The network for 'negative regulation of keratinocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of keratinocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.

NameDescriptionProbabilityFunc Analog Organism
RNPS1RNA binding protein S1, serine-rich domain0.998
HOXB5homeobox B50.992
HOXA10homeobox A100.841
HOXA4homeobox A40.774
HOXB7homeobox B70.665
HOXB6homeobox B60.621
SREK1splicing regulatory glutamine/lysine-rich protein 10.611
HOXA11homeobox A110.548
HOXB9homeobox B90.535
HOXA5homeobox A50.497
HOXB3homeobox B30.455
KRT5keratin 50.449
H3F3BH3 histone, family 3B (H3.3B)0.443
SATB2SATB homeobox 20.419
HOXA6homeobox A60.397
SRPK2SRSF protein kinase 20.331
HOXC10homeobox C100.296
HOXA7homeobox A70.295
HOXA2homeobox A20.243
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.227
CABLES1Cdk5 and Abl enzyme substrate 10.212
SRRM2serine/arginine repetitive matrix 20.203
HOXC4homeobox C40.150
HNRNPMheterogeneous nuclear ribonucleoprotein M0.142
SRRM1serine/arginine repetitive matrix 10.121
HOXC6homeobox C60.114
HOXA1homeobox A10.112
MSX1msh homeobox 10.092
KRT15keratin 150.078
HOXB2homeobox B20.074
KRT6Ckeratin 6C0.064
HOXA3homeobox A30.059
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.050
TOE1target of EGR1, member 1 (nuclear)0.048
HOXC9homeobox C90.041
HOXC5homeobox C50.038
HOXC11homeobox C110.035
SART1squamous cell carcinoma antigen recognized by T cells0.034
HOXA13homeobox A130.030
HOXD10homeobox D100.027
NXF1nuclear RNA export factor 10.027
CCNL1cyclin L10.027
MAT2Amethionine adenosyltransferase II, alpha0.026
S1PR5sphingosine-1-phosphate receptor 50.024
HOXC13homeobox C130.023
HOXC8homeobox C80.021
HNRNPCL1heterogeneous nuclear ribonucleoprotein C-like 10.021
SMAD6SMAD family member 60.020
HOXB4homeobox B40.020
PITX2paired-like homeodomain 20.019
FOXL1forkhead box L10.018
HOXD8homeobox D80.018
TERF2IPtelomeric repeat binding factor 2, interacting protein0.016
DLX2distal-less homeobox 20.016
DLX5distal-less homeobox 50.016
GRHL2grainyhead-like 2 (Drosophila)0.015
ZNF676zinc finger protein 6760.015
NKTRnatural killer-tumor recognition sequence0.015
TWIST1twist homolog 1 (Drosophila)0.014
CHERPcalcium homeostasis endoplasmic reticulum protein0.013
HOXB13homeobox B130.012
BNC1basonuclin 10.012
HOXD9homeobox D90.012
TFCP2L1transcription factor CP2-like 10.012
HOXB8homeobox B80.012
HOXD11homeobox D110.011
CIRBPcold inducible RNA binding protein0.011
FXYD3FXYD domain containing ion transport regulator 30.011
KRT14keratin 140.011
LAD1ladinin 10.011
PRSS8protease, serine, 80.011
FOXD1forkhead box D10.010
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.010
PRR15Lproline rich 15-like0.010
UACAuveal autoantigen with coiled-coil domains and ankyrin repeats0.010
MAP1Amicrotubule-associated protein 1A0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Msx2homeobox, msh-like 20.960
Pax3paired box gene 30.951
Trp63transformation related protein 630.950
Shhsonic hedgehog0.916
Fgfr2fibroblast growth factor receptor 20.870
Ptenphosphatase and tensin homolog0.807
Sox9SRY-box containing gene 90.714
Prrx1paired related homeobox 10.427
Dlx5distal-less homeobox 50.411
Trp53transformation related protein 530.368
Ctnnb1catenin (cadherin associated protein), beta 10.362
Lef1lymphoid enhancer binding factor 10.305
Runx2runt related transcription factor 20.245
Esr1estrogen receptor 1 (alpha)0.226
Trp73transformation related protein 730.224
Bmp7bone morphogenetic protein 70.213
Alx4aristaless-like homeobox 40.189
Hand1heart and neural crest derivatives expressed transcript 10.168
Gli3GLI-Kruppel family member GLI30.167
Pax9paired box gene 90.167
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.163
Egfrepidermal growth factor receptor0.163
Eya1eyes absent 1 homolog (Drosophila)0.154
Rspo2R-spondin 2 homolog (Xenopus laevis)0.152
Reg1regenerating islet-derived 10.146
2210010C04RikRIKEN cDNA 2210010C04 gene0.145
Foxc1forkhead box C10.143
Otx2orthodenticle homolog 2 (Drosophila)0.139
Cdx2caudal type homeobox 20.117
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.115
Reg2regenerating islet-derived 20.106
Pitx1paired-like homeodomain transcription factor 10.093
Apcadenomatosis polyposis coli0.091
Zg16zymogen granule protein 160.090
Reg3bregenerating islet-derived 3 beta0.089
Reg3gregenerating islet-derived 3 gamma0.085
Rararetinoic acid receptor, alpha0.083
Wnt3awingless-related MMTV integration site 3A0.074
Reg3dregenerating islet-derived 3 delta0.072
Tbx3T-box 30.070
Krt14keratin 140.070
Dlx2distal-less homeobox 20.069
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.068
Rxraretinoid X receptor alpha0.068
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.067
Alx1ALX homeobox 10.062
Prss2protease, serine, 20.062
Hoxa13homeobox A130.061
Plac1placental specific protein 10.059
Srsf2serine/arginine-rich splicing factor 20.059
Sp6trans-acting transcription factor 60.057
Dmbt1deleted in malignant brain tumors 10.057
Gli2GLI-Kruppel family member GLI20.056
Bmp4bone morphogenetic protein 40.056
Muc13mucin 13, epithelial transmembrane0.055
Tcfap2atranscription factor AP-2, alpha0.052
Mmp7matrix metallopeptidase 70.052
Prrx2paired related homeobox 20.050
Pax6paired box gene 60.048
Emx1empty spiracles homolog 1 (Drosophila)0.047
Meox2mesenchyme homeobox 20.047
Hnrpdlheterogeneous nuclear ribonucleoprotein D-like0.046
Gp2glycoprotein 2 (zymogen granule membrane)0.046
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.046
Smosmoothened homolog (Drosophila)0.045
Ms4a10membrane-spanning 4-domains, subfamily A, member 100.044
Ins1insulin I0.043
Fgf10fibroblast growth factor 100.041
Prss32protease, serine, 320.041
Cpa1carboxypeptidase A10.041
Tff2trefoil factor 2 (spasmolytic protein 1)0.039
Yap1yes-associated protein 10.039
Itga3integrin alpha 30.039
Tbx15T-box 150.039
Reg3aregenerating islet-derived 3 alpha0.038
Pklrpyruvate kinase liver and red blood cell0.038
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.038
Gucy2cguanylate cyclase 2c0.036
Krt4keratin 40.034
Rb1retinoblastoma 10.033
Tff3trefoil factor 3, intestinal0.033
Il10interleukin 100.033
Ptf1apancreas specific transcription factor, 1a0.032
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.032
Gscgoosecoid homeobox0.031
Fut2fucosyltransferase 20.031
Gpr87G protein-coupled receptor 870.031
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.030
Foxe3forkhead box E30.030
Dsc3desmocollin 30.029
Ptch1patched homolog 10.029
BrafBraf transforming gene0.029
Hoxa2homeobox A20.028
Chukconserved helix-loop-helix ubiquitous kinase0.028
Lrp6low density lipoprotein receptor-related protein 60.028
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism