The network for 'collagen metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

collagen metabolic process

The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).

NameDescriptionProbabilityFunc Analog Organism
COL1A1collagen, type I, alpha 10.982
COL6A1collagen, type VI, alpha 10.968
COL3A1collagen, type III, alpha 10.905
TEKTEK tyrosine kinase, endothelial0.863
COL6A2collagen, type VI, alpha 20.780
BMPR1Abone morphogenetic protein receptor, type IA0.721
COL1A2collagen, type I, alpha 20.704
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.693
FLNAfilamin A, alpha0.639
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.627
COL4A1collagen, type IV, alpha 10.506
BMP1bone morphogenetic protein 10.496
FGAfibrinogen alpha chain0.495
BGNbiglycan0.472
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.451
COL4A2collagen, type IV, alpha 20.416
CAV1caveolin 1, caveolae protein, 22kDa0.390
POSTNperiostin, osteoblast specific factor0.384
COL5A2collagen, type V, alpha 20.322
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.303
COL5A1collagen, type V, alpha 10.275
DDR2discoidin domain receptor tyrosine kinase 20.262
TIMP1TIMP metallopeptidase inhibitor 10.260
PCOLCEprocollagen C-endopeptidase enhancer0.242
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.219
PXDNperoxidasin homolog (Drosophila)0.218
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.199
TMBIM6transmembrane BAX inhibitor motif containing 60.198
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.191
ALBalbumin0.186
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.180
PKD1polycystic kidney disease 1 (autosomal dominant)0.177
MMP11matrix metallopeptidase 11 (stromelysin 3)0.158
FSTL1follistatin-like 10.147
COL6A3collagen, type VI, alpha 30.133
ANGPT2angiopoietin 20.131
ADAM12ADAM metallopeptidase domain 120.130
THY1Thy-1 cell surface antigen0.128
SERPINH1serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)0.111
THBS2thrombospondin 20.103
LAMC1laminin, gamma 1 (formerly LAMB2)0.103
MXRA5matrix-remodelling associated 50.102
FBN1fibrillin 10.102
CYR61cysteine-rich, angiogenic inducer, 610.101
CD248CD248 molecule, endosialin0.097
THBS1thrombospondin 10.094
LAMB1laminin, beta 10.094
PDIA3protein disulfide isomerase family A, member 30.091
MMP12matrix metallopeptidase 12 (macrophage elastase)0.089
LTBP2latent transforming growth factor beta binding protein 20.086
FKBP10FK506 binding protein 10, 65 kDa0.082
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.081
FGGfibrinogen gamma chain0.078
WISP1WNT1 inducible signaling pathway protein 10.078
CYTH1cytohesin 10.077
LUMlumican0.072
MFAP2microfibrillar-associated protein 20.071
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.071
TIMP2TIMP metallopeptidase inhibitor 20.069
ANGPTL2angiopoietin-like 20.068
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.067
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.063
GRB7growth factor receptor-bound protein 70.063
PRSS3protease, serine, 30.062
PLXDC1plexin domain containing 10.060
CDCP1CUB domain containing protein 10.060
PLOD1procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 10.057
FBLN2fibulin 20.055
WNT2wingless-type MMTV integration site family member 20.054
S100BS100 calcium binding protein B0.054
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.053
NID2nidogen 2 (osteonidogen)0.053
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.053
CD63CD63 molecule0.051
TMSB4Xthymosin beta 4, X-linked0.051
HSPG2heparan sulfate proteoglycan 20.051
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.050
EMILIN1elastin microfibril interfacer 10.049
COMPcartilage oligomeric matrix protein0.048
IGFBP3insulin-like growth factor binding protein 30.047
PRKCDBPprotein kinase C, delta binding protein0.046
COL13A1collagen, type XIII, alpha 10.046
SLC39A1solute carrier family 39 (zinc transporter), member 10.046
C1Scomplement component 1, s subcomponent0.045
ITGBL1integrin, beta-like 1 (with EGF-like repeat domains)0.043
PLECplectin0.043
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.043
VCANversican0.042
FGF18fibroblast growth factor 180.042
COL11A1collagen, type XI, alpha 10.042
PTRFpolymerase I and transcript release factor0.041
SDF4stromal cell derived factor 40.041
LOXL2lysyl oxidase-like 20.041
GLRXglutaredoxin (thioltransferase)0.040
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.040
LRRC15leucine rich repeat containing 150.039
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.039
A2Malpha-2-macroglobulin0.038
COL14A1collagen, type XIV, alpha 10.037
EHD2EH-domain containing 20.037
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
col1a2collagen, type I, alpha 20.981
col1a1acollagen, type I, alpha 1a0.902
itgb1b.2integrin, beta 1b.20.847
ctskcathepsin K0.822
itgb1bintegrin, beta 1b0.811
sparcsecreted acidic cysteine rich glycoprotein0.761
tgfbitransforming growth factor, beta-induced0.617
col12a1collagen, type XII, alpha 10.614
col2a1acollagen type II, alpha-1a0.602
col5a1procollagen, type V, alpha 10.553
rcn3reticulocalbin 3, EF-hand calcium binding domain0.452
itgb1aintegrin, beta 1a0.426
hapln1ahyaluronan and proteoglycan link protein 1a0.389
itgb1b.1integrin, beta 1b.10.343
ctgfconnective tissue growth factor0.340
cd63Cd63 antigen0.325
mtpmicrosomal triglyceride transfer protein0.320
cdx1bcaudal type homeobox 1 b0.319
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.311
postnperiostin, osteoblast specific factor0.304
LOC569128hypothetical protein LOC5691280.298
pkd2polycystic kidney disease 20.259
prrx1apaired related homeobox 1a0.257
vcanbversican b0.246
bmp2bbone morphogenetic protein 2b0.235
xbp1X-box binding protein 10.229
mpxmyeloid-specific peroxidase0.225
LOC100334210growth/differentiation factor 5-like0.214
ntd5ntl-dependent gene 50.208
osr1odd-skipped related 1 (Drosophila)0.207
rhagRhesus blood group-associated glycoprotein0.203
mmp14bmatrix metalloproteinase 14b (membrane-inserted)0.202
plod2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.194
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.189
spry4sprouty (Drosophila) homolog 40.187
matn4matrilin 40.179
igf2binsulin-like growth factor 2b0.179
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.179
gcm2glial cells missing homolog 2 (Drosophila)0.178
col1a1bcollagen, type I, alpha 1b0.172
tpm4tropomyosin 40.169
ctsccathepsin C0.168
fbn2bfibrillin 2b0.162
satb2SATB homeobox 20.159
LOC100003330melanocortin-2 receptor accessory protein 2-like0.153
ctsbacathepsin B, a0.149
mmp13amatrix metalloproteinase 13a0.146
fstl1bfollistatin-like 1b0.146
fabp11afatty acid binding protein 11a0.145
jag1bjagged 1b0.145
col27a1acollagen, type XXVII, alpha 1a0.138
ahr2aryl hydrocarbon receptor 20.135
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.132
mmp15bmatrix metallopeptidase 15b0.132
ppibpeptidylprolyl isomerase B (cyclophilin B)0.124
ctszcathepsin Z0.124
b2mbeta-2-microglobulin0.118
angptl2angiopoietin-like 20.117
twist1btwist1b0.111
psapprosaposin0.110
igfbp6binsulin-like growth factor binding protein 6b0.108
col11a1acollagen, type XI, alpha 1a0.107
tgfb2transforming growth factor, beta 20.106
ucp2uncoupling protein 20.104
ptgs2aprostaglandin-endoperoxide synthase 2a0.103
drldraculin0.101
col5a2lcollagen, type V, alpha 2-like0.100
si:ch211-212m21.5si:ch211-212m21.50.096
ctsdcathepsin D0.096
crabp2acellular retinoic acid binding protein 2, a0.095
vasnvasorin0.090
hspa5heat shock protein 50.090
runx2arunt-related transcription factor 2a0.090
zgc:55891zgc:558910.090
zgc:92903zgc:929030.088
id1inhibitor of DNA binding 10.088
wu:fv91b12wu:fv91b120.086
anxa2aannexin A2a0.086
id3inhibitor of DNA binding 30.085
pcsk5bproprotein convertase subtilisin/kexin type 5b0.084
bhlhe41basic helix-loop-helix family, member e410.083
si:dkeyp-22b2.3si:dkeyp-22b2.30.083
aqp1a.1aquaporin 1a, tandem duplicate 10.082
myh10myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle0.082
timp2atissue inhibitor of metalloproteinase 2a0.081
igfbp6ainsulin-like growth factor binding protein 6a0.080
sat1aspermidine/spermine N1-acetyltransferase 1a0.079
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.079
ctsl1acathepsin L, 1 a0.079
fabp6fatty acid binding protein 6, ileal (gastrotropin)0.077
ehd2EH-domain containing 20.077
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.076
ctssb.1cathepsin S, b.10.076
il6stinterleukin 6 signal transducer0.075
bnc2basonuclin 20.075
ssr4signal sequence receptor, delta0.075
fxyd1FXYD domain containing ion transport regulator 1 (phospholemman)0.074
twist2twist20.073
zgc:172161zgc:1721610.072
ptch2patched 20.072
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nos3nitric oxide synthase 3, endothelial cell0.800
Neurod1neurogenic differentiation 10.790
Ascl1achaete-scute complex homolog 1 (Drosophila)0.470
Neurog2neurogenin 20.430
Hspg2perlecan (heparan sulfate proteoglycan 2)0.425
Pkd1polycystic kidney disease 1 homolog0.414
Gli3GLI-Kruppel family member GLI30.379
Hand1heart and neural crest derivatives expressed transcript 10.353
Bgnbiglycan0.293
Loxl1lysyl oxidase-like 10.261
Hif1ahypoxia inducible factor 1, alpha subunit0.261
Il6stinterleukin 6 signal transducer0.227
Onecut1one cut domain, family member 10.221
Acvrl1activin A receptor, type II-like 10.216
Pax3paired box gene 30.205
Ptf1apancreas specific transcription factor, 1a0.194
Ptenphosphatase and tensin homolog0.183
Nhlh1nescient helix loop helix 10.182
Hoxd13homeobox D130.176
Pax6paired box gene 60.162
Gata6GATA binding protein 60.152
Col2a1collagen, type II, alpha 10.148
Gli2GLI-Kruppel family member GLI20.145
Adam17a disintegrin and metallopeptidase domain 170.140
Ctsdcathepsin D0.139
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.138
Gata1GATA binding protein 10.136
Vhlvon Hippel-Lindau tumor suppressor0.135
Fbn1fibrillin 10.135
Ror2receptor tyrosine kinase-like orphan receptor 20.134
Neurod4neurogenic differentiation 40.130
Tcf4transcription factor 40.124
Lepleptin0.120
Foxc2forkhead box C20.118
Sox11SRY-box containing gene 110.116
Fgfr2fibroblast growth factor receptor 20.115
Csf1colony stimulating factor 1 (macrophage)0.114
Irx3Iroquois related homeobox 3 (Drosophila)0.114
Nkx3-2NK3 homeobox 20.109
Twist2twist homolog 2 (Drosophila)0.107
Zeb1zinc finger E-box binding homeobox 10.106
Ltbp2latent transforming growth factor beta binding protein 20.104
Tcf3transcription factor 30.103
Hic1hypermethylated in cancer 10.103
Foxf1aforkhead box F1a0.101
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.097
Tlr4toll-like receptor 40.095
Sox9SRY-box containing gene 90.094
Irx5Iroquois related homeobox 5 (Drosophila)0.089
Fkbp10FK506 binding protein 100.088
Nr3c1nuclear receptor subfamily 3, group C, member 10.088
Apoeapolipoprotein E0.087
Otx2orthodenticle homolog 2 (Drosophila)0.087
Fgf18fibroblast growth factor 180.082
Npr2natriuretic peptide receptor 20.082
Ccl2chemokine (C-C motif) ligand 20.081
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.077
Lyz2lysozyme 20.072
Foxd2forkhead box D20.071
Smosmoothened homolog (Drosophila)0.069
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.069
Lhx5LIM homeobox protein 50.067
Sim2single-minded homolog 2 (Drosophila)0.066
Mmp2matrix metallopeptidase 20.064
Col1a2collagen, type I, alpha 20.064
Fstl1follistatin-like 10.061
Olig2oligodendrocyte transcription factor 20.060
Gdnfglial cell line derived neurotrophic factor0.060
Col22a1collagen, type XXII, alpha 10.060
Shhsonic hedgehog0.058
Irx2Iroquois related homeobox 2 (Drosophila)0.058
Ltbp3latent transforming growth factor beta binding protein 30.058
Leprel2leprecan-like 20.057
Col6a1collagen, type VI, alpha 10.057
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.057
Neurog3neurogenin 30.056
Efna2ephrin A20.056
Nos2nitric oxide synthase 2, inducible0.055
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.054
Lmnalamin A0.053
Thbs1thrombospondin 10.052
Pdx1pancreatic and duodenal homeobox 10.052
Hoxa11homeobox A110.051
Pax7paired box gene 70.051
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.051
Pnpla2patatin-like phospholipase domain containing 20.050
Mfap4microfibrillar-associated protein 40.050
Gja1gap junction protein, alpha 10.050
Tcfap2atranscription factor AP-2, alpha0.049
Fgf15fibroblast growth factor 150.046
Sostsclerostin0.045
Saa4serum amyloid A 40.045
Engendoglin0.044
Notch2Notch gene homolog 2 (Drosophila)0.044
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.044
Glra1glycine receptor, alpha 1 subunit0.043
Foxc1forkhead box C10.043
Clec4dC-type lectin domain family 4, member d0.042
Tgfb3transforming growth factor, beta 30.042
