The network for 'negative regulation of leukocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of leukocyte differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.

NameDescriptionProbabilityFunc Analog Organism
C1QAcomplement component 1, q subcomponent, A chain0.998
HLA-Cmajor histocompatibility complex, class I, C0.996
ZNF43zinc finger protein 430.985
HLA-Amajor histocompatibility complex, class I, A0.982
HLA-Bmajor histocompatibility complex, class I, B0.974
CD80CD80 molecule0.883
IL4Rinterleukin 4 receptor0.881
PTPN6protein tyrosine phosphatase, non-receptor type 60.861
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.849
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.834
PILRApaired immunoglobin-like type 2 receptor alpha0.791
HOXB5homeobox B50.787
ZNF253zinc finger protein 2530.776
TAL1T-cell acute lymphocytic leukemia 10.731
HLA-Emajor histocompatibility complex, class I, E0.726
CD86CD86 molecule0.630
BMPR1Abone morphogenetic protein receptor, type IA0.606
ZNF675zinc finger protein 6750.558
HLA-Gmajor histocompatibility complex, class I, G0.549
CCR5chemokine (C-C motif) receptor 50.535
ZNF273zinc finger protein 2730.533
NCOR2nuclear receptor corepressor 20.502
HLA-Fmajor histocompatibility complex, class I, F0.480
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.470
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.458
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.455
CDK6cyclin-dependent kinase 60.435
RXRAretinoid X receptor, alpha0.424
HOXA10homeobox A100.409
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.403
FSTL1follistatin-like 10.336
CCL4chemokine (C-C motif) ligand 40.311
CCND1cyclin D10.290
EPORerythropoietin receptor0.290
RUNX1runt-related transcription factor 10.268
ZNF430zinc finger protein 4300.255
ZNF117zinc finger protein 1170.252
CXCL9chemokine (C-X-C motif) ligand 90.208
MDFIMyoD family inhibitor0.207
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.198
GRAP2GRB2-related adaptor protein 20.175
CCL2chemokine (C-C motif) ligand 20.170
HOXA7homeobox A70.169
GHRgrowth hormone receptor0.165
ZNF91zinc finger protein 910.165
CXCL10chemokine (C-X-C motif) ligand 100.162
TAPBPTAP binding protein (tapasin)0.158
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.151
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.150
HOXA5homeobox A50.150
ZNF93zinc finger protein 930.149
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.145
HLA-DPB1major histocompatibility complex, class II, DP beta 10.139
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.132
ICAM1intercellular adhesion molecule 10.132
BMP2bone morphogenetic protein 20.131
GAB1GRB2-associated binding protein 10.130
ZNF254zinc finger protein 2540.128
CCL13chemokine (C-C motif) ligand 130.128
ZNF708zinc finger protein 7080.127
C1QCcomplement component 1, q subcomponent, C chain0.121
HOXB3homeobox B30.117
SKIv-ski sarcoma viral oncogene homolog (avian)0.115
CD14CD14 molecule0.106
C1QBcomplement component 1, q subcomponent, B chain0.105
HOXA11homeobox A110.104
CCL8chemokine (C-C motif) ligand 80.102
CCND3cyclin D30.100
IL4interleukin 40.098
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.098
TUBA1Atubulin, alpha 1a0.095
HOXB9homeobox B90.094
CCR1chemokine (C-C motif) receptor 10.094
TMEM176Btransmembrane protein 176B0.088
RBBP4retinoblastoma binding protein 40.088
ZNF85zinc finger protein 850.082
IL2RGinterleukin 2 receptor, gamma0.081
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.079
FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)0.078
PINK1PTEN induced putative kinase 10.077
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.076
ZNF680zinc finger protein 6800.075
SH3BP2SH3-domain binding protein 20.075
RARAretinoic acid receptor, alpha0.071
CCL22chemokine (C-C motif) ligand 220.069
MDM2Mdm2 p53 binding protein homolog (mouse)0.067
CCL5chemokine (C-C motif) ligand 50.067
HOXB6homeobox B60.067
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.066
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.063
SIGLEC7sialic acid binding Ig-like lectin 70.059
DDB1damage-specific DNA binding protein 1, 127kDa0.057
CCL19chemokine (C-C motif) ligand 190.057
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.055
SLAMF1signaling lymphocytic activation molecule family member 10.054
CD40CD40 molecule, TNF receptor superfamily member 50.054
CCR7chemokine (C-C motif) receptor 70.054
HOXB7homeobox B70.054
TYMPthymidine phosphorylase0.051
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hhexhematopoietically expressed homeobox0.289
id1inhibitor of DNA binding 10.276
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.260
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.244
otx1borthodenticle homolog 1b0.238
wnt8awingless-type MMTV integration site family, member 8a0.233
cpoxcoproporphyrinogen oxidase0.215
nkx2.5NK2 transcription factor related 50.211
nf1aneurofibromin 1a0.209
hmgb1bhigh-mobility group box 1b0.208
lmo4aLIM domain only 4a0.204
foxa2forkhead box A20.184
bmp2bbone morphogenetic protein 2b0.138
bmperBMP binding endothelial regulator0.124
mychmyelocytomatosis oncogene homolog0.119
pglyrp6peptidoglycan recognition protein 60.118
foxp1bforkhead box P1b0.116
crip2cysteine-rich protein 20.112
bcl2l10BCL2-like 10 (apoptosis facilitator)0.108
cdx4caudal type homeo box transcription factor 40.107
osr1odd-skipped related 1 (Drosophila)0.105
sox2SRY-box containing gene 20.103
hmgb2ahigh-mobility group box 2a0.099
sox19bSRY-box containing gene 19b0.098
fn1fibronectin 10.094
etv2ets variant gene 20.086
prdm1aPR domain containing 1a, with ZNF domain0.078
rxrgaretinoid x receptor, gamma a0.076
ndr2nodal-related 20.072
raraaretinoic acid receptor, alpha a0.072
gata2aGATA-binding protein 2a0.063
tbx2bT-box 2b0.062
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.062
rbpms2RNA binding protein with multiple splicing 20.062
hmgb1ahigh-mobility group box 1a0.058
irf8interferon regulatory factor 80.058
nrarpanotch-regulated ankyrin repeat protein a0.058
lfnglunatic fringe homolog0.057
dbx1adeveloping brain homeobox 1a0.055
mmp13amatrix metalloproteinase 13a0.054
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.053
nf1bneurofibromin 1b0.052
mpxmyeloid-specific peroxidase0.051
bcl2B-cell leukemia/lymphoma 20.051
gsnagelsolin a0.050
pitx2paired-like homeodomain transcription factor 20.049
tal1T-cell acute lymphocytic leukemia 10.049
hand2heart and neural crest derivatives expressed transcript 20.048
otx2orthodenticle homolog 20.048
angptl2angiopoietin-like 20.048
runx1runt-related transcription factor 10.047
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.047
tfr1atransferrin receptor 1a0.047
aplnrbapelin receptor b0.046
foxd3forkhead box D30.046
gata1aGATA binding protein 1a0.045
jag1bjagged 1b0.045
hoxa2bhomeo box A2b0.044
fevFEV (ETS oncogene family)0.043
col8a1acollagen, type VIII, alpha 1a0.042
prrx1apaired related homeobox 1a0.042
mef2camyocyte enhancer factor 2ca0.042
mapk3mitogen-activated protein kinase 30.041
hs3st3b1aheparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a0.041
znfl2azinc finger-like gene 2a0.041
col12a1collagen, type XII, alpha 10.040
pcdh8protocadherin 80.040
rarabretinoic acid receptor, alpha b0.039
fzd8afrizzled homolog 8a0.038
cx43connexin 430.038
lef1lymphocyte enhancer binding factor 10.037
wnt11rwingless-type MMTV integration site family, member 11, related0.037
gdf6agrowth differentiation factor 6a0.036
dhrs3adehydrogenase/reductase (SDR family) member 3a0.036
fzd7bfrizzled homolog 7b0.036
sbno2bstrawberry notch homolog 2b0.034
adora2aaadenosine A2a receptor a0.034
esdesterase D/formylglutathione hydrolase0.034
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.034
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.034
anxa11aannexin A11a0.033
foxa3forkhead box A30.032
ahcyS-adenosylhomocysteine hydrolase0.032
hprt1hypoxanthine phosphoribosyltransferase 10.032
znf711zinc finger protein 7110.032
slc30a7solute carrier family 30 (zinc transporter), member 70.032
frzbfrizzled-related protein0.031
bmp4bone morphogenetic protein 40.031
foxi3aforkhead box I3a0.031
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.030
fli1afriend leukemia integration 1a0.030
fli1bfriend leukemia integration 1b0.030
sdc2syndecan 20.030
sepp1aselenoprotein P, plasma, 1a0.030
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Stat3signal transducer and activator of transcription 30.999
Ikzf1IKAROS family zinc finger 10.997
Trp53transformation related protein 530.995
Gli2GLI-Kruppel family member GLI20.994
Ighimmunoglobulin heavy chain complex0.990
Robo1roundabout homolog 1 (Drosophila)0.990
Cdkn1bcyclin-dependent kinase inhibitor 1B0.978
Nf1neurofibromatosis 10.971
Rararetinoic acid receptor, alpha0.957
Ptenphosphatase and tensin homolog0.954
Fgfr2fibroblast growth factor receptor 20.950
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.933
Zeb1zinc finger E-box binding homeobox 10.926
Sox9SRY-box containing gene 90.925
Rxraretinoid X receptor alpha0.919
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.918
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.908
Tgfb1transforming growth factor, beta 10.900
Id3inhibitor of DNA binding 30.887
Foxp3forkhead box P30.876
Bcl3B-cell leukemia/lymphoma 30.860
Jak2Janus kinase 20.829
Ptpn11protein tyrosine phosphatase, non-receptor type 110.827
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.806
Id1inhibitor of DNA binding 10.800
Ctnnb1catenin (cadherin associated protein), beta 10.796
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.782
Rb1retinoblastoma 10.773
Fgf10fibroblast growth factor 100.769
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.760
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.758
Sfpi1SFFV proviral integration 10.748
Il6stinterleukin 6 signal transducer0.727
Trp63transformation related protein 630.710
Slit3slit homolog 3 (Drosophila)0.668
Stat6signal transducer and activator of transcription 60.665
Slit2slit homolog 2 (Drosophila)0.651
Cd40CD40 antigen0.650
Apcadenomatosis polyposis coli0.649
Ptch1patched homolog 10.646
Notch1Notch gene homolog 1 (Drosophila)0.643
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.603
Ptprcprotein tyrosine phosphatase, receptor type, C0.600
Csf1colony stimulating factor 1 (macrophage)0.586
Tgfb2transforming growth factor, beta 20.579
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.573
Sfrp2secreted frizzled-related protein 20.563
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.555
Rargretinoic acid receptor, gamma0.554
CblCasitas B-lineage lymphoma0.540
Dok1docking protein 10.525
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.520
Irf8interferon regulatory factor 80.519
Robo2roundabout homolog 2 (Drosophila)0.517
Kitkit oncogene0.503
Socs3suppressor of cytokine signaling 30.499
Pax3paired box gene 30.494
Gli3GLI-Kruppel family member GLI30.494
Cd19CD19 antigen0.458
Rarbretinoic acid receptor, beta0.444
Tcf3transcription factor 30.436
Bmp4bone morphogenetic protein 40.427
Chd7chromodomain helicase DNA binding protein 70.405
Tbx2T-box 20.384
Sox10SRY-box containing gene 100.373
Jak3Janus kinase 30.369
Tnftumor necrosis factor0.367
H2-DMahistocompatibility 2, class II, locus DMa0.356
Mdm4transformed mouse 3T3 cell double minute 40.353
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.343
Mdm2transformed mouse 3T3 cell double minute 20.329
Plcg1phospholipase C, gamma 10.323
Twist2twist homolog 2 (Drosophila)0.319
Il2rbinterleukin 2 receptor, beta chain0.317
Rag1recombination activating gene 10.306
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.297
Cdkn2acyclin-dependent kinase inhibitor 2A0.293
Trp73transformation related protein 730.291
BlnkB-cell linker0.288
Leprleptin receptor0.285
Mapk8mitogen-activated protein kinase 80.282
Foxn1forkhead box N10.280
Eporerythropoietin receptor0.279
Stat2signal transducer and activator of transcription 20.277
TcraT-cell receptor alpha chain0.272
Prdm1PR domain containing 1, with ZNF domain0.266
Kdrkinase insert domain protein receptor0.257
Retret proto-oncogene0.253
Gpr97G protein-coupled receptor 970.252
Hhexhematopoietically expressed homeobox0.247
Icosinducible T-cell co-stimulator0.239
H2-Aahistocompatibility 2, class II antigen A, alpha0.239
Msh2mutS homolog 2 (E. coli)0.238
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.229
Sorbs3sorbin and SH3 domain containing 30.228
Fgf9fibroblast growth factor 90.224
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.220
Dll1delta-like 1 (Drosophila)0.220
Sfrp1secreted frizzled-related protein 10.219
Itgb1integrin beta 1 (fibronectin receptor beta)0.218
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rpl15ribosomal protein L150.116
Rps12ribosomal protein S120.111
LOC100362298ribosomal protein S18-like0.072
Rps6ribosomal protein S60.064
LOC499782similar to 60S ribosomal protein L120.052
Rps15ribosomal protein S150.048
Rpl5ribosomal protein L50.039
Nme2non-metastatic cells 2, protein (NM23B) expressed in0.030
Rpl4ribosomal protein L40.016
Anxa1annexin A10.012
Rpl10aribosomal protein L10A0.012
Rpl28ribosomal protein L280.012
Rps7ribosomal protein S70.012
Dhx15DEAH (Asp-Glu-Ala-His) box polypeptide 150.012
Gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2 like 10.011
RGD1304704similar to Hypothetical protein CGI-990.011
Tcea1transcription elongation factor A (SII) 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism