The network for 'positive regulation of cellular protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cellular protein catabolic process

Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process.

NameDescriptionProbabilityFunc Analog Organism
CDC20cell division cycle 20 homolog (S. cerevisiae)0.997
CDC27cell division cycle 27 homolog (S. cerevisiae)0.987
MDM2Mdm2 p53 binding protein homolog (mouse)0.983
SMAD1SMAD family member 10.980
SMAD4SMAD family member 40.971
SMURF2SMAD specific E3 ubiquitin protein ligase 20.967
TP53tumor protein p530.936
SMAD2SMAD family member 20.918
RB1retinoblastoma 10.911
DVL3dishevelled, dsh homolog 3 (Drosophila)0.863
RNF11ring finger protein 110.799
GSK3Bglycogen synthase kinase 3 beta0.788
UBCubiquitin C0.774
CSNK1Ecasein kinase 1, epsilon0.687
ANAPC4anaphase promoting complex subunit 40.645
PLK1polo-like kinase 10.637
SKP1S-phase kinase-associated protein 10.631
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.594
DVL1dishevelled, dsh homolog 1 (Drosophila)0.593
PIAS4protein inhibitor of activated STAT, 40.540
AXIN1axin 10.536
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.530
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.528
MAP3K5mitogen-activated protein kinase kinase kinase 50.456
JUNjun proto-oncogene0.452
MDM4Mdm4 p53 binding protein homolog (mouse)0.443
CUL2cullin 20.422
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.416
SMAD7SMAD family member 70.410
TADA3transcriptional adaptor 30.406
EPORerythropoietin receptor0.399
SOCS1suppressor of cytokine signaling 10.393
SKILSKI-like oncogene0.390
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.373
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.363
DVL2dishevelled, dsh homolog 2 (Drosophila)0.325
SMAD5SMAD family member 50.324
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.316
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.309
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.302
LRRK2leucine-rich repeat kinase 20.297
UHRF2ubiquitin-like with PHD and ring finger domains 20.281
ATF5activating transcription factor 50.280
ANAPC11anaphase promoting complex subunit 110.265
PTTG1pituitary tumor-transforming 10.252
SMAD3SMAD family member 30.246
HSPA8heat shock 70kDa protein 80.232
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.230
ATXN3ataxin 30.220
HDAC6histone deacetylase 60.197
JUNBjun B proto-oncogene0.197
RYBPRING1 and YY1 binding protein0.180
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.177
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.169
MAPTmicrotubule-associated protein tau0.168
AIPL1aryl hydrocarbon receptor interacting protein-like 10.168
ARandrogen receptor0.164
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.160
UBQLN1ubiquilin 10.156
OTUB1OTU domain, ubiquitin aldehyde binding 10.155
DAXXdeath-domain associated protein0.149
PRNPprion protein0.149
CDC16cell division cycle 16 homolog (S. cerevisiae)0.144
E2F1E2F transcription factor 10.137
CREBBPCREB binding protein0.137
CDC26cell division cycle 26 homolog (S. cerevisiae)0.135
FBXL15F-box and leucine-rich repeat protein 150.134
CSNK1Dcasein kinase 1, delta0.133
NEDD4neural precursor cell expressed, developmentally down-regulated 40.131
BBS10Bardet-Biedl syndrome 100.126
ADRBK1adrenergic, beta, receptor kinase 10.118
FUNDC2FUN14 domain containing 20.113
SMURF1SMAD specific E3 ubiquitin protein ligase 10.109
BADBCL2-associated agonist of cell death0.109
GORABgolgin, RAB6-interacting0.107
CDK2cyclin-dependent kinase 20.105
FOSFBJ murine osteosarcoma viral oncogene homolog0.102
BCL2L1BCL2-like 10.102
DDIT3DNA-damage-inducible transcript 30.101
PTPN1protein tyrosine phosphatase, non-receptor type 10.099
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.095
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.093
TGFBR1transforming growth factor, beta receptor 10.092
SOCS2suppressor of cytokine signaling 20.090
HSF1heat shock transcription factor 10.089
ATF3activating transcription factor 30.089
PDCD6IPprogrammed cell death 6 interacting protein0.085
AURKBaurora kinase B0.084
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.083
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.081
UBR1ubiquitin protein ligase E3 component n-recognin 10.079
FYNFYN oncogene related to SRC, FGR, YES0.075
RBL2retinoblastoma-like 2 (p130)0.075
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.073
SOCS3suppressor of cytokine signaling 30.072
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.071
ANAPC7anaphase promoting complex subunit 70.070
JAK2Janus kinase 20.069
GCLMglutamate-cysteine ligase, modifier subunit0.065
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rnr-1Protein RNR-10.117
ima-3Protein IMA-30.107
pcn-1Protein PCN-10.087
pme-3Protein PME-30.087
klp-16Protein KLP-160.075
mex-3Protein MEX-30.071
trcs-2Protein TRCS-20.064
mcm-7Protein MCM-70.059
rpn-3Protein RPN-30.057
zen-4Protein ZEN-40.050
pry-1Protein PRY-10.049
bath-42Protein BATH-420.048
tpxl-1Protein TPXL-10.047
C56G2.7Protein C56G2.70.046
imb-2Protein IMB-20.045
clec-87Protein CLEC-870.044
mcm-5Protein MCM-50.040
Y47D3A.29Protein Y47D3A.290.039
mex-5Protein MEX-50.039
zyg-1Protein ZYG-10.038
mcm-3Protein MCM-30.037
rpt-1Protein RPT-10.037
cks-1Protein CKS-10.037
spn-4Protein SPN-40.036
CELE_C08F11.13Protein C08F11.130.035
cdc-48.2Protein CDC-48.20.035
pup-2Protein PUP-20.035
knl-1Protein KNL-10.035
lin-36Protein LIN-360.034
mom-2Protein MOM-20.034
mab-5Protein MAB-50.034
CELE_T03F6.3Protein T03F6.30.033
hcp-2Protein HCP-20.032
csnk-1Protein CSNK-10.032
rpn-1Protein RPN-10.032
T14G11.1Protein T14G11.10.031
cyb-1Protein CYB-10.031
cyb-3Protein CYB-30.031
hsr-9Protein HSR-90.031
K02F6.7Protein K02F6.70.029
egl-30Protein EGL-300.028
uaf-1Protein UAF-10.028
mex-6Protein MEX-60.028
lst-1Protein LST-10.027
tag-296Protein TAG-2960.027
R11A8.2Protein R11A8.20.027
F58G11.3Protein F58G11.30.027
mog-4Protein MOG-40.026
axl-1Protein AXL-10.026
C10E2.6Protein C10E2.60.025
CELE_C24H12.5Protein C24H12.50.025
ubc-25Protein UBC-250.025
rpt-6Protein RPT-60.025
C44B9.3Protein C44B9.30.025
rpt-2Protein RPT-20.025
mbk-2Protein MBK-20.025
nhr-10Protein NHR-100.025
ife-3Protein IFE-30.024
cyb-2.1Protein CYB-2.10.024
klp-19Protein KLP-190.024
T10B11.8Protein T10B11.80.024
skpt-1Protein SKPT-10.024
CELE_T05H4.11Protein T05H4.110.024
air-1Protein AIR-10.023
air-2Protein AIR-20.023
C07A9.2Protein C07A9.20.023
daf-3Protein DAF-30.023
nos-3Protein NOS-30.023
tbb-1Protein TBB-10.023
F18A1.7Protein F18A1.70.023
gon-4Protein GON-40.023
spk-1Protein SPK-10.022
stam-1Protein STAM-10.022
ptr-2Protein PTR-20.022
mdf-2Protein MDF-20.022
CELE_F20D1.1Protein F20D1.10.021
cdc-25.1Protein CDC-25.10.021
hcp-6Protein HCP-60.021
cyb-2.2Protein CYB-2.20.021
ubxn-4Protein UBXN-40.021
Y25C1A.7Protein Y25C1A.70.021
hsp-1Protein HSP-10.021
skr-1Protein SKR-10.020
hgrs-1Protein HGRS-10.020
pap-1Protein PAP-10.020
dnj-23Protein DNJ-230.020
zif-1Protein ZIF-10.020
hmg-4Protein HMG-40.020
K02A6.3Protein K02A6.30.020
syx-17Protein SYX-170.020
gla-3Protein GLA-30.019
rheb-1Protein RHEB-10.019
T19H12.2Protein T19H12.20.019
E04D5.1Protein E04D5.10.019
CELE_Y106G6H.6Protein Y106G6H.60.019
hrpf-2Protein HRPF-20.019
prpf-4Protein PRPF-40.019
imb-1Protein IMB-10.019
usp-14Protein USP-140.019
mec-15Protein MEC-150.019
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Vap-33-1CG5014 gene product from transcript CG5014-RB0.195
drkdownstream of receptor kinase0.144
Pi3K92ECG4141 gene product from transcript CG4141-RB0.071
CycBCyclin B0.054
tefutelomere fusion0.054
cdc16CG6759 gene product from transcript CG6759-RA0.047
CSN4COP9 complex homolog subunit 40.041
CG30382CG30382 gene product from transcript CG30382-RB0.036
CG12321CG12321 gene product from transcript CG12321-RA0.036
RYBPRing and YY1 Binding Protein0.036
UbcD2Ubiquitin conjugating enzyme 20.035
gbbglass bottom boat0.033
Pp4-19CProtein phosphatase 19C0.032
Uch-L3Ubiquitin C-terminal hydrolase0.031
Ptp61FProtein tyrosine phosphatase 61F0.031
CycACyclin A0.028
bratbrain tumor0.027
Pros35Proteasome 35kD subunit0.026
cicubitus interruptus0.024
Aats-metMethionyl-tRNA synthetase0.024
Prosbeta7Proteasome beta7 subunit0.023
l(1)G0222lethal (1) G02220.022
PtenCG5671 gene product from transcript CG5671-RB0.022
Drp1Dynamin related protein 10.022
slmbsupernumerary limbs0.022
CG4673CG4673 gene product from transcript CG4673-RB0.021
Elongin-BElongin B0.020
polyCG9829 gene product from transcript CG9829-RB0.020
CG11347CG11347 gene product from transcript CG11347-RE0.020
Top1Topoisomerase 10.020
Mov34CG3416 gene product from transcript CG3416-RA0.020
dltdiscs lost0.020
CSN8COP9 complex homolog subunit 80.019
Fcp1CG12252 gene product from transcript CG12252-RA0.019
kermitCG11546 gene product from transcript CG11546-RB0.019
dosdaughter of sevenless0.019
Prosbeta3Proteasome beta3 subunit0.018
cdc23CG2508 gene product from transcript CG2508-RA0.018
Pros26Proteasome 26kD subunit0.017
Psf2CG18013 gene product from transcript CG18013-RA0.016
grimCG4345 gene product from transcript CG4345-RA0.016
Nipped-ACG33554 gene product from transcript CG33554-RE0.016
Rpn6Proteasome p44.5 subunit0.015
Pros25Proteasome 25kD subunit0.015
fs(1)Yafemale sterile (1) Young arrest0.015
SamuelSAM-motif ubiquitously expressed punctatedly localized protein0.015
jubAjuba LIM protein0.015
idaimaginal discs arrested0.014
CSN1bCOP9 complex homolog subunit 1 b0.014
PlapPhospholipase A2 activator protein0.014
HoHeme oxygenase0.014
UchUbiquitin carboxy-terminal hydrolase0.014
skpACG16983 gene product from transcript CG16983-RD0.013
CycGCyclin G0.013
Orc1Origin recognition complex subunit 10.013
Su(var)2-10Suppressor of variegation 2-100.013
PcafCG4107 gene product from transcript CG4107-RA0.013
RbfRetinoblastoma-family protein0.012
CG9772CG9772 gene product from transcript CG9772-RB0.012
l(2)35Bglethal (2) 35Bg0.012
chbchromosome bows0.012
Klp10ACG1453 gene product from transcript CG1453-RA0.012
dupdouble parked0.012
Pk61CProtein kinase 61C0.012
stanstarry night0.011
Nuf2CG8902 gene product from transcript CG8902-RA0.011
Ulp1CG12359 gene product from transcript CG12359-RA0.011
pashapartner of drosha0.011
CG11286CG11286 gene product from transcript CG11286-RA0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gsk3bglycogen synthase kinase 3 beta1.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Axin1axin 10.999
Trp53transformation related protein 530.976
Per1period homolog 1 (Drosophila)0.771
Akt1thymoma viral proto-oncogene 10.729
Hprthypoxanthine guanine phosphoribosyl transferase0.714
Apcadenomatosis polyposis coli0.664
Smad7MAD homolog 7 (Drosophila)0.623
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.564
Per2period homolog 2 (Drosophila)0.540
Ccnb2cyclin B20.396
Psen1presenilin 10.386
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.374
Npm1nucleophosmin 10.369
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.363
Atf4activating transcription factor 40.352
Smad2MAD homolog 2 (Drosophila)0.349
Prkceprotein kinase C, epsilon0.336
Dvl2dishevelled 2, dsh homolog (Drosophila)0.334
Lrp6low density lipoprotein receptor-related protein 60.329
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.315
Ccnb1cyclin B10.314
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.313
Ptenphosphatase and tensin homolog0.310
Ube2cubiquitin-conjugating enzyme E2C0.282
Psma2proteasome (prosome, macropain) subunit, alpha type 20.263
Cdk1cyclin-dependent kinase 10.257
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.241
Dctn1dynactin 10.233
Ncoa3nuclear receptor coactivator 30.228
Psma4proteasome (prosome, macropain) subunit, alpha type 40.228
Plk1polo-like kinase 1 (Drosophila)0.213
Pdpk13-phosphoinositide dependent protein kinase 10.204
Gclmglutamate-cysteine ligase, modifier subunit0.193
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.181
Hif1ahypoxia inducible factor 1, alpha subunit0.168
Usp9xubiquitin specific peptidase 9, X chromosome0.163
Csnk1ecasein kinase 1, epsilon0.159
Smurf2SMAD specific E3 ubiquitin protein ligase 20.158
Lef1lymphoid enhancer binding factor 10.155
Ldb3LIM domain binding 30.153
BlnkB-cell linker0.146
Ccna2cyclin A20.143
Pick1protein interacting with C kinase 10.141
Fam64afamily with sequence similarity 64, member A0.141
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.137
Cyldcylindromatosis (turban tumor syndrome)0.134
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.132
Appamyloid beta (A4) precursor protein0.128
Kif2ckinesin family member 2C0.124
Rnf111ring finger 1110.123
Vhlvon Hippel-Lindau tumor suppressor0.122
Traf2TNF receptor-associated factor 20.115
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.114
Notch1Notch gene homolog 1 (Drosophila)0.113
Birc5baculoviral IAP repeat-containing 50.107
Dlg1discs, large homolog 1 (Drosophila)0.106
Tbx3T-box 30.106
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.105
Ccnfcyclin F0.103
Kif20akinesin family member 20A0.101
Tceb1transcription elongation factor B (SIII), polypeptide 10.098
Bcar1breast cancer anti-estrogen resistance 10.098
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.095
Add1adducin 1 (alpha)0.094
Ireb2iron responsive element binding protein 20.093
Ncor2nuclear receptor co-repressor 20.092
Gtse1G two S phase expressed protein 10.091
Traf6TNF receptor-associated factor 60.091
Kif4kinesin family member 40.089
Galnt2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20.089
Cry2cryptochrome 2 (photolyase-like)0.084
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.082
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.081
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.081
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.081
Mdm4transformed mouse 3T3 cell double minute 40.080
Kif22kinesin family member 220.080
Itgb1integrin beta 1 (fibronectin receptor beta)0.079
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.078
Bcl2B-cell leukemia/lymphoma 20.077
Ilkintegrin linked kinase0.076
Psma6proteasome (prosome, macropain) subunit, alpha type 60.075
Rab27aRAB27A, member RAS oncogene family0.074
Psmb7proteasome (prosome, macropain) subunit, beta type 70.074
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.074
Aampangio-associated migratory protein0.073
Sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.073
Spred1sprouty protein with EVH-1 domain 1, related sequence0.072
Cdc25ccell division cycle 25 homolog C (S. pombe)0.072
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.072
Ehmt2euchromatic histone lysine N-methyltransferase 20.069
Bmpr1abone morphogenetic protein receptor, type 1A0.068
Pias2protein inhibitor of activated STAT 20.067
Gtf2igeneral transcription factor II I0.067
Ckap2cytoskeleton associated protein 20.067
Psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.066
Vps72vacuolar protein sorting 72 (yeast)0.066
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism