The network for 'modification of morphology or physiology of other organism involved in symbiotic interaction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

modification of morphology or physiology of other organism involved in symbiotic interaction

The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction.

NameDescriptionProbabilityFunc Analog Organism
SP1Sp1 transcription factor0.868
SMAD3SMAD family member 30.776
BCL2B-cell CLL/lymphoma 20.759
JUNjun proto-oncogene0.745
IL8interleukin 80.742
BCL2L1BCL2-like 10.741
RARAretinoic acid receptor, alpha0.691
SMAD2SMAD family member 20.645
CCR5chemokine (C-C motif) receptor 50.504
ARID1BAT rich interactive domain 1B (SWI1-like)0.360
CXCL3chemokine (C-X-C motif) ligand 30.298
RRAGCRas-related GTP binding C0.293
SMURF2SMAD specific E3 ubiquitin protein ligase 20.265
BCL2L11BCL2-like 11 (apoptosis facilitator)0.227
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.201
BAXBCL2-associated X protein0.182
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.168
CXCL2chemokine (C-X-C motif) ligand 20.166
SMAD7SMAD family member 70.143
SMAD4SMAD family member 40.137
EP300E1A binding protein p3000.120
KDM6Alysine (K)-specific demethylase 6A0.118
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.104
CCL2chemokine (C-C motif) ligand 20.102
ATF3activating transcription factor 30.101
FOSFBJ murine osteosarcoma viral oncogene homolog0.096
CAV1caveolin 1, caveolae protein, 22kDa0.095
CCL8chemokine (C-C motif) ligand 80.093
CXCL9chemokine (C-X-C motif) ligand 90.081
UTRNutrophin0.079
SOX10SRY (sex determining region Y)-box 100.077
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.077
PAX3paired box 30.076
DPP4dipeptidyl-peptidase 40.075
IL1Binterleukin 1, beta0.070
SMAD1SMAD family member 10.068
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.068
SMAD5SMAD family member 50.067
IL6interleukin 6 (interferon, beta 2)0.067
SKILSKI-like oncogene0.065
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.065
ICAM1intercellular adhesion molecule 10.063
CXCL5chemokine (C-X-C motif) ligand 50.063
NCOA1nuclear receptor coactivator 10.061
FOXD3forkhead box D30.060
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.060
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.057
DMDdystrophin0.056
CREBBPCREB binding protein0.055
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.054
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.054
SOX2SRY (sex determining region Y)-box 20.053
CCL4chemokine (C-C motif) ligand 40.052
BAK1BCL2-antagonist/killer 10.050
WWP2WW domain containing E3 ubiquitin protein ligase 20.050
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.049
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.048
HDAC1histone deacetylase 10.042
HMGA1high mobility group AT-hook 10.041
CCL22chemokine (C-C motif) ligand 220.040
CCL13chemokine (C-C motif) ligand 130.040
HIPK2homeodomain interacting protein kinase 20.040
CCR7chemokine (C-C motif) receptor 70.040
CXCL10chemokine (C-X-C motif) ligand 100.039
ESR1estrogen receptor 10.039
CCL7chemokine (C-C motif) ligand 70.038
RBBP4retinoblastoma binding protein 40.038
LAMTOR1late endosomal/lysosomal adaptor, MAPK and MTOR activator 10.037
BADBCL2-associated agonist of cell death0.035
TNFtumor necrosis factor0.033
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.032
CCL20chemokine (C-C motif) ligand 200.032
BIDBH3 interacting domain death agonist0.032
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.032
OCIAD1OCIA domain containing 10.031
CCL3chemokine (C-C motif) ligand 30.031
ATF2activating transcription factor 20.031
CXCL11chemokine (C-X-C motif) ligand 110.031
IGF1Rinsulin-like growth factor 1 receptor0.029
FAM46Afamily with sequence similarity 46, member A0.029
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.029
RNF11ring finger protein 110.029
TBPTATA box binding protein0.028
RRAGDRas-related GTP binding D0.028
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.027
RAB6ARAB6A, member RAS oncogene family0.027
MAGEB18melanoma antigen family B, 180.027
PROX1prospero homeobox 10.026
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.026
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.026
MMP12matrix metallopeptidase 12 (macrophage elastase)0.025
KCTD17potassium channel tetramerisation domain containing 170.025
TNFRSF9tumor necrosis factor receptor superfamily, member 90.025
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.025
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.025
ENGendoglin0.024
TGFBR1transforming growth factor, beta receptor 10.024
IL1RNinterleukin 1 receptor antagonist0.024
NR0B2nuclear receptor subfamily 0, group B, member 20.024
RNR2l-rRNA0.023
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
lamc1laminin, gamma 10.178
tp53tumor protein p530.165
insrbinsulin receptor b0.128
wlswntless homolog (Drosophila)0.119
axin1axin 10.103
LOC567131calcitonin gene-related peptide type 1 receptor-like0.092
mibmind bomb0.089
rnd1lRho family GTPase 1 like0.080
tgfbr2transforming growth factor, beta receptor II0.074
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.073
mmp13amatrix metalloproteinase 13a0.067
mcl1amyeloid cell leukemia sequence 1a0.062
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.061
hsp90a.1heat shock protein 90-alpha 10.057
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.055
junbljun B proto-oncogene, like0.054
epas1bendothelial PAS domain protein 1b0.054
kdrlkinase insert domain receptor like0.052
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.052
mcl1bmyeloid cell leukemia sequence 1b0.051
mychmyelocytomatosis oncogene homolog0.051
rargaretinoic acid receptor gamma a0.049
tcf12transcription factor 120.048
zgc:77366zgc:773660.048
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.046
rereaarginine-glutamic acid dipeptide (RE) repeats a0.045
ext1bexostoses (multiple) 1b0.044
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.043
lama1laminin, alpha 10.043
vangl2vang-like 2 (van gogh, Drosophila)0.043
faddFas (tnfrsf6)-associated via death domain0.040
ldb1aLIM-domain binding factor 1a0.040
bmp1abone morphogenetic protein 1a0.040
cops3COP9 constitutive photomorphogenic homolog subunit 30.040
gcm2glial cells missing homolog 2 (Drosophila)0.040
arntl1baryl hydrocarbon receptor nuclear translocator-like 1b0.039
LOC566020Gig2-like protein DreO0.039
baxabcl2-associated X protein, a0.039
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.038
prpf8pre-mRNA processing factor 80.037
cyp2aa1cytochrome P450, family 2, subfamily AA, polypeptide 10.037
spry4sprouty (Drosophila) homolog 40.037
ilf3binterleukin enhancer binding factor 3b0.037
hhiphedgehog interacting protein0.037
trim13tripartite motif-containing 130.036
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.036
atp2b4ATPase, Ca++ transporting, plasma membrane 40.036
cxcr4bchemokine (C-X-C motif), receptor 4b0.035
bcl2B-cell leukemia/lymphoma 20.033
sulf1sulfatase 10.033
slc2a11lsolute carrier family 2 (facilitated glucose transporter), member 11-like0.033
ewsr1aEwing sarcoma breakpoint region 1a0.032
gdf6agrowth differentiation factor 6a0.032
smad3aMAD homolog 3a (Drosophila)0.032
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.032
snrnp70small nuclear ribonucleoprotein 70 (U1)0.031
tgfb2transforming growth factor, beta 20.031
tp53bp2tumor protein p53 binding protein, 20.031
cecr1acat eye syndrome chromosome region, candidate 1a0.030
disp1dispatched homolog 1 (Drosophila)0.030
cflarCASP8 and FADD-like apoptosis regulator0.030
acsl1acyl-CoA synthetase long-chain family member 10.030
ptpraprotein tyrosine phosphatase, receptor type, A0.030
casp9caspase 9, apoptosis-related cysteine protease0.029
grk5G protein-coupled receptor kinase 50.029
clock3clock homolog 3 (mouse)0.029
mical3flavoprotein oxidoreductase MICAL30.028
pcsk5bproprotein convertase subtilisin/kexin type 5b0.028
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.028
crygm6crystallin, gamma M60.028
mef2dmyocyte enhancer factor 2d0.028
rhogbras homolog gene family, member Gb0.028
ifnphi1interferon phi 10.028
cirbpcold inducible RNA binding protein0.028
pbx4pre-B-cell leukemia transcription factor 40.027
cdh23cadherin-like 230.027
snrk1SNF related kinase 10.027
spry2sprouty homolog 20.027
nfe2l2nuclear factor (erythroid-derived 2)-like 20.027
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.027
kctd15apotassium channel tetramerisation domain containing 15a0.027
tfip11tuftelin interacting protein 110.027
zgc:56306zgc:563060.026
dedd1death effector domain-containing 10.026
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.025
col12a1collagen, type XII, alpha 10.025
si:dkey-12o15.1si:dkey-12o15.10.025
furinbfurin (paired basic amino acid cleaving enzyme) b0.025
mycamyelocytomatosis oncogene a0.025
irgq1immunity-related GTPase family, q10.025
ing5inhibitor of growth family, member 5a0.025
tfe3atranscription factor binding to IGHM enhancer 3a0.024
stat3signal transduction and activation of transcription 30.024
ripk2receptor-interacting serine-threonine kinase 20.024
dmddystrophin0.024
lama2laminin, alpha 20.024
atf3activating transcription factor 30.024
hdac4histone deacetylase 40.024
scarb1scavenger receptor class B, member 10.024
vdravitamin D receptor a0.024
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ccl2chemokine (C-C motif) ligand 20.974
Ccr2chemokine (C-C motif) receptor 20.937
Il10interleukin 100.794
Trp53transformation related protein 530.788
Cd44CD44 antigen0.750
Nos2nitric oxide synthase 2, inducible0.741
Ifnginterferon gamma0.619
Tlr4toll-like receptor 40.591
Leprleptin receptor0.493
Csf1colony stimulating factor 1 (macrophage)0.413
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.408
Mpomyeloperoxidase0.390
Bcl2B-cell leukemia/lymphoma 20.376
Ccl3chemokine (C-C motif) ligand 30.366
Il6interleukin 60.349
Vdrvitamin D receptor0.322
Mmp9matrix metallopeptidase 90.318
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.311
Ngpneutrophilic granule protein0.291
S100a8S100 calcium binding protein A8 (calgranulin A)0.255
Ctsgcathepsin G0.252
Tnfaip3tumor necrosis factor, alpha-induced protein 30.226
Cxcl2chemokine (C-X-C motif) ligand 20.221
Ptgs2prostaglandin-endoperoxide synthase 20.206
Irg1immunoresponsive gene 10.150
Col1a1collagen, type I, alpha 10.147
Ccl4chemokine (C-C motif) ligand 40.143
FosFBJ osteosarcoma oncogene0.135
Tcf7transcription factor 7, T-cell specific0.128
Cpa3carboxypeptidase A3, mast cell0.126
Tlr2toll-like receptor 20.122
Ppargperoxisome proliferator activated receptor gamma0.119
Esr1estrogen receptor 1 (alpha)0.117
Atf3activating transcription factor 30.116
Spp1secreted phosphoprotein 10.115
Vav2vav 2 oncogene0.108
Aoahacyloxyacyl hydrolase0.103
Hdac2histone deacetylase 20.102
LOC100504404h-2 class II histocompatibility antigen, E-K alpha chain-like0.102
Lmnalamin A0.098
Arid1aAT rich interactive domain 1A (SWI-like)0.097
Selpselectin, platelet0.093
Mmp8matrix metallopeptidase 80.089
Campcathelicidin antimicrobial peptide0.089
Ldlrlow density lipoprotein receptor0.086
Htthuntingtin0.079
Ccl7chemokine (C-C motif) ligand 70.076
Akr1c6aldo-keto reductase family 1, member C60.075
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.073
Elaneelastase, neutrophil expressed0.070
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.069
Ccr5chemokine (C-C motif) receptor 50.069
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.068
Sfpi1SFFV proviral integration 10.067
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.066
Fgfr2fibroblast growth factor receptor 20.064
Nos1nitric oxide synthase 1, neuronal0.064
Cd8aCD8 antigen, alpha chain0.063
Aprtadenine phosphoribosyl transferase0.062
Tnfaip2tumor necrosis factor, alpha-induced protein 20.062
Dusp1dual specificity phosphatase 10.061
FaslFas ligand (TNF superfamily, member 6)0.061
Fcgr1Fc receptor, IgG, high affinity I0.060
Ccr1chemokine (C-C motif) receptor 10.059
Gfi1bgrowth factor independent 1B0.059
Sin3atranscriptional regulator, SIN3A (yeast)0.059
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.059
Sp1trans-acting transcription factor 10.059
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.057
Prg2proteoglycan 2, bone marrow0.054
Stat3signal transducer and activator of transcription 30.053
Omt2boocyte maturation, beta0.053
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.053
Tgfbr2transforming growth factor, beta receptor II0.053
Socs1suppressor of cytokine signaling 10.053
Sp3trans-acting transcription factor 30.052
Myd88myeloid differentiation primary response gene 880.052
Gzmagranzyme A0.052
Klra9killer cell lectin-like receptor subfamily A, member 90.051
Tbx21T-box 210.049
Niacr1niacin receptor 10.047
Nfe2l2nuclear factor, erythroid derived 2, like 20.045
Apoeapolipoprotein E0.043
Irf1interferon regulatory factor 10.043
Lepleptin0.043
Gypaglycophorin A0.042
Ccr3chemokine (C-C motif) receptor 30.042
Ccl8chemokine (C-C motif) ligand 80.042
Cma2chymase 2, mast cell0.042
Ubdubiquitin D0.042
Mapk3mitogen-activated protein kinase 30.041
Mplmyeloproliferative leukemia virus oncogene0.041
Mcpt4mast cell protease 40.041
Ccl12chemokine (C-C motif) ligand 120.040
Cxcl10chemokine (C-X-C motif) ligand 100.038
Mmp13matrix metallopeptidase 130.038
H2-M9histocompatibility 2, M region locus 90.038
Trp73transformation related protein 730.038
Il1rninterleukin 1 receptor antagonist0.037
Lyz2lysozyme 20.037
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism