The network for 'regulation of mitotic sister chromatid separation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of mitotic sister chromatid separation

Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis.

NameDescriptionProbabilityFunc Analog Organism
CDC27cell division cycle 27 homolog (S. cerevisiae)1.000
CDC20cell division cycle 20 homolog (S. cerevisiae)1.000
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)1.000
CDK2cyclin-dependent kinase 21.000
ANAPC4anaphase promoting complex subunit 41.000
CCNA2cyclin A20.997
ANAPC7anaphase promoting complex subunit 70.985
CDC16cell division cycle 16 homolog (S. cerevisiae)0.985
ANAPC1anaphase promoting complex subunit 10.982
CCNB1cyclin B10.980
CDC23cell division cycle 23 homolog (S. cerevisiae)0.977
ANAPC5anaphase promoting complex subunit 50.948
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.945
TCP1t-complex 10.941
SKP2S-phase kinase-associated protein 2 (p45)0.932
RB1retinoblastoma 10.890
CDT1chromatin licensing and DNA replication factor 10.762
CKS1BCDC28 protein kinase regulatory subunit 1B0.690
RBL1retinoblastoma-like 1 (p107)0.677
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.655
CCT8chaperonin containing TCP1, subunit 8 (theta)0.569
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.569
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.540
ANAPC11anaphase promoting complex subunit 110.498
CDC26cell division cycle 26 homolog (S. cerevisiae)0.460
SMC3structural maintenance of chromosomes 30.448
ORC1origin recognition complex, subunit 10.401
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.393
STAG1stromal antigen 10.361
CCNE1cyclin E10.355
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.318
ORC2origin recognition complex, subunit 20.292
CCT6Achaperonin containing TCP1, subunit 6A (zeta 1)0.267
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.266
E2F1E2F transcription factor 10.257
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.254
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.252
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.231
CHAF1Achromatin assembly factor 1, subunit A (p150)0.219
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.203
PTTG1pituitary tumor-transforming 10.198
CBX5chromobox homolog 50.197
SMAD2SMAD family member 20.175
CDKN3cyclin-dependent kinase inhibitor 30.169
CCT4chaperonin containing TCP1, subunit 4 (delta)0.168
CUL1cullin 10.163
SKA1spindle and kinetochore associated complex subunit 10.161
AURKBaurora kinase B0.145
BRCA1breast cancer 1, early onset0.135
UHRF2ubiquitin-like with PHD and ring finger domains 20.131
PLK1polo-like kinase 10.129
SMC6structural maintenance of chromosomes 60.128
SKA2spindle and kinetochore associated complex subunit 20.126
RAD21RAD21 homolog (S. pombe)0.126
FBXO5F-box protein 50.118
BRCA2breast cancer 2, early onset0.114
VHLvon Hippel-Lindau tumor suppressor0.112
CCNB2cyclin B20.103
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.101
TCEB2transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)0.099
CD44CD44 molecule (Indian blood group)0.095
TFDP1transcription factor Dp-10.092
PTENphosphatase and tensin homolog0.091
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.088
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.085
RBBP8retinoblastoma binding protein 80.080
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.080
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.080
SKA3spindle and kinetochore associated complex subunit 30.075
CUL2cullin 20.075
NEK2NIMA (never in mitosis gene a)-related kinase 20.072
ZWINTZW10 interactor0.069
MDC1mediator of DNA-damage checkpoint 10.067
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.063
SMC1Astructural maintenance of chromosomes 1A0.060
STAG2stromal antigen 20.057
TTKTTK protein kinase0.056
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.056
RBL2retinoblastoma-like 2 (p130)0.054
C19orf39chromosome 19 open reading frame 390.054
EZRezrin0.053
KIF18Akinesin family member 18A0.051
NEK9NIMA (never in mitosis gene a)- related kinase 90.048
TBC1D10ATBC1 domain family, member 10A0.048
OTUB1OTU domain, ubiquitin aldehyde binding 10.048
CUL4Acullin 4A0.047
LRR1leucine rich repeat protein 10.047
CASC5cancer susceptibility candidate 50.046
CCNE2cyclin E20.046
PRC1protein regulator of cytokinesis 10.042
PTK2BPTK2B protein tyrosine kinase 2 beta0.041
SGOL2shugoshin-like 2 (S. pombe)0.040
CKS2CDC28 protein kinase regulatory subunit 20.040
RIF1RAP1 interacting factor homolog (yeast)0.039
CCND1cyclin D10.038
CLSPNclaspin0.038
CDC45cell division cycle 45 homolog (S. cerevisiae)0.038
ANKRD52ankyrin repeat domain 520.037
PXNpaxillin0.036
SGOL1shugoshin-like 1 (S. pombe)0.035
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycBCyclin B0.743
CycB3Cyclin B30.600
dupdouble parked0.591
ncdnon-claret disjunctional0.540
Mcm10Sensitized chromosome inheritance modifier 190.509
gwlgreatwall0.478
cmetCENP-meta0.460
CycACyclin A0.430
Rpd3CG7471 gene product from transcript CG7471-RA0.380
fzyfizzy0.367
Cdc37CG12019 gene product from transcript CG12019-RA0.346
Cenp-CCG31258 gene product from transcript CG31258-RA0.305
Orc2Origin recognition complex subunit 20.303
Klp61FKinesin-like protein at 61F0.270
aspabnormal spindle0.266
stgstring0.259
SMC2CG10212 gene product from transcript CG10212-RA0.256
poloCG12306 gene product from transcript CG12306-RA0.255
DrefDNA replication-related element factor0.249
BubR1Bub1-related kinase0.243
Cap-GCG34438 gene product from transcript CG34438-RF0.242
marsCG17064 gene product from transcript CG17064-RB0.239
hpohippo0.226
borrborealin-related0.194
aslasterless0.178
SseSeparase0.176
cdc16CG6759 gene product from transcript CG6759-RA0.164
thrthree rows0.154
Psf2CG18013 gene product from transcript CG18013-RA0.143
DNApol-alpha60DNA polymerase alpha 60kD0.131
Spc105RSpc105-related0.130
Vap-33-1CG5014 gene product from transcript CG5014-RB0.117
pavpavarotti0.117
piepineapple eye0.114
Ras85DRas oncogene at 85D0.113
idaimaginal discs arrested0.110
nbsCG6754 gene product from transcript CG6754-RC0.110
tefutelomere fusion0.107
IswiImitation SWI0.105
CG9772CG9772 gene product from transcript CG9772-RB0.098
gemininCG3183 gene product from transcript CG3183-RA0.090
cidcentromere identifier0.090
mspsmini spindles0.087
Cks85ACyclin-dependent kinase subunit 85A0.081
Kmn1kinetochore Mis12-Ndc80 network component 10.080
Rpt3CG16916 gene product from transcript CG16916-RA0.075
pimpimples0.074
cavcaravaggio0.070
MybMyb oncogene-like0.069
Nuf2CG8902 gene product from transcript CG8902-RA0.065
dapdacapo0.065
shtdshattered0.065
CG9986CG9986 gene product from transcript CG9986-RA0.064
chbchromosome bows0.064
cdc2CG5363 gene product from transcript CG5363-RA0.061
tumtumbleweed0.060
Fcp1CG12252 gene product from transcript CG12252-RA0.059
cdc23CG2508 gene product from transcript CG2508-RA0.059
Cdc27CG8610 gene product from transcript CG8610-RA0.057
nodno distributive disjunction0.054
prodproliferation disrupter0.054
ballballchen0.053
larpLa related protein0.051
Aos1CG12276 gene product from transcript CG12276-RA0.051
pitaCG3941 gene product from transcript CG3941-RA0.050
DetDeterin0.050
Klp10ACG1453 gene product from transcript CG1453-RA0.049
gammaTub23Cgamma-Tubulin at 23C0.049
NiPp1Nuclear inhibitor of Protein phosphatase 10.048
vtdverthandi0.048
Klp3AKinesin-like protein at 3A0.047
SAKSak kinase0.045
Su(H)Suppressor of Hairless0.044
dpadisc proliferation abnormal0.044
brmbrahma0.044
Mi-2CG8103 gene product from transcript CG8103-RA0.043
p53CG33336 gene product from transcript CG33336-RB0.041
nejnejire0.041
bratbrain tumor0.041
CG4680CG4680 gene product from transcript CG4680-RA0.040
Rpt4CG3455 gene product from transcript CG3455-RA0.040
DNApol-alpha180DNA polymerase alpha 180kD0.039
Bj1Bj1 protein0.038
Cks30ACyclin-dependent kinase subunit 30A0.037
ruxroughex0.037
zwilchCG18729 gene product from transcript CG18729-RA0.035
Nek2CG17256 gene product from transcript CG17256-RA0.035
scrascraps0.035
gammaTub37Cgamma-Tubulin at 37C0.033
Ndc80CG9938 gene product from transcript CG9938-RA0.033
kukkugelkern0.033
Orc6Origin recognition complex subunit 60.032
msb1lCG10364 gene product from transcript CG10364-RA0.032
RbfRetinoblastoma-family protein0.032
Z600CG17962 gene product from transcript CG17962-RA0.032
Rca1Regulator of cyclin A10.031
Uch-L3Ubiquitin C-terminal hydrolase0.031
kstkarst0.031
pUf68poly U binding factor 68kD0.030
CG11071CG11071 gene product from transcript CG11071-RA0.030
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.695
Ctnnb1catenin (cadherin associated protein), beta 10.165
Ccnb1cyclin B10.123
Brca1breast cancer 10.085
Mki67antigen identified by monoclonal antibody Ki 670.076
Cenpkcentromere protein K0.069
Cdk1cyclin-dependent kinase 10.063
Sgol1shugoshin-like 1 (S. pombe)0.055
Kif20akinesin family member 20A0.054
Ccna2cyclin A20.050
Sgol2shugoshin-like 2 (S. pombe)0.044
Brca2breast cancer 20.043
Ptenphosphatase and tensin homolog0.041
Cdk2cyclin-dependent kinase 20.038
Rb1retinoblastoma 10.037
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.037
Kif2ckinesin family member 2C0.035
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.035
Stag1stromal antigen 10.034
Mis18bp1MIS18 binding protein 10.034
Cdkn1bcyclin-dependent kinase inhibitor 1B0.034
StilScl/Tal1 interrupting locus0.033
Melkmaternal embryonic leucine zipper kinase0.032
Mdm2transformed mouse 3T3 cell double minute 20.032
Chek1checkpoint kinase 1 homolog (S. pombe)0.032
Hmmrhyaluronan mediated motility receptor (RHAMM)0.030
Kif4kinesin family member 40.030
Ccnb2cyclin B20.030
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.027
Birc5baculoviral IAP repeat-containing 50.027
Ccnfcyclin F0.027
Trip13thyroid hormone receptor interactor 130.027
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.025
Prc1protein regulator of cytokinesis 10.025
Spag5sperm associated antigen 50.025
Axin1axin 10.023
Kif22kinesin family member 220.023
Cdca8cell division cycle associated 80.022
Ube2cubiquitin-conjugating enzyme E2C0.021
Dtldenticleless homolog (Drosophila)0.021
Gtse1G two S phase expressed protein 10.017
Wdhd1WD repeat and HMG-box DNA binding protein 10.017
Cul4acullin 4A0.017
E2f8E2F transcription factor 80.017
Plk4polo-like kinase 4 (Drosophila)0.017
E2f1E2F transcription factor 10.016
Cdca5cell division cycle associated 50.015
C330027C09RikRIKEN cDNA C330027C09 gene0.015
Cdc25ccell division cycle 25 homolog C (S. pombe)0.015
Ccne1cyclin E10.015
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.014
Aurkbaurora kinase B0.014
Ptprqprotein tyrosine phosphatase, receptor type, Q0.013
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.013
Dlgap5discs, large (Drosophila) homolog-associated protein 50.013
Rad51ap1RAD51 associated protein 10.012
Cdkn3cyclin-dependent kinase inhibitor 30.012
Nf2neurofibromatosis 20.012
Lin9lin-9 homolog (C. elegans)0.012
Nlrp5NLR family, pyrin domain containing 50.012
Iqgap3IQ motif containing GTPase activating protein 30.012
Cenpacentromere protein A0.012
Nbnnibrin0.012
Suv39h2suppressor of variegation 3-9 homolog 2 (Drosophila)0.011
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.011
TtkTtk protein kinase0.011
Fignl1fidgetin-like 10.011
Stk11serine/threonine kinase 110.011
Kif23kinesin family member 230.011
Ooepoocyte expressed protein homolog (dog)0.011
Ect2ect2 oncogene0.011
BlmBloom syndrome, RecQ helicase-like0.011
Rrm2ribonucleotide reductase M20.011
Aurkaaurora kinase A0.010
Ccdc99coiled-coil domain containing 990.010
Ube2tubiquitin-conjugating enzyme E2T (putative)0.010
Arl6ip6ADP-ribosylation factor-like 6 interacting protein 60.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Foxm1forkhead box M10.415
Ccnb1cyclin B10.153
LOC100310874antisense RNA overlapping MCH0.144
Top2atopoisomerase (DNA) II alpha0.139
Dlgap5discs, large (Drosophila) homolog-associated protein 50.127
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.103
Spag5sperm associated antigen 50.077
Cdca3cell division cycle associated 30.066
Kif22kinesin family member 220.054
Dhfrdihydrofolate reductase0.053
Eif2c2eukaryotic translation initiation factor 2C, 20.046
Ppm1bprotein phosphatase 1B, magnesium dependent, beta isoform0.045
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.045
Fbxo11F-box protein 110.044
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.042
Pttg1pituitary tumor-transforming 10.038
Lbrlamin B receptor0.038
Kif2ckinesin family member 2C0.037
Arfip1ADP-ribosylation factor interacting protein 10.037
LOC689399hypothetical protein LOC6893990.034
Ube2tubiquitin-conjugating enzyme E2T (putative)0.034
Troaptrophinin associated protein0.031
Traf4af1TRAF4 associated factor 10.031
Tpm4tropomyosin 40.031
Haus4HAUS augmin-like complex, subunit 40.030
Ripk3receptor-interacting serine-threonine kinase 30.029
E2f1E2F transcription factor 10.028
Ccnb2cyclin B20.027
Dhx9DEAH (Asp-Glu-Ala-His) box polypeptide 90.025
Kif18bkinesin family member 18B0.024
Ppp4r2protein phosphatase 4, regulatory subunit 20.024
Gna12guanine nucleotide binding protein (G protein) alpha 120.024
Melkmaternal embryonic leucine zipper kinase0.024
Kifc1kinesin family member C10.024
Cenpicentromere protein I0.024
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.024
Brca2breast cancer 20.024
Nr3c2nuclear receptor subfamily 3, group C, member 20.023
Myo1bmyosin Ib0.023
Litaflipopolysaccharide-induced TNF factor0.023
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.023
Ttntitin0.023
Myh10myosin, heavy chain 10, non-muscle0.023
Tymsthymidylate synthetase0.023
Arih1ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)0.022
Ube2cubiquitin-conjugating enzyme E2C0.022
Kcnn1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 10.021
Cd82Cd82 molecule0.021
Ccne1cyclin E10.021
Usp9xubiquitin specific peptidase 9, X-linked0.021
Ccnccyclin C0.020
Gata3GATA binding protein 30.020
Depdc1bDEP domain containing 1B0.020
Slain2SLAIN motif family, member 20.020
Ckap2cytoskeleton associated protein 20.020
Mgat2mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase0.019
Prc1protein regulator of cytokinesis 10.019
Espl1extra spindle pole bodies homolog 1 (S. cerevisiae)0.019
Mcm5minichromosome maintenance complex component 50.019
Ect2epithelial cell transforming sequence 2 oncogene0.019
Kif4kinesin family member 40.019
MGC112830similar to transcription factor0.019
Eps15epidermal growth factor receptor pathway substrate 150.019
Bcrbreakpoint cluster region0.018
Slmapsarcolemma associated protein0.018
Hmmrhyaluronan mediated motility receptor (RHAMM)0.018
Mbd2methyl-CpG binding domain protein 20.018
Lrch4leucine-rich repeats and calponin homology (CH) domain containing 40.018
Stk17bserine/threonine kinase 17b0.018
Cdk1cyclin-dependent kinase 10.018
Btg1B-cell translocation gene 1, anti-proliferative0.018
Zfp91zinc finger protein 910.018
Eif4g2eukaryotic translation initiation factor 4, gamma 20.018
Klf16Kruppel-like factor 160.018
Klk1c10T-kininogenase0.018
Tcf4transcription factor 40.017
Ptp4a2protein tyrosine phosphatase 4a20.017
Cttncortactin0.017
Bard1BRCA1 associated RING domain 10.017
Tjp2tight junction protein 20.016
Kntc1kinetochore associated 10.016
Depdc1DEP domain containing 10.016
Aurkaaurora kinase A0.016
Cdk2cyclin dependent kinase 20.016
TtkTtk protein kinase0.016
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.016
Ppp1r9aprotein phosphatase 1, regulatory (inhibitor) subunit 9A0.016
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.016
Kif20bkinesin family member 20B0.016
Ccnfcyclin F0.016
Cd24CD24 molecule0.015
Clic4chloride intracellular channel 40.015
Aurkbaurora kinase B0.015
Cops2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.015
Tgfbr2transforming growth factor, beta receptor II0.015
TraipTRAF-interacting protein0.015
Rcc2regulator of chromosome condensation 20.014
Mre11aMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.014
Pds5aPDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)0.014
Ndrg2N-myc downstream regulated gene 20.014
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC16Cdc16p0.986
DOC1Doc1p0.980
MAD2Mad2p0.979
CDC20Cdc20p0.962
SLK19Slk19p0.953
MTW1Mtw1p0.941
APC4Apc4p0.924
CDC23Cdc23p0.902
PPH21Pph21p0.898
BUB1Bub1p0.880
CDC26Cdc26p0.867
NSL1Nsl1p0.861
TID3Tid3p0.847
SPC105Spc105p0.784
CDC27Cdc27p0.777
CSE4Cse4p0.773
SMC4Smc4p0.751
APC2Apc2p0.741
IML3Iml3p0.699
SLI15Sli15p0.681
DSN1Dsn1p0.660
HHF2Hhf2p0.637
APC5Apc5p0.599
HTA1Hta1p0.563
CTF3Ctf3p0.530
SPC24Spc24p0.509
PPH22Pph22p0.467
APC1Apc1p0.453
BUB3Bub3p0.448
KIP1Kip1p0.447
MND2Mnd2p0.430
MCM21Mcm21p0.423
CHL4Chl4p0.380
MIF2Mif2p0.360
FMP48Fmp48p0.341
YPI1Ypi1p0.336
MAD3Mad3p0.328
APC9Apc9p0.252
PDS1Pds1p0.245
PPZ1Ppz1p0.237
NUF2Nuf2p0.231
CDC55Cdc55p0.197
SWM1Swm1p0.193
AME1Ame1p0.192
MAD1Mad1p0.191
MPS1Mps1p0.185
ASE1Ase1p0.183
GLC7Glc7p0.175
CDH1Cdh1p0.159
YBP2Ybp2p0.140
CBF2Cbf2p0.137
CIN8Cin8p0.135
RTS1Rts1p0.135
SPC25Spc25p0.122
APC11Apc11p0.113
MMS21Mms21p0.112
SMC6Smc6p0.111
TIP41Tip41p0.107
IPL1Ipl1p0.099
NNF1Nnf1p0.089
MCM22Mcm22p0.089
SMC2Smc2p0.087
GIP2Gip2p0.086
SDS22Sds22p0.085
OKP1Okp1p0.085
CTF13Ctf13p0.078
SMC5Smc5p0.072
CTF19Ctf19p0.067
BRN1Brn1p0.063
PSH1Psh1p0.060
BIR1Bir1p0.057
PSY4Psy4p0.051
PTI1Pti1p0.048
HTB1Htb1p0.048
ECO1Eco1p0.048
CIN1Cin1p0.045
EAF1Eaf1p0.044
NBL1Nbl1p0.043
ESP1Esp1p0.042
CBF1Cbf1p0.041
SUR1Sur1p0.039
PKC1Pkc1p0.039
SKP1Skp1p0.037
PRP28Prp28p0.037
KEL1Kel1p0.037
PCL10Pcl10p0.036
SDC1Sdc1p0.035
TAF7Taf7p0.035
YNL155Whypothetical protein0.035
ZDS1Zds1p0.034
HHT1Hht1p0.034
DAM1Dam1p0.032
CAB3Cab3p0.032
HUL5Hul5p0.031
CRP1Crp1p0.031
MPS2Mps2p0.031
KIC1Kic1p0.031
RPT4Rpt4p0.030
FIN1Fin1p0.030
SPT2Spt2p0.029