The network for 'negative regulation of cell motility' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell motility

Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FN1fibronectin 10.994
FGFR2fibroblast growth factor receptor 20.975
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.971
JAG1jagged 10.967
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.966
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.939
TEKTEK tyrosine kinase, endothelial0.935
C1QAcomplement component 1, q subcomponent, A chain0.930
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.920
KRT15keratin 150.874
FLNAfilamin A, alpha0.869
THBS1thrombospondin 10.828
VCAM1vascular cell adhesion molecule 10.819
BMP2bone morphogenetic protein 20.809
TGFB1transforming growth factor, beta 10.765
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.706
IFITM2interferon induced transmembrane protein 2 (1-8D)0.661
IFITM1interferon induced transmembrane protein 1 (9-27)0.659
CCR5chemokine (C-C motif) receptor 50.657
TAL1T-cell acute lymphocytic leukemia 10.655
HOXB5homeobox B50.653
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.635
TBX5T-box 50.633
FGF1fibroblast growth factor 1 (acidic)0.630
IFITM3interferon induced transmembrane protein 3 (1-8U)0.628
FKBP1AFK506 binding protein 1A, 12kDa0.622
HIPK2homeodomain interacting protein kinase 20.617
APOEapolipoprotein E0.611
NOTCH3notch 30.561
NCOA1nuclear receptor coactivator 10.548
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.537
NOTCH1notch 10.505
EMP3epithelial membrane protein 30.495
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.490
KRT8keratin 80.479
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.464
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.455
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.441
SMAD3SMAD family member 30.437
KRT6Bkeratin 6B0.434
CXCL12chemokine (C-X-C motif) ligand 120.426
METmet proto-oncogene (hepatocyte growth factor receptor)0.422
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.418
CCL5chemokine (C-C motif) ligand 50.408
ESRRGestrogen-related receptor gamma0.392
GRB7growth factor receptor-bound protein 70.378
BAIAP2BAI1-associated protein 20.376
ACVR1activin A receptor, type I0.364
ANGPT2angiopoietin 20.364
COL1A1collagen, type I, alpha 10.346
COX17COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)0.343
MMP14matrix metallopeptidase 14 (membrane-inserted)0.335
PTK2PTK2 protein tyrosine kinase 20.334
APOC1apolipoprotein C-I0.328
ABI2abl-interactor 20.327
TBXA2Rthromboxane A2 receptor0.324
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.318
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.308
JUNjun proto-oncogene0.306
CD63CD63 molecule0.301
STRN3striatin, calmodulin binding protein 30.301
ADRB1adrenergic, beta-1-, receptor0.298
NCOR1nuclear receptor corepressor 10.292
PTPN1protein tyrosine phosphatase, non-receptor type 10.290
BMP1bone morphogenetic protein 10.290
NPR1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.289
ADORA2Aadenosine A2a receptor0.285
HOXB6homeobox B60.284
ZNF746zinc finger protein 7460.284
NCOR2nuclear receptor corepressor 20.283
MEF2Amyocyte enhancer factor 2A0.282
C1QBcomplement component 1, q subcomponent, B chain0.281
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.277
MEF2Cmyocyte enhancer factor 2C0.274
PLATplasminogen activator, tissue0.272
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.271
TIMP1TIMP metallopeptidase inhibitor 10.270
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.268
UBE2L6ubiquitin-conjugating enzyme E2L 60.265
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.263
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.261
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.261
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.258
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.258
KRT6Akeratin 6A0.254
CCL4chemokine (C-C motif) ligand 40.253
PVRL3poliovirus receptor-related 30.250
CTNND1catenin (cadherin-associated protein), delta 10.250
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.248
TGFB3transforming growth factor, beta 30.248
BCL6B-cell CLL/lymphoma 60.240
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.237
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.236
CCL2chemokine (C-C motif) ligand 20.234
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.385
efnb2aephrin B2a0.354
notch3notch homolog 30.160
jag1bjagged 1b0.150
sulf1sulfatase 10.104
lhx2bLIM homeobox 2b0.092
tbx1T-box 10.088
itgb1b.2integrin, beta 1b.20.087
ilkintegrin linked kinase0.087
fgf3fibroblast growth factor 30.086
mmp2matrix metalloproteinase 20.083
clstn1calsyntenin 10.075
lmx1b.1LIM homeobox transcription factor 1, beta 10.066
ntn1anetrin 1a0.065
fgfr2fibroblast growth factor receptor 20.064
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.063
nf1aneurofibromin 1a0.063
prkciprotein kinase C, iota0.059
gli1GLI-Kruppel family member 10.059
notch1anotch homolog 1a0.057
gcm2glial cells missing homolog 2 (Drosophila)0.057
epha4aeph receptor A4a0.055
tnfatumor necrosis factor a (TNF superfamily, member 2)0.050
hey1hairy/enhancer-of-split related with YRPW motif 10.049
pdlim1PDZ and LIM domain 1 (elfin)0.047
sall1asal-like 1a (Drosophila)0.046
dag1dystroglycan 10.046
sox10SRY-box containing gene 100.046
srfserum response factor0.043
fabp11afatty acid binding protein 11a0.043
dll4delta-like 4 (Drosophila)0.043
gata3GATA-binding protein 30.042
ptger2aprostaglandin E receptor 2a (subtype EP2)0.042
tbx2bT-box 2b0.041
appaamyloid beta (A4) precursor protein a0.041
sulf2lsulfatase 2, like0.039
tmem2transmembrane protein 20.039
ptmaaprothymosin, alpha a0.038
slit3slit (Drosophila) homolog 30.037
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.036
nrarpanotch-regulated ankyrin repeat protein a0.036
tie2endothelium-specific receptor tyrosine kinase 20.035
robo3roundabout homolog 30.034
ubiad1UbiA prenyltransferase domain containing 10.034
itgb1aintegrin, beta 1a0.034
foxg1aforkhead box G1a0.033
itgb1bintegrin, beta 1b0.032
mtpmicrosomal triglyceride transfer protein0.030
spry4sprouty (Drosophila) homolog 40.029
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.029
unc5bunc-5 homolog B (C. elegans)0.029
cxcr4bchemokine (C-X-C motif), receptor 4b0.029
plp1aproteolipid protein 1a0.029
rtn4breticulon 4b0.029
eya1eyes absent homolog 10.028
foxn1forkhead box N10.028
wnt10awingless-type MMTV integration site family, member 10a0.027
fbn2bfibrillin 2b0.026
ptp4a1protein tyrosine phosphatase type IVA, member 10.026
foxn4forkhead box N40.026
wnt11rwingless-type MMTV integration site family, member 11, related0.026
stc1lstanniocalcin 1, like0.026
aldh1a2aldehyde dehydrogenase 1 family, member A20.025
pitx3paired-like homeodomain transcription factor 30.025
zdhhc8bzinc finger, DHHC-type containing 8b0.025
nrg2aneuregulin 2a0.024
pou3f1POU class 3 homeobox 10.024
ascl1aachaete-scute complex-like 1a (Drosophila)0.024
xirp2axin actin-binding repeat containing 2a0.024
pkd2polycystic kidney disease 20.024
bocbrother of CDO0.024
rtn1areticulon 1a0.023
pak2ap21 (CDKN1A)-activated kinase 2a0.023
sox32SRY-box containing gene 320.023
col7a1lcollagen type VII alpha 1-like0.023
prox1prospero-related homeobox gene 10.022
adipoql2adiponectin, C1Q and collagen domain containing, like 20.022
hoxa13bhomeo box A13b0.022
otpborthopedia homolog b0.022
notch1bnotch homolog 1b0.021
clic4chloride intracellular channel 40.021
cdh23cadherin-like 230.021
esrraestrogen-related receptor alpha0.021
spns2spinster homolog 2 (Drosophila)0.021
myod1myogenic differentiation 10.021
bmp2abone morphogenetic protein 2a0.020
irx2airoquois homeobox protein 2, a0.020
birc2baculoviral IAP repeat-containing 20.020
tgfb1atransforming growth factor, beta 1a0.020
bmp4bone morphogenetic protein 40.020
aplnraapelin receptor a0.020
otcornithine carbamoyltransferase0.020
adipoqladiponectin, C1Q and collagen domain containing, like0.020
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.042
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.994
Nos3nitric oxide synthase 3, endothelial cell0.991
Gli2GLI-Kruppel family member GLI20.986
Fbn1fibrillin 10.964
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.961
Notch2Notch gene homolog 2 (Drosophila)0.953
Loxlysyl oxidase0.924
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.920
Kitkit oncogene0.810
Notch1Notch gene homolog 1 (Drosophila)0.790
Ctnnb1catenin (cadherin associated protein), beta 10.638
Lrp1low density lipoprotein receptor-related protein 10.629
Dll1delta-like 1 (Drosophila)0.625
Dll4delta-like 4 (Drosophila)0.614
Esr1estrogen receptor 1 (alpha)0.580
Trp53transformation related protein 530.575
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.561
Bmpr1abone morphogenetic protein receptor, type 1A0.546
Cdkn1bcyclin-dependent kinase inhibitor 1B0.538
Bcl2B-cell leukemia/lymphoma 20.528
Lama5laminin, alpha 50.501
Fgfr1fibroblast growth factor receptor 10.475
C1qccomplement component 1, q subcomponent, C chain0.469
Srcin1SRC kinase signaling inhibitor 10.428
Vaspvasodilator-stimulated phosphoprotein0.412
Tbx3T-box 30.409
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.403
Fgfr2fibroblast growth factor receptor 20.402
Col5a2collagen, type V, alpha 20.376
Cdh5cadherin 50.375
Itgb1integrin beta 1 (fibronectin receptor beta)0.368
Stat5bsignal transducer and activator of transcription 5B0.364
Snai1snail homolog 1 (Drosophila)0.362
Arandrogen receptor0.356
Itga3integrin alpha 30.342
C1qacomplement component 1, q subcomponent, alpha polypeptide0.330
Pcsk5proprotein convertase subtilisin/kexin type 50.327
Col3a1collagen, type III, alpha 10.325
Pcolceprocollagen C-endopeptidase enhancer protein0.317
Hspg2perlecan (heparan sulfate proteoglycan 2)0.308
Pgrprogesterone receptor0.306
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.299
Foxf1aforkhead box F1a0.295
Slit3slit homolog 3 (Drosophila)0.292
Pax1paired box gene 10.276
Smad3MAD homolog 3 (Drosophila)0.270
Kdrkinase insert domain protein receptor0.259
Tnks1bp1tankyrase 1 binding protein 10.256
Itga5integrin alpha 5 (fibronectin receptor alpha)0.255
Nrp1neuropilin 10.252
Flt4FMS-like tyrosine kinase 40.252
Adra2cadrenergic receptor, alpha 2c0.250
Sox10SRY-box containing gene 100.243
Scn5asodium channel, voltage-gated, type V, alpha0.239
Gdnfglial cell line derived neurotrophic factor0.235
Enahenabled homolog (Drosophila)0.235
Ptenphosphatase and tensin homolog0.235
C1qbcomplement component 1, q subcomponent, beta polypeptide0.233
Psen1presenilin 10.232
Meox2mesenchyme homeobox 20.231
Ror2receptor tyrosine kinase-like orphan receptor 20.230
Ptprnprotein tyrosine phosphatase, receptor type, N0.228
Tgfb2transforming growth factor, beta 20.226
Cldn5claudin 50.222
Pax3paired box gene 30.220
Nos1nitric oxide synthase 1, neuronal0.220
Col13a1collagen, type XIII, alpha 10.219
Fstl1follistatin-like 10.219
Egfrepidermal growth factor receptor0.218
Prl8a2prolactin family 8, subfamily a, member 20.218
Sox7SRY-box containing gene 70.216
Col6a2collagen, type VI, alpha 20.215
Sstr5somatostatin receptor 50.214
Flt1FMS-like tyrosine kinase 10.210
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.209
Pdgfbplatelet derived growth factor, B polypeptide0.208
Loxl1lysyl oxidase-like 10.207
Tgfatransforming growth factor alpha0.205
Gja5gap junction protein, alpha 50.204
Plcg1phospholipase C, gamma 10.202
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.199
Robo1roundabout homolog 1 (Drosophila)0.198
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.196
Fzd1frizzled homolog 1 (Drosophila)0.196
Dkk1dickkopf homolog 1 (Xenopus laevis)0.194
Col12a1collagen, type XII, alpha 10.193
Prlrprolactin receptor0.187
Amhr2anti-Mullerian hormone type 2 receptor0.186
Hoxc9homeobox C90.185
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.185
Col4a1collagen, type IV, alpha 10.184
C3ar1complement component 3a receptor 10.177
Itgb3integrin beta 30.174
F2rcoagulation factor II (thrombin) receptor0.171
Smad1MAD homolog 1 (Drosophila)0.170
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd4Cd4 molecule0.012
A3galt2alpha 1,3-galactosyltransferase 20.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism