The network for 'negative regulation of hemostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of hemostasis

Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis.

NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.998
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.994
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.980
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.971
NRP1neuropilin 10.968
C1QAcomplement component 1, q subcomponent, A chain0.967
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.898
PLAUplasminogen activator, urokinase0.889
CDH5cadherin 5, type 2 (vascular endothelium)0.755
C1QCcomplement component 1, q subcomponent, C chain0.744
FGBfibrinogen beta chain0.721
VEGFAvascular endothelial growth factor A0.630
PLCG1phospholipase C, gamma 10.608
PLATplasminogen activator, tissue0.541
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.510
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.483
PDGFAplatelet-derived growth factor alpha polypeptide0.477
PDGFCplatelet derived growth factor C0.474
C1Scomplement component 1, s subcomponent0.372
PTPRBprotein tyrosine phosphatase, receptor type, B0.320
FGAfibrinogen alpha chain0.315
S100A10S100 calcium binding protein A100.304
C3complement component 30.269
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.261
PGFplacental growth factor0.254
C1Rcomplement component 1, r subcomponent0.250
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.244
METmet proto-oncogene (hepatocyte growth factor receptor)0.243
APOA2apolipoprotein A-II0.240
APOC1apolipoprotein C-I0.234
COL4A1collagen, type IV, alpha 10.209
KNG1kininogen 10.196
FN1fibronectin 10.181
MASP2mannan-binding lectin serine peptidase 20.179
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.176
AXLAXL receptor tyrosine kinase0.157
LDLRlow density lipoprotein receptor0.144
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.133
ANXA1annexin A10.131
SPINT1serine peptidase inhibitor, Kunitz type 10.130
APOHapolipoprotein H (beta-2-glycoprotein I)0.111
CDCP1CUB domain containing protein 10.109
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.109
FLT4fms-related tyrosine kinase 40.105
HRGhistidine-rich glycoprotein0.096
F11coagulation factor XI0.090
C1QBcomplement component 1, q subcomponent, B chain0.084
LCATlecithin-cholesterol acyltransferase0.082
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.078
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.078
C2complement component 20.078
PTPRJprotein tyrosine phosphatase, receptor type, J0.077
APOC3apolipoprotein C-III0.075
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.072
C8Acomplement component 8, alpha polypeptide0.059
ORM1orosomucoid 10.057
LPAlipoprotein, Lp(a)0.054
C8Bcomplement component 8, beta polypeptide0.053
VWFvon Willebrand factor0.051
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.049
SLC38A3solute carrier family 38, member 30.048
SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.048
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.047
EGFRepidermal growth factor receptor0.047
APOBapolipoprotein B (including Ag(x) antigen)0.047
APOEapolipoprotein E0.046
SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 50.046
KITLGKIT ligand0.043
HMGCL3-hydroxymethyl-3-methylglutaryl-CoA lyase0.040
C6complement component 60.039
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.039
GPLD1glycosylphosphatidylinositol specific phospholipase D10.038
VEGFCvascular endothelial growth factor C0.037
STAB1stabilin 10.036
CYP2A7cytochrome P450, family 2, subfamily A, polypeptide 70.036
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.035
ROBO4roundabout homolog 4, magic roundabout (Drosophila)0.035
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.034
ADH6alcohol dehydrogenase 6 (class V)0.033
LIPClipase, hepatic0.032
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.032
F2coagulation factor II (thrombin)0.032
NNMTnicotinamide N-methyltransferase0.032
F3coagulation factor III (thromboplastin, tissue factor)0.031
GAB1GRB2-associated binding protein 10.031
PRODH2proline dehydrogenase (oxidase) 20.030
PTK2BPTK2B protein tyrosine kinase 2 beta0.030
LATlinker for activation of T cells0.029
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.028
F10coagulation factor X0.028
GAB2GRB2-associated binding protein 20.028
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.845
Apoa1apolipoprotein A-I0.647
Itgb3integrin beta 30.551
Ptgs2prostaglandin-endoperoxide synthase 20.504
F2coagulation factor II0.403
ND6NADH dehydrogenase subunit 60.317
Kng1kininogen 10.274
Ceacam2carcinoembryonic antigen-related cell adhesion molecule 20.206
Ambpalpha 1 microglobulin/bikunin0.202
Asgr2asialoglycoprotein receptor 20.194
Nos1nitric oxide synthase 1, neuronal0.173
Ppargperoxisome proliferator activated receptor gamma0.167
Fggfibrinogen gamma chain0.166
Cficomplement component factor i0.139
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.126
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.125
Lgals3lectin, galactose binding, soluble 30.123
Saa4serum amyloid A 40.113
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.113
Fgbfibrinogen beta chain0.111
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.107
Pzppregnancy zone protein0.107
F12coagulation factor XII (Hageman factor)0.098
Vhlvon Hippel-Lindau tumor suppressor0.092
Fgafibrinogen alpha chain0.091
1300017J02RikRIKEN cDNA 1300017J02 gene0.091
Itih4inter alpha-trypsin inhibitor, heavy chain 40.089
Gcgrglucagon receptor0.086
Hchemolytic complement0.084
Itih1inter-alpha trypsin inhibitor, heavy chain 10.081
S100a11S100 calcium binding protein A11 (calgizzarin)0.081
F7coagulation factor VII0.075
Ilkintegrin linked kinase0.071
Apoa5apolipoprotein A-V0.065
Gcgroup specific component0.063
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.060
S100a10S100 calcium binding protein A10 (calpactin)0.058
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.058
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.054
Itgb1integrin beta 1 (fibronectin receptor beta)0.051
Hgdhomogentisate 1, 2-dioxygenase0.050
S100a6S100 calcium binding protein A6 (calcyclin)0.050
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.049
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.044
Igfbp1insulin-like growth factor binding protein 10.042
Apoa4apolipoprotein A-IV0.042
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.042
C9complement component 90.040
Anxa5annexin A50.040
Halhistidine ammonia lyase0.040
F10coagulation factor X0.040
Hamphepcidin antimicrobial peptide0.039
Lipclipase, hepatic0.039
Agxtalanine-glyoxylate aminotransferase0.038
Anxa4annexin A40.036
Notch2Notch gene homolog 2 (Drosophila)0.036
Plauplasminogen activator, urokinase0.036
Apoc4apolipoprotein C-IV0.035
Apomapolipoprotein M0.033
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.032
Cpn1carboxypeptidase N, polypeptide 10.032
Foxa3forkhead box A30.032
Anxa3annexin A30.031
Apofapolipoprotein F0.030
Mplmyeloproliferative leukemia virus oncogene0.030
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.029
Aldh8a1aldehyde dehydrogenase 8 family, member A10.029
Slc26a1solute carrier family 26 (sulfate transporter), member 10.029
Cd9CD9 antigen0.028
Hgfachepatocyte growth factor activator0.028
Cd5lCD5 antigen-like0.028
Inhbeinhibin beta E0.028
Masp2mannan-binding lectin serine peptidase 20.026
Gp1baglycoprotein 1b, alpha polypeptide0.026
Hnf4ahepatic nuclear factor 4, alpha0.026
Egfrepidermal growth factor receptor0.026
Gp9glycoprotein 9 (platelet)0.026
Trfr2transferrin receptor 20.025
Timd2T-cell immunoglobulin and mucin domain containing 20.025
Mat1amethionine adenosyltransferase I, alpha0.025
Ldb3LIM domain binding 30.024
Mbl2mannose-binding lectin (protein C) 20.024
Mbl1mannose-binding lectin (protein A) 10.024
Amdhd1amidohydrolase domain containing 10.024
Lmnalamin A0.023
Aqp9aquaporin 90.023
Gulogulonolactone (L-) oxidase0.023
Gckrglucokinase regulatory protein0.023
Prodh2proline dehydrogenase (oxidase) 20.023
Mug2murinoglobulin 20.022
Dmgdhdimethylglycine dehydrogenase precursor0.022
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.022
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.022
Psg21pregnancy-specific glycoprotein 210.021
Nos3nitric oxide synthase 3, endothelial cell0.021
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa5annexin A50.851
S100a6S100 calcium binding protein A60.458
Anxa2annexin A20.446
Anxa1annexin A10.326
AhnakAHNAK nucleoprotein0.294
Lgals3lectin, galactoside-binding, soluble, 30.200
Cd9CD9 molecule0.155
Pzppregnancy-zone protein0.154
Lmnalamin A0.103
S100a10S100 calcium binding protein A100.097
C1scomplement component 1, s subcomponent0.090
Cma1chymase 1, mast cell0.083
Ctsbcathepsin B0.066
Ifitm3interferon induced transmembrane protein 30.064
Cd151CD151 molecule (Raph blood group)0.061
Timp2TIMP metallopeptidase inhibitor 20.045
Agtr1aangiotensin II receptor, type 1a0.044
Gja1gap junction protein, alpha 10.040
S100a11S100 calcium binding protein A11 (calizzarin)0.033
Ctsl1cathepsin L10.031
Arpc1bactin related protein 2/3 complex, subunit 1B0.031
Mbl2mannose-binding lectin (protein C) 20.029
Krt5keratin 50.029
Haao3-hydroxyanthranilate 3,4-dioxygenase0.028
Pmp22peripheral myelin protein 220.025
Pnliprp2pancreatic lipase-related protein 20.024
Txnipthioredoxin interacting protein0.022
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.020
Mbl1mannose-binding lectin (protein A) 10.019
Anxa4annexin A40.019
Myadmmyeloid-associated differentiation marker0.018
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.017
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.017
Cnn3calponin 3, acidic0.016
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.016
Fabp1fatty acid binding protein 1, liver0.015
Clec4fC-type lectin domain family 4, member f0.015
Ucp1uncoupling protein 1 (mitochondrial, proton carrier)0.015
Procprotein C0.014
Olr1078olfactory receptor 10780.014
Aqp9aquaporin 90.013
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.013
Tpsab1tryptase alpha/beta 10.013
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.012
Apohapolipoprotein H (beta-2-glycoprotein I)0.012
Ctrcchymotrypsin C (caldecrin)0.012
Pgcpplasma glutamate carboxypeptidase0.011
Sod3superoxide dismutase 3, extracellular0.011
Ptger3prostaglandin E receptor 3 (subtype EP3)0.010
Csrp1cysteine and glycine-rich protein 10.010
Vamp3vesicle-associated membrane protein 30.010
Gcgroup specific component0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism