alpha0.165
SORBS3sorbin and SH3 domain containing 30.163
C1QAcomplement component 1, q subcomponent, A chain0.153
NR0B2nuclear receptor subfamily 0, group B, member 20.147
ARF4ADP-ribosylation factor 40.136
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.135
PPARGperoxisome proliferator-activated receptor gamma0.135
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.133
JUNjun proto-oncogene0.130
BCAR1breast cancer anti-estrogen resistance 10.121
RAB5ARAB5A, member RAS oncogene family0.117
SH2B1SH2B adaptor protein 10.114
ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)0.109
DDIT3DNA-damage-inducible transcript 30.107
ATF2activating transcription factor 20.104
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.100
AKT1v-akt murine thymoma viral oncogene homolog 10.100
NEU1sialidase 1 (lysosomal sialidase)0.097
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.093
BCL2L11BCL2-like 11 (apoptosis facilitator)0.092
PPARAperoxisome proliferator-activated receptor alpha0.092
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.091
FOXO3forkhead box O30.090
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.090
AGXT2alanine--glyoxylate aminotransferase 20.089
SQSTM1sequestosome 10.087
TRIB3tribbles homolog 3 (Drosophila)0.087
SESN2sestrin 20.086
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.081
CREBZFCREB/ATF bZIP transcription factor0.081
DCNdecorin0.080
FHL2four and a half LIM domains 20.077
ENO1enolase 1, (alpha)0.075
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.074
SORBS1sorbin and SH3 domain containing 10.072
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.071
OASL2'-5'-oligoadenylate synthetase-like0.071
STAT5Bsignal transducer and activator of transcription 5B0.071
TALDO1transaldolase 10.067
ZNF746zinc finger protein 7460.067
SH3KBP1SH3-domain kinase binding protein 10.067
LTBP4latent transforming growth factor beta binding protein 40.067
USP22ubiquitin specific peptidase 220.066
TRIM23tripartite motif containing 230.065
SREBF2sterol regulatory element binding transcription factor 20.062
ESRRGestrogen-related receptor gamma0.061
APCadenomatous polyposis coli0.061
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PgkPhosphoglycerate kinase0.082
Got2Glutamate oxaloacetate transaminase 20.050
PgmPhosphogluconate mutase0.043
GpdhGlycerol 3 phosphate dehydrogenase0.033
PgdPhosphogluconate dehydrogenase0.027
ThorCG8846 gene product from transcript CG8846-RA0.022
CG8036CG8036 gene product from transcript CG8036-RB0.020
Ca-P60ACalcium ATPase at 60A0.019
AdhAlcohol dehydrogenase0.019
CG7998CG7998 gene product from transcript CG7998-RA0.015
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 10.014
GlyPGlycogen phosphorylase0.014
S6kRPS6-p70-protein kinase0.013
Atg9Autophagy-specific gene 90.013
foxoforkhead box, sub-group O0.011
Akt1CG4006 gene product from transcript CG4006-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lepleptin0.999
Leprleptin receptor0.997
Insrinsulin receptor0.975
Igf1rinsulin-like growth factor I receptor0.965
Ppargperoxisome proliferator activated receptor gamma0.955
Clockcircadian locomotor output cycles kaput0.952
Mapk14mitogen-activated protein kinase 140.937
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.935
Onecut1one cut domain, family member 10.929
FosFBJ osteosarcoma oncogene0.923
Aldoaaldolase A, fructose-bisphosphate0.887
Pdx1pancreatic and duodenal homeobox 10.883
Per2period homolog 2 (Drosophila)0.875
Npy1rneuropeptide Y receptor Y10.870
Ldhalactate dehydrogenase A0.860
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.837
Tpi1triosephosphate isomerase 10.836
Nos1nitric oxide synthase 1, neuronal0.823
Ptenphosphatase and tensin homolog0.819
Gm5506predicted gene 55060.809
Cry2cryptochrome 2 (photolyase-like)0.803
Pkm2pyruvate kinase, muscle0.794
C1qccomplement component 1, q subcomponent, C chain0.794
Arntlaryl hydrocarbon receptor nuclear translocator-like0.788
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.784
Prlrprolactin receptor0.780
Hnf4ahepatic nuclear factor 4, alpha0.758
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.739
Stat5asignal transducer and activator of transcription 5A0.699
Clk1CDC-like kinase 10.690
Zeb1zinc finger E-box binding homeobox 10.683
JunJun oncogene0.650
Pgk1phosphoglycerate kinase 10.620
Gpi1glucose phosphate isomerase 10.618
Dusp1dual specificity phosphatase 10.598
Otporthopedia homolog (Drosophila)0.595
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.586
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.585
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.581
Mup5major urinary protein 50.573
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.572
Clk4CDC like kinase 40.543
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.527
BtkBruton agammaglobulinemia tyrosine kinase0.527
Drd2dopamine receptor D20.519
Nr1h4nuclear receptor subfamily 1, group H, member 40.511
Kiss1KiSS-1 metastasis-suppressor0.509
Tcf7transcription factor 7, T-cell specific0.486
Pim1proviral integration site 10.470
Cdkn1bcyclin-dependent kinase inhibitor 1B0.456
S100a5S100 calcium binding protein A50.456
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.450
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.440
Ins2insulin II0.428
Pgam1phosphoglycerate mutase 10.428
F2coagulation factor II0.420
Irs2insulin receptor substrate 20.418
Agrpagouti related protein0.416
Ccnl2cyclin L20.406
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.403
Foxa2forkhead box A20.402
Hoxd3homeobox D30.399
Lrp6low density lipoprotein receptor-related protein 60.395
Pgls6-phosphogluconolactonase0.383
Esr1estrogen receptor 1 (alpha)0.380
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.373
Trib3tribbles homolog 3 (Drosophila)0.365
Ep300E1A binding protein p3000.355
Edaectodysplasin-A0.355
Axin1axin 10.351
Cideccell death-inducing DFFA-like effector c0.345
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.342
Atf2activating transcription factor 20.337
Zfp36zinc finger protein 360.334
Pthlhparathyroid hormone-like peptide0.334
Vdrvitamin D receptor0.326
Rxraretinoid X receptor alpha0.320
Cfdcomplement factor D (adipsin)0.316
Asgr2asialoglycoprotein receptor 20.313
Toxthymocyte selection-associated high mobility group box0.313
Usp2ubiquitin specific peptidase 20.313
Fgfr1fibroblast growth factor receptor 10.313
Mup9major urinary protein 90.312
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.310
Nr3c1nuclear receptor subfamily 3, group C, member 10.309
Gcgrglucagon receptor0.307
Mc5rmelanocortin 5 receptor0.307
Fgf5fibroblast growth factor 50.303
Gpr27G protein-coupled receptor 270.299
Thrathyroid hormone receptor alpha0.297
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.291
Crhr1corticotropin releasing hormone receptor 10.290
Bmp4bone morphogenetic protein 40.290
Prkceprotein kinase C, epsilon0.288
Pim3proviral integration site 30.288
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.278
Plin1perilipin 10.278
Hoxd1homeobox D10.274
Mup10major urinary protein 100.271
Prpf39PRP39 pre-mRNA processing factor 39 homolog (yeast)0.270
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Eno1enolase 1, (alpha)0.830
Ldhalactate dehydrogenase A0.788
Aldoaaldolase A, fructose-bisphosphate0.521
Gpiglucose phosphate isomerase0.354
Pgam1phosphoglycerate mutase 1 (brain)0.311
Cpt2carnitine palmitoyltransferase 20.285
G6pcglucose-6-phosphatase, catalytic subunit0.279
Tpi1triosephosphate isomerase 10.276
Etfdhelectron-transferring-flavoprotein dehydrogenase0.187
Rab1bRAB1B, member RAS oncogene family0.163
Nfibnuclear factor I/B0.153
Metmet proto-oncogene0.150
DbpD site of albumin promoter (albumin D-box) binding protein0.145
Aldobaldolase B, fructose-bisphosphate0.112
Ubtfupstream binding transcription factor, RNA polymerase I0.110
Apoa4apolipoprotein A-IV0.100
MlxiplMLX interacting protein-like0.097
Ldhdlactate dehydrogenase D0.095
Fbp1fructose-1,6-bisphosphatase 10.094
Tuba1ctubulin, alpha 1C0.093
Faahfatty acid amide hydrolase0.091
Pfkmphosphofructokinase, muscle0.090
Pgm1phosphoglucomutase 10.090
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.089
Mifmacrophage migration inhibitory factor0.088
Dckdeoxycytidine kinase0.087
Hmox1heme oxygenase (decycling) 10.080
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.075
Irs1insulin receptor substrate 10.074
PVRpoliovirus receptor0.072
Ptprsprotein tyrosine phosphatase, receptor type, S0.071
Acadsacyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain0.071
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.070
Ccl2chemokine (C-C motif) ligand 20.070
LOC1003636626-phosphogluconate dehydrogenase, decarboxylating-like0.069
Pgk1phosphoglycerate kinase 10.067
A1cfAPOBEC1 complementation factor0.067
Zadh2zinc binding alcohol dehydrogenase, domain containing 20.066
Asphaspartate-beta-hydroxylase0.061
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.060
Irs3insulin receptor substrate 30.060
Tshrthyroid stimulating hormone receptor0.059
Pyglphosphorylase, glycogen, liver0.058
Acot2acyl-CoA thioesterase 20.058
Eef2eukaryotic translation elongation factor 20.058
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.057
Vipr1vasoactive intestinal peptide receptor 10.055
Ccl3chemokine (C-C motif) ligand 30.053
Ccnd3cyclin D30.053
Hist1h2bahistone cluster 1, H2ba0.053
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.053
Plaurplasminogen activator, urokinase receptor0.052
LOC100366119Mpv17 transgene, kidney disease mutant-like (predicted)-like0.052
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.051
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.051
Inhbeinhibin beta E0.049
Tkttransketolase0.049
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.049
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.049
Grinl1aglutamate receptor, ionotropic, N-methyl D-aspartate-like 1A0.049
Pkm2pyruvate kinase, muscle0.048
Glud1glutamate dehydrogenase 10.048
Litaflipopolysaccharide-induced TNF factor0.048
Rararetinoic acid receptor, alpha0.048
Mylk2myosin light chain kinase 20.047
Creb1cAMP responsive element binding protein 10.047
Ap2m1adaptor-related protein complex 2, mu 1 subunit0.047
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.047
Oaz2ornithine decarboxylase antizyme 20.047
Casp2caspase 20.047
Pygmphosphorylase, glycogen, muscle0.046
Acacbacetyl-Coenzyme A carboxylase beta0.045
Foxa3forkhead box A30.045
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.044
Albalbumin0.044
Pgam2phosphoglycerate mutase 2 (muscle)0.044
Tgfbr2transforming growth factor, beta receptor II0.044
Fabp5fatty acid binding protein 5, epidermal0.043
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.043
Serinc1serine incorporator 10.043
Akap8lA kinase (PRKA) anchor protein 8-like0.043
Ptpn6protein tyrosine phosphatase, non-receptor type 60.043
Macrod1MACRO domain containing 10.042
Slc20a2solute carrier family 20 (phosphate transporter), member 20.042
Cxcl10chemokine (C-X-C motif) ligand 100.041
Fn3kfructosamine 3 kinase0.041
Obp3alpha-2u globulin PGCL40.041
Ppp1r3cprotein phosphatase 1, regulatory (inhibitor) subunit 3C0.041
Slc25a42solute carrier family 25, member 420.040
Impdh2IMP (inosine monophosphate) dehydrogenase 20.040
Taldo1transaldolase 10.040
Myo9amyosin IXA0.040
Akap1A kinase (PRKA) anchor protein 10.040
Aprtadenine phosphoribosyl transferase0.039
Ndrg2N-myc downstream regulated gene 20.039
Runx1runt-related transcription factor 10.039
Angptl4angiopoietin-like 40.038
Lypla1lysophospholipase 10.038
Vdac1voltage-dependent anion channel 10.038
Apoa1apolipoprotein A-I0.038
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SOR1Sor1p0.982
FYV10Fyv10p0.977
ADH1Adh1p0.955
GAL1Gal1p0.939
ENO1Eno1p0.917
GND2Gnd2p0.912
ENO2Eno2p0.884
GAL10Gal10p0.884
FBA1Fba1p0.882
UGP1Ugp1p0.829
TDH2Tdh2p0.827
PGK1Pgk1p0.821
PDC1Pdc1p0.781
GAL4Gal4p0.756
ERR3Err3p0.694
CAK1Cak1p0.685
GAL3Gal3p0.669
PGI1Pgi1p0.626
GND1Gnd1p0.593
PYC2Pyc2p0.557
ALD6Ald6p0.548
VID30Vid30p0.539
RMD5Rmd5p0.534
MTH1Mth1p0.533
TDH3Tdh3p0.532
TAL1Tal1p0.530
MOH1Moh1p0.525
TPI1Tpi1p0.502
GID8Gid8p0.478
GAL7Gal7p0.477
HXK2Hxk2p0.460
ERR1Err1p0.456
GPM1Gpm1p0.447
PFK1Pfk1p0.440
HXT2Hxt2p0.439
CMK2Cmk2p0.424
SNF3Snf3p0.422
GID7Gid7p0.421
SOR2Sor2p0.417
BDH1Bdh1p0.397
POT1Pot1p0.392
ERR2Err2p0.386
HXT16Hxt16p0.386
CAT8Cat8p0.380
GIP2Gip2p0.374
IMA4Ima4p0.351
GLO1Glo1p0.349
GPM2Gpm2p0.338
NQM1Nqm1p0.333
SDS24Sds24p0.326
VID28Vid28p0.323
MLS1Mls1p0.305
AIM17Aim17p0.302
SNF1Snf1p0.286
YAP6Yap6p0.275
ROD1Rod1p0.274
ADH3Adh3p0.270
GAL83Gal83p0.260
TDH1Tdh1p0.260
MPH3Mph3p0.254
HXT10Hxt10p0.252
RDS2Rds2p0.240
YLR345Whypothetical protein0.228
GLG2Glg2p0.227
SPE3Spe3p0.224
CIT2Cit2p0.219
GPD1Gpd1p0.207
RTC3Rtc3p0.194
YNR073Chypothetical protein0.187
GRE3Gre3p0.186
NDE2Nde2p0.186
HXT3Hxt3p0.183
GSY2Gsy2p0.183
MIG1Mig1p0.171
SIP4Sip4p0.170
CKA2Cka2p0.167
ZWF1Zwf1p0.164
MSH6Msh6p0.162
YMR291Whypothetical protein0.161
PIG2Pig2p0.151
GAL80Gal80p0.150
RAD30Rad30p0.149
THI3Thi3p0.149
WWM1Wwm1p0.146
THO2Tho2p0.144
HXT15Hxt15p0.143
KIN1Kin1p0.142
TPS1Tps1p0.142
TKL2Tkl2p0.141
ALD4Ald4p0.141
AZF1Azf1p0.139
YGR126Whypothetical protein0.133
GAL2Gal2p0.132
HRK1Hrk1p0.124
YAR028Whypothetical protein0.123
BNA5Bna5p0.122
NCE103Nce103p0.122
VID24Vid24p0.122
FBP1Fbp1p0.119
HOM6Hom6p0.117