Gpr50G-protein-coupled receptor 500.042
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd4Cd4 molecule0.064
Mmp23matrix metallopeptidase 230.064
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.053
Loxl1lysyl oxidase-like 10.051
Col12a1collagen, type XII, alpha 10.042
Olfml2bolfactomedin-like 2B0.038
Fgfr1Fibroblast growth factor receptor 10.036
Asamadipocyte-specific adhesion molecule0.036
Elnelastin0.030
Plauplasminogen activator, urokinase0.030
Cox4i1cytochrome c oxidase subunit IV isoform 10.027
Lect1leukocyte cell derived chemotaxin 10.027
Col4a1collagen, type IV, alpha 10.026
Fn1fibronectin 10.026
Edn1endothelin 10.026
Eef2eukaryotic translation elongation factor 20.025
Calcbcalcitonin-related polypeptide, beta0.024
Loxlysyl oxidase0.023
Fkbp10FK506 binding protein 100.023
AxlAxl receptor tyrosine kinase0.023
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.023
B2mbeta-2 microglobulin0.021
S100a10S100 calcium binding protein A100.021
Egr2early growth response 20.020
Fuca1fucosidase, alpha-L- 1, tissue0.019
Mmp3matrix metallopeptidase 30.019
Hckhemopoietic cell kinase0.019
Col15a1collagen, type XV, alpha 10.018
Rab1bRAB1B, member RAS oncogene family0.018
Nr4a1nuclear receptor subfamily 4, group A, member 10.018
Vcanversican0.018
BokBCL2-related ovarian killer0.018
Cpxm2carboxypeptidase X (M14 family), member 20.018
Il2rainterleukin 2 receptor, alpha0.017
Bgnbiglycan0.017
Fam198bfamily with sequence similarity 198, member B0.017
Aspgasparaginase homolog (S. cerevisiae)0.017
Fgfr2fibroblast growth factor receptor 20.017
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.017
Plxnd1plexin D10.017
Copz2coatomer protein complex, subunit zeta 20.017
Clic4chloride intracellular channel 40.016
Il1ainterleukin 1 alpha0.016
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.016
Cercamcerebral endothelial cell adhesion molecule0.015
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.015
Aebp1AE binding protein 10.015
Mmp2matrix metallopeptidase 20.015
Arhgap10Rho GTPase activating protein 100.015
Fmnl1formin-like 10.015
Clec11aC-type lectin domain family 11, member a0.015
Col3a1collagen, type III, alpha 10.014
Hist1h1ahistone cluster 1, H1a0.014
Ldb3LIM domain binding 30.014
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.014
Fstl1follistatin-like 10.014
Hrhairless0.014
Prrx2paired related homeobox 20.013
Trim47tripartite motif-containing 470.013
Id3inhibitor of DNA binding 30.013
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.013
Ctsscathepsin S0.012
Aqp8aquaporin 80.012
P4hbprolyl 4-hydroxylase, beta polypeptide0.012
Prr13proline rich 130.012
LOC683313similar to keratin complex 2, basic, gene 6a0.012
F2rl3coagulation factor II (thrombin) receptor-like 30.012
Mmp9matrix metallopeptidase 90.012
Il1r1interleukin 1 receptor, type I0.012
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.012
Fzd2frizzled homolog 2 (Drosophila)0.012
LOC286980putative pheromone receptor (Go-VN13B)0.012
RGD1561143similar to cell surface receptor FDFACT0.012
Ccnd3cyclin D30.012
Calucalumenin0.012
Cd63Cd63 molecule0.012
Ltbp2latent transforming growth factor beta binding protein 20.012
Ptk2bPTK2B protein tyrosine kinase 2 beta0.012
Fth1ferritin, heavy polypeptide 10.012
Irf5interferon regulatory factor 50.012
Igfbp6insulin-like growth factor binding protein 60.011
Ly6allymphocyte antigen 6 complex, locus A-like0.011
Gna12guanine nucleotide binding protein (G protein) alpha 120.011
Gprc5aG protein-coupled receptor, family C, group 5, member A0.011
Egr1early growth response 10.011
Col18a1collagen, type XVIII, alpha 10.011
Bmp1bone morphogenetic protein 10.011
Rabac1Rab acceptor 1 (prenylated)0.011
Ibspintegrin-binding sialoprotein0.011
Afmafamin0.011
Sprr3small proline-rich protein 30.011
GperG protein-coupled estrogen receptor 10.011
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.010
Foxa3forkhead box A30.010
Stat6signal transducer and activator of transcription 60.010
Epas1endothelial PAS domain protein 10.010
Pdpnpodoplanin0.010
Wnt5awingless-type MMTV integration site family, member 5A0.010
Procprotein C0.010
Scamp2secretory carrier membrane protein 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism