The network for 'signal transduction involved in dna integrity checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction involved in dna integrity checkpoint

A signal transduction process that contributes to a DNA integrity checkpoint.

NameDescriptionProbabilityFunc Analog Organism
MDM2Mdm2 p53 binding protein homolog (mouse)0.868
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.651
APAF1apoptotic peptidase activating factor 10.574
CASP2caspase 2, apoptosis-related cysteine peptidase0.569
PAX3paired box 30.557
RB1retinoblastoma 10.454
CASP3caspase 3, apoptosis-related cysteine peptidase0.436
XIAPX-linked inhibitor of apoptosis0.391
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.257
LRDDleucine-rich repeats and death domain containing0.207
POU5F1POU class 5 homeobox 10.169
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.139
NLRC4NLR family, CARD domain containing 40.128
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.104
RIPK2receptor-interacting serine-threonine kinase 20.101
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.090
CASP4caspase 4, apoptosis-related cysteine peptidase0.080
CHEK2CHK2 checkpoint homolog (S. pombe)0.078
U2AF2U2 small nuclear RNA auxiliary factor 20.061
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.055
FASFas (TNF receptor superfamily, member 6)0.055
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.051
FADDFas (TNFRSF6)-associated via death domain0.050
POU3F2POU class 3 homeobox 20.047
HIPK2homeodomain interacting protein kinase 20.045
IER3immediate early response 30.045
TP53tumor protein p530.045
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.042
BIRC2baculoviral IAP repeat containing 20.038
SMAD7SMAD family member 70.037
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.036
BCL2B-cell CLL/lymphoma 20.030
CFLARCASP8 and FADD-like apoptosis regulator0.028
DAXXdeath-domain associated protein0.026
CCND3cyclin D30.025
PLRG1pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)0.021
DIABLOdiablo, IAP-binding mitochondrial protein0.021
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.021
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.020
BCAS2breast carcinoma amplified sequence 20.020
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.019
TELO2TEL2, telomere maintenance 2, homolog (S. cerevisiae)0.019
ATRataxia telangiectasia and Rad3 related0.017
DZIP1DAZ interacting protein 10.016
ELF4E74-like factor 4 (ets domain transcription factor)0.016
CASP8caspase 8, apoptosis-related cysteine peptidase0.015
AKT1v-akt murine thymoma viral oncogene homolog 10.015
HDAC4histone deacetylase 40.015
FASLGFas ligand (TNF superfamily, member 6)0.015
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.015
CASP7caspase 7, apoptosis-related cysteine peptidase0.014
CASP9caspase 9, apoptosis-related cysteine peptidase0.013
NUCB2nucleobindin 20.013
NOD1nucleotide-binding oligomerization domain containing 10.013
TGIF1TGFB-induced factor homeobox 10.013
BANPBTG3 associated nuclear protein0.013
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.013
SALL2sal-like 2 (Drosophila)0.013
NOTCH1notch 10.012
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.012
UHRF2ubiquitin-like with PHD and ring finger domains 20.011
AXIN1axin 10.011
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.011
GORABgolgin, RAB6-interacting0.011
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.010
PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent, 1D0.010
MED1mediator complex subunit 10.010
GNL3Lguanine nucleotide binding protein-like 3 (nucleolar)-like0.010
RBL2retinoblastoma-like 2 (p130)0.010
MARCKSL1MARCKS-like 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
CELE_F14D7.2Protein F14D7.20.013
F02D10.6Protein F02D10.60.013
C04B4.2Protein C04B4.20.012
ent-5Protein ENT-50.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.994
Ptenphosphatase and tensin homolog0.992
Mdm2transformed mouse 3T3 cell double minute 20.989
Mdm4transformed mouse 3T3 cell double minute 40.962
Apcadenomatosis polyposis coli0.938
Rb1retinoblastoma 10.936
Brca1breast cancer 10.912
Ctnnb1catenin (cadherin associated protein), beta 10.868
Col1a1collagen, type I, alpha 10.809
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.784
Fgfr2fibroblast growth factor receptor 20.729
Brca2breast cancer 20.682
Kitkit oncogene0.564
Cdkn1bcyclin-dependent kinase inhibitor 1B0.490
Rararetinoic acid receptor, alpha0.340
SkilSKI-like0.336
Itgb1integrin beta 1 (fibronectin receptor beta)0.316
DaxxFas death domain-associated protein0.314
Cdkn2acyclin-dependent kinase inhibitor 2A0.309
Ptpn11protein tyrosine phosphatase, non-receptor type 110.295
BrafBraf transforming gene0.292
Thbs1thrombospondin 10.234
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.232
Sfnstratifin0.226
Stk11serine/threonine kinase 110.202
Nbnnibrin0.186
Trp63transformation related protein 630.180
Runx1runt related transcription factor 10.148
Meox2mesenchyme homeobox 20.139
E2f1E2F transcription factor 10.128
Nf1neurofibromatosis 10.122
Hipk1homeodomain interacting protein kinase 10.118
Trp73transformation related protein 730.109
Ccnd1cyclin D10.108
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.106
Atmataxia telangiectasia mutated homolog (human)0.103
Rxraretinoid X receptor alpha0.089
WrnWerner syndrome homolog (human)0.077
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.073
Stat3signal transducer and activator of transcription 30.064
Sox9SRY-box containing gene 90.061
Rbl1retinoblastoma-like 1 (p107)0.057
Ptch1patched homolog 10.054
Hif1ahypoxia inducible factor 1, alpha subunit0.049
Tgfb1transforming growth factor, beta 10.049
Ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.044
Sin3atranscriptional regulator, SIN3A (yeast)0.044
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.043
Cldn7claudin 70.043
Mybl2myeloblastosis oncogene-like 20.041
Vhlvon Hippel-Lindau tumor suppressor0.040
Esr1estrogen receptor 1 (alpha)0.037
Vdrvitamin D receptor0.036
Adam17a disintegrin and metallopeptidase domain 170.036
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.036
Smad3MAD homolog 3 (Drosophila)0.035
Yap1yes-associated protein 10.035
Msh2mutS homolog 2 (E. coli)0.033
Nf2neurofibromatosis 20.032
Huwe1HECT, UBA and WWE domain containing 10.031
Notch1Notch gene homolog 1 (Drosophila)0.029
Rassf1Ras association (RalGDS/AF-6) domain family member 10.029
Dok1docking protein 10.029
Il6stinterleukin 6 signal transducer0.029
Nfyanuclear transcription factor-Y alpha0.028
Gadd45agrowth arrest and DNA-damage-inducible 45 alpha0.028
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.027
Xpaxeroderma pigmentosum, complementation group A0.026
Tia1cytotoxic granule-associated RNA binding protein 10.026
Lig4ligase IV, DNA, ATP-dependent0.026
Smad5MAD homolog 5 (Drosophila)0.025
Ahraryl-hydrocarbon receptor0.024
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.024
Asxl1additional sex combs like 1 (Drosophila)0.024
Mlh1mutL homolog 1 (E. coli)0.024
Shhsonic hedgehog0.023
Hhathedgehog acyltransferase0.022
Tsc1tuberous sclerosis 10.022
Gata3GATA binding protein 30.022
Kitlkit ligand0.022
Rnf8ring finger protein 80.022
Hrhairless0.022
Psen1presenilin 10.021
Lyz2lysozyme 20.021
FaddFas (TNFRSF6)-associated via death domain0.020
Fbn1fibrillin 10.020
Crlf3cytokine receptor-like factor 30.020
Tcf3transcription factor 30.020
Timm13translocase of inner mitochondrial membrane 13 homolog (yeast)0.020
Cxcr4chemokine (C-X-C motif) receptor 40.020
FasFas (TNF receptor superfamily member 6)0.020
Hoxa13homeobox A130.019
Smn1survival motor neuron 10.019
Irf6interferon regulatory factor 60.019
Elf3E74-like factor 30.019
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.019
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.019
Nfe2l2nuclear factor, erythroid derived 2, like 20.019
Itga3integrin alpha 30.018
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism