The network for 'regulation of mitochondrial membrane permeability involved in apoptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of mitochondrial membrane permeability involved in apoptotic process

Any regulation of mitochondrial membrane permeability that is involved in apoptotic process.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.999
BCL2L11BCL2-like 11 (apoptosis facilitator)0.997
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.995
BAK1BCL2-antagonist/killer 10.973
BAXBCL2-associated X protein0.960
BCL2L1BCL2-like 10.901
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.874
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.871
BIDBH3 interacting domain death agonist0.834
BECN1beclin 1, autophagy related0.667
BADBCL2-associated agonist of cell death0.619
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.607
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.535
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.394
VDAC1voltage-dependent anion channel 10.366
PXMP2peroxisomal membrane protein 2, 22kDa0.265
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.264
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.253
BBC3BCL2 binding component 30.249
FKBP8FK506 binding protein 8, 38kDa0.242
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.210
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.189
JUNjun proto-oncogene0.164
BIKBCL2-interacting killer (apoptosis-inducing)0.158
PGK1phosphoglycerate kinase 10.135
SLC25A5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.121
AXIN1axin 10.093
VDAC2voltage-dependent anion channel 20.086
TP53BP2tumor protein p53 binding protein, 20.080
ACAT1acetyl-CoA acetyltransferase 10.078
FOSFBJ murine osteosarcoma viral oncogene homolog0.078
ZHX1zinc fingers and homeoboxes 10.075
OCIAD1OCIA domain containing 10.070
IER2immediate early response 20.067
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.066
ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.062
HUWE1HECT, UBA and WWE domain containing 10.062
UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.056
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.055
ATF3activating transcription factor 30.054
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.052
TOMM22translocase of outer mitochondrial membrane 22 homolog (yeast)0.049
AMBRA1autophagy/beclin-1 regulator 10.046
OXA1Loxidase (cytochrome c) assembly 1-like0.046
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.043
MAPK8mitogen-activated protein kinase 80.042
RNF144Bring finger protein 144B0.042
HDAC6histone deacetylase 60.040
PGAM1phosphoglycerate mutase 1 (brain)0.039
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.038
TMEM11transmembrane protein 110.034
FHfumarate hydratase0.034
ATP5G3ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)0.034
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.033
MDM4Mdm4 p53 binding protein homolog (mouse)0.032
ALDH2aldehyde dehydrogenase 2 family (mitochondrial)0.031
MAGEH1melanoma antigen family H, 10.030
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.030
LDHAlactate dehydrogenase A0.029
CDK10cyclin-dependent kinase 100.028
RHOAras homolog gene family, member A0.028
NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)0.027
MS4A7membrane-spanning 4-domains, subfamily A, member 70.027
HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit0.026
GNB5guanine nucleotide binding protein (G protein), beta 50.026
NDUFA4L2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 20.023
QARSglutaminyl-tRNA synthetase0.023
SIX1SIX homeobox 10.023
DLG4discs, large homolog 4 (Drosophila)0.022
YPEL5yippee-like 5 (Drosophila)0.021
GHITMgrowth hormone inducible transmembrane protein0.020
EGR1early growth response 10.019
CXCL2chemokine (C-X-C motif) ligand 20.019
ELK1ELK1, member of ETS oncogene family0.018
GBP2guanylate binding protein 2, interferon-inducible0.018
SNAPINSNAP-associated protein0.018
GLRX5glutaredoxin 50.017
MARCH5membrane-associated ring finger (C3HC4) 50.017
UQCRC2ubiquinol-cytochrome c reductase core protein II0.017
SNX3sorting nexin 30.017
HMOX2heme oxygenase (decycling) 20.016
BHLHE40basic helix-loop-helix family, member e400.016
ATP5C1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.016
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.016
GRIA4glutamate receptor, ionotrophic, AMPA 40.016
UBR1ubiquitin protein ligase E3 component n-recognin 10.016
GOT2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)0.015
CNOcappuccino homolog (mouse)0.015
IRF2BP1interferon regulatory factor 2 binding protein 10.015
HDAC4histone deacetylase 40.015
SDHCsuccinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa0.015
ZFYVE1zinc finger, FYVE domain containing 10.015
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.015
PRNPprion protein0.015
JUNBjun B proto-oncogene0.014
ZRANB1zinc finger, RAN-binding domain containing 10.014
POLHpolymerase (DNA directed), eta0.014
UVRAGUV radiation resistance associated gene0.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
BaxBCL2-associated X protein0.999
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.987
Trp53transformation related protein 530.963
Bcl2B-cell leukemia/lymphoma 20.814
Ptenphosphatase and tensin homolog0.773
Mcl1myeloid cell leukemia sequence 10.628
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.499
Kitkit oncogene0.457
Bak1BCL2-antagonist/killer 10.230
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.229
SharpinSHANK-associated RH domain interacting protein0.199
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.185
Apcadenomatosis polyposis coli0.173
Pdcd6ipprogrammed cell death 6 interacting protein0.157
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.137
Mdm2transformed mouse 3T3 cell double minute 20.116
Tnfaip3tumor necrosis factor, alpha-induced protein 30.079
Mapk8mitogen-activated protein kinase 80.072
Trp73transformation related protein 730.072
Rararetinoic acid receptor, alpha0.064
Dnm1dynamin 10.062
Mta1metastasis associated 10.056
Mtap2microtubule-associated protein 20.053
Tbx1T-box 10.052
Lystlysosomal trafficking regulator0.050
Vhlvon Hippel-Lindau tumor suppressor0.049
Atxn2ataxin 20.048
Gipc1GIPC PDZ domain containing family, member 10.046
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.043
BrafBraf transforming gene0.041
Actn2actinin alpha 20.040
Ctnnb1catenin (cadherin associated protein), beta 10.039
Acdadrenocortical dysplasia0.039
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.037
Btbd2BTB (POZ) domain containing 20.036
Smad3MAD homolog 3 (Drosophila)0.030
Emx1empty spiracles homolog 1 (Drosophila)0.028
Emx2empty spiracles homolog 2 (Drosophila)0.026
Ighimmunoglobulin heavy chain complex0.026
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.025
Mapk14mitogen-activated protein kinase 140.025
Rock2Rho-associated coiled-coil containing protein kinase 20.025
Dlg4discs, large homolog 4 (Drosophila)0.024
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.023
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.022
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.022
Mapk1mitogen-activated protein kinase 10.022
Bhlhe40basic helix-loop-helix family, member e400.022
BidBH3 interacting domain death agonist0.022
Bcl2l1BCL2-like 10.021
Sox2SRY-box containing gene 20.021
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.021
Rbck1RanBP-type and C3HC4-type zinc finger containing 10.021
Arcactivity regulated cytoskeletal-associated protein0.021
Ikzf1IKAROS family zinc finger 10.020
Etfaelectron transferring flavoprotein, alpha polypeptide0.020
Dlx2distal-less homeobox 20.020
Trpc2transient receptor potential cation channel, subfamily C, member 20.020
Klf6Kruppel-like factor 60.019
BmfBCL2 modifying factor0.019
Foxp3forkhead box P30.019
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.018
Mdm4transformed mouse 3T3 cell double minute 40.017
Rb1retinoblastoma 10.017
Mapk9mitogen-activated protein kinase 90.017
Mfn2mitofusin 20.016
Lef1lymphoid enhancer binding factor 10.016
2700094K13RikRIKEN cDNA 2700094K13 gene0.015
Pbx1pre B-cell leukemia transcription factor 10.015
Rarbretinoic acid receptor, beta0.015
Ep300E1A binding protein p3000.015
Pax6paired box gene 60.014
Ccnd1cyclin D10.014
Etfdhelectron transferring flavoprotein, dehydrogenase0.013
Casp3caspase 30.013
Retsatretinol saturase (all trans retinol 13,14 reductase)0.013
Fbxw7F-box and WD-40 domain protein 70.012
Namptnicotinamide phosphoribosyltransferase0.012
Gnb2guanine nucleotide binding protein (G protein), beta 20.011
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.011
Pgk1phosphoglycerate kinase 10.011
Pmm1phosphomannomutase 10.011
Galk1galactokinase 10.011
Kitlkit ligand0.011
Rps27lribosomal protein S27-like0.011
Id1inhibitor of DNA binding 10.011
Park2Parkinson disease (autosomal recessive, juvenile) 2, parkin0.010
Gstz1glutathione transferase zeta 1 (maleylacetoacetate isomerase)0.010
Snrpgsmall nuclear ribonucleoprotein polypeptide G0.010
Rxraretinoid X receptor alpha0.010
Drap1Dr1 associated protein 1 (negative cofactor 2 alpha)0.010
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.010
Lrp6low density lipoprotein receptor-related protein 60.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